LOCUS AF095745 2970 bp mRNA linear HUM 25-APR-2001 DEFINITION Homo sapiens ubiquitin protein ligase ITCH mRNA, complete cds. ACCESSION AF095745 VERSION AF095745.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2970) AUTHORS Chen,X., Wen,S., Fukuda,M.N., Gavva,N.R., Hsu,D., Akama,T.O., Yang-Feng,T. and Shen,C.K. TITLE Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2 JOURNAL Genomics 73 (2), 238-241 (2001) PUBMED 11318614 REFERENCE 2 (bases 1 to 2970) AUTHORS Chen,X. and Shen,C.K.J. TITLE Direct Submission JOURNAL Submitted (28-SEP-1998) Molecular and Cellular Biology, UC Davis, 149 Briggs Hall, Davis, CA 95616, USA FEATURES Location/Qualifiers source 1..2970 /db_xref="H-InvDB:HIT000068443" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="20" /map="20q11.22-q11.23" /cell_line="K562" CDS 7..2595 /note="contains one C2 domain, four WW domains and one HECT domain; similar to mouse ITCH" /codon_start=1 /product="ubiquitin protein ligase ITCH" /protein_id="AAK39399.1" /translation="MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVE VTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDI YETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESA SQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRP PPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGP RPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIY YVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKE FDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVD GIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIK ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNP MYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYK RILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPN GGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPV GGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET EGFGQE" BASE COUNT 941 a 574 c 653 g 802 t ORIGIN 1 ggtggtatgt ctgacagtgg atcacaactt ggttcaatgg gtagcctcac catgaaatca 61 cagcttcaga tcactgtcat ctcagcaaaa cttaaggaaa ataagaagaa ttggtttgga 121 ccaagtcctt acgtagaggt cacagtagat ggacagtcaa agaagacaga aaaatgcaac 181 aacacaaaca gtcccaagtg gaagcaaccc cttacagtta tcgttacccc tgtgagtaaa 241 ttacattttc gtgtgtggag tcaccagaca ctgaaatctg atgttttgtt gggaactgct 301 gcattagata tttatgaaac attaaagtca aacaatatga aacttgaaga agtagttgtg 361 actttgcagc ttggaggtga caaagagcca acagagacaa taggagactt gtcaatttgt 421 cttgatgggc tacagttaga gtctgaagtt gttaccaatg gtgaaactac atgttcagaa 481 agtgcttctc agaatgatga tggctccaga tccaaggatg aaacaagagt gagcacaaat 541 ggatcagatg accctgaaga tgcaggagct ggtgaaaata ggagagtcag tgggaataat 601 tctccatcac tctcaaatgg tggttttaaa ccttctagac ctccaagacc ttcacgacca 661 ccaccaccca ccccacgtag accagcatct gtcaatggtt caccatctgc cacttctgaa 721 agtgatgggt ctagtacagg ctctctgccg ccgacaaata caaatacaaa tacatctgaa 781 ggagcaacat ctggattaat aattcctctt actatatctg gaggctcagg ccctaggcca 841 ttaaatcctg taactcaagc tcccttgcca cctggttggg agcagagagt ggaccagcac 901 gggcgagttt actatgtaga tcatgttgag aaaagaacaa catgggatag accagaacct 961 ctacctcctg gctgggaacg gcgggttgac aacatgggac gtatttatta tgttgaccat 1021 ttcacaagaa caacaacgtg gcagaggcca acactggaat ccgtccggaa ctatgaacaa 1081 tggcagctac agcgtagtca gcttcaagga gcaatgcagc agtttaacca gagattcatt 1141 tatgggaatc aagatttatt tgctacatca caaagtaaag aatttgatcc tcttggtcca 1201 ttgccacctg gatgggagaa gagaacagac agcaatggca gagtatattt cgtcaaccac 1261 aacacacgaa ttacacaatg ggaagacccc agaagtcaag gtcaattaaa tgaaaagccc 1321 ttacctgaag gttgggaaat gagattcaca gtggatggaa ttccatattt tgtggaccac 1381 aatagaagaa ctaccaccta tatagatccc cgcacaggaa aatctgccct agacaatgga 1441 cctcagatag cctatgttcg ggacttcaaa gcaaaggttc agtatttccg gttctggtgt 1501 cagcaactgg ccatgccaca gcacataaag attacagtga caagaaaaac attgtttgag 1561 gattcctttc aacagataat gagcttcagt ccccaagatc tgcgaagacg tttgtgggtg 1621 atttttccag gagaagaagg tttagattat ggaggtgtag caagagaatg gttctttctt 1681 ttgtcacatg aagtgttgaa cccaatgtat tgcctgtttg aatatgcagg gaaggataac 1741 tactgcttgc agataaaccc cgcttcttac atcaatccag atcacctgaa atattttcgt 1801 tttattggca gatttattgc catggctctg ttccatggga aattcataga cacgggtttt 1861 tctttaccat tctataagcg tatcttgaac aaaccagttg gactcaagga tttagaatct 1921 attgatccag aattttacaa ttctctcatc tgggttaagg aaaacaatat tgaggaatgt 1981 gatttggaaa tgtacttctc cgttgacaaa gaaattctag gtgaaattaa gagtcatgat 2041 ctgaaaccta atggtggcaa tattcttgta acagaagaaa ataaagagga atacatcaga 2101 atggtagctg agtggaggtt gtctcgaggt gttgaagaac agacacaagc tttctttgaa 2161 ggctttaatg aaattcttcc ccagcaatat ttgcaatact ttgatgcaaa ggaattagag 2221 gtccttttat gtggaatgca agagattgat ttgaatgact ggcaaagaca tgccatctac 2281 cgtcattatg caaggaccag caaacaaatc atgtggtttt ggcagtttgt taaagaaatt 2341 gataatgaga agagaatgag acttctgcag tttgttactg gaacctgccg attgccagta 2401 ggaggatttg ctgatctcat ggggagcaat ggaccacaga aattctgcat tgaaaaagtt 2461 gggaaagaaa attggctacc cagaagtcat acctgtttta atcgcctgga cctgccacca 2521 tacaagagct atgagcaact gaaggaaaag ctgttgtttg ccatagaaga aacagaagga 2581 tttggacaag agtaacttct gagaacttgc accatgaatg ggcaagaact tatttgcaat 2641 gtttgtcctt ctctgcctgt tgcacatctt gtaaaattgg acaatggctc tttagagagt 2701 tatctgagtg taagtaaatt aatgttctca tttagattta tctcccagtg atttctactc 2761 agcgtttcca gaaatcaggt ctgcaaatga ctagtcagaa ccttgcataa catgagattt 2821 taacacaaca atgaaatttg ccttgtctta ttccactagt ttattccttt aacaacaata 2881 ttttatatgt gtcaaaagtc ccacttggga gtagtgtttt tttcttttag acattctgca 2941 gacatgcagg gaagtccttt ggtaactgca //