LOCUS       AF095745                2970 bp    mRNA    linear   HUM 25-APR-2001
DEFINITION  Homo sapiens ubiquitin protein ligase ITCH mRNA, complete cds.
ACCESSION   AF095745
VERSION     AF095745.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Chen,X., Wen,S., Fukuda,M.N., Gavva,N.R., Hsu,D., Akama,T.O.,
            Yang-Feng,T. and Shen,C.K.
  TITLE     Human ITCH is a coregulator of the hematopoietic transcription
            factor NF-E2
  JOURNAL   Genomics 73 (2), 238-241 (2001)
   PUBMED   11318614
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Chen,X. and Shen,C.K.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-SEP-1998) Molecular and Cellular Biology, UC Davis,
            149 Briggs Hall, Davis, CA 95616, USA
FEATURES             Location/Qualifiers
     source          1..2970
                     /db_xref="H-InvDB:HIT000068443"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22-q11.23"
                     /cell_line="K562"
     CDS             7..2595
                     /note="contains one C2 domain, four WW domains and one
                     HECT domain; similar to mouse ITCH"
                     /codon_start=1
                     /product="ubiquitin protein ligase ITCH"
                     /protein_id="AAK39399.1"
                     /translation="MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVE
                     VTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDI
                     YETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESA
                     SQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRP
                     PPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGP
                     RPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIY
                     YVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKE
                     FDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVD
                     GIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIK
                     ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNP
                     MYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYK
                     RILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPN
                     GGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL
                     LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPV
                     GGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET
                     EGFGQE"
BASE COUNT          941 a          574 c          653 g          802 t
ORIGIN      
        1 ggtggtatgt ctgacagtgg atcacaactt ggttcaatgg gtagcctcac catgaaatca
       61 cagcttcaga tcactgtcat ctcagcaaaa cttaaggaaa ataagaagaa ttggtttgga
      121 ccaagtcctt acgtagaggt cacagtagat ggacagtcaa agaagacaga aaaatgcaac
      181 aacacaaaca gtcccaagtg gaagcaaccc cttacagtta tcgttacccc tgtgagtaaa
      241 ttacattttc gtgtgtggag tcaccagaca ctgaaatctg atgttttgtt gggaactgct
      301 gcattagata tttatgaaac attaaagtca aacaatatga aacttgaaga agtagttgtg
      361 actttgcagc ttggaggtga caaagagcca acagagacaa taggagactt gtcaatttgt
      421 cttgatgggc tacagttaga gtctgaagtt gttaccaatg gtgaaactac atgttcagaa
      481 agtgcttctc agaatgatga tggctccaga tccaaggatg aaacaagagt gagcacaaat
      541 ggatcagatg accctgaaga tgcaggagct ggtgaaaata ggagagtcag tgggaataat
      601 tctccatcac tctcaaatgg tggttttaaa ccttctagac ctccaagacc ttcacgacca
      661 ccaccaccca ccccacgtag accagcatct gtcaatggtt caccatctgc cacttctgaa
      721 agtgatgggt ctagtacagg ctctctgccg ccgacaaata caaatacaaa tacatctgaa
      781 ggagcaacat ctggattaat aattcctctt actatatctg gaggctcagg ccctaggcca
      841 ttaaatcctg taactcaagc tcccttgcca cctggttggg agcagagagt ggaccagcac
      901 gggcgagttt actatgtaga tcatgttgag aaaagaacaa catgggatag accagaacct
      961 ctacctcctg gctgggaacg gcgggttgac aacatgggac gtatttatta tgttgaccat
     1021 ttcacaagaa caacaacgtg gcagaggcca acactggaat ccgtccggaa ctatgaacaa
     1081 tggcagctac agcgtagtca gcttcaagga gcaatgcagc agtttaacca gagattcatt
     1141 tatgggaatc aagatttatt tgctacatca caaagtaaag aatttgatcc tcttggtcca
     1201 ttgccacctg gatgggagaa gagaacagac agcaatggca gagtatattt cgtcaaccac
     1261 aacacacgaa ttacacaatg ggaagacccc agaagtcaag gtcaattaaa tgaaaagccc
     1321 ttacctgaag gttgggaaat gagattcaca gtggatggaa ttccatattt tgtggaccac
     1381 aatagaagaa ctaccaccta tatagatccc cgcacaggaa aatctgccct agacaatgga
     1441 cctcagatag cctatgttcg ggacttcaaa gcaaaggttc agtatttccg gttctggtgt
     1501 cagcaactgg ccatgccaca gcacataaag attacagtga caagaaaaac attgtttgag
     1561 gattcctttc aacagataat gagcttcagt ccccaagatc tgcgaagacg tttgtgggtg
     1621 atttttccag gagaagaagg tttagattat ggaggtgtag caagagaatg gttctttctt
     1681 ttgtcacatg aagtgttgaa cccaatgtat tgcctgtttg aatatgcagg gaaggataac
     1741 tactgcttgc agataaaccc cgcttcttac atcaatccag atcacctgaa atattttcgt
     1801 tttattggca gatttattgc catggctctg ttccatggga aattcataga cacgggtttt
     1861 tctttaccat tctataagcg tatcttgaac aaaccagttg gactcaagga tttagaatct
     1921 attgatccag aattttacaa ttctctcatc tgggttaagg aaaacaatat tgaggaatgt
     1981 gatttggaaa tgtacttctc cgttgacaaa gaaattctag gtgaaattaa gagtcatgat
     2041 ctgaaaccta atggtggcaa tattcttgta acagaagaaa ataaagagga atacatcaga
     2101 atggtagctg agtggaggtt gtctcgaggt gttgaagaac agacacaagc tttctttgaa
     2161 ggctttaatg aaattcttcc ccagcaatat ttgcaatact ttgatgcaaa ggaattagag
     2221 gtccttttat gtggaatgca agagattgat ttgaatgact ggcaaagaca tgccatctac
     2281 cgtcattatg caaggaccag caaacaaatc atgtggtttt ggcagtttgt taaagaaatt
     2341 gataatgaga agagaatgag acttctgcag tttgttactg gaacctgccg attgccagta
     2401 ggaggatttg ctgatctcat ggggagcaat ggaccacaga aattctgcat tgaaaaagtt
     2461 gggaaagaaa attggctacc cagaagtcat acctgtttta atcgcctgga cctgccacca
     2521 tacaagagct atgagcaact gaaggaaaag ctgttgtttg ccatagaaga aacagaagga
     2581 tttggacaag agtaacttct gagaacttgc accatgaatg ggcaagaact tatttgcaat
     2641 gtttgtcctt ctctgcctgt tgcacatctt gtaaaattgg acaatggctc tttagagagt
     2701 tatctgagtg taagtaaatt aatgttctca tttagattta tctcccagtg atttctactc
     2761 agcgtttcca gaaatcaggt ctgcaaatga ctagtcagaa ccttgcataa catgagattt
     2821 taacacaaca atgaaatttg ccttgtctta ttccactagt ttattccttt aacaacaata
     2881 ttttatatgt gtcaaaagtc ccacttggga gtagtgtttt tttcttttag acattctgca
     2941 gacatgcagg gaagtccttt ggtaactgca
//