LOCUS AF095714 1856 bp mRNA linear HUM 31-JUL-1999
DEFINITION Homo sapiens silencing information regulator 2-like protein (SIR2L)
mRNA, complete cds.
ACCESSION AF095714
VERSION AF095714.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1856)
AUTHORS Afshar,G. and Murnane,J.P.
TITLE Characterization of a human gene with sequence homology to
Saccharomyces cerevisiae SIR2
JOURNAL Gene 234 (1), 161-168 (1999)
PUBMED 10393250
REFERENCE 2 (bases 1 to 1856)
AUTHORS Afshar,G. and Murnane,J.P.
TITLE Direct Submission
JOURNAL Submitted (29-SEP-1998) Radiation Oncology Research Laboratories,
University of California at San Francisco, 1855 Folsom Street, San
Francisco, CA 94143-0806, USA
FEATURES Location/Qualifiers
source 1..1856
/db_xref="H-InvDB:HIT000068435"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="ATCC:355619"
/db_xref="taxon:9606"
/clone="ATCC 355619"
gene 1..1856
/gene="SIR2L"
CDS 185..1243
/gene="SIR2L"
/note="similar to Saccharomyces cerevisiae SIR2; similar
to sequences presented in GenBank Accession Numbers R05448
and R05553 and in Brachmann et al. 1995, Genes Dev 9:
2888-2902"
/codon_start=1
/product="silencing information regulator 2-like protein"
/protein_id="AAD45971.1"
/translation="MDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVIC
LVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELY
PGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVS
ASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVD
LLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKK
AYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKK
SPPPAKDEARTTEREKPQ"
BASE COUNT 429 a 579 c 504 g 344 t
ORIGIN
1 ggccactagg cacgggacag agcagtcggt gacaggacag agcagtcggt gacgggacac
61 agtggttggt gacgggacag agcggtcggt gacagcctca agggcttcag caccgcgccc
121 atggcagagc cagaccgact cagattcaga ctctgaggga ggagccgctg gtggagaagc
181 agacatggac ttcctgcgga acttattctc ccagacgctc agcctgggca gccagaagga
241 gcgtctgctg gacgagctga ccttggaagg ggtggcccgg tacatgcaga gcgaacgctg
301 tcgcagagtc atctgtttgg tgggagctgg aatctccaca tccgcaggca tccccgactt
361 tcgctctcca tccaccggcc tctatgacaa cctagagaag taccatcttc cctacccaga
421 ggccatcttt gagatcagct atttcaagaa acatccggaa cccttcttcg ccctcgccaa
481 ggaactctat cctgggcagt tcaagccaac catctgtcac tacttcatgc gcctgctgaa
541 ggacaagggg ctactcctgc gctgctacac gcagaacata gataccctgg agcgaatagc
601 cgggctggaa caggaggact tggtggaggc gcacggcacc ttctacacat cacactgcgt
661 cagcgccagc tgccggcacg aatacccgct aagctggatg aaagagaaga tcttctctga
721 ggtgacgccc aagtgtgaag actgtcagag cctggtgaag cctgatatcg tcttttttgg
781 tgagagcctc ccagcgcgtt tcttctcctg tatgcagtca gacttcctga aggtggacct
841 cctcctggtc atgggtacct ccttgcaggt gcagcccttt gcctccctca tcagcaaggc
901 acccctctcc acccctcgcc tgctcatcaa caaggagaaa gctggccagt cggacccttt
961 cctggggatg attatgggcc tcggaggagg catggacttt gactccaaga aggcctacag
1021 ggacgtggcc tggctgggtg aatgcgacca gggctgcctg gcccttgctg agctccttgg
1081 atggaagaag gagctggagg accttgtccg gagggagcac gccagcatag atgcccagtc
1141 gggggcgggg gtccccaacc ccagcacttc agcttccccc aagaagtccc cgccacctgc
1201 caaggacgag gccaggacaa cagagaggga gaaaccccag tgacagctgc atctcccagg
1261 cgggatgccg agctcctcag ggacagctga gccccaaccg ggcctggccc cctcttaacc
1321 agcagttctt gtctggggag ctcagaacat cccccaatct cttacagctc cctccccaaa
1381 actggggtcc cagcaaccct ggcccccaac cccagcaaat ctctaacacc tcctagaggc
1441 caaggcttaa acaggcatct ctaccagccc cactgtctct aaccactcct gggctaagga
1501 gtaacctccc tcatctctaa ctgcccccac ggggccaggg ctaccccaga acttttaact
1561 cttccaggac aggggagctt cgggccccca ctctgtctcc tgcccctggg ggcctgtggc
1621 taagtaaacc atacctaacc taccccagtg tgggtgtggg cctctgaata taaccccaca
1681 cccagcgtag ggggagtctg agccgggagg gctcccgagt ctctgccttc agctcccaaa
1741 gtgggtggtg ggcccccttc acgtgggacc cacttcccat gctggatggg cagaagacat
1801 tgcttattgg agacaaatta aaaacaaaaa caactaacaa aaaaaaaaaa aaaaaa
//