LOCUS AF094480 2138 bp mRNA linear HUM 29-JUN-1999
DEFINITION Homo sapiens cholesterol 24-hydroxylase mRNA, complete cds.
ACCESSION AF094480
VERSION AF094480.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2138)
AUTHORS Lund,E.G., Guileyardo,J.M. and Russell,D.W.
TITLE cDNA cloning of cholesterol 24-hydroxylase, a mediator of
cholesterol homeostasis in the brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (13), 7238-7243 (1999)
PUBMED 10377398
REFERENCE 2 (bases 1 to 2138)
AUTHORS Lund,E.G. and Russell,D.W.
TITLE Direct Submission
JOURNAL Submitted (23-SEP-1998) Department of Molecular Genetics,
University of Texas Southwestern Medical Center at Dallas, 5323
Harry Hines Boulevard, Dallas, TX 75235-9046, USA
FEATURES Location/Qualifiers
source 1..2138
/db_xref="H-InvDB:HIT000068405"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q32.1"
/tissue_type="brain"
/clone_lib="Stratagene library, Cat number 936206"
/dev_stage="fetus"
CDS 1..1503
/note="neuronal cytochrome P450"
/codon_start=1
/product="cholesterol 24-hydroxylase"
/protein_id="AAD41244.1"
/translation="MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLG
HLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKY
NKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEK
AEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM
LEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL
TQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE
VIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL
FSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVV
MAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC"
BASE COUNT 451 a 686 c 588 g 413 t
ORIGIN
1 atgagccccg ggctgctgct gctcggcagc gccgtcctgc tcgccttcgg cctctgctgc
61 accttcgtgc accgcgctcg cagccgctac gagcacatcc ccgggccgcc gcggcccagt
121 ttccttctag gacacctccc ctgcttttgg aaaaaggatg aggttggtgg ccgtgtgctc
181 caagatgtgt ttttggattg ggctaagaag tatggacctg ttgtgcgggt caacgtcttc
241 cacaaaacct cagtcatcgt cacgagtcct gagtcggtta agaagttcct gatgtcaacc
301 aagtacaaca aggactccaa gatgtaccgt gcgctccaga ctgtgtttgg tgagagactc
361 ttcggccaag gcttggtgtc cgaatgcaac tatgagcgct ggcacaagca gcggagagtc
421 atagacctgg ccttcagccg gagctccttg gttagcttaa tggaaacatt caacgagaag
481 gctgagcagc tggtggagat tctagaagcc aaggcagatg ggcagacccc agtgtccatg
541 caggacatgc tgacctacac cgccatggac atcctggcca aggcagcttt tgggatggag
601 accagtatgc tgctgggtgc ccagaagcct ctgtcccagg cagtgaaact tatgttggag
661 ggaatcactg cgtcccgcaa cactctggca aagttcctgc cagggaagag gaagcagctc
721 cgggaggtcc gggagagcat tcgcttcctg cgccaggtgg gcagggactg ggtccagcgc
781 cgccgggaag ccctgaagag gggcgaggag gttcctgccg acatcctcac acagattctg
841 aaagctgaag agggagccca ggacgacgag ggtctgctgg acaacttcgt caccttcttc
901 attgctggtc acgagacctc tgccaaccac ttggcgttca cagtgatgga gctgtctcgc
961 cagccagaga tcgtggcaag gctgcaggcc gaggtggatg aggtcattgg ttctaagagg
1021 tacctggatt tcgaggacct ggggagactg cagtacctgt cccaggtcct caaagagtcg
1081 ctgaggctgt acccaccagc atggggcacc tttcgcctgc tggaagagga gaccttgatt
1141 gatggggtca gagtccccgg caacaccccg ctcttgttca gcacctatgt catggggcgg
1201 atggacacat actttgagga cccgctgact ttcaaccccg atcgcttcgg ccctggagca
1261 cccaagccac ggttcaccta cttccccttc tccctgggcc accgctcctg catcgggcag
1321 cagtttgctc agatggaggt gaaggtggtc atggcaaagc tgctgcagag gctggagttc
1381 cggctggtgc ccgggcagcg cttcgggctg caggagcagg ccacactcaa gccactggac
1441 cccgtgctgt gcaccctgcg gccccgcggc tggcagcccg cacccccacc acccccctgc
1501 tgagggggcc tccaggcagg acgagactcc tcgggcaagg gccgtgcccg cccacctctg
1561 ctgcccacgg ccacccaccc ttctcccctg ccccgtcccc tgggccaccc ttcacgctgg
1621 cttccagcgg gccctctgcc gaccgcctgc ttcacacccc tcagcgctcc ctgtcgcctg
1681 cggactccat ggcccttcct ggactggccc ttgcccaact cccagccacc accactgtcc
1741 ctaccactga gcccttgcac aggccacttg ctcagacgag acaccctaac tcttgctcac
1801 tccctaaagc cctcttcagg ggtcacctcc tccaagaagc cctccttgcc accccccgcc
1861 ggcaggggcc cctcctctgt gctccctcgg tcacctgtgc tacctctaac accacactga
1921 ccacactgta tcgtgagtgt ccgttgacgt gaccaattgc cctgccaggc tgtcagcgcc
1981 tcaagggtag ggtctgcgtg tgatttgtct ctgagccccc tgtgcccacc cagggcccgg
2041 cacagagtcg atgctcaata aatgtgtgtt gactgcaaaa aaaaaaaaaa aaaaaaaaaa
2101 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//