LOCUS AF092565 7239 bp mRNA linear HUM 05-FEB-2001
DEFINITION Homo sapiens splicing factor Prp8 mRNA, complete cds.
ACCESSION AF092565
VERSION AF092565.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7239)
AUTHORS Luo,H.R., Moreau,G.A., Levin,N. and Moore,M.J.
TITLE The human Prp8 protein is a component of both U2- and U12-dependent
spliceosomes
JOURNAL RNA 5 (7), 893-908 (1999)
PUBMED 10411133
REFERENCE 2 (bases 1 to 7239)
AUTHORS Luo,H.R., Moreau,G.A., Levin,N. and Moore,M.J.
TITLE Direct Submission
JOURNAL Submitted (16-SEP-1998) Biochemistry, Brandeis University, Waltham,
MA 02254, USA
FEATURES Location/Qualifiers
source 1..7239
/db_xref="H-InvDB:HIT000068368"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 39..7046
/codon_start=1
/product="splicing factor Prp8"
/protein_id="AAC61776.1"
/translation="MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKR
YAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKL
LENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRH
FKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRK
YVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGG
PKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHT
PNVVFIKTEDPDLPAFYFDPLINPISHRHSVKSQEPLPDDDEEFELPEFVEPFLKDTP
LYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKL
LKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLI
HRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRL
GNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKG
PGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFD
LELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMIL
RYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDG
PYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRL
NQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPL
EKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGE
CNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGI
IRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLF
CRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHD
VNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSY
EEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNK
WNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESE
FIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGW
RVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTY
FPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQ
VQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQ
KETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRW
GDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLI
QQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTN
VYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTA
EEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVE
KFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDK
TTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEI
SAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWR
VRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVS
PPDNPQVKEIRCIVMVPQWGTHQTVHLPGQLPQHEYLKEMEPLGWIHTQPNESPQLSP
QDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNP
KGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYH
EVHRPSHFLNFALLQEGEVYSADREDLYA"
BASE COUNT 1838 a 1963 c 1804 g 1634 t
ORIGIN
1 gcggcctctt gtgtgagggc ctgtgggatt ctccggatat ggccggagtg tttccttatc
61 gagggccggg taacccggtg cctggccctc tagccccgct accggactac atgtcggagg
121 agaagctgca ggagaaagct cgaaaatggc agcaattgca ggccaagcgc tatgcagaaa
181 agcggaagtt tgggtttgtg gatgcccaga aggaagacat gcccccagaa catgtcagga
241 agatcattcg agaccatgga gacatgacca acaggaagtt ccgccatgac aaaagggttt
301 acttgggtgc cctaaagtac atgccccacg cagtcctcaa actcctggag aacatgccta
361 tgccttggga gcagattcgg gatgtgcctg tgctgtacca catcactgga gccatttcct
421 tcgtcaatga gattccctgg gtcattgaac ctgtctacat ctcccagtgg gggtcaatgt
481 ggattatgat gcgccgagaa aaaagagata ggaggcattt caagaggatg cgttttcccc
541 cttttgatga tgaggagccg cccttggact atgctgacaa catcctagat gttgagccac
601 tggaggccat tcagctagag ctggaccctg aggaggacgc ccctgtgttg gactggttct
661 atgaccacca gccgttgagg gacagcagga agtatgtaaa tggctccact taccagcgct
721 ggcagttcac actacctatg atgtcgactc tctaccgcct ggctaatcag ctcctgacag
781 acttggtgga tgacaactac ttctacctgt ttgatttgaa ggccttcttt acgtccaagg
841 cactcaatat ggccattcct ggaggcccca aatttgaacc ccttgttcga gacatcaacc
901 tacaggatga agactggaat gaattcaatg atattaacaa gattatcatc cggcagccta
961 tccgcactga gtacaagatt gcttttcctt acttgtacaa caatcttcca caccatgtcc
1021 acctcacctg gtaccatact cccaatgttg tattcatcaa aactgaggat cctgacttgc
1081 cagctttcta ctttgaccct ttgatcaacc caatctccca taggcactca gtcaagagcc
1141 aggaaccatt gccggatgat gatgaggaat ttgagctccc ggagtttgtg gagcccttcc
1201 tgaaggacac acccctctat acagacaata cagccaatgg cattgccctg ctctgggccc
1261 cgcggccctt caacctacgc tctggtcgca cccgtcgggc cctggacata ccccttgtca
1321 agaactggta tcgggagcat tgtcctgccg ggcagcctgt gaaagtgagg gtctcctacc
1381 agaagctgct taagtactat gtgctgaatg ccctgaagca tcggccccct aaggctcaaa
1441 agaagaggta tttgttccgc tccttcaaag ccaccaaatt ctttcagtcc acaaagctgg
1501 actgggtgga ggttgggctc caggtttgcc gccagggcta caacatgctc aaccttctca
1561 ttcaccgcaa aaacctcaac tacctgcacc tggactacaa cttcaacctc aagcctgtga
1621 aaacgctcac caccaaggaa agaaagaaat ctcgttttgg gaatgctttc cacctgtgtc
1681 gggaagttct gcgtttgact aagctggtgg tggatagtca cgtgcagtat cggctgggca
1741 atgtggatgc cttccagctg gcagatggat tgcagtatat atttgcccat gttgggcagt
1801 tgacgggcat gtatcgatac aaatacaagc tgatgcgaca gattcgcatg tgcaaggacc
1861 tgaagcatct catctattat cgtttcaaca cgggccctgt agggaagggt cctggctgtg
1921 gcttctgggc tgccggttgg cgagtctggc tctttttcat gcgtggcatt acccctttat
1981 tagagcgatg gcttggcaac ctcctggccc ggcagtttga aggtcgacac tcaaaggggg
2041 tggcaaagac agtaacaaag cagcgagtgg agtcacattt tgaccttgag ctgcgggcag
2101 ctgtgatgca tgatattctg gacatgatgc ctgaggggat caagcagaac aaggcccgga
2161 caatcctgca gcacctcagt gaagcctggc gctgctggaa agccaacatt ccctggaagg
2221 tccctgggct gccgacgccc atagagaata tgatccttcg atacgtgaag gccaaggctg
2281 actggtggac caacactgcc cactacaacc gagaacggat ccgccgaggg gccactgtgg
2341 acaagactgt ttgtaaaaag aatctgggcc gcctcacccg gctctatctg aaggcagaac
2401 aggagcggca gcacaactac ctgaaggacg ggccttacat cacagcggag gaagcagtgg
2461 cagtatatac caccacagtg cattggttgg aaagccgcag gttttcaccc atcccattcc
2521 ccccactctc ctataagcat gacaccaagt tgctcatctt ggcattggag cggctcaagg
2581 aagcttatag tgtgaagtct cggttgaacc agtctcagag ggaggagcta ggtctgatcg
2641 agcaggccta cgataacccc cacgaggcgc tgtcccgcat caagcgtcac ctcctcacac
2701 agagagcctt caaagaggtg ggcattgagt tcatggatct gtatagccac ctcgttccag
2761 tatatgatgt tgagcccctg gagaagataa ctgatgctta cctggaccag tacctgtggt
2821 atgaagccga caagcgccgc ctgttcccac cctggattaa gcctgcagac acagaaccac
2881 ctccactgct tgtttacaag tggtgtcaag gcatcaataa cctgcaggac gtgtgggaga
2941 cgagtgaagg cgagtgcaat gtcatgctgg aatcccgctt tgagaagatg tatgagaaga
3001 tcgacttgac tctgctcaac aggctgctgc gcctcatcgt ggaccacaac atagccgact
3061 acatgacagc caagaacaac gtcgtcatca actataagga catgaaccat acgaattcat
3121 atgggatcat cagaggcctg cagtttgcct cattcatcgt gcagtattat ggcctggtga
3181 tggatttgct tgtattggga ttgcaccggg ccagtgagat ggctgggccc cctcagatgc
3241 caaatgactt tctcagtttc caggacatag ccactgaggc tgcccacccc atccgtctct
3301 tctgcagata cattgatcgc atccatattt ttttcaggtt cacagcagat gaggctcggg
3361 acctgattca acgttacctg acagagcacc ctgaccccaa taatgaaaac atcgttggct
3421 ataataacaa gaagtgctgg ccccgagatg cccgcatgcg cctcatgaaa catgatgtta
3481 acttaggccg ggcggtattc tgggacatca agaaccgctt gccacggtca gtgactacag
3541 ttcagtggga gaacagcttc gtgtctgtgt acagtaagga caaccccaac ctgctgttca
3601 acatgtgtgg cttcgagtgc cgcatcctgc ctaagtgccg caccagctat gaggagttca
3661 cccacaagga cggggtctgg aacctgcaga atgaggttac taaggagcgc acagctcagt
3721 gtttcctgcg tgtggacgat gagtcaatgc agcgcttcca caaccgcgtg cgtcagattc
3781 tcatggcctc tgggtccacc accttcacca agattgtgaa taagtggaat acagctctca
3841 ttggccttat gacatacttt cgggaggctg tggtgaacac ccaagagctc ttggacttac
3901 tggtgaagtg tgagaacaaa atccagacac gtatcaagat tggactcaac tccaagatgc
3961 caagtcggtt ccccccggtt gtgttctaca cccctaagga gttgggtgga ctcggcatgc
4021 tctcaatggg ccatgtgctc atcccccaat ccgacctcag gtggtccaaa cagacagatg
4081 taggtatcac acactttcgt tcaggaatga gccatgaaga agaccagctc attcccaact
4141 tgtaccgcta catacagcca tgggagagcg agttcattga ttctcagcgg gtctgggctg
4201 agtacgcact caagaggcaa gaggccattg ctcagaacag acgcctgact ttagaagacc
4261 tagaagattc atgggatcgt ggcattcctc gaatcaatac cctcttccag aaggaccggc
4321 acacactggc ttatgataag ggctggcgtg tcagaactga ctttaagcag tatcaggttt
4381 tgaagcagaa tccgttctgg tggacacacc agcggcatga tgggaagctc tggaacctga
4441 acaactaccg tacagacatg atccaggccc tgggcggtgt ggaaggcatt ctggaacaca
4501 cactctttaa gggcacttac ttccctacct gggaggggct cttctgggag aaggccagtg
4561 gctttgagga atctatgaag tggaagaagc taactaatgc tcagcgatca ggactgaacc
4621 agattcccaa tcgtagattc accctctggt ggtccccgac cattaatcga gccaatgtat
4681 atgtaggctt tcaggtgcag ctagacctga cgggtatctt catgcacggc aagatcccca
4741 cgctgaagat ctctctcatc cagatcttcc gagctcactt gtggcagaag atccatgaga
4801 gcattgttat ggacttatgt caggtgtttg accaggaact tgatgcactg gaaattgaga
4861 cagtacaaaa ggagacaatc catccccgaa agtcatataa gatgaactct tcctgtgcag
4921 atatcctgct ctttgcctcc tataagtgga atgtctcccg gccctcattg ctggctgact
4981 ccaaggatgt gatggacagc accaccaccc agaaatactg gattgacatc cagttgcgct
5041 ggggggacta tgattcccac gacattgagc gctacgcccg ggccaagttc ctggactaca
5101 ccaccgacaa catgagtatc tacccttcgc ccacaggtgt actcatcgcc attgacctgg
5161 cctataactt gcacagtgcc tatggaaact ggttcccagg cagcaagcct ctcatacaac
5221 aggccatggc caagatcatg aaggcaaacc ctgccctgta tgtgttacgt gaacggatcc
5281 gcaaggggct acagctctat tcatctgaac ccactgagcc ttatttgtct tctcagaact
5341 atggtgagct cttctccaac cagattatct ggtttgtgga tgacaccaac gtctacagag
5401 tgactattca caagaccttt gaagggaact tgacaaccaa gcccatcaac ggagccatct
5461 tcatcttcaa cccacgcaca gggcagctgt tcctcaagat aatccacacg tccgtgtggg
5521 cgggacagaa gcgtttgggg cagttggcta agtggaagac agctgaggag gtggccgccc
5581 tgatccgatc tctgcctgtg gaggagcagc ccaagcagat cattgtcacc aggaagggca
5641 tgctggaccc actggaggtg cacttactgg acttccccaa tattgtcatc aaaggatcgg
5701 agctccaact ccctttccag gcgtgtctca aggtggaaaa attcggggat ctcatcctta
5761 aagccactga gccccagatg gttctcttca acctctatga cgactggctc aagactattt
5821 catcttacac ggccttctcc cgtctcatcc tgattctgcg tgccctacat gtgaacaacg
5881 atcgggcaaa agtgatcctg aagccagaca agactactat tacagaacca caccacatct
5941 ggcccactct gactgacgaa gaatggatca aggtcgaggt gcagctcaag gatctgatct
6001 tggctgacta cggcaagaaa aacaatgtga acgtggcatc actgacacaa tcagaaattc
6061 gagacatcat cctgggtatg gagatctcgg caccgtcaca gcagcggcag cagatcgctg
6121 agatcgagaa gcagactaag gaacaatcgc agctgacggc aacacagact cgcactgtca
6181 acaagcatgg cgatgagatc atcacctcca ccaccagcaa ctatgagacc cagactttct
6241 catccaagac tgagtggagg gtcagggcca tctctgctgc caacctgcac ctaaggacca
6301 atcacatcta tgtttcatct gacgacatca aggagactgg ctacacctac atccttccca
6361 agaatgtgct taagaagttc atctgcatat ctgaccttcg ggcccaaatt gcaggatacc
6421 tatatggggt gagcccacca gataaccccc aggtgaagga gatccgctgc attgtgatgg
6481 tgccgcagtg gggcactcac cagaccgtgc acctgcctgg ccagctgccc cagcatgagt
6541 acctcaagga gatggaaccc ttaggttgga tccacactca gcccaatgag tccccgcagt
6601 tatcacccca ggatgtcacc acccatgcca agatcatggc tgacaaccca tcttgggatg
6661 gcgagaagac cattatcatc acatgcagct tcacgccagg ctcctgtaca ctgacggcct
6721 acaagctgac ccccagtggc tacgaatggg gccgccagaa cacagacaag ggcaacaacc
6781 ccaagggcta cctgccttca cactatgaga gggtgcagat gctgctgtcg gaccgtttcc
6841 ttggcttctt catggtccct gcccagtcct cgtggaacta caacttcatg ggtgttcggc
6901 atgaccccaa catgaaatat gagctacagc tggcgaaccc caaagagttc taccacgagg
6961 tgcacaggcc ctctcacttt ctcaactttg ctctcctgca ggagggggag gtttactctg
7021 cggatcggga ggacctgtat gcctgaccgt ttccctgcct cctgcttcag cactcccgag
7081 gccgaagcct cagcccctcc agacaggccg ctgacattca gcagtttggc ctctttccct
7141 ctgtctgtgc ttgtgttgtt gacctcctga tggcttgtca tcctgaataa aatataataa
7201 taaattttgt ataaatagga aaaaaaaaaa aaaaaaaaa
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