LOCUS AF092092 1348 bp mRNA linear HUM 17-MAR-1999
DEFINITION Homo sapiens AP-3 adaptor complex mu3A subunit mRNA, complete cds.
ACCESSION AF092092
VERSION AF092092.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1348)
AUTHORS Dell'Angelica,E.C., Shotelersuk,V., Aguilar,R.C., Gahl,W.A. and
Bonifacino,J.S.
TITLE Altered trafficking of lysosomal proteins in Hermansky-Pudlak
syndrome due to mutations in the beta 3A subunit of the AP-3
adaptor
JOURNAL Mol. Cell 3 (1), 11-21 (1999)
PUBMED 10024875
REFERENCE 2 (bases 1 to 1348)
AUTHORS Dell'Angelica,E.C. and Bonifacino,J.S.
TITLE Direct Submission
JOURNAL Submitted (16-SEP-1998) CBMB-NICHD, National Institutes of Health,
Bldg. 18T, Rm. 101, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..1348
/db_xref="H-InvDB:HIT000068344"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="fibroblast"
CDS 1..1257
/function="involved in the recognition of tyrosine-based
sorting signals"
/note="AP-3 complex is related to the clathrin coat
adaptors, AP-1 and AP-2; AP-3 complex plays a role in
protein trafficking to lysosomes and specialized
organelles"
/codon_start=1
/product="AP-3 adaptor complex mu3A subunit"
/protein_id="AAD20446.1"
/translation="MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVEN
VPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAI
KDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTG
QLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDL
SLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYV
KHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDP
VTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAISGLKVNRL
DMYGEKYKPFKGVKYVTKAGKFQVRT"
BASE COUNT 415 a 280 c 282 g 371 t
ORIGIN
1 atgatccaca gtctatttct cataaactgt tccggtgaca tatttctaga gaagcactgg
61 aagagcgttg tgagccagtc tgtctgtgat tatttctttg aagctcaaga gaaagctgct
121 gatgttgaaa atgtaccacc tgtcatttca acacctcacc actacctcat cagtatctac
181 cgggataagc tcttctttgt atctgtcata cagaccgaag tgccacctct ctttgtaatt
241 gagttcctac atcgagttgc tgacactttt caggactact ttggtgagtg ttcagaggct
301 gcaattaagg ataatgtggt catagtatat gaactcttag aagaaatgtt agacaatgga
361 tttccactgg ctaccgaatc taacattttg aaagaattga ttaaaccacc aacaattcta
421 cgctctgttg tcaactctat tacaggcagt agtaatgttg gggacacact ccccaccggg
481 cagctgtcca acataccatg gcgtcgggca ggggtaaagt acacaaacaa tgaagcctat
541 tttgatgttg ttgaagaaat agacgcaatt atagataaat caggatctac agtctttgca
601 gaaattcagg gggtcattga tgcttgcatt aaactatctg gaatgcctga tctctccctt
661 tctttcatga accctaggct tctggatgat gtcagctttc acccctgcat ccggttcaag
721 cgttgggaat ctgaaagagt tttgtcattt attcctccag atggaaattt ccgactcata
781 tcataccgtg tcagctcaca aaatctagtg gcaataccag tgtatgtgaa acatagtatc
841 agctttaagg agaacagttc ttgcggcaga tttgatataa caattggacc aaagcagaat
901 atggggaaaa ctattgaagg aattacagtg acagttcaca tgccaaaagt tgtgctgaac
961 atgaacctga cacccacaca aggcagctat acatttgatc cagtcaccaa ggtactaaca
1021 tgggatgtgg gaaaaattac tccacaaaag ctcccaagtc ttaaaggact ggtaaattta
1081 cagtctggag cccccaaacc agaagagaat ccgagcctca acatacagtt taagatccag
1141 cagcttgcta tttcaggctt aaaagtaaac cgtttggaca tgtatgggga gaaatataag
1201 ccatttaaag gagtcaaata cgtcacgaaa gctggaaagt tccaagtgag gacatgagaa
1261 gaggccaaaa ttcctcagga ccagtttgtt ttccaagtgt cattacgatg tatcactatt
1321 aggtaccaag tgagtgggaa tacatatt
//