LOCUS AF091619 2526 bp mRNA linear HUM 17-DEC-1999
DEFINITION Homo sapiens dynein intermediate chain DNAI1 (DNAI1) mRNA, complete
cds.
ACCESSION AF091619
VERSION AF091619.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2526)
AUTHORS Pennarun,G., Escudier,E., Chapelin,C., Bridoux,A.M., Cacheux,V.,
Roger,G., Clement,A., Goossens,M., Amselem,S. and Duriez,B.
TITLE Loss-of-function mutations in a human gene related to Chlamydomonas
reinhardtii dynein IC78 result in primary ciliary dyskinesia
JOURNAL Am. J. Hum. Genet. 65 (6), 1508-1519 (1999)
PUBMED 10577904
REFERENCE 2 (bases 1 to 2526)
AUTHORS Pennarun,G., Chapelin,C., Escudier,E., Bridoux,A.M., Cacheux,V.,
Goossens,M., Amselem,S. and Duriez,B.
TITLE Direct Submission
JOURNAL Submitted (11-SEP-1998) unite 468, INSERM, Hopital Henri Mondor,
Creteil 94010, France
FEATURES Location/Qualifiers
source 1..2526
/db_xref="H-InvDB:HIT000068334"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p13-p21"
/tissue_type="trachea; testis"
/note="degenerated primers were P1 (antisense,
GGAWGTSSAYGCACATGACGCC), P2(sense, CMARGATKCTRACAGCCAACAA)
and P3 (sense, AGGTTGGGIGASAGCTTGAG); specific primers
were P4 (antisense, TTGTGTGTGGTCAAGGAGACGG), P5(antisense,
AAGGAACAGAACAAGAAGGGAA), P6 (sense,
TTGTCTTCAGACGAGGGAGCGTTTTGTAGG), P7 (antisense,
CAATGTTCTGGGGTGCGTGTGGGTTGTTGG) and P10
(sense,CAAAATGACAAAGCCAAGCG)"
gene 1..2526
/gene="DNAI1"
CDS 172..2271
/gene="DNAI1"
/note="axonemal dynein intermediate chain; similar to
Chlamydomonas reinhardtii IC78"
/codon_start=1
/product="dynein intermediate chain DNAI1"
/protein_id="AAF18570.1"
/translation="MIPASAKAPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQ
SKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAV
HYTQVGNLIPKDSDEGRRQHYRDELVAGSQESVKVISETGNLEEDEEPKELETEPGSQ
TDVPAAGAAEKVTEEELMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPR
TNFSATANQWEIYDAYVEELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDL
IKLSQAAKIMERMVNQNTYDDIAQDFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLS
VTALCWNPKYRDLFAVGYGSYDFMKQSRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIH
VDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN
FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEI
DYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVK
IWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQP
VAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSPNLRKMPKEKKGQEVQKGPAVEI
AKLDKLLNLVREVKIKT"
BASE COUNT 723 a 656 c 636 g 510 t
ORIGIN
1 attctatcct gcaagggcac ggggacccac aacgacggct gtccctaaag aaccgttgcg
61 actggtaact gaagtggaag agagtccaga tttcttgtgt gtggtcaagg agacggacaa
121 actttttgtc ttcagacgag ggagcgtttt gtaggctctc caggggttga gatgattcct
181 gcttctgcga aggctcccca taaacagcct cataagcaga gcatcagcat aggcagagga
241 accaggaaga gagatgaaga ttcagggact gaagtgggag aaggcacaga tgaatgggcc
301 caatccaaag ccacagttag accccctgac cagctggagt tgaccgatgc ggagttaaag
361 gaggagttca ctcggatttt gacagccaac aacccacacg caccccagaa cattgtcagg
421 tacagcttca aagaaggcac atataagcct attggctttg tgaaccaact ggcagttcac
481 tacacccagg ttgggaacct gatccccaaa gactcagatg aaggacggcg gcagcattac
541 cgcgatgaat tagtggcagg ttctcaggag tctgtcaagg tgatttcaga aacaggaaac
601 ctcgaagaag acgaagagcc caaggagtta gaaactgagc ctgggagtca aacagatgtg
661 cctgcagctg gggcagctga aaaagtgact gaagaagaat tgatgactcc taagcagccc
721 aaggagagaa agctcactaa ccagttcaac ttcagtgaga gggcctcaca gacctacaac
781 aaccctgtcc gggatcgaga atgccagacg gagcctcctc ccaggacaaa cttttcagcc
841 acagccaatc agtgggagat ctatgatgcc tatgtagagg aacttgagaa gcaggaaaag
901 accaaagaga aggagaaggc aaagacccca gtggctaaaa aatcagggaa gatggccatg
961 aggaagctga catctatgga gtctcagact gatgatctca tcaaattgtc ccaagctgct
1021 aagatcatgg agcggatggt caaccagaat acatatgatg acattgctca agattttaag
1081 tactatgacg atgctgctga tgaataccgg gaccaggtgg gtaccctgct gccgctctgg
1141 aagttccaaa atgacaaagc caagcgcctg tccgtcactg ccctctgctg gaatccaaag
1201 tacagggatc tgtttgcagt gggatatggc tcttatgact tcatgaagca gagccggggc
1261 atgctgctgc tctacagcct gaagaacccc agcttccctg agtacatgtt cagcagcaac
1321 agcggcgtca tgtgtctcga catccacgtg gaccacccct acctggtggc agtaggccac
1381 tatgacggca acgtggccat ttacaacctc aagaagcccc actcccagcc ctccttctgc
1441 agctcagcca agtctggcaa gcactcagac cctgtgtggc aggtcaagtg gcagaaggat
1501 gacatggacc aaaaccttaa cttcttctct gtgtcatctg acggcaggat tgtgtcttgg
1561 actctcgtga agagaaagct ggttcacata gatgtcatca agctgaaggt ggaaggcagc
1621 accacggaag ttcctgaggg gttgcagctg cacccagtgg gttgtggcac tgcctttgac
1681 ttccacaaag agattgacta catgttccta gtgggcacag aggagggaaa aatctacaag
1741 tgctctaaat cctactccag ccaattcctc gacacctatg acgcccacaa catgtcagtg
1801 gacactgtgt cctggaaccc ataccacacc aaggtcttca tgtcctgcag ctccgactgg
1861 acagtgaaga tctgggacca caccatcaag accccgatgt tcatctatga cctgaactca
1921 gccgtgggtg atgtggcctg ggcgccatac tcttctactg tgttcgcagc agtcaccaca
1981 gatgggaagg cccacatatt tgacttagcc atcaacaagt atgaggccat ctgcaaccag
2041 cctgtggcgg ccaaaaagaa caggctcacc cacgtgcagt tcaatctcat ccaccccatc
2101 atcattgtgg gcgatgaccg tgggcacatc atcagcctca agctctcacc caatttgcgc
2161 aagatgccaa aggaaaagaa ggggcaggag gtgcagaagg gtccagctgt ggagattgcg
2221 aaactggaca aactgctgaa cctggtgagg gaagtgaaaa tcaagacctg aggggctggc
2281 ctcagtctct gtcccatcgc ttgaatacag tactcctagg gcttgaccct ggtacccagc
2341 ccagccttag cacccagcat gtgaccccac tcctgatcag gtcccagcat cttcccttct
2401 tgttctgttc cttaaggtcc cagcacctta ccccaggawt tggtcttcaa ccaccattac
2461 ccctctaact ttgcacaaat aaacctgtgt agaaacacaa aaaaaaaaaa aaaaaaaaaa
2521 aaaaaa
//