LOCUS       AF091582                4776 bp    mRNA    linear   HUM 14-NOV-1998
DEFINITION  Homo sapiens bile salt export pump (BSEP) mRNA, complete cds.
ACCESSION   AF091582
VERSION     AF091582.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4776)
  AUTHORS   Strautnieks,S., Bull,L., Knisely,A., Kocoshis,S., Dahl,N.,
            Arnell,H., Sokal,E., Dahan,K., Childs,S., Ling,V., Tanner,M.,
            Kagalwalla,A., Nemeth,A., Pawlowska,J., Baker,A., Mieli-Vergani,G.,
            Freimer,N., Gardiner,R. and Thompson,R.
  TITLE     A gene encoding a liver-specific ABC transporter is mutated in
            progressive familial intrahepatic cholestasis
  JOURNAL   Nat. Genet. 20 (3), 233-238 (1998)
   PUBMED   9806540
REFERENCE   2  (bases 1 to 4776)
  AUTHORS   Strautnieks,S.S., Gardiner,R.M. and Thompson,R.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-SEP-1998) Paediatrics, University College London
            Medical School, University Street, London WC1E 6JJ, UK
FEATURES             Location/Qualifiers
     source          1..4776
                     /db_xref="H-InvDB:HIT000068332"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24"
     gene            1..4776
                     /gene="BSEP"
     CDS             127..4092
                     /gene="BSEP"
                     /codon_start=1
                     /product="bile salt export pump"
                     /protein_id="AAC77455.1"
                     /translation="MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVR
                     VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQI
                     PGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQI
                     CFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMA
                     LFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAK
                     AGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIF
                     LCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATS
                     IFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEM
                     TALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLF
                     STTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQR
                     VAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAAD
                     TIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTF
                     SRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAP
                     VRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGV
                     CLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGA
                     LTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALS
                     GATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFK
                     TAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATA
                     LGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYP
                     SRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK
                     VNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSL
                     PEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALD
                     KAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPI
                     S"
BASE COUNT         1345 a          974 c         1162 g         1278 t
ORIGIN      
        1 gaatgatgaa aaccgaggtt ggaaaaggtt gtgaaacctt ttaactctcc acagtggagt
       61 ccattatttc ctctggcttc ctcaaattca tattcacagg gtcgttggct gtgggttgca
      121 attaccatgt ctgactcagt aattcttcga agtataaaga aatttggaga ggagaatgat
      181 ggttttgagt cagataaatc atataataat gataagaaat caaggttaca agatgagaag
      241 aaaggtgatg gcgttagagt tggcttcttt caattgtttc ggttttcttc atcaactgac
      301 atttggctga tgtttgtggg aagtttgtgt gcatttctcc atggaatagc ccagccaggc
      361 gtgctactca tttttggcac aatgacagat gtttttattg actacgacgt tgagttacaa
      421 gaactccaga ttccaggaaa agcatgtgtg aataacacca ttgtatggac taacagttcc
      481 ctcaaccaga acatgacaaa tggaacacgt tgtgggttgc tgaacatcga gagcgaaatg
      541 atcaaatttg ccagttacta tgctggaatt gctgtcgcag tacttatcac aggatatatt
      601 caaatatgct tttgggtcat tgccgcagct cgtcagatac agaaaatgag aaaattttac
      661 tttaggagaa taatgagaat ggaaataggg tggtttgact gcaattcagt gggggagctg
      721 aatacaagat tctctgatga tattaataaa atcaatgatg ccatagctga ccaaatggcc
      781 cttttcattc agcgcatgac ctcgaccatc tgtggtttcc tgttgggatt tttcaggggt
      841 tggaaactga ccttggttat tatttctgtc agccctctca ttgggattgg agcagccacc
      901 attggtctga gtgtgtccaa gtttacggac tatgagctga aggcctatgc caaagcaggg
      961 gtggtggctg atgaagtcat ttcatcaatg agaacagtgg ctgcttttgg tggtgagaaa
     1021 agagaggttg aaaggtatga gaaaaatctt gtgttcgccc agcgttgggg aattagaaaa
     1081 ggaatagtga tgggattctt tactggattc gtgtggtgtc tcatcttttt gtgttatgca
     1141 gtggccttct ggtacggctc cacacttgtc ctggatgaag gagaatatac accaggaacc
     1201 cttgtccaga ttttcctcag tgtcatagta ggagctttaa atcttggcaa tgcctctcct
     1261 tgtttggaag cctttgcaac tggacgtgca gcagccacca gcatttttga gacaatagac
     1321 aggaaaccca tcattgactg catgtcagaa gatggttaca agttggatcg aatcaagggt
     1381 gaaattgaat tccataatgt gaccttccat tatccttcca gaccagaggt gaagattcta
     1441 aatgacctca acatggtcat taaaccaggg gaaatgacag ctctggtagg acccagtgga
     1501 gctggaaaaa gtacagcact gcaactcatt cagcgattct atgacccctg tgaaggaatg
     1561 gtgaccgtgg atggccatga cattcgctct cttaacattc agtggcttag agatcagatt
     1621 gggatagtgg agcaagagcc agttctgttc tctaccacca ttgcagaaaa tattcgctat
     1681 ggcagagaag atgcaacaat ggaagacata gtccaagctg ccaaggaggc caatgcctac
     1741 aacttcatca tggacctgcc acagcaattt gacacccttg ttggagaagg aggaggccag
     1801 atgagtggtg gccagaaaca aagggtagct atcgccagag ccctcatccg aaatcccaag
     1861 attctgcttt tggacatggc cacctcagct ctggacaatg agagtgaagc catggtgcaa
     1921 gaagtgctga gtaagattca gcatgggcac acaatcattt cagttgctca tcgcttgtct
     1981 acggtcagag ctgcagatac catcattggt tttgaacatg gcactgcagt ggaaagaggg
     2041 acccatgaag aattactgga aaggaaaggt gtttacttca ctctagtgac tttgcaaagc
     2101 cagggaaatc aagctcttaa tgaagaggac ataaaggatg caactgaaga tgacatgctt
     2161 gcgaggacct ttagcagagg gagctaccag gatagtttaa gggcttccat ccggcaacgc
     2221 tccaagtctc agctttctta cctggtgcac gaacctccat tagctgttgt agatcataag
     2281 tctacctatg aagaagatag aaaggacaag gacattcctg tgcaggaaga agttgaacct
     2341 gccccagtta ggaggattct gaaattcagt gctccagaat ggccctacat gctggtaggg
     2401 tctgtgggtg cagctgtgaa cgggacagtc acacccttgt atgccttttt attcagccag
     2461 attcttggga ctttttcaat tcctgataaa gaggaacaaa ggtcacagat caatggtgtg
     2521 tgcctacttt ttgtagcaat gggctgtgta tctcttttca cccaatttct acagggatat
     2581 gcctttgcta aatctgggga gctcctaaca aaaaggctac gtaaatttgg tttcagggca
     2641 atgctggggc aagatattgc ctggtttgat gacctcagaa atagccctgg agcattgaca
     2701 acaagacttg ctacagatgc ttcccaagtt caaggggctg ccggctctca gatcgggatg
     2761 atagtcaatt ccttcactaa cgtcactgtg gccatgatca ttgccttctc ctttagctgg
     2821 aagctgagcc tggtcatctt gtgcttcttc cccttcttgg ctttatcagg agccacacag
     2881 accaggatgt tgacaggatt tgcctctcga gataagcagg ccctggagat ggtgggacag
     2941 attacaaatg aagccctcag taacatccgc actgttgctg gaattggaaa ggagaggcgg
     3001 ttcattgaag cacttgagac tgagctggag aagcccttca agacagccat tcagaaagcc
     3061 aatatttacg gattctgctt tgcctttgcc cagtgcatca tgtttattgc gaattctgct
     3121 tcctacagat atggaggtta cttaatctcc aatgaggggc tccatttcag ctatgtgttc
     3181 agggtgatct ctgcagttgt actgagtgca acagctcttg gaagagcctt ctcttacacc
     3241 ccaagttatg caaaagctaa aatatcagct gcacgctttt ttcaactgct ggaccgacaa
     3301 cccccaatca gtgtatacaa tactgcaggt gaaaaatggg acaacttcca ggggaagatt
     3361 gattttgttg attgtaaatt tacatatcct tctcgacctg actcgcaagt tctgaatggt
     3421 ctctcagtgt cgattagtcc agggcagaca ctggcgtttg ttgggagcag tggatgtggc
     3481 aaaagcacta gcattcagct gttggaacgt ttctatgatc ctgatcaagg gaaggtgatg
     3541 atagatggtc atgacagcaa aaaagtaaat gtccagttcc tccgctcaaa cattggaatt
     3601 gtttcccagg aaccagtgtt gtttgcctgt agcataatgg acaatatcaa gtatggagac
     3661 aacaccaaag aaattcccat ggaaagagtc atagcagctg caaaacaggc tcagctgcat
     3721 gattttgtca tgtcactccc agagaaatat gaaactaacg ttgggtccca ggggtctcaa
     3781 ctctctagag gggagaaaca acgcattgct attgctcggg ccattgtacg agatcctaaa
     3841 atcttgctac tagatgaagc cacttctgcc ttagacacag aaagtgaaaa gacggtgcag
     3901 gttgctctag acaaagccag agagggtcgg acctgcattg tcattgccca tcgcttgtcc
     3961 accatccaga acgcggatat cattgctgtc atggcacagg gggtggtgat tgaaaagggg
     4021 acccatgaag aactgatggc ccaaaaagga gcctactaca aactagtcac cactggatcc
     4081 cccatcagtt gacccaatgc aagaatctca gacacacatg acgcaccagt tacaggggtt
     4141 gtttttaaag aaaaaaacaa tcccagcacg agggattgct gggattgttt tttctttaaa
     4201 gaagaatntn nntattttac ttttacnnnc nttttcctac atcggaatcc aanctaattt
     4261 ctaatggcct tccataataa ttctgcttta gatgtgtata cagaaaatga aagaaactag
     4321 ggtccatgtg agggaaaacc caatgtcaag tggcagctca gccaccactc agtgcttctc
     4381 tgtgcaggag ccagtcctga ttaatatgtg ggaattagtg agacatcagg gagtaagtga
     4441 cactttgaac tcctcaagga cagagaactg tctttcattt ttgaaccctc ggtgtacaca
     4501 gaggcgggtc tgtaacaggc aatcaacaaa cgtttcttga gctagaccaa ggtcagattt
     4561 gaaaagaaca gaaggactga agaccagctg tgtttcttaa ctaaatttgt ctttcaagtg
     4621 aaaccagctt ccttcatctc taaggctaag gatagggaaa gggtgggatg ctctcangct
     4681 gagggaggca naaagggaaa gtattancat gagctttcca nttagggctg ttgatttatg
     4741 ctttaacttc anantgagtg tagggtggtg anncta
//