LOCUS AF090990 6028 bp mRNA linear HUM 28-APR-1999
DEFINITION Homo sapiens high-risk human papilloma viruses E6 oncoproteins
targeted protein E6TP1 beta mRNA, complete cds.
ACCESSION AF090990
VERSION AF090990.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6028)
AUTHORS Gao,Q., Srinivasan,S., Boyer,S.N., Wazer,D.E. and Band,V.
TITLE The E6 oncoproteins of high-risk papillomaviruses bind to a novel
putative GAP protein, E6TP1, and target it for degradation
JOURNAL Mol. Cell. Biol. 19 (1), 733-744 (1999)
PUBMED 9858596
REFERENCE 2 (bases 1 to 6028)
AUTHORS Gao,Q., Srinivasan,S., Boyer,S.N., Wazer,D.E. and Band,V.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-1998) Radiation Oncology, New England Medical
Center Hospital, Box 824, 750 Washington St., Boston, MA 02111, USA
FEATURES Location/Qualifiers
source 1..6028
/db_xref="H-InvDB:HIT000068284"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 349..5763
/note="putative GAP protein beta"
/codon_start=1
/product="high-risk human papilloma viruses E6
oncoproteins targeted protein E6TP1 beta"
/protein_id="AAD12544.1"
/translation="MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNG
SLGSSVMAPVGPPRSEGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIET
SSCLDSLSSKSSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYP
SSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTS
GESFFDLLKGYKDDKSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFK
EREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHY
DVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDL
NSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFEST
LSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGAD
ENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTAR
GLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQST
EEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEI
MFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVR
VHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKS
EKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSM
GAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSL
KIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEG
IVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDD
CTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPSQVQSP
MTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQC
RNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSW
QRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRLMR
QDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQ
GTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLE
TESHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVV
FTSARSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTI
NSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTP
ESQKSFKFHALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALP
NDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLM
PLPDTAADLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKP
YSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQ
NASDKLKKFTEWVFNTIDMS"
BASE COUNT 1731 a 1517 c 1434 g 1346 t
ORIGIN
1 ggtgtggacg ttgtctaaat ttcggtagcc atggcacaag aatataagaa agcatgggat
61 tatggcaacc acagaatctc agtagtacaa gttccattca gttttttctg aaagaaagcc
121 ctctgttaaa gtgaagcaaa gaaactgttg tggattataa cgtttagaag ttccaatttt
181 tcagtgcttt acaaataaag catcatttaa ccttttaaat gaaaaagatt aagatctcat
241 gcaactgttg tattttctgg aagccattct ccaaaaggga agtgcacatt taaaacacag
301 atatgatggt ccttgctgca gggatttaag tctacttgct tttacatcat gaccagcttg
361 aaacggtcac agacagaaag gcctcttgcc actgacaggg cctctgttgt tggcacagac
421 ggcaccccca aagtccacac tgatgatttc tacatgcggc gcttccggtc ccaaaatggc
481 agcttaggat catcagttat ggctcctgta ggaccccccc gaagtgaagg ttctcaccat
541 ataacctcaa cccccggagt cccaaaaatg ggggtaaggg caaggattgc agattggccc
601 ccaagaaagg aaaacataaa agaatctagc cgttcaagcc aggaaataga aacctcaagt
661 tgccttgata gcctgtcctc caaaagcagt cctgtgagtc agggaagttc tgttagcctc
721 aattccaatg actcagccat gctgaaaagc atacagaaca cgctgaaaaa caagacaaga
781 ccgtcggaga acatggactc cagatttctc atgcctgaag cctaccccag ctcccccaga
841 aaagctcttc gcagaatacg ccagcgaagc aacagtgata tcaccataag tgaacttgat
901 gtggatagct ttgatgaatg tatctcacct acatacaaga ctggaccatc actgcacagg
961 gaatatggta gcacatcttc aattgataaa cagggaacat ctggagaaag cttttttgat
1021 ttgttaaagg gctacaaaga tgacaaatct gatcgaggtc caactccaac caagctcagt
1081 gactttctca ttactggtgg tggcaagggt tctggtttct ctttggatgt aatagacggg
1141 cctatctcac agagagagaa cctcaggctt tttaaggaaa gggaaaaacc actcaagcga
1201 cgttcaaaat ctgaaactgg agactcctct atttttcgta aattgcgcaa tgccaaaggt
1261 gaagaacttg ggaagtcatc agatcttgaa gataaccgat cagaagactc tgtcaggccc
1321 tggacatgtc caaagtgctt tgcccactat gatgtccaga gtatattatt tgatttgaat
1381 gaggcaatta tgaacaggca caatgttatt aagaggagaa acaccaccac tggagcttcc
1441 gcagctgccg tggcatcctt ggtctctgga cctctgtctc attcagccag ttttagctcc
1501 ccaatgggca gcacagagga cctgaattcc aaaggaagcc tcagcatgga ccagggagat
1561 gataaaagca atgagcttgt aatgagctgt ccatattttc ggaatgagat aggtggagaa
1621 ggggagagga aaatcagcct ttcaaaatca aattctggct cctttagtgg atgtgaaagt
1681 gcctcctttg agtctaccct tagttcccat tgcacaaatg caggagtggc agtacttgaa
1741 gtgcccaagg agaacttggt gttgcaccta gatagagtga aaagatacat cgtggaacac
1801 gtagatctgg gtgcatacta ttatagaaaa tttttctacc agaaggaaca ctggaactat
1861 tttggggctg atgagaatct tggtccagtg gctgtgagca ttcgaaggga aaaaccagat
1921 gaaatgaaag aaaatggatc tccgtacaac taccgaataa tttttagaac tagtgagctc
1981 atgacactga gaggttcggt cctggaggac gccattccgt cgacagccaa gcactcgaca
2041 gccagaggcc tgcctctcaa agaagtgctg gagcacgtgg ttcctgagct caatgtccag
2101 tgcctgcggt tggccttcaa cacacccaag gtcacagagc agctcatgaa actggatgaa
2161 caagggctga actaccagca gaaagtaggc atcatgtact gcaaagctgg acagagcact
2221 gaagaagaga tgtacaacaa tgagtcagct ggcccagcct ttgaagaatt ccttcaacta
2281 ttgggagagc gagttcggct caaaggattt gagaagtatc gagcacagct tgataccaaa
2341 actgactcca ctggaaccca ttctctgtac acaacataca aagattatga aattatgttc
2401 catgtttcta ccatgctgcc atacacaccc aacaacaaac aacagctcct gaggaagcgg
2461 cacattggaa atgatatcgt aacaattgtt ttccaagagc ctggagcaca gccattcagc
2521 ccaaaaaaca tccgatccca cttccagcac gttttcgtca tcgtcagggt gcacaatccg
2581 tgctctgaca gtgtctgtta tagtgtggct gttaccaggt ccagagatgt gccttccttt
2641 gggcctccca ttcctaaagg ggtcactttc cctaagtcaa atgtgttcag ggacttcctt
2701 ttggcgaaag tgattaatgc agaaaatgct gctcataaat cggagaagtt tcgggccatg
2761 gcaactcgga cccgccagga atacctgaaa gatctggcag aaaagaatgt caccaacacc
2821 cctatcgacc cttctggcaa gtttccgttc atctctctgg cttccaagaa gaaggaaaag
2881 tctaagccat atccaggagc cgagctcagc agcatggggg ccattgtatg ggcagtccgg
2941 gctgaagact acaacaaggc catggaacta gactgccttt tagggatctc caatgagttc
3001 attgtgctca ttgaacagga aacaaagagc gtggtcttca attgttcctg tagagatgtg
3061 atagggtgga cttcaactga caccagcctc aaaatcttct atgaacgagg agaatgtgtt
3121 tcagtgggta gttttattaa cattgaggag atcaaagaga ttgtcaaaag gttgcagttt
3181 gtttcaaaag gctgtgaatc ggtggagatg actctgcgaa gaaatgggct aggacagctt
3241 ggcttccatg tcaactatga gggcattgtg gcggatgtgg agccctacgg ttatgcctgg
3301 caggcagggc tgaggcaggg cagtcgcctg gtggagatct gcaaggtggc ggtagccact
3361 ctgagccatg agcagatgat cgacctcctg agaacatctg tcacggtgaa ggttgtcatc
3421 attcccccgc atgatgactg caccccgcgg aggagttgct ctgaaaccta ccgcatgcca
3481 gtgatggagt acaaaatgaa tgaaggtgtt tcatacgaat tcaagtttcc cttccgaaat
3541 aataacaagt ggcagaggaa cgccagcaag gggcctcatt cacctcaagt cccgtcccag
3601 gtgcagagtc ccatgacctc gcggctgaat gctggaaaag gagatgggaa gatgcctcct
3661 ccagaaagag ccgccaacat ccctcgaagc atctccagtg acgggcgccc actagagagg
3721 cggctgtctc ctggttcgga catctatgtg acggtctcat ccatggcttt agcaagatcc
3781 cagtgtcgga actctcctag caacttgtct tcatccagtg atactggttc tgtggggggc
3841 acttacaggc agaagtccat gcccgaaggg tttggagtga gccgtagatc cccagcctcc
3901 attgacaggc agaacaccca gtcagatatt ggtggcagcg gaaaatccac gcctagctgg
3961 caaagaagtg aggatagcat tgctgaccag atggcttaca gttatagagg acctcaggat
4021 ttcaattctt ttgtcctcga gcagcatgaa tatacagagc caacatgcca tctcccagca
4081 gtatcaaagg tactgccagc tttccgagag agccccagtg ggagattaat gcggcaggat
4141 ccagtggttc atttgtctcc aaacaaacaa gggcattctg atagccacta ctcgagccac
4201 tccagtagca atactctctc cagcaatgcg tcaagtgccc atagtgatga gaagtggtac
4261 gatggggacc gcacagaatc cgaactcaac agctataact atctgcaagg cacctctgct
4321 gacagtggca ttgacaccac ctcttatggc cccagccacg gcagcacagc ctcgctgggg
4381 gctgccacat cgtcacctcg ctcagggcca ggcaaggaga aagtggcacc cctatggcac
4441 agctccagtg aagtaatctc catggcagat cggactttgg agacagagag ccacggcctg
4501 gaccggaaaa cagagtcttc cctgagctta gacatacaca gcaagagcca agccggctcg
4561 acccctctga caagggagaa cagcaccttc agtataaacg atgctgcttc ccacacaagt
4621 accatgagct cccgacactc tgccagccca gtggttttca ccagtgcccg gagttcacct
4681 aaagaagagc ttcatccagc tgccccctca cagctcgcac catccttctc ctcctcttcc
4741 tcctcctcct ctggtcctag gagtttttac cctcgccagg gcgctactag caagtacctg
4801 attggatgga aaaaacccga aggaaccata aactccgtgg gatttatgga cacgagaaag
4861 cgtcatcaga gcgatggcaa tgaaatagcc cacaccaggc tgcgtgcctc aaccagagac
4921 ctccgggcat ctcctaagcc aacctccaag tccaccattg aagaagatct aaagaaacta
4981 attgatcttg aaagcccaac tcctgaatca cagaagagtt ttaagttcca cgcactctcc
5041 tctcctcagt ctcctttccc cagcaccccc acctcacggc gggccttgca cagaacactg
5101 tcggacgaga gcatttacaa tagccagagg gagcactttt tcacctccag ggcgtcactt
5161 ctggaccaag ccctgcccaa cgacgtcctc ttcagtagca cgtacccttc tctccccaag
5221 tcgctcccgt tgaggaggcc ttcttacacc ttaggaatga aatcgctgca tggagagttc
5281 tcagcctcgg acagctccct cactgacatc caggagaccc gcaggcagcc tatgcccgac
5341 cctggcctga tgcccctgcc tgacactgct gcagacttgg attggtccaa cctggtagat
5401 gctgccaaag cctatgaggt ccagagagcc tcattttttg ctgctagtga tgaaaaccat
5461 cgccccttga gtgctgcatc caacagtgat cagctggagg accaggctct ggcccagatg
5521 aagccttaca gcagcagtaa agactcctct cccactctgg cttctaaagt ggaccagctg
5581 gaaggtatgc tgaagatgct tcgggaagat ttgaagaagg aaaaagaaga caaagctcac
5641 cttcaggcgg aggtgcagca cctgcgagag gacaacctga ggctacagga ggagtcccag
5701 aacgcctcgg acaagctgaa gaagttcaca gaatgggtct tcaacaccat agacatgagc
5761 tagggaaggc tgaggaggac aggagaaggg cccagacact ccctccagtg agtgtcctgc
5821 agcccttatt ccctccatag aaagcatcct cagagcacct tccctggctt cctactctgc
5881 cccctttcgg ggagtgcaca acacaatagt tgcagatcaa caatcatcac ctgccttttg
5941 tagaaaagaa aaacaaaaaa agtaaataaa aattttaaac agtaaaataa aagtttaact
6001 gctaaaaaaa aaaaaaaaaa aaaaaaaa
//