LOCUS AF090989 5965 bp mRNA linear HUM 28-APR-1999
DEFINITION Homo sapiens high-risk human papilloma viruses E6 oncoproteins
targeted protein E6TP1 alpha mRNA, complete cds.
ACCESSION AF090989
VERSION AF090989.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5965)
AUTHORS Gao,Q., Srinivasan,S., Boyer,S.N., Wazer,D.E. and Band,V.
TITLE The E6 oncoproteins of high-risk papillomaviruses bind to a novel
putative GAP protein, E6TP1, and target it for degradation
JOURNAL Mol. Cell. Biol. 19 (1), 733-744 (1999)
PUBMED 9858596
REFERENCE 2 (bases 1 to 5965)
AUTHORS Gao,Q., Srinivasan,S., Boyer,S.N., Wazer,D.E. and Band,V.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-1998) Radiation Oncology, New England Medical
Center Hospital, Box 824, 750 Washington St., Boston, MA 02111, USA
FEATURES Location/Qualifiers
source 1..5965
/db_xref="H-InvDB:HIT000068283"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 349..5700
/note="putative GAP protein alpha"
/codon_start=1
/product="high-risk human papilloma viruses E6
oncoproteins targeted protein E6TP1 alpha"
/protein_id="AAD12543.1"
/translation="MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNG
SLGSSVMAPVGPPRSEGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIET
SSCLDSLSSKSSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYP
SSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTS
GESFFDLLKGYKDDKSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFK
EREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHY
DVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDL
NSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFEST
LSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGAD
ENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTAR
GLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQST
EEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEI
MFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVR
VHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKS
EKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSM
GAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSL
KIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEG
IVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDD
CTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPSQVQSP
MTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQC
RNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSW
QRSEDSIADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSS
HSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDTTSYGPSHGSTA
SLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSK
SQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLA
PSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAH
TRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKFHALSSPQSPFPST
PTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRP
SYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKAY
EVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASKVDQLEGM
LKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS"
BASE COUNT 1713 a 1504 c 1422 g 1326 t
ORIGIN
1 ggtgtggacg ttgtctaaat ttcggtagcc atggcacaag aatataagaa agcatgggat
61 tatggcaacc acagaatctc agtagtacaa gttccattca gttttttctg aaagaaagcc
121 ctctgttaaa gtgaagcaaa gaaactgttg tggattataa cgtttagaag ttccaatttt
181 tcagtgcttt acaaataaag catcatttaa ccttttaaat gaaaaagatt aagatctcat
241 gcaactgttg tattttctgg aagccattct ccaaaaggga agtgcacatt taaaacacag
301 atatgatggt ccttgctgca gggatttaag tctacttgct tttacatcat gaccagcttg
361 aaacggtcac agacagaaag gcctcttgcc actgacaggg cctctgttgt tggcacagac
421 ggcaccccca aagtccacac tgatgatttc tacatgcggc gcttccggtc ccaaaatggc
481 agcttaggat catcagttat ggctcctgta ggaccccccc gaagtgaagg ttctcaccat
541 ataacctcaa cccccggagt cccaaaaatg ggggtaaggg caaggattgc agattggccc
601 ccaagaaagg aaaacataaa agaatctagc cgttcaagcc aggaaataga aacctcaagt
661 tgccttgata gcctgtcctc caaaagcagt cctgtgagtc agggaagttc tgttagcctc
721 aattccaatg actcagccat gctgaaaagc atacagaaca cgctgaaaaa caagacaaga
781 ccgtcggaga acatggactc cagatttctc atgcctgaag cctaccccag ctcccccaga
841 aaagctcttc gcagaatacg ccagcgaagc aacagtgata tcaccataag tgaacttgat
901 gtggatagct ttgatgaatg tatctcacct acatacaaga ctggaccatc actgcacagg
961 gaatatggta gcacatcttc aattgataaa cagggaacat ctggagaaag cttttttgat
1021 ttgttaaagg gctacaaaga tgacaaatct gatcgaggtc caactccaac caagctcagt
1081 gactttctca ttactggtgg tggcaagggt tctggtttct ctttggatgt aatagacggg
1141 cctatctcac agagagagaa cctcaggctt tttaaggaaa gggaaaaacc actcaagcga
1201 cgttcaaaat ctgaaactgg agactcctct atttttcgta aattgcgcaa tgccaaaggt
1261 gaagaacttg ggaagtcatc agatcttgaa gataaccgat cagaagactc tgtcaggccc
1321 tggacatgtc caaagtgctt tgcccactat gatgtccaga gtatattatt tgatttgaat
1381 gaggcaatta tgaacaggca caatgttatt aagaggagaa acaccaccac tggagcttcc
1441 gcagctgccg tggcatcctt ggtctctgga cctctgtctc attcagccag ttttagctcc
1501 ccaatgggca gcacagagga cctgaattcc aaaggaagcc tcagcatgga ccagggagat
1561 gataaaagca atgagcttgt aatgagctgt ccatattttc ggaatgagat aggtggagaa
1621 ggggagagga aaatcagcct ttcaaaatca aattctggct cctttagtgg atgtgaaagt
1681 gcctcctttg agtctaccct tagttcccat tgcacaaatg caggagtggc agtacttgaa
1741 gtgcccaagg agaacttggt gttgcaccta gatagagtga aaagatacat cgtggaacac
1801 gtagatctgg gtgcatacta ttatagaaaa tttttctacc agaaggaaca ctggaactat
1861 tttggggctg atgagaatct tggtccagtg gctgtgagca ttcgaaggga aaaaccagat
1921 gaaatgaaag aaaatggatc tccgtacaac taccgaataa tttttagaac tagtgagctc
1981 atgacactga gaggttcggt cctggaggac gccattccgt cgacagccaa gcactcgaca
2041 gccagaggcc tgcctctcaa agaagtgctg gagcacgtgg ttcctgagct caatgtccag
2101 tgcctgcggt tggccttcaa cacacccaag gtcacagagc agctcatgaa actggatgaa
2161 caagggctga actaccagca gaaagtaggc atcatgtact gcaaagctgg acagagcact
2221 gaagaagaga tgtacaacaa tgagtcagct ggcccagcct ttgaagaatt ccttcaacta
2281 ttgggagagc gagttcggct caaaggattt gagaagtatc gagcacagct tgataccaaa
2341 actgactcca ctggaaccca ttctctgtac acaacataca aagattatga aattatgttc
2401 catgtttcta ccatgctgcc atacacaccc aacaacaaac aacagctcct gaggaagcgg
2461 cacattggaa atgatatcgt aacaattgtt ttccaagagc ctggagcaca gccattcagc
2521 ccaaaaaaca tccgatccca cttccagcac gttttcgtca tcgtcagggt gcacaatccg
2581 tgctctgaca gtgtctgtta tagtgtggct gttaccaggt ccagagatgt gccttccttt
2641 gggcctccca ttcctaaagg ggtcactttc cctaagtcaa atgtgttcag ggacttcctt
2701 ttggcgaaag tgattaatgc agaaaatgct gctcataaat cggagaagtt tcgggccatg
2761 gcaactcgga cccgccagga atacctgaaa gatctggcag aaaagaatgt caccaacacc
2821 cctatcgacc cttctggcaa gtttccgttc atctctctgg cttccaagaa gaaggaaaag
2881 tctaagccat atccaggagc cgagctcagc agcatggggg ccattgtatg ggcagtccgg
2941 gctgaagact acaacaaggc catggaacta gactgccttt tagggatctc caatgagttc
3001 attgtgctca ttgaacagga aacaaagagc gtggtcttca attgttcctg tagagatgtg
3061 atagggtgga cttcaactga caccagcctc aaaatcttct atgaacgagg agaatgtgtt
3121 tcagtgggta gttttattaa cattgaggag atcaaagaga ttgtcaaaag gttgcagttt
3181 gtttcaaaag gctgtgaatc ggtggagatg actctgcgaa gaaatgggct aggacagctt
3241 ggcttccatg tcaactatga gggcattgtg gcggatgtgg agccctacgg ttatgcctgg
3301 caggcagggc tgaggcaggg cagtcgcctg gtggagatct gcaaggtggc ggtagccact
3361 ctgagccatg agcagatgat cgacctcctg agaacatctg tcacggtgaa ggttgtcatc
3421 attcccccgc atgatgactg caccccgcgg aggagttgct ctgaaaccta ccgcatgcca
3481 gtgatggagt acaaaatgaa tgaaggtgtt tcatacgaat tcaagtttcc cttccgaaat
3541 aataacaagt ggcagaggaa cgccagcaag gggcctcatt cacctcaagt cccgtcccag
3601 gtgcagagtc ccatgacctc gcggctgaat gctggaaaag gagatgggaa gatgcctcct
3661 ccagaaagag ccgccaacat ccctcgaagc atctccagtg acgggcgccc actagagagg
3721 cggctgtctc ctggttcgga catctatgtg acggtctcat ccatggcttt agcaagatcc
3781 cagtgtcgga actctcctag caacttgtct tcatccagtg atactggttc tgtggggggc
3841 acttacaggc agaagtccat gcccgaaggg tttggagtga gccgtagatc cccagcctcc
3901 attgacaggc agaacaccca gtcagatatt ggtggcagcg gaaaatccac gcctagctgg
3961 caaagaagtg aggatagcat tgctgaccag atggagccaa catgccatct cccagcagta
4021 tcaaaggtac tgccagcttt ccgagagagc cccagtggga gattaatgcg gcaggatcca
4081 gtggttcatt tgtctccaaa caaacaaggg cattctgata gccactactc gagccactcc
4141 agtagcaata ctctctccag caatgcgtca agtgcccata gtgatgagaa gtggtacgat
4201 ggggaccgca cagaatccga actcaacagc tataactatc tgcaaggcac ctctgctgac
4261 agtggcattg acaccacctc ttatggcccc agccacggca gcacagcctc gctgggggct
4321 gccacatcgt cacctcgctc agggccaggc aaggagaaag tggcacccct atggcacagc
4381 tccagtgaag taatctccat ggcagatcgg actttggaga cagagagcca cggcctggac
4441 cggaaaacag agtcttccct gagcttagac atacacagca agagccaagc cggctcgacc
4501 cctctgacaa gggagaacag caccttcagt ataaacgatg ctgcttccca cacaagtacc
4561 atgagctccc gacactctgc cagcccagtg gttttcacca gtgcccggag ttcacctaaa
4621 gaagagcttc atccagctgc cccctcacag ctcgcaccat ccttctcctc ctcttcctcc
4681 tcctcctctg gtcctaggag tttttaccct cgccagggcg ctactagcaa gtacctgatt
4741 ggatggaaaa aacccgaagg aaccataaac tccgtgggat ttatggacac gagaaagcgt
4801 catcagagcg atggcaatga aatagcccac accaggctgc gtgcctcaac cagagacctc
4861 cgggcatctc ctaagccaac ctccaagtcc accattgaag aagatctaaa gaaactaatt
4921 gatcttgaaa gcccaactcc tgaatcacag aagagtttta agttccacgc actctcctct
4981 cctcagtctc ctttccccag cacccccacc tcacggcggg ccttgcacag aacactgtcg
5041 gacgagagca tttacaatag ccagagggag cactttttca cctccagggc gtcacttctg
5101 gaccaagccc tgcccaacga cgtcctcttc agtagcacgt acccttctct ccccaagtcg
5161 ctcccgttga ggaggccttc ttacacctta ggaatgaaat cgctgcatgg agagttctca
5221 gcctcggaca gctccctcac tgacatccag gagacccgca ggcagcctat gcccgaccct
5281 ggcctgatgc ccctgcctga cactgctgca gacttggatt ggtccaacct ggtagatgct
5341 gccaaagcct atgaggtcca gagagcctca ttttttgctg ctagtgatga aaaccatcgc
5401 cccttgagtg ctgcatccaa cagtgatcag ctggaggacc aggctctggc ccagatgaag
5461 ccttacagca gcagtaaaga ctcctctccc actctggctt ctaaagtgga ccagctggaa
5521 ggtatgctga agatgcttcg ggaagatttg aagaaggaaa aagaagacaa agctcacctt
5581 caggcggagg tgcagcacct gcgagaggac aacctgaggc tacaggagga gtcccagaac
5641 gcctcggaca agctgaagaa gttcacagaa tgggtcttca acaccataga catgagctag
5701 ggaaggctga ggaggacagg agaagggccc agacactccc tccagtgagt gtcctgcagc
5761 ccttattccc tccatagaaa gcatcctcag agcaccttcc ctggcttcct actctgcccc
5821 ctttcgggga gtgcacaaca caatagttgc agatcaacaa tcatcacctg ccttttgtag
5881 aaaagaaaaa caaaaaaagt aaataaaaat tttaaacagt aaaataaaag tttaactgct
5941 aaaaaaaaaa aaaaaaaaaa aaaaa
//