LOCUS AF088886 2039 bp mRNA linear HUM 13-FEB-2004
DEFINITION Homo sapiens cathepsin F precursor, mRNA, complete cds.
ACCESSION AF088886
VERSION AF088886.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2039)
AUTHORS Nagler,D.K., Sulea,T. and Menard,R.
TITLE Full-length cDNA of human cathepsin F predicts the presence of a
cystatin domain at the N-terminus of the cysteine protease zymogen
JOURNAL Biochem. Biophys. Res. Commun. 257 (2), 313-318 (1999)
PUBMED 10198209
REFERENCE 2 (bases 1 to 2039)
AUTHORS Nagler,D.K. and Menard,R.
TITLE Direct Submission
JOURNAL Submitted (01-SEP-1998) Biopharmaceutical sector, Biotechnology
Research Institute, 6100 Royalmount Avenue, Montreal, Quebec H4P
2R2, Canada
REFERENCE 3 (bases 1 to 2039)
AUTHORS Nagler,D.K. and Menard,R.
TITLE Direct Submission
JOURNAL Submitted (05-NOV-1998) Biopharmaceutical sector, Biotechnology
Research Institute, 6100 Royalmount Avenue, Montreal, Quebec H4P
2R2, Canada
REMARK Sequence update submitted by submitter
REFERENCE 4 (bases 1 to 2039)
AUTHORS Nagler,D.K. and Menard,R.
TITLE Direct Submission
JOURNAL Submitted (03-MAY-1999) Biopharmaceutical sector, Biotechnology
Research Institute, 6100 Royalmount Avenue, Montreal, Quebec H4P
2R2, Canada
REMARK Sequence update by submitter
COMMENT On May 3, 1999 this sequence version replaced AF088886.1.
Name: cathepsin F.
FEATURES Location/Qualifiers
source 1..2039
/db_xref="H-InvDB:HIT000068140"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="#3, #26, #9"
/tissue_type="ovary"
CDS 91..1545
/note="preproprotein; cysteine protease of the papain
family"
/codon_start=1
/product="cathepsin F precursor"
/protein_id="AAD26616.2"
/translation="MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTR
FALEMFNRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKK
TLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRN
ETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRA
QKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWD
WRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACM
GGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAA
WLAKRGPISVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIK
NSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD"
sig_peptide 91..147
misc_feature 148..1542
/note="encodes cathepsin F proprotein"
misc_feature 148..465
/note="Region: cystatin-like domain"
misc_feature 568..576
/note="glycosylation site"
misc_feature 673..681
/note="glycosylation site"
mat_peptide 901..1542
/product="cathepsin F"
misc_feature 1189..1197
/note="glycosylation site"
misc_feature 1222..1230
/note="glycosylation site"
misc_feature 1408..1416
/note="glycosylation site"
variation 455
/replace="g"
variation 565
/replace="g"
regulatory 1991..1996
/regulatory_class="polyA_signal_sequence"
BASE COUNT 421 a 592 c 609 g 417 t
ORIGIN
1 ggaggactca ggccccgctg gccgcgggct cggtacccgg tgggtcggtg gagcgtctgt
61 tgggtccggg ccgccggctt cgccctcgcc atggcgccct ggctgcagct cctgtcgctg
121 ctggggctgc tcccgggcgc agtggccgcc cccgcccagc cccgagccgc cagctttcag
181 gcctgggggc cgccgtcccc ggagctgctg gcgcctaccc gcttcgcgct ggagatgttc
241 aaccgcggcc gggctgcggg gacgcgggcc gtgctgggcc ttgtgcgcgg ccgcgtccgc
301 cgggcgggcc aagggtcgct gtactccctg gaggccaccc tggaggagcc accctgcaac
361 gaccccatgg tgtgccggct ccccgtgtcc aagaaaaccc tgctctgcag cttccaagtc
421 ctggatgagc tcggaagaca cgtgctgctg cggaaggact gtggcccagt ggacaccaag
481 gttccaggtg ctggggagcc caagtcagcc ttcactcagg gctcagccat gatttcttct
541 ctgtcccaaa accatccaga caacagaaac gagactttca gctcagtcat ttccctgttg
601 aatgaggatc ccctgtccca ggacttgcct gtgaagatgg cttcaatctt caagaacttt
661 gtcattacct ataaccggac atatgagtca aaggaagaag cccggtggcg cctgtccgtc
721 tttgtcaata acatggtgcg agcacagaag atccaggccc tggaccgtgg cacagctcag
781 tatggagtca ccaagttcag tgatctcaca gaggaggagt tccgcactat ctacctgaat
841 actctcctga gaaaagagcc tggcaacaag atgaagcaag ccaagtctgt gggtgacctc
901 gccccacctg aatgggactg gaggagtaag ggggctgtca caaaagtcaa agaccagggc
961 atgtgtggct cctgctgggc cttctcagtc acaggcaatg tggagggcca gtggtttctc
1021 aaccagggga ccctgctctc cctctctgaa caggagctct tggactgtga caagatggac
1081 aaggcctgca tgggcggctt gccctccaat gcctactcgg ccataaagaa tttgggaggg
1141 ctggagacag aggatgacta cagctaccag ggtcacatgc agtcctgcaa cttctcagca
1201 gagaaggcca aggtctacat caatgactcc gtggagctga gccagaacga gcagaagctg
1261 gcagcctggc tggccaagag aggcccaatc tccgtggcca tcaatgcctt tggcatgcag
1321 ttttaccgcc acgggatctc ccgccctctc cggcccctct gcagcccttg gctcattgac
1381 catgcggtgt tgcttgtggg ctacggcaac cgctctgacg ttcccttttg ggccatcaag
1441 aacagctggg gcactgactg gggtgagaag ggttactact acttgcatcg cgggtccggg
1501 gcctgtggcg tgaacaccat ggccagctcg gcggtggtgg actgaagagg ggcccccagc
1561 tcgggacctg gtgctgatca gagtggctgc tgccccagcc tgacatgtgt ccaggcccct
1621 ccccgggagg tacagctggc agagggaaag gcactgggta cctcagggtg agcagagggc
1681 actgggctgg ggcacagccc ctgcttccct gcaccccatt cccaccctga agttctgcac
1741 ctgcaccttt gttgaattgt ggtagcttag gaggatgtcg gggtgaaggg tggtatcttg
1801 gcagttgaag ctggggcaag aactctgggc ttgggtaatg agcaggaaga aaattttctg
1861 atcttaagcc cagctctgtt ctgcccccgc tttcctctgt ttgatactat aaattttctg
1921 gttcccttgg atttagggat agtgtccctc tccatgtcca ggaaacttgt aaccaccctt
1981 ttctaacagc aataaagagg tgtccttgta aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
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