LOCUS AF087573 1428 bp mRNA linear HUM 19-JUL-1999
DEFINITION Homo sapiens DNA fragmentation factor DFF35 (DFF35) mRNA, complete
cds.
ACCESSION AF087573
VERSION AF087573.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1428)
AUTHORS Gu,J., Dong,R.P., Zhang,C., McLaughlin,D.F., Wu,M.X. and
Schlossman,S.F.
TITLE Functional interaction of DFF35 and DFF45 with caspase-activated
DNA fragmentation nuclease DFF40
JOURNAL J. Biol. Chem. 274 (30), 20759-20762 (1999)
PUBMED 10409614
REFERENCE 2 (bases 1 to 1428)
AUTHORS Gu,J.J., Dong,R.P., Zhang,C.H. and Schlossman,S.F.
TITLE Direct Submission
JOURNAL Submitted (27-AUG-1998) Tumor Immunology, Dana-Farber Cancer
Institute, 44 Binney Street, Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..1428
/db_xref="H-InvDB:HIT000067483"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="Jurkat"
gene 1..1428
/gene="DFF35"
CDS 38..844
/gene="DFF35"
/function="bind and inhibit caspase-dependent DNA
fragmentation nuclease DFF40 (CPAN)"
/note="nuclease inhibitor"
/codon_start=1
/product="DNA fragmentation factor DFF35"
/protein_id="AAD32953.1"
/translation="MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRS
KACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNNSDGG
TAWISQESFDVDETDSGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQE
LRQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAAFGE
EVDAVDTGISRETSSDVALASHILTALREKQAPELSLSSQDLEVGGNQGH"
BASE COUNT 379 a 329 c 401 g 319 t
ORIGIN
1 gcacgagcga aggtgggcag gtcccacctt gtggaggatg gaggtgaccg gggacgccgg
61 ggtaccagaa tctggcgaga tccggactct aaagccgtgt ctgctgcgcc gcaactacag
121 ccgcgaacag cacggcgtgg ccgcctcctg cctcgaagac ctgaggagca aggcctgtga
181 cattctggcc attgataagt ccctgacacc agtcaccctg gtcctggcag aggatggcac
241 catagtggat gatgacgatt actttctgtg tctaccttcc aatactaagt ttgtggcatt
301 ggctagtaat gagaaatggg catacaacaa ttcagatgga ggtacagctt ggatttccca
361 agagtccttt gatgtagatg aaacagacag cggggcaggg ttgaagtgga agaatgtggc
421 caggcagctg aaagaagatc tgtccagcat catcctccta tcagaggagg acctccagat
481 gcttgttgac gctccctgct cagacctggc tcaggaacta cgtcagagtt gtgccaccgt
541 ccagcggctg cagcacacac tccaacaggt gcttgaccaa agagaggaag tgcgtcagtc
601 caagcagctc ctgcagctgt acctccaggc tttggagaaa gagggcagcc tcttgtcaaa
661 gcaggaagag tccaaagctg cctttggtga ggaggtggat gcagtagaca cgggtatcag
721 cagagagacc tcctcggacg ttgcgctggc gagccacatc cttactgcac tgagggagaa
781 gcaggctcca gagctgagct tatctagtca ggatttggag gtgggcggaa accagggtca
841 ctgagctaca gaggaggaca tgccctggga tgtagtagta tcatgcagag gtgtgtgggc
901 ccttttgttc acctctgcag actgtgaatc ctagctgcca gtttgcctat tatatgccaa
961 ggcatttgca aaaatctcat taatctaaat caaaatagct ttaaagaaaa atgcatacac
1021 ttcctcagat catcaaacag actctggtcc aaggttggta atgaaatgac tgttcctgac
1081 agggaggaat agcagggccc aatcttctga gatggcttct gggtctttcc atggtcagag
1141 aagatctata gtccgtcctg aggtctgtca atgtcacagg aaaaggcaaa cttgagggga
1201 tcgtcgcctg ctggctaaga ccagggagct aaaaacttga ggaagggaac ctgcctgggt
1261 gggtgctact tctgattcat tgtccttgtc cctgtcataa gtacctccct attgtagata
1321 gaagggaagg aaactgttga cttgagcttg gctaaatttc ctgaaggtgg aggaccttag
1381 agttgctcca agtaaacttt ccaaggactt aaaaaaaaaa aaaaaaaa
//