LOCUS AF086904 1735 bp mRNA linear HUM 09-DEC-1998
DEFINITION Homo sapiens protein kinase Chk2 (CHK2) mRNA, complete cds.
ACCESSION AF086904
VERSION AF086904.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1735)
AUTHORS Matsuoka,S., Huang,M. and Elledge,S.J.
TITLE Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
JOURNAL Science 282 (5395), 1893-1897 (1998)
PUBMED 9836640
REFERENCE 2 (bases 1 to 1735)
AUTHORS Matsuoka,S.
TITLE Direct Submission
JOURNAL Submitted (25-AUG-1998) Biochemistry, Baylor College of Medicine,
One Baylor Plaza, Houston, TX 77030, USA
FEATURES Location/Qualifiers
source 1..1735
/db_xref="H-InvDB:HIT000067470"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
gene 1..1735
/gene="CHK2"
CDS 1..1632
/gene="CHK2"
/function="controls cell cycle checkpoint"
/note="contains FHA domain"
/codon_start=1
/product="protein kinase Chk2"
/protein_id="AAC83693.1"
/translation="MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTS
TMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDG
FANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYI
EDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRD
EYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI
LKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLA
VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA
PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPE
VWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTAL
PQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL"
BASE COUNT 494 a 366 c 409 g 466 t
ORIGIN
1 atgtctcggg agtcggatgt tgaggctcag cagtctcatg gcagcagtgc ctgttcacag
61 ccccatggca gcgttaccca gtcccaaggc tcctcctcac agtcccaggg catatccagc
121 tcctctacca gcacgatgcc aaactccagc cagtcctctc actccagctc tgggacactg
181 agctccttag agacagtgtc cactcaggaa ctctattcta ttcctgagga ccaagaacct
241 gaggaccaag aacctgagga gcctacccct gccccctggg ctcgattatg ggcccttcag
301 gatggatttg ccaatcttga atgtgtgaat gacaactact ggtttgggag ggacaaaagc
361 tgtgaatatt gctttgatga accactgctg aaaagaacag ataaataccg aacatacagc
421 aagaaacact ttcggatttt cagggaagtg ggtcctaaaa actcttacat tgcatacata
481 gaagatcaca gtggcaatgg aacctttgta aatacagagc ttgtagggaa aggaaaacgc
541 cgtcctttga ataacaattc tgaaattgca ctgtcactaa gcagaaataa agtttttgtc
601 ttttttgatc tgactgtaga tgatcagtca gtttatccta aggcattaag agatgaatac
661 atcatgtcaa aaactcttgg aagtggtgcc tgtggagagg taaagctggc tttcgagagg
721 aaaacatgta agaaagtagc cataaagatc atcagcaaaa ggaagtttgc tattggttca
781 gcaagagagg cagacccagc tctcaatgtt gaaacagaaa tagaaatttt gaaaaagcta
841 aatcatcctt gcatcatcaa gattaaaaac ttttttgatg cagaagatta ttatattgtt
901 ttggaattga tggaaggggg agagctgttt gacaaagtgg tggggaataa acgcctgaaa
961 gaagctacct gcaagctcta tttttaccag atgctcttgg ctgtgcagta ccttcatgaa
1021 aacggtatta tacaccgtga cttaaagcca gagaatgttt tactgtcatc tcaagaagag
1081 gactgtctta taaagattac tgattttggg cactccaaga ttttgggaga gacctctctc
1141 atgagaacct tatgtggaac ccccacctac ttggcgcctg aagttcttgt ttctgttggg
1201 actgctgggt ataaccgtgc tgtggactgc tggagtttag gagttattct ttttatctgc
1261 cttagtgggt atccaccttt ctctgagcat aggactcaag tgtcactgaa ggatcagatc
1321 accagtggaa aatacaactt cattcctgaa gtctgggcag aagtctcaga gaaagctctg
1381 gaccttgtca agaagttgtt ggtagtggat ccaaaggcac gttttacgac agaagaagcc
1441 ttaagacacc cgtggcttca ggatgaagac atgaagagaa agtttcaaga tcttctgtct
1501 gaggaaaatg aatccacagc tctaccccag gttctagccc agccttctac tagtcgaaag
1561 cggccccgtg aaggggaagc cgagggtgcc gagaccacaa agcgcccagc tgtgtgtgct
1621 gctgtgttgt gaactccgtg gtttgaacac gaaagaaatg tccttctttc actctgcatc
1681 tttcttttct ttgagtcgtt ttttatagtt ggatttaatt atggaataat ggttt
//