LOCUS AF084941 11822 bp DNA linear HUM 06-DEC-1998
DEFINITION Homo sapiens pre-T cell receptor alpha chain 1 precursor, gene,
complete cds.
ACCESSION AF084941
VERSION AF084941.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 11822)
AUTHORS Del Porto,P., Bruno,L., Mattei,M.G., von Boehmer,H. and
Saint-Ruf,C.
TITLE Cloning and comparative analysis of the human pre-T-cell receptor
alpha-chain gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12105-12109 (1995)
PUBMED 8618853
REFERENCE 2 (bases 1 to 11822)
AUTHORS Saint-Ruf,C., Lechner,O., Feinberg,J. and von Boehmer,H.
TITLE Genomic structure of the human pre-T cell receptor alpha chain and
expression of two mRNA isoforms
JOURNAL Eur. J. Immunol. 28 (11), 3824-3831 (1998)
PUBMED 9842925
REFERENCE 3 (bases 1 to 11822)
AUTHORS Saint-Ruf,C. and von Boehmer,H.
TITLE Direct Submission
JOURNAL Submitted (17-AUG-1998) INSERM 373, Institut Necker, 156 rue
Vaugirard, Paris 75015, France
FEATURES Location/Qualifiers
source 1..11822
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.3"
/cell_line="RPET001huma(4X)"
/cell_type="lymphoblastoid"
mRNA join(<1489..1546,8802..9122,10013..10057,11112..>11533)
/product="pre-T cell receptor alpha chain 1 precursor"
CDS join(1489..1546,8802..9122,10013..10057,11112..11533)
/note="immunoglobulin-like transmembrane glycoprotein;
alternatively spliced short form lacking exon 2;
pTalpha-1"
/codon_start=1
/product="pre-T cell receptor alpha chain 1 precursor"
/protein_id="AAC83346.1"
/translation="MAGTWLLLLLALGCPALPTGVGGTPFPSLAPPIMLLVDGKQQMV
VVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASW
EPLVCHTGPGAEGHSRSTQPMHLSGEASTARTCPQEPLRGTPGGALWLGVLRLLLFKL
LLFDLLLTCSCLCDPAGPLPSPATTTRLRALGSHRLHPATETGGREATSSPRPQPRDR
RWGDTPPGRKPGSPVWGEGSYLSSYPTCPAQAWCSRSRLRAPSSSLGAFFAGDLPPPL
QAGAA"
BASE COUNT 2965 a 2914 c 3096 g 2847 t
ORIGIN
1 tcgatgtgca gaggtcccac tcttgggaag gcagcagagg atcgcttggg actgggaggc
61 agatgttgca ttgaggtgat catgccactg cactcccggc ctgagtgata aatccagact
121 gtctcgcaaa aaatccaaaa ggctgaggtg ggaggattgc ttgagcccag gatttcaaga
181 gtgtagtgag gcctgtgatc cgatcactgc tctgccagcc tggggtgaca gagtaaaagc
241 ctgtctctta aaaaaaaaaa aaaagttaaa atggtataat aaatgccagg catgtggctc
301 acaccagtac tcccagcact tcgggaagcc agagcaggag gatcgcttga gccaggagta
361 cgaaaccaac ataggcaaca aagcaagact ccatctctac aaaaaatcaa aataaaaata
421 aattagctgg gtgtggtagc gcatgcctgt ggtcttagct actcaggagg ctgacgaagg
481 aggatcactt gagcccagga gttcaagact gcagtgagct atcattgtac tgccgcattc
541 tagcctgggc aacaaagaaa gaaccccatc tctaaaaaaa aaattaaata aataaaagga
601 gggctgtaac aacatggcaa aaagtttact gggcatcttt ttttattttt tttttttgag
661 atggcgtctc gctctgtcgc ccaggttgga gtgcagtggc caaatcttgg ctcactgcaa
721 gctccacctc ccgggttcac accattctcc tgcctcagcc tcctgaatag ctgggactac
781 aggagcccgt caccacaccc agctaatttt tttgtatttt tagtagagac cggggttcac
841 cgtgttagcc aggaatggtc ttgatctcct gaccttgaga tcccgctcgt ctcagcctcc
901 caaagtgctg ggattaccag gcgtgcagac tgcgcctggc cctgggtatc tttttgccta
961 taataaagcc agccatctaa aaacagttca agccctggct ctggtacctg tcagctgtgt
1021 ggccctgggc ggtccctcac tctctgtgag cctcagttgc ctctcctgtg aaatgtaact
1081 cagtggttga gtggaattgc cgtcaccttg gaaattgaac tcatgtgtgg atgggatcaa
1141 gtgaagggct gtatgtcaag cccctgtcaa gccacctggt gctccgtgtc ctgtggatgg
1201 tagcagccct gaagcgggac tttgcagact gaagtgctgt ctcttcagag ggagtgcagg
1261 tgtccggctc ctggtgtgga gaggcaccct gtgtgctccc tggcccgtga gacaagattg
1321 ggtttggggg ccagggcagg agtaggggcc cgtcactagg ggtttcggct cgtggtagag
1381 cagctgaggt gcagctggcc tgtggcctag aaggcagtct tgtgggtgcc tcctccccca
1441 gccgcaactc aggtctgcag ctgggtcctg cctccttccg agtgggccat ggccggtaca
1501 tggctgctac ttctcctggc ccttgggtgt ccagccctac ccacaggtga gccccctctt
1561 tgccttcctc tctgtccctc ctcagtctgc cgaagcccaa cccctcactc tggacctccc
1621 tgggtactga tgggctgcag ggaggcagga caagagatat ttagggacct ctggggaggg
1681 tccctctggg aggggacctc tggggagggg accctatata gagggccact attctcttcc
1741 cattgtactc ttcctcccag ccaccttgct ctggggctcc tatgtcctcc tgccctggag
1801 cccacagtgt tgatagggag gctgcccctc ttagaggtat agagaaatga gaacaaactg
1861 gatctggaca tccatagaag gtggggttag ggtagccagt gtgtgtgatg tgatatgcaa
1921 tgatgtcata tgggtaacag tgtgaggtcc tgtcctgtcc ttcttgccct caggatgcct
1981 gccctagttc aataggactc agggtgtctc aagttcactc acagctcacg cttatcagtg
2041 ggctcaggat aggacccaag gcctcttccc agggtattta cccccagccc tcccatgatc
2101 aaggctggag ccaaaggact catgttttga ggggaaaatt ccagcttcat ctagaagcat
2161 gtgcatgtgt gcatgtacgt ggtgggggaa ggtccatgac ttttgagtca ggggggtctc
2221 cttgatctag agcaggcccc aagtatctca caggcactcc ttcattaggg agataaacca
2281 cacctatgtg gaacacaggg agcccatggc aggaggctga gctcgggaag gaagtaacca
2341 gggtaagcag ggacaatcct gggatgcttc atggaagaag tggaagctga actcaacttg
2401 gggaatgtct ctatctatat aactgaaaag gctctggagg ttgagtctgg agctcgtgcc
2461 cagcctactc tactaccttt gtttgcaatg ccttattaat attaatatca acaattgcac
2521 taatacttat ctgccagggc attttacact tatggccttt actcttcaca acaattttgc
2581 tgggctggta ttattaacag cattatatta ttattattat tattattatt attattatta
2641 tttatttttg agacagagtc tcgcactgtc gcccgggctg gagtacaatg gtgtgatctt
2701 ggctcactac aacctccacc tcccgggttc acttgattct cctgcctcag cctcccaagt
2761 agctgggatt acaggcacct gccaccacgc ccagctaatt ttttgtattt ttagtacaga
2821 cggagtttca ctgtgttggc caggctggtc ttgaactcct gacctcatga tccgcccgcc
2881 tcagcctccc aaagtgctgg gattacagac gtgagccacc tcacccagcc cgttatatta
2941 ttattattat tattattatt attattatta ttattattag acagagtttg ctctgttgcc
3001 cagattggag tgcaatggca caatctcaac tcactgcatc ctctgcctcc caggttcaag
3061 cggttctcct gcctcagctt cccaatgtag ctgggattac agccgcccac catcatgccc
3121 ggctaatttt ttgtattttt agtggaaaca ggggttcacc acgttggcca tactggtccg
3181 aactcctgac ttcagtgatt cacctgactc cgcctcccaa agtgctggga ctacaggcat
3241 aagccactga gcccggccta acaccattat attgatgaga ccattgggac tcacaaaaaa
3301 tattgttcct tcaacctaaa taaataaata aatacataca taatgaaaac aaaacaaaac
3361 aaacaaaaag agtcagaaaa ttggctgggc gcggtggctt acgcctgtaa ttccagcact
3421 ttggaaggcc aaggcgggca gatcacttgg aagtcaggag tttgagacca gcctggccaa
3481 catgacgaaa ccccatcttt actaaaaaat acaaaaatta acctggacat gtggcaggtg
3541 cctgtaatcc agctatatag gatgctgagg caggagaatt gcttgaaccc gggaggagga
3601 ggttgcactg agccaagatc ccaccactgc actccaggct aggcgacaga accagaatca
3661 gtctcaaaaa aaaaaaaagc caggcatggg gctcatgcct gtaatcctag cactttgcac
3721 tttgggaggc tgaggcaggt ggatcacgag gtcaggagtt caagaccagc ctggccaaga
3781 tggtgaaacc ccatctctac taaaaataca aaaatttaca cgcgtggtgg taggtgcctg
3841 tagtcccagc tactcaggag gctgaggcag gagaatcgct tgaacccggt gggtggaggt
3901 tgcagtgaac agagatcctg ccactgcact ccagcctggg caacagagtg agactccatc
3961 tcaaaaataa taataataat aataatgaaa taaaataaag actcagaaaa ttaagtgaac
4021 gagtcaggag tcacgcttag ctctgtctga agctatgtcc tagacggtcc actgtgtcac
4081 atggcaaaat cttagtcatc cttcaaagtg agatggttta ggggatttgg agtcacaaga
4141 gatctgagag ttcaaatcct gaatggacaa cttaccattt atgtgttagt aggataattt
4201 tttttttttt ttttttgaga cagagacacg cactgtcgcc caggctggag tgcagtggtg
4261 caatcttggc tcactgtaag ctccgcctcc cggggttcac gccattctcc tgcctcagcc
4321 tcccgagagc tgggactaca ggcgcctgcc aaccatgcct ggctaatttt ttgtattttt
4381 agtagagaca gggtttcacc atgttagcca ggatggtctc gatctcctga cctcatgatc
4441 cgtccaccta tatttttttt ttttaatttt ttgagacaga gtcccgctct gtcgccaggc
4501 tggagtgcaa ttctcctgcc tcagcctcca gagtagctgg gattacaggc gcgtgccacc
4561 acgcccggct aattttttgt attttagtag agacggggtt tcaccatgtt agccaggatg
4621 gtctcgatct cctgaccttg tgatctgccc acctcagcct cccaaagtgc tgggaataaa
4681 agcgtgagcc accacgcctg ggcctaggct aattatttgg cttgtgagaa atctttccta
4741 agtgcccttt acccctacat cctcacaaga ttctctggcc tccttccctg cactctggga
4801 catttctttc gtttggctat acctaattca caaaaaactg caggctggac aaagtggctc
4861 atgcctataa tcccagcact ttgggaggcc caggcatgag gatctcttcg agcgctgaag
4921 ttcaagacca gctaggacaa catagtgaaa ccctatttct acaaaaaata aaaaataaat
4981 tagccaggta tggtggcacg tgcctgtagt ccctgctact gggaaggctg aggtgggagg
5041 actgcctgaa cccgggtggt caaagcctca gtaagccatg atcatgccat tgcactccgg
5101 cctgggcaag agagagagac tctgtctcaa aaaaaaaaga aaaaaaatta caatgttcaa
5161 aaataacatt ctgggccagg tgcggtggct cacgtctgta atcccagcac tttgaggagg
5221 ctgaggtgag tggtcatttg aggtcaggag ttggagacca gcctggccaa catggtgaaa
5281 ccttgtctct acaaaaaata caaaaaaaat cagccagacc tggtggcgca cacctgtaat
5341 cccaattact cggagggctt aagcagggag aatttcttga accccagaag tggagattgc
5401 agtgagctga gattgtgcta ctgcactcca gcctgggtaa gatagtgaga ctccatctca
5461 aaaaaataaa agaaaatttt tgttacatat taaatgagtc atctttgctg aaaagaataa
5521 gattgcagcc tgggcctgtt gactcatgcc tgtaatccca gcactttggg aggctgaggt
5581 ggaagaatag cttgagccta ggagtttgag accaccccag gcaacatagg gagacccatg
5641 tctctacagg tattttaaaa atgtagccgg gtgttgtgac acgtgcctgt ggtcacagct
5701 acttggcagg ccaggaggtc aaggctccag tgaactgtga tcacaccatt gcagtccagc
5761 ctggatgaca gagctagacc ctgtctcaaa aaataataat aataggccgg gtgaggtggc
5821 tcacgcctgt aatcccagca ctttgggagg tcgaggcagg cggatcacga ggcaaggaga
5881 tggagaccat cctggctaac acagtgaaac cccttctcta ctaaaaatat aaacaattag
5941 ccaggcgtgt tggcgggcgc ctgtagtccc agctactcgt gaggctgagg caggagaatg
6001 gcgtgaaccc gggaggcgga gcttgcagtg agccgagatc gcgccagatg cacttgagcc
6061 tgggcgacag agagagactc cgtctctcaa aaaataaaat aataaagtaa gtaaaagatt
6121 gtgggaaata gggattattt tggaaaatat aggaaaaatg tttgtagtac ccatcatgac
6181 ttagttcttt cttttatttt tatttttttt gagacggagt cttgctctgt cgcccaggct
6241 ggagtgcaga ggcgcgatct tggctcactg cgagctccgc ctcccgggtt cacgccattc
6301 tcctgcctca gcctcccgag taaatgggac tacaggcggc tgccacccac gcccggctaa
6361 ttattttgta tttttagtag agacggggtt tcaccgtgtt agccaggatg gtctctatct
6421 cctgacctcg tgatccaccc accttggcct cccaaagtgc tgggattaca ggcttgagcc
6481 acagcgccca gccatgactt agttcttaag attattaaat aatacaccta tacttcaaat
6541 gggtgaattg tctggtatgt ggactatatc taaacaaagc tttttttttt ttttttcact
6601 ctgtcaccca ggctggagtg cagtgacgcg atctcagctc actgcaacct ttgcccgggt
6661 tcaagcgatt cttgtgcctc agtctccaga gtagctggga ctacaggcac gtgccaccac
6721 acgcagctaa tttttttgta tttttagtag agatggggtt tcgccatgtt ggccagggtg
6781 ttttctcgaa ctcctgacct caggtgatct gcctgccttg gccccccaaa gtgctgggat
6841 tacaagcatg aaccgaccac acccagcctt ttttgttgtt gttgttgttt tgagacagaa
6901 tcttgtgctg ttgcccaagg ctggagtgta gtggcatgat cttggctcac tgcaacctcc
6961 gcctctgggt ttaagcgatt ctcctgcttc aagcctcctg agtagctggg actacgggta
7021 tgcaccacca cgcccgacta attttgtatt tttagtagag atggggttcc accatgttgg
7081 ccaggctggt ctcaaactcc tgacctcagg tgatcgccct gcctcagcct cccaaagtgc
7141 taggattaca tgcgtgagcc accgcaccca gcacaacaaa gcttcttttt tttttttttt
7201 tttttttttg agagagagtc ttgctctgtc gccaggctgg agtgcagtgg cgtgatctag
7261 gctcactgca acttccgctt ccctggttca agtgattctc ctgccgcagc ctcccaagta
7321 gctgggatta caggcgacac accactaagc ccacctaatt tttgtatttt tagtagagat
7381 ggggtttcac catgttggcc aggatagtct cgatctcctg acctcgtgat ctgcccacct
7441 tggcctcccg aagtgctggg aattacaggc atgagccacc gtgcccggcc aacaaagctt
7501 tttttttcaa aaaaaaaaaa aaaaaaggct gggtgtggtg cctcacgcct gtaatcctag
7561 cactttggga ggccagggca ggcagatcac ctgaggtcag gagtcagaga ccagcctgac
7621 caacatggag aaacccagtc tctagtaaaa acataaaaat aaaaatgaac tggcttggtg
7681 gcgtgggaac ttgggaggct gaggcagaag aatggcttga acccagaagg cagaggttgc
7741 agtgagccga catggtgcca ctgcactcca gtctgggaga cgtagcaaga ctccgtctca
7801 aaaagcaagc aaaaaaacaa acaaacaaaa ctacaggcta cagaaaaagg ctgagaataa
7861 aagaaaaaat acccaagcac actccaccta gattaacaaa cgtttaacat tttgccatat
7921 ttaaatcaga cttttaaaaa aagaaacaaa aagttacaga tatatttgaa gccccttcta
7981 atctcattcc aggtcctgtt tccttccctt cctcaccaga ggctgccaca acagggtatt
8041 acaagtattt tttttacaca tctactgtct ttcccatgga actgagttcc ttgagagcag
8101 ggacaatgac ttacccaatg ttgtatctct agttcctgaa cagaaagggg ctcggatatc
8161 atagacaagt ggatggaagg agaggtgggt agatggatag atagacacat agatgaaagg
8221 tagaaagaat agatggaggt ggccgggcat ggtggctcac acctgtaatc ccagcacttt
8281 gggaggacga ggcgggtgga tcacgaggtc aggagatcga gaccatcctg gctaacacgt
8341 ctctactaaa aataaaaata aaaattagcc gggcgctgtg gcgggcacct gtagtcccag
8401 ctactcagga ggctgaggca ggaagatggc atgaacccag gaggtggaac ttgcagtgag
8461 ctgagatcgc gccactgcac tctagcctgg gcaacagagc aaaattccat ctcaaaaaaa
8521 aaaaaaagaa agaaagaata catggaggat agatggctga tagaagaaag gatggataaa
8581 caggtgagtg aatgaaagga tgggcagatg gagggaagga agggtggcta gatgggaaaa
8641 tgccaaggag gaatggatga gtggctagaa ggacatgtag atggatggtg gaaggatgga
8701 tggatggaaa gacagaaatg tagaacccta gcctacaaca caatgctggc ctgggaggcc
8761 aaaagctggt ctagcaccca caggtacatg ctctcttgca ggtgtgggcg gcacaccctt
8821 tccttctctg gccccaccaa tcatgctgct ggtggatgga aagcagcaga tggtggtggt
8881 ctgcctggtc cttgatgttg caccccctgg ccttgacagc cccatctggt tctcagccgg
8941 caatggcagt gcactggatg ccttcaccta tggcccttcc ccagcaacgg atggcacctg
9001 gaccaacttg gcccatctct ccctgccttc tgaggagctg gcatcctggg agcctttggt
9061 ctgccacact gggcctgggg ctgagggtca cagcaggagt acacagccca tgcatctgtc
9121 aggtggggat ggagcctggg cccttgcgga tgctccctgt ccccttccac acaccaggat
9181 atggttggag ggagggcacg ctccaggcca caaagggcat gaagggtgtc caagcggcag
9241 agcctctggg tgaggtgaca cctgggctca gggagagtgg cctcagggca tgaattttgg
9301 gatttgccac tgcaatatct gtttgaaatc caggctttgc agcatggctt ccaaaaggat
9361 aaaaatgcct ccttccacct aggattcatt atacacacat agataatcac cctgtgtaca
9421 tgacacccta ttttttttta aggaccaaac taattaacaa atcactacca gttattgagt
9481 gtttactctg ttccaggcag tgttctacag acttacactt tagtgacagg tcatataatt
9541 ccctcaattt tacaggcaca gggaggttaa gcaacatgtc taaagccagc tatttttgtt
9601 tccccctcca ttgtattttg aaacagtcag ctattattat cactgaccag atgacttact
9661 tcctctctag ggattatctc aattttgtca tctttcaaat gggaatgttt gttaactaag
9721 tgccctgact tccaaagaat gcagcgaaga cagtcagttc cttatctgag agttccgggc
9781 tccccagcct ccccagggca cagaacaggg gacactgcaa agtgagggat gtttgggtct
9841 tcagaggact tgcagcaaat gggctcaggg tttctgctgc tggctcactt gtccatttac
9901 cccaaatgcc tcgacaccca ccctgtgcca gggcctgggc atagcactgg ggatgccctc
9961 cagagtgcat ggcccatccc caaagactca ttcgcttctc cctggacaac aggagaggct
10021 tctacagcca ggacctgccc ccaggagcct ctcaggggtg agtactccgg gcaaggggtg
10081 gggaataaga ggctgggacc aggaccttgg gcccgggggg tggggcttca gctctggcct
10141 aatgggtctt acactggagg tcagtaggtg tcccatgtag aggctgtcat gctaggttgg
10201 ggcactgggc taggcatggg cctcagtcta cctagcataa gatgggggtg aatcctttga
10261 ccccagccta attcctggac attagttgag aagcacaggt gacagctaac agaggggtct
10321 ttggagtcct ccttgggcag cccctaacag aggggtcttt ggagtcctcc ttgggcagcc
10381 caggcagggg ggtctcagca ttagaggccg tgtaaaaggc aggggggtct cagcattaga
10441 ggccgtgtaa atgggaggct gtctggggtg atggaaagag cctggacgga cagtcatgaa
10501 gttgggctgt ggtccaactc tgcttcccga ccaaatagag aattttgagg ccgggagcgg
10561 tggctcacac ctgtaatccc agcactttgg gaggccgagg tgggtggatc acgaggtcag
10621 gagttcgaga ccagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaat
10681 tagccgagcg tgatggcaca cgcctgtagt cccagctact caggaggctg aggtagaaga
10741 atcacttgaa cccgggaggt ggaggttgca gtgagatgag atcgtgccac tgccctccag
10801 cctgggtgac agagtgagac tccatctaaa aaaaaaaaag aattttgagc tagttactct
10861 ctgcatcaga tgctaattaa ttcctgcgtg gcccccaccc ctacccccat gattgtttgg
10921 ggaataaaat aaggccagga aggtatttat tattaccagt aagaacggag gctagacacc
10981 cggaaggact ttccctggag gagggggtga aggggacggg caagggcaga ggacaaggcc
11041 ctctccgccg ttctctcctg gggtaggggg ctgcgggctc ctgcgggctc ctgagcggtt
11101 cctcctcgca gggacaccgg gtggggcgct gtggctgggg gtcctgcggc tgctgctctt
11161 caagctgctg ctgtttgacc tgctcctgac ctgcagctgc ctgtgcgacc ccgcgggccc
11221 gctgccttcc cccgcaacca ccacccgcct gcgagccctc ggctcccatc gactgcaccc
11281 ggccacggag actgggggac gagaggccac cagctcaccc agaccccagc ctcgggaccg
11341 ccgctggggt gacacccctc cgggtcggaa gcccgggagc ccagtatggg gggaagggtc
11401 ttacctcagc agttacccca cttgcccagc acaggcctgg tgctcaagat ctcgcctcag
11461 ggctccttcc tccagtcttg gagcattttt tgcaggtgac ctgcctcctc ctctgcaggc
11521 tggagctgcc tgagggcagg gctctacctc ccctgcgtca cactgtgtga ggctgtgtct
11581 ctgccatcca aaagggggcc ccttgagaat ggtgatccac ccagttacag gggcatttag
11641 ggagcagatg actgagaaca ttaaaaaaga acttaaatga cacagcaaat gaaaaatatt
11701 tgaattcatg tctatcctgg gaggaaggaa tttggcagag ttagaagtag gaaaaatcca
11761 ggaaagctcc cttgaggaag agggcttcct gagacagaac ttgggaactg cagagtggga
11821 ct
//