LOCUS AF083551 6172 bp mRNA linear HUM 02-JUL-1999
DEFINITION Homo sapiens exostosin (EXTL3) mRNA, complete cds.
ACCESSION AF083551
VERSION AF083551.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6172)
AUTHORS Sato,T.
TITLE The human EXTL1L/EXTR1/EXTL3 gene at 8p11-p12, the third breast
cancer susceptibility gene locus, is not mutated in breast and
various cancers
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 6172)
AUTHORS Sato,T.
TITLE Direct Submission
JOURNAL Submitted (11-AUG-1998) Otolaryngology/Pathology, Columbia
University, 630 West 168th St., P&S 11-451, New York, NY 10032, USA
FEATURES Location/Qualifiers
source 1..6172
/db_xref="H-InvDB:HIT000066585"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p11-p12"
gene 1..6172
/gene="EXTL3"
/gene_synonym="EXTL1L"
/gene_synonym="EXTR1"
/note="candidate gene for breast cancer susceptibility
BRCA3"
CDS 594..3353
/gene="EXTL3"
/gene_synonym="EXTL1L"
/gene_synonym="EXTR1"
/codon_start=1
/product="exostosin"
/protein_id="AAD42041.1"
/translation="MTGYTMLRNGGAGNGGQTCMLRWSNRIRLTWLSFTLFVILVFFP
LIAHYYLTTLDEADEAGKRIFGPRVGNELCEVKHVLDLCRIRESVSEELLQLEAKRQE
LNSEIAKLNLKIEACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLL
PEKDDAGLPPPKATRGCRLHNCFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAF
QATARANVYVTENADIACLYVILVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVII
NLSRKSDTQNLLYNVSTGRAMVAQSTFYTVQYRPGFDLVVSPLVHAMSEPNFMEIPPQ
VPVKRKYLFTFQGEKIESLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLD
QVLVEFTCKNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPRLVISSGCATR
LFEALEVGAVPVVLGEQVQLPYQDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAM
RRQGRFLWETYFSTADSIFNTVLAMIRTRIQIPAAPIREEAAAEIPHRSGKAAGTDPN
MADNGDLDLGPVETEPPYASPRYLRNFTLTVTDFYRSWNCAPGPFHLFPHTPFDPVLP
SEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPREQFTVVMLTYEREEVLMNSLER
LNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRTEKNSLNNRFLPWNEIETEAI
LSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHQSWLYNSNYSCELSMV
LTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPPIKVTSRWT
FRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPHDKTK
CFKFI"
BASE COUNT 1280 a 1681 c 1692 g 1519 t
ORIGIN
1 ggcgggtccc tgagctggaa gccggagagc aagccctgga ggttcactct ttcaagaagt
61 cgtgtgctga ggtgtaatgc tacacaagtc agaggaagga agggtcctga aacacatggc
121 ctgattgttg gcaaaggcat cataagaagc tggcatttat ttctgttcta acctattact
181 gtataactgt gaatagacac tatgcatatt tgttggtcag caaaaccaag aaacaagagc
241 tatggcattt gaaaaagtct gtctgattcc agggtgtttt tcctgggttt catcatcagg
301 tacctcctcc ctttcatctc agcaagaatg tggcaccttt tatcgtttga taaagattaa
361 ggacatgttc tttggtcaac agccagaact taaaatctgc tggaataggg tcagagacca
421 tttcagctgc agctgaggaa aatgaaatgt tcattttatt tggtgccttg tctggggagc
481 acactaactc ttctggaaac gtgtcagtga aacagagatc gttttgtgga atagcaaccc
541 atggttatgg cgagtgaccc gacgtgatct ggggggcagg ctgcagagga ctcatgacag
601 gctataccat gctgcggaat gggggcgcgg ggaacggagg tcagacctgc atgctgcgct
661 ggtccaaccg catccgcctc acgtggctca gcttcacgct ctttgtcatc ctggtcttct
721 tcccgctcat cgcccactat tacctcacca ctctggatga ggctgatgag gcaggcaagc
781 ggatttttgg tccccgggtg gggaacgagc tgtgcgaggt gaagcacgtg ctggatctgt
841 gccgcatccg ggagtcggtg agtgaagagc tcctgcagct ggaggccaag cgccaagagc
901 tgaacagcga gatcgccaag ctgaatctga agatcgaagc ctgtaagaag agcattgaga
961 acgccaagca ggacctgctc cagctcaaga atgtcatcag ccagaccgag cattcctaca
1021 aggagctcat ggcccagaac cagcccaagc tgtccctgcc catccgactg ctcccagaga
1081 aggacgatgc cggcctccct cccccgaagg ccactcgggg ctgccggcta cacaactgct
1141 ttgattattc tcgttgccct ctcacctctg gcttcccggt ctacgtctat gacagtgacc
1201 agtttgtctt tggcagctac ctggatccct tggtcaagca ggcttttcag gcgacagcac
1261 gagctaacgt ttatgttaca gaaaatgcag acatcgcctg cctttacgtg atactagtgg
1321 gagagatgca ggagcccgtg gtgctgcggc ctgctgagct ggagaagcag ttgtattccc
1381 tgccacactg gcggacggat ggacacaacc atgtcatcat caatctgtca cgtaagtcag
1441 atacacagaa ccttctctat aacgtcagta ctggccgtgc catggtggcc cagtccacct
1501 tctacactgt ccagtacaga cctggctttg acttggtcgt atcaccgctg gtccatgcca
1561 tgtctgagcc caacttcatg gaaatcccac cacaggtgcc ggtgaagcgg aaatatctct
1621 tcaccttcca gggcgagaag attgagtctc tgaggtctag ccttcaggag gcccgctcct
1681 tcgaagagga aatggagggc gaccctcccg ccgactacga tgaccggatc attgccaccc
1741 tgaaggcggt gcaggacagc aagctggatc aggtcctggt ggaattcacc tgcaaaaacc
1801 agcccaaacc cagcctgccg actgagtggg cactgtgtgg agagcgggag gaccgcttgg
1861 aattgctgaa gctctccacc ttcgccctca tcattacccc cggggaccct cgcttggtta
1921 tttcctctgg gtgtgcaaca cggctcttcg aagccctgga agtcggtgcc gtcccggtgg
1981 tgctggggga gcaggtccag cttccctacc aggacatgct gcagtggaac gaggcggccc
2041 tggtggtgcc aaagcctcgt gttaccgagg ttcatttcct gctcagaagc ctctccgata
2101 gtgacctcct ggctatgagg cggcaaggcc gctttctctg ggagacttac ttctccactg
2161 ctgacagtat ttttaatacc gtgctggcta tgattaggac tcgcatccag atcccagccg
2221 ctcccatccg ggaagaggcg gcagctgaga tcccccaccg ttcaggcaag gcggctggaa
2281 ctgaccccaa catggctgac aacggggacc tggacctggg gccagtggag acggagccgc
2341 cctacgcctc acccagatac ctccgcaatt tcactctgac tgtcactgac ttttaccgca
2401 gctggaactg tgctccaggg cctttccatc ttttccccca cactcccttt gaccctgtgt
2461 tgccctcaga ggccaaattc ttgggctcag ggactggctt tcggcctatt ggtggtggag
2521 ctgggggttc tggcaaggaa tttcaggcag cgcttggagg caatgttccc cgagagcagt
2581 tcacggtggt gatgttgact tatgagcggg aggaagtgct tatgaactct ttagagaggc
2641 tgaatggcct cccttacctg aacaaggtcg tggtggtgtg gaattctccc aagctgccat
2701 cagaggacct tctgtggcct gacattggcg ttcccatcat ggtggtccgt actgagaaga
2761 acagtttgaa caaccgattc ttaccctgga atgaaattga gacagaggcc atcctgtcca
2821 ttgatgacga tgctcacctc cgccatgacg aaatcatgtt tgggttccgg gtgtggagag
2881 aagctcggga ccgcatcgtg ggcttccctg gccgttacca cgcatgggac atcccccatc
2941 agtcctggct ctacaactcc aactactcct gtgagctgtc catggtgctg acaggtgctg
3001 ccttctttca caagtattat gcctacctgt attcttatgt gatgccccag gccatccggg
3061 acatggtgga tgaatacatc aactgtgagg acattgccat gaacttcctt gtctcccaca
3121 tcactcggaa gccccccatc aaggtgacct cacggtggac attccgatgc ccaggatgcc
3181 ctcaggccct gtctcatgat gactcccact tccacgagcg gcacaagtgc atcaacttct
3241 tcgtgaaggt gtacggctac atgcccctcc tgtacacgca gttcagggtg gattctgtgc
3301 tcttcaagac acgcctgccc catgacaaga ccaagtgctt caagttcatc taggggcagc
3361 gcacggtctg gggaagagga tgagcagagg gaggaagatg gctcccaagg ttcctaggca
3421 ttgcaggacc ttgggcacat ctgctggtgg gtggcccaga gcctctgctg gaaggggcag
3481 caggaggagt ggaaggaaac cgctgccttt atcttgaagt cagccacact gggcctggag
3541 ccctgggcgg agtccccggg gttccccaca cagggcactg actgatagct tacactgagg
3601 actgtggcga ctctgcagag tcactcacac cgttcgtacg cccaggacag ctggttcgtg
3661 gtttttacat tcaataacaa ctattatgat tatttaaaaa gagaaagttt cagatttgcc
3721 attcaaggct tatttatata tatgtgtgtg tatataaata catgcacaca cttgcataca
3781 tatatatttt tggctggggg agtgtgagtt ttgcctttct aagggaggga ccgcgcaggc
3841 tcctttgttc tgtattctgg cggagatggg tcctggcctt gtgtcactgg cttatcctta
3901 aagatcatct cccatcctcc ccagcgccat ctgtgtgcag caaccagaaa gggatgaact
3961 tggccctctt gcgggcctgg acaaggtctc ttccttaccc tttctgttgc cagtcagcaa
4021 cctgtaactc acattctctt cccagtgaat ccctgggagc gcctgaccct ggtgggctgt
4081 tcagcttcct gctgctgggg ccagcgattt ttgaggattt atctttaggc caggcttgcc
4141 tccgtactta tccctgctct cccatttctc tcttgtttga gagagaatga ggaagcaaag
4201 agtgagaaag aataggggct gaagacgcca ctcccagatg gctctttcta tcctgctctt
4261 ctgttgaaac acacgtgctg tgggcctcag gcgtttctga agtgctcttt cttggattgg
4321 acaggagatc agcagcgtgc acatctgctg tggtctgaag tggtttgcag gtcagcctcc
4381 tctccctagt gtagagcaag ccagtgtcct tcgaggaacc cacccggctg gccgggaagt
4441 tttacagcaa ggcgcctgcc ttgggataat tccttggtga aattcacctt ccccccgcct
4501 ctgtctggag ccccatcctg tgttatctgt ggtttttgga cccctaatgt cagcttggct
4561 gtaggactcc ccgaggtttg gtatgtgcta gaacaatggg aggctgtgat ttgctgtgta
4621 agctcacatc cagccttgga atctaacggg cattcacaac ccgagttacc actttccact
4681 ccctgcttag gattctgttc cctgggctga aactgaaata agctaatttt ttgggtcacg
4741 gtggcagtag gggaacctag gagggtgtga gtggcatttg tcagggattt agcccatgac
4801 gtgtttcttg aaccctactt tctggaagtg gagttgactc tggaagtttt ctagcaactg
4861 aacaaaagct caggtttgtc ctggtcatgc acatgcctta agccagttcc gtcttcccta
4921 gaccttggca tcctgtgctt ctatttcttg gaatacgttc tcctctgacc tgcctgtacc
4981 acgtgggtcc tcttcaagta ctgttttgaa gctgggctct tttgtgtagc tcccacccac
5041 ctgtagggct agctcggctt aagggaactc tccccattgg caaaccggac ccggccgccg
5101 ccaggactgt gtttccaaag gttccccgcc cccaacccca gcatcagcct gtagctcccc
5161 tgctgaggca gtgtggttat gttcccagca gtgggggtca gacgcccttc ctcagaactt
5221 tctagttgcc ctctacctga ctcctgactt gtattccttt tagcagtagc cttcttccct
5281 cggggagcca aagagtgtgg tgtgtggcgc tatattgtgg ctgctatttc atctggtttc
5341 ttttaatgtg aggaactcac atactgactt cagtgggact cggtgagccg gggccgtctg
5401 tgtggtggga ccccctttag cgggactcag tgagctgggg ccgtctgtgt ggtggagcca
5461 gggcctctcc ctttagtgga gccaggttgt cgggccccga atgtcactgg tggatctaag
5521 aagggctgag tggtctgaca ccaaaacatg ccgcagggag ggctgtggtg ccggtgcttc
5581 caacaaggac agccctcctt gaccctgaaa ggaacactgg cttgaaggac tgcagacagg
5641 ctctgagggg cacgccctcc tcagcgagag gcagcaaggt ggccacagtg tcactggtca
5701 ggtgcttctc accacgggaa agccgccgac ctgtgactcg cttgagatgg gaaagcggcg
5761 ccacagaccc cgggtctcct tggctgtctg tgggccgccc ctggccacct tgtcctggct
5821 cgcagggtgc aggagcgcct cgttctctgg gtggccggct tgctgctccg gtttgggctg
5881 tcttaccata acaccgtccc agggctctgc aggccactgt gagcgctggc tccctgggca
5941 gtgctcctcc gtgtggactg tgcctcaggc cagggctcac cagctggggt cctgtccgga
6001 aggatgggat ctttctggga gctgcgccgg acagagtggg gagctcctag tttgtggggg
6061 gaagctttga tatccatgcc acgtccatcc accccacccc ttttcgtcac gagcacaatg
6121 gtcttacatt ggatttttgt aaaaaaataa aaataaatgg agactttaac tc
//