LOCUS       AF083386                7886 bp    mRNA    linear   HUM 25-MAR-1999
DEFINITION  Homo sapiens putative WHSC1 protein (WHSC1) mRNA, complete cds.
ACCESSION   AF083386
VERSION     AF083386.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7886)
  AUTHORS   Stec,I., Wright,T.J., van Ommen,G.J., de Boer,P.A., van
            Haeringen,A., Moorman,A.F., Altherr,M.R. and den Dunnen,J.T.
  TITLE     WHSC1, a 90 kb SET domain-containing gene, expressed in early
            development and homologous to a Drosophila dysmorphy gene maps in
            the Wolf-Hirschhorn syndrome critical region and is fused to IgH in
            t(4;14) multiple myeloma
  JOURNAL   Hum. Mol. Genet. 7 (7), 1071-1082 (1998)
   PUBMED   9618163
REFERENCE   2  (bases 1 to 7886)
  AUTHORS   Stec,I. and den Dunnen,J.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-AUG-1998) Department of Human Genetics, Leiden
            University Medical Center, Wassenaarseweg 72, Leiden 2333 AL,
            Netherlands
FEATURES             Location/Qualifiers
     source          1..7886
                     /db_xref="H-InvDB:HIT000066572"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            <1..7886
                     /gene="WHSC1"
                     /note="genomic sequence deposited in GenBank Accession
                     Numbers Z49236, Z68276, Z68164 and Z68165"
     5'UTR           <1..494
                     /gene="WHSC1"
     CDS             495..4592
                     /gene="WHSC1"
                     /codon_start=1
                     /product="putative WHSC1 protein"
                     /protein_id="AAD19343.1"
                     /translation="MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNREC
                     SVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFES
                     QEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQK
                     PENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLL
                     KYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWI
                     FEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAAS
                     MSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVRE
                     ECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPR
                     SRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFAL
                     VAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKT
                     ARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLT
                     ENEVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLC
                     EGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYH
                     EACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDAC
                     LAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPD
                     CLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHE
                     IGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREI
                     KLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDS
                     ECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEF
                     VNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQP
                     NCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGD
                     RPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKA
                     YHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGR
                     SYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK"
     misc_feature    1152..1295
                     /gene="WHSC1"
                     /note="Region: PWWP domain"
     misc_feature    1881..2000
                     /gene="WHSC1"
                     /note="Region: HMG-box"
     misc_feature    2994..3110
                     /gene="WHSC1"
                     /note="Region: PHD-type zinc finger domain"
     misc_feature    3714..4034
                     /gene="WHSC1"
                     /note="Region: SET domain"
     3'UTR           4593..7886
                     /gene="WHSC1"
     polyA_site      5479
                     /gene="WHSC1"
                     /note="alternative site"
     polyA_site      7886
                     /gene="WHSC1"
BASE COUNT         1968 a         1955 c         2122 g         1841 t
ORIGIN      
        1 tggtcttgaa ctcctgacct tgtgatccgc tcgcctcagc ctcccaaagt gctgggatta
       61 caggcatgag ccaccgtgcc tgtcctagaa ccactggtaa ctcttaactg agacaagatt
      121 tcgccatgtt gcccaggctg gtctcgaact tctgagctca agcgatctac ctgcctcgtc
      181 ctcccaaagt gttggaattg caggtgtgag ccactgcacc cggcccttgc ctcatgtttg
      241 aatgataatt tacctgggca taaaattctg gacacttgtg gtggcacgag ctgtctgctt
      301 ttctgtggag actgcgggtt gcagacacca gcagccccct attgctgcac gtcaggtgtc
      361 ctccacctca gtactgtgga catctcgggc cgcatagccc tgttgcgcgg gcatcctgtg
      421 cgttgcagga gatgcagcag catccatgac cgcaacccat cagagtgttc taagaacgga
      481 agcatctggg ctggatggaa tttagcatca agcagagtcc cctttctgtt cagagtgttg
      541 taaagtgcat aaagatgaag caggcaccag aaatcctcgg cagtgccaac gggaagactc
      601 cgagctgcga ggtgaaccgc gagtgttctg tgttcctcag caaagcccag ctctccagta
      661 gcctgcagga gggggtcatg cagaagttta acggccacga cgccctgccc tttattccag
      721 ccgacaagct gaaagatctt acttcccggg tgtttaatgg agaacccggc gcacacgatg
      781 ccaaactgcg ttttgagtcc caggaaatga aagggattgg gacaccccct aacactaccc
      841 ctatcaaaaa tggctctcca gaaattaagc tgaaaatcac caaaacatac atgaatggga
      901 agcctctctt tgaatcttcc atttgtggtg acagtgctgc tgatgtgtct cagtcagaag
      961 aaaatggaca aaaaccagaa aacaaggcga gaaggaacag gaagaggagc ataaaatatg
     1021 actccttgct ggagcagggc cttgtcgaag cagctcttgt gtctaagatc tcaagtcctt
     1081 cagataaaaa gattccagct aagaaagagt cttgtccaaa cactggaaga gacaaagacc
     1141 acctgttgaa atacaacgtt ggtgatttgg tgtggtccaa agtgtcgggt tacccttggt
     1201 ggccttgcat ggtttctgca gatccactcc ttcacagcta taccaaactt aaaggtcaga
     1261 aaaagagtgc acgccagtat cacgtacagt tctttggtga cgccccagaa agagcttgga
     1321 tatttgagaa gagcctcgta gcttttgaag gagaaggaca gtttgaaaaa ttatgccagg
     1381 aaagtgccaa gcaggcaccc acgaaagctg agaaaattaa gctattgaaa ccaatttcag
     1441 ggaaattgag ggcccagtgg gaaatgggca ttgttcaagc agaagaagct gcaagcatgt
     1501 cagtggagga gcggaaagcc aagttcacct ttctctatgt gggggaccag cttcatctca
     1561 accctcaagt agccaaggag gctggcattg ctgcagagtc tttgggagaa atggcagaat
     1621 cctcaggagt cagtgaagaa gctgctgaaa accccaagtc tgtgagagaa gagtgcattc
     1681 ccatgaagag aaggcggagg gccaaactgt gtagctctgc agagaccctg gagagtcacc
     1741 ccgacatagg gaagagtact cctcaaaaga cggcagaggc tgaccccaga agaggagtag
     1801 ggtctcctcc tgggaggaag aagaccacag tctccatgcc acgaagcagg aagggagatg
     1861 cagcatccca gtttttggtc ttctgtcaaa aacacaggga tgaggtggta gctgagcacc
     1921 cagatgcttc aggtgaggag attgaagagc tgctcaggtc acagtggagt ctgctgagtg
     1981 agaagcagag agcacgctac aacaccaagt ttgccctggt ggcccctgtc caggctgaag
     2041 aagactctgg taatgtaaat gggaaaaaaa gaaaccacac aaagaggata caggacccta
     2101 cagaagatgc tgaagctgag gacacaccca ggaaaagact caggacggac aagcacagtc
     2161 ttcggaagag agacacaatc actgacaaaa cggccagaac aagctcttac aaggccatgg
     2221 aggcagcctc ctcgctcaag agccaggcag caacgaaaaa tctgtctgat gcatgtaaac
     2281 cactgaagaa gcgaaatcgg gcttccacgg cagcatcttc agctcttggg tttagcaaaa
     2341 gttcatctcc ttctgcatcc ttaactgaga atgaggtctc ggacagcccg ggagacgagc
     2401 cctcggagtc cccatacgaa agtgcagacg aaacacaaac tgaagtatct gtctcatcca
     2461 aaaagtctga gcgaggagtg actgccaaaa aggagtatgt gtgccagctg tgtgagaagc
     2521 cgggcagcct cctgctctgt gaaggaccct gctgcggagc tttccacctc gcctgccttg
     2581 ggctttcccg gaggccagaa gggaggttca cctgcagcga gtgtgcctca gggattcact
     2641 catgtttcgt gtgtaaagag agcaagacag atgttaagcg ctgtgtggta actcagtgtg
     2701 gaaaatttta ccatgaggct tgtgtgaaaa aataccctct gactgtattt gagagccgag
     2761 gtttccgctg ccccctccac agctgtgtga gctgccatgc ttccaaccct tcaaacccaa
     2821 ggccgtcaaa aggtaaaatg atgcggtgtg tccgctgccc cgttgcctat cacagcgggg
     2881 atgcttgtct ggcagcagga tgctcagtga tcgcctccaa cagcatcatc tgcactgccc
     2941 acttcactgc tcggaagggg aagcgacacc acgcccacgt caacgtgagc tggtgcttcg
     3001 tgtgctccaa aggggggagc cttctgtgct gtgagtcctg cccagcggcc ttccaccctg
     3061 actgcctgaa catcgagatg cctgacggca gctggttctg caatgactgc agggctggga
     3121 agaagctgca cttccaggat atcatttggg tgaaacttgg gaactacaga tggtggccgg
     3181 cagaagtttg ccatcccaaa aatgttcccc caaatattca gaaaatgaag cacgagattg
     3241 gagaattccc tgtgtttttc tttgggtcta aagattatta ctggacgcat caggcgcgag
     3301 tgttcccgta catggagggg gaccggggca gccgctacca gggggtcaga gggatcggaa
     3361 gagtcttcaa aaacgcactg caagaagctg aagctcgttt tcgtgaaatt aagcttcaga
     3421 gggaagcccg agaaacacag gagagcgagc gcaagccccc accatacaag cacatcaagg
     3481 tgaataagcc ttacgggaaa gtccagatct acacagcgga tatttcagaa atccctaagt
     3541 gcaactgcaa gcccacagat gagaatcctt gtggctttga ttcggagtgt ctgaacagga
     3601 tgctgatgtt tgagtgccac ccgcaggtgt gtcccgcggg cgagttctgc cagaaccagt
     3661 gcttcaccaa gcgccagtac ccagagacca agatcatcaa gacagatggc aaagggtggg
     3721 gcctggtcgc caagagggac atcagaaagg gagaatttgt taacgagtac gttggggagc
     3781 tgatcgacga ggaggagtgc atggcgagaa tcaagcacgc acacgagaac gacatcaccc
     3841 acttctacat gctcactata gacaaggacc gtataataga cgctggcccc aaaggaaact
     3901 actctcgatt tatgaatcac agctgccagc ccaactgtga gaccctcaag tggacagtga
     3961 atggggacac tcgtgtgggc ctgtttgccg tctgtgacat tcctgcaggg acggagctga
     4021 cttttaacta caacctcgat tgtctgggca atgaaaaaac ggtctgccgg tgtggagcct
     4081 ccaattgcag tggattcctc ggggatagac caaagacctc gacgaccctt tcatcagagg
     4141 aaaagggcaa aaagaccaag aagaaaacga ggcggcgcag agcaaaaggg gaagggaaga
     4201 ggcagtcaga ggacgagtgc ttccgctgcg gtgatggcgg gcagctggtg ctgtgtgacc
     4261 gcaagttctg caccaaggcc taccacctgt cctgcctggg ccttggcaag cggcccttcg
     4321 ggaagtggga atgtccttgg catcattgtg acgtgtgtgg caaaccttcg acttcatttt
     4381 gccacctctg ccccaattcg ttctgtaagg agcaccagga cgggacagcc ttcagctgca
     4441 ccccggacgg gcggtcctac tgctgtgagc atgacttagg ggcggcatcg gtcagaagca
     4501 ccaagactga gaagcccccc ccagagccag ggaagccgaa ggggaagagg cggcggcgga
     4561 ggggctggcg gagagtcaca gagggcaaat agcgccaggc ggccgcttgg ccggatccag
     4621 gggcggtgca gggcggccgg ccctgcctgc gggagagggc gagcatgaac tggcccggag
     4681 gacccagctc gagccgccag gacacagacg tacaggcctc ctcgggaggg agcgcctccc
     4741 caccactgag ccatcctcag cagcgtccgc tgcgtctgca ctgatgaccg tctgagccca
     4801 gctcagcgtt cctggacaaa cagcctcact cctcagcgtt accgccacac ttgaatttct
     4861 ccgaatgtca aggttccctc ccactctatt tttttaggtt aaagttaatt ggcatatgga
     4921 atgttttaat ctcctctgaa atgtgtagcg taggcttttc ccaagggtcg ctagaaactc
     4981 gtcttcgcgt tgcccccttt ctggctctca gcgccgtcgc cactcgggag aggctgggtg
     5041 aggcccgtgt gaggactgac cctggattcc tcgaaactgc cattgtgatc attactctgc
     5101 tctttggaaa tggctgtatc atttttttgt actaatgtga attgttcctc agaaacgctt
     5161 cttttccatc ctagtgagaa gctggccctg caggtggtgg cagcaatggt gttgtaagat
     5221 ttcctcccgt agttttttct cctcatggat ttgaatgaaa tgccaataac acgtccactt
     5281 tcaacgtgta gtttacgcgg agcactttcg aggcctggcc gggttgggcc tacttctcac
     5341 ctgggcctat cttctgaact cgctaggttc ttatcaacat ttgggggata actttgtata
     5401 tttttttcat ttggcttttc tttaccagtt tctgattttt attctcaata tatttttgct
     5461 aaacctattt cacaaatcac caccgactga agtgtgtgtt tactgatgcg gccctgagct
     5521 ccatggcgaa aggagtgact ttgcagggcg tgagaccgca gtctgcttag agcacaggaa
     5581 gtgacaactt agggagcccc gtagggcgct gcaggccccg gggaccccag cacgtgggtc
     5641 taaagagaga cggagtctag ctctcctgcc acccagagtg gcttccatct cagcactctg
     5701 tgggtctggt gatggaagat gcagtctctg ctgatcacat gtgccctctg ccagggcacc
     5761 tactgagagg tgcggtcctg ggggtggagg cctgcctggc aggtgtgcgt gcctcgtacg
     5821 tgtgttatgg gcactggtct aggccaggta tgacacccac tctcctgtga gatttcactt
     5881 tagtttttaa aaggtccagt tctacagagt gagacctatc tatctgagta ctacatatgt
     5941 tttaagactt ggttcttttt ttgagggatc cttgaccctg ggaagtctgg agcaccctga
     6001 gaagggggca ccatgtgtgc ctttgcccac gtgtcctgag gggctgcttg tctgggaggg
     6061 agggagagaa cattcagcag caggtgcttt tttatggcct tttcttaaaa taacctaagg
     6121 gggacacatc catcttgcag agaagtttac agaactcccc ttgaaaactg ctgctgaggc
     6181 tcctgttaaa ttttctgtgg catcttttat gccttggtaa aaactgcagt gtctttggac
     6241 ctgagagtgg ctactccgtg gttttgtgac ctgtaagcgt ggggttcagg ggtgtgtggc
     6301 cctgcagggt cccacgcctc cctgagcact gactggaagt ttcactggct ggtggctgtc
     6361 ccttctccca tcagggtccc cagcaaagtt aactacacag aggacccagg ggaaacgagc
     6421 tgtgtagcca ctgacttgct cgcgcggccg tggcctctga ggggcactcg ccggttaaga
     6481 cagggtggga gtagtgcttt ccagttcaga ctctaacttc tcccaaagtg tcctaagaaa
     6541 atactggatc ggctcataga tttatgctcc ttatgatgcc ctaacttgga aggttgttct
     6601 agggacaggc cgggcagtgt ccccacacac accttagagt cgaaggcccc agggccccgc
     6661 tgtcacttgc ccaaaagatc ccttccggca ggtaagggac taccaatgct tacgtcaaaa
     6721 cagcagaatc ggctttgcag tgcactttgg ggagcagata ttaacttatt tttgtgttgg
     6781 acagtagtga aatcttgtga tttttaatcg ctttgataat acttccaaat tttatgattt
     6841 ttctgaagga aataatgcaa acattttaaa tatgtttctc cccctttcca aaaactgtta
     6901 aactaatgag caagtaacac taactttgaa tgtctctaca atacccgttg ataactcagt
     6961 ggagccaggc tttggggtag cggccctgag cttgcagggt ttctcgccac tggggctgac
     7021 cacgccccca gctgtgaccg tgggtgtggc tggctctcgg ccctgcccag ctttgttctg
     7081 aggacgtggt gacttcctga acatcagctt caatcctcca tcattaatgt gaagcaaaac
     7141 acaaaaaccg ccccaatccc tcaggattcc ttggcatccg aaaccagcat ctgcacctaa
     7201 acccataccc acccgtgtgc gcccacaggg ggatgtgtcc gaatgggcag cttaaaatgt
     7261 ggtcacctgt gggggaaact cttcaggcac ctgaagtgag aacccagctg tccgtcctca
     7321 ggccggcctt tcttccggcg acacccgtcc atggctggct gggtcccctt cgcagtgttt
     7381 gtctgtcttg acatctaaac cccggcgtgt gcagtgccca tcttccagga ctaccttatt
     7441 ttccagaatt aaacctgttt tataattcaa gttaatgcaa atgactgtca gttgccaaat
     7501 atcttgatcc tgtgagtgta gttgatgact gtttgttagt cagtagagta aaatgctgtg
     7561 tccacggggt gtcacagcct caccataccc tgttgaggtg tgaaatgccc cgtcagaaat
     7621 taaatacaaa cttaaatgtg cctattggtg tctaaacttc atacaatgta aggtcagatt
     7681 ccttttagga atactgggtg ctgtcaccag gtttgatagt tagacttaaa aacttgaaat
     7741 tcactttttg gggggaggga tatactgaaa tagagagttg agacttgcca gttgggggaa
     7801 aatagcattt aaaatggaaa gctgtgtttg gaaaattgtg tatgagtatt tttgtattaa
     7861 aaacatttta aaggcttttt tcttaa
//