LOCUS AF083386 7886 bp mRNA linear HUM 25-MAR-1999 DEFINITION Homo sapiens putative WHSC1 protein (WHSC1) mRNA, complete cds. ACCESSION AF083386 VERSION AF083386.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7886) AUTHORS Stec,I., Wright,T.J., van Ommen,G.J., de Boer,P.A., van Haeringen,A., Moorman,A.F., Altherr,M.R. and den Dunnen,J.T. TITLE WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma JOURNAL Hum. Mol. Genet. 7 (7), 1071-1082 (1998) PUBMED 9618163 REFERENCE 2 (bases 1 to 7886) AUTHORS Stec,I. and den Dunnen,J.T. TITLE Direct Submission JOURNAL Submitted (11-AUG-1998) Department of Human Genetics, Leiden University Medical Center, Wassenaarseweg 72, Leiden 2333 AL, Netherlands FEATURES Location/Qualifiers source 1..7886 /db_xref="H-InvDB:HIT000066572" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" gene <1..7886 /gene="WHSC1" /note="genomic sequence deposited in GenBank Accession Numbers Z49236, Z68276, Z68164 and Z68165" 5'UTR <1..494 /gene="WHSC1" CDS 495..4592 /gene="WHSC1" /codon_start=1 /product="putative WHSC1 protein" /protein_id="AAD19343.1" /translation="MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNREC SVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFES QEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQK PENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLL KYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWI FEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAAS MSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVRE ECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPR SRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFAL VAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKT ARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLT ENEVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLC EGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYH EACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDAC LAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPD CLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHE IGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREI KLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDS ECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEF VNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQP NCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGD RPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKA YHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGR SYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK" misc_feature 1152..1295 /gene="WHSC1" /note="Region: PWWP domain" misc_feature 1881..2000 /gene="WHSC1" /note="Region: HMG-box" misc_feature 2994..3110 /gene="WHSC1" /note="Region: PHD-type zinc finger domain" misc_feature 3714..4034 /gene="WHSC1" /note="Region: SET domain" 3'UTR 4593..7886 /gene="WHSC1" polyA_site 5479 /gene="WHSC1" /note="alternative site" polyA_site 7886 /gene="WHSC1" BASE COUNT 1968 a 1955 c 2122 g 1841 t ORIGIN 1 tggtcttgaa ctcctgacct tgtgatccgc tcgcctcagc ctcccaaagt gctgggatta 61 caggcatgag ccaccgtgcc tgtcctagaa ccactggtaa ctcttaactg agacaagatt 121 tcgccatgtt gcccaggctg gtctcgaact tctgagctca agcgatctac ctgcctcgtc 181 ctcccaaagt gttggaattg caggtgtgag ccactgcacc cggcccttgc ctcatgtttg 241 aatgataatt tacctgggca taaaattctg gacacttgtg gtggcacgag ctgtctgctt 301 ttctgtggag actgcgggtt gcagacacca gcagccccct attgctgcac gtcaggtgtc 361 ctccacctca gtactgtgga catctcgggc cgcatagccc tgttgcgcgg gcatcctgtg 421 cgttgcagga gatgcagcag catccatgac cgcaacccat cagagtgttc taagaacgga 481 agcatctggg ctggatggaa tttagcatca agcagagtcc cctttctgtt cagagtgttg 541 taaagtgcat aaagatgaag caggcaccag aaatcctcgg cagtgccaac gggaagactc 601 cgagctgcga ggtgaaccgc gagtgttctg tgttcctcag caaagcccag ctctccagta 661 gcctgcagga gggggtcatg cagaagttta acggccacga cgccctgccc tttattccag 721 ccgacaagct gaaagatctt acttcccggg tgtttaatgg agaacccggc gcacacgatg 781 ccaaactgcg ttttgagtcc caggaaatga aagggattgg gacaccccct aacactaccc 841 ctatcaaaaa tggctctcca gaaattaagc tgaaaatcac caaaacatac atgaatggga 901 agcctctctt tgaatcttcc atttgtggtg acagtgctgc tgatgtgtct cagtcagaag 961 aaaatggaca aaaaccagaa aacaaggcga gaaggaacag gaagaggagc ataaaatatg 1021 actccttgct ggagcagggc cttgtcgaag cagctcttgt gtctaagatc tcaagtcctt 1081 cagataaaaa gattccagct aagaaagagt cttgtccaaa cactggaaga gacaaagacc 1141 acctgttgaa atacaacgtt ggtgatttgg tgtggtccaa agtgtcgggt tacccttggt 1201 ggccttgcat ggtttctgca gatccactcc ttcacagcta taccaaactt aaaggtcaga 1261 aaaagagtgc acgccagtat cacgtacagt tctttggtga cgccccagaa agagcttgga 1321 tatttgagaa gagcctcgta gcttttgaag gagaaggaca gtttgaaaaa ttatgccagg 1381 aaagtgccaa gcaggcaccc acgaaagctg agaaaattaa gctattgaaa ccaatttcag 1441 ggaaattgag ggcccagtgg gaaatgggca ttgttcaagc agaagaagct gcaagcatgt 1501 cagtggagga gcggaaagcc aagttcacct ttctctatgt gggggaccag cttcatctca 1561 accctcaagt agccaaggag gctggcattg ctgcagagtc tttgggagaa atggcagaat 1621 cctcaggagt cagtgaagaa gctgctgaaa accccaagtc tgtgagagaa gagtgcattc 1681 ccatgaagag aaggcggagg gccaaactgt gtagctctgc agagaccctg gagagtcacc 1741 ccgacatagg gaagagtact cctcaaaaga cggcagaggc tgaccccaga agaggagtag 1801 ggtctcctcc tgggaggaag aagaccacag tctccatgcc acgaagcagg aagggagatg 1861 cagcatccca gtttttggtc ttctgtcaaa aacacaggga tgaggtggta gctgagcacc 1921 cagatgcttc aggtgaggag attgaagagc tgctcaggtc acagtggagt ctgctgagtg 1981 agaagcagag agcacgctac aacaccaagt ttgccctggt ggcccctgtc caggctgaag 2041 aagactctgg taatgtaaat gggaaaaaaa gaaaccacac aaagaggata caggacccta 2101 cagaagatgc tgaagctgag gacacaccca ggaaaagact caggacggac aagcacagtc 2161 ttcggaagag agacacaatc actgacaaaa cggccagaac aagctcttac aaggccatgg 2221 aggcagcctc ctcgctcaag agccaggcag caacgaaaaa tctgtctgat gcatgtaaac 2281 cactgaagaa gcgaaatcgg gcttccacgg cagcatcttc agctcttggg tttagcaaaa 2341 gttcatctcc ttctgcatcc ttaactgaga atgaggtctc ggacagcccg ggagacgagc 2401 cctcggagtc cccatacgaa agtgcagacg aaacacaaac tgaagtatct gtctcatcca 2461 aaaagtctga gcgaggagtg actgccaaaa aggagtatgt gtgccagctg tgtgagaagc 2521 cgggcagcct cctgctctgt gaaggaccct gctgcggagc tttccacctc gcctgccttg 2581 ggctttcccg gaggccagaa gggaggttca cctgcagcga gtgtgcctca gggattcact 2641 catgtttcgt gtgtaaagag agcaagacag atgttaagcg ctgtgtggta actcagtgtg 2701 gaaaatttta ccatgaggct tgtgtgaaaa aataccctct gactgtattt gagagccgag 2761 gtttccgctg ccccctccac agctgtgtga gctgccatgc ttccaaccct tcaaacccaa 2821 ggccgtcaaa aggtaaaatg atgcggtgtg tccgctgccc cgttgcctat cacagcgggg 2881 atgcttgtct ggcagcagga tgctcagtga tcgcctccaa cagcatcatc tgcactgccc 2941 acttcactgc tcggaagggg aagcgacacc acgcccacgt caacgtgagc tggtgcttcg 3001 tgtgctccaa aggggggagc cttctgtgct gtgagtcctg cccagcggcc ttccaccctg 3061 actgcctgaa catcgagatg cctgacggca gctggttctg caatgactgc agggctggga 3121 agaagctgca cttccaggat atcatttggg tgaaacttgg gaactacaga tggtggccgg 3181 cagaagtttg ccatcccaaa aatgttcccc caaatattca gaaaatgaag cacgagattg 3241 gagaattccc tgtgtttttc tttgggtcta aagattatta ctggacgcat caggcgcgag 3301 tgttcccgta catggagggg gaccggggca gccgctacca gggggtcaga gggatcggaa 3361 gagtcttcaa aaacgcactg caagaagctg aagctcgttt tcgtgaaatt aagcttcaga 3421 gggaagcccg agaaacacag gagagcgagc gcaagccccc accatacaag cacatcaagg 3481 tgaataagcc ttacgggaaa gtccagatct acacagcgga tatttcagaa atccctaagt 3541 gcaactgcaa gcccacagat gagaatcctt gtggctttga ttcggagtgt ctgaacagga 3601 tgctgatgtt tgagtgccac ccgcaggtgt gtcccgcggg cgagttctgc cagaaccagt 3661 gcttcaccaa gcgccagtac ccagagacca agatcatcaa gacagatggc aaagggtggg 3721 gcctggtcgc caagagggac atcagaaagg gagaatttgt taacgagtac gttggggagc 3781 tgatcgacga ggaggagtgc atggcgagaa tcaagcacgc acacgagaac gacatcaccc 3841 acttctacat gctcactata gacaaggacc gtataataga cgctggcccc aaaggaaact 3901 actctcgatt tatgaatcac agctgccagc ccaactgtga gaccctcaag tggacagtga 3961 atggggacac tcgtgtgggc ctgtttgccg tctgtgacat tcctgcaggg acggagctga 4021 cttttaacta caacctcgat tgtctgggca atgaaaaaac ggtctgccgg tgtggagcct 4081 ccaattgcag tggattcctc ggggatagac caaagacctc gacgaccctt tcatcagagg 4141 aaaagggcaa aaagaccaag aagaaaacga ggcggcgcag agcaaaaggg gaagggaaga 4201 ggcagtcaga ggacgagtgc ttccgctgcg gtgatggcgg gcagctggtg ctgtgtgacc 4261 gcaagttctg caccaaggcc taccacctgt cctgcctggg ccttggcaag cggcccttcg 4321 ggaagtggga atgtccttgg catcattgtg acgtgtgtgg caaaccttcg acttcatttt 4381 gccacctctg ccccaattcg ttctgtaagg agcaccagga cgggacagcc ttcagctgca 4441 ccccggacgg gcggtcctac tgctgtgagc atgacttagg ggcggcatcg gtcagaagca 4501 ccaagactga gaagcccccc ccagagccag ggaagccgaa ggggaagagg cggcggcgga 4561 ggggctggcg gagagtcaca gagggcaaat agcgccaggc ggccgcttgg ccggatccag 4621 gggcggtgca gggcggccgg ccctgcctgc gggagagggc gagcatgaac tggcccggag 4681 gacccagctc gagccgccag gacacagacg tacaggcctc ctcgggaggg agcgcctccc 4741 caccactgag ccatcctcag cagcgtccgc tgcgtctgca ctgatgaccg tctgagccca 4801 gctcagcgtt cctggacaaa cagcctcact cctcagcgtt accgccacac ttgaatttct 4861 ccgaatgtca aggttccctc ccactctatt tttttaggtt aaagttaatt ggcatatgga 4921 atgttttaat ctcctctgaa atgtgtagcg taggcttttc ccaagggtcg ctagaaactc 4981 gtcttcgcgt tgcccccttt ctggctctca gcgccgtcgc cactcgggag aggctgggtg 5041 aggcccgtgt gaggactgac cctggattcc tcgaaactgc cattgtgatc attactctgc 5101 tctttggaaa tggctgtatc atttttttgt actaatgtga attgttcctc agaaacgctt 5161 cttttccatc ctagtgagaa gctggccctg caggtggtgg cagcaatggt gttgtaagat 5221 ttcctcccgt agttttttct cctcatggat ttgaatgaaa tgccaataac acgtccactt 5281 tcaacgtgta gtttacgcgg agcactttcg aggcctggcc gggttgggcc tacttctcac 5341 ctgggcctat cttctgaact cgctaggttc ttatcaacat ttgggggata actttgtata 5401 tttttttcat ttggcttttc tttaccagtt tctgattttt attctcaata tatttttgct 5461 aaacctattt cacaaatcac caccgactga agtgtgtgtt tactgatgcg gccctgagct 5521 ccatggcgaa aggagtgact ttgcagggcg tgagaccgca gtctgcttag agcacaggaa 5581 gtgacaactt agggagcccc gtagggcgct gcaggccccg gggaccccag cacgtgggtc 5641 taaagagaga cggagtctag ctctcctgcc acccagagtg gcttccatct cagcactctg 5701 tgggtctggt gatggaagat gcagtctctg ctgatcacat gtgccctctg ccagggcacc 5761 tactgagagg tgcggtcctg ggggtggagg cctgcctggc aggtgtgcgt gcctcgtacg 5821 tgtgttatgg gcactggtct aggccaggta tgacacccac tctcctgtga gatttcactt 5881 tagtttttaa aaggtccagt tctacagagt gagacctatc tatctgagta ctacatatgt 5941 tttaagactt ggttcttttt ttgagggatc cttgaccctg ggaagtctgg agcaccctga 6001 gaagggggca ccatgtgtgc ctttgcccac gtgtcctgag gggctgcttg tctgggaggg 6061 agggagagaa cattcagcag caggtgcttt tttatggcct tttcttaaaa taacctaagg 6121 gggacacatc catcttgcag agaagtttac agaactcccc ttgaaaactg ctgctgaggc 6181 tcctgttaaa ttttctgtgg catcttttat gccttggtaa aaactgcagt gtctttggac 6241 ctgagagtgg ctactccgtg gttttgtgac ctgtaagcgt ggggttcagg ggtgtgtggc 6301 cctgcagggt cccacgcctc cctgagcact gactggaagt ttcactggct ggtggctgtc 6361 ccttctccca tcagggtccc cagcaaagtt aactacacag aggacccagg ggaaacgagc 6421 tgtgtagcca ctgacttgct cgcgcggccg tggcctctga ggggcactcg ccggttaaga 6481 cagggtggga gtagtgcttt ccagttcaga ctctaacttc tcccaaagtg tcctaagaaa 6541 atactggatc ggctcataga tttatgctcc ttatgatgcc ctaacttgga aggttgttct 6601 agggacaggc cgggcagtgt ccccacacac accttagagt cgaaggcccc agggccccgc 6661 tgtcacttgc ccaaaagatc ccttccggca ggtaagggac taccaatgct tacgtcaaaa 6721 cagcagaatc ggctttgcag tgcactttgg ggagcagata ttaacttatt tttgtgttgg 6781 acagtagtga aatcttgtga tttttaatcg ctttgataat acttccaaat tttatgattt 6841 ttctgaagga aataatgcaa acattttaaa tatgtttctc cccctttcca aaaactgtta 6901 aactaatgag caagtaacac taactttgaa tgtctctaca atacccgttg ataactcagt 6961 ggagccaggc tttggggtag cggccctgag cttgcagggt ttctcgccac tggggctgac 7021 cacgccccca gctgtgaccg tgggtgtggc tggctctcgg ccctgcccag ctttgttctg 7081 aggacgtggt gacttcctga acatcagctt caatcctcca tcattaatgt gaagcaaaac 7141 acaaaaaccg ccccaatccc tcaggattcc ttggcatccg aaaccagcat ctgcacctaa 7201 acccataccc acccgtgtgc gcccacaggg ggatgtgtcc gaatgggcag cttaaaatgt 7261 ggtcacctgt gggggaaact cttcaggcac ctgaagtgag aacccagctg tccgtcctca 7321 ggccggcctt tcttccggcg acacccgtcc atggctggct gggtcccctt cgcagtgttt 7381 gtctgtcttg acatctaaac cccggcgtgt gcagtgccca tcttccagga ctaccttatt 7441 ttccagaatt aaacctgttt tataattcaa gttaatgcaa atgactgtca gttgccaaat 7501 atcttgatcc tgtgagtgta gttgatgact gtttgttagt cagtagagta aaatgctgtg 7561 tccacggggt gtcacagcct caccataccc tgttgaggtg tgaaatgccc cgtcagaaat 7621 taaatacaaa cttaaatgtg cctattggtg tctaaacttc atacaatgta aggtcagatt 7681 ccttttagga atactgggtg ctgtcaccag gtttgatagt tagacttaaa aacttgaaat 7741 tcactttttg gggggaggga tatactgaaa tagagagttg agacttgcca gttgggggaa 7801 aatagcattt aaaatggaaa gctgtgtttg gaaaattgtg tatgagtatt tttgtattaa 7861 aaacatttta aaggcttttt tcttaa //