LOCUS AH006405 2653 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens chromosome 1 signaling molecule LEFTY-B gene, complete
cds.
ACCESSION AH006405 AF081504 AF081505 AF081506 AF081507
VERSION AH006405.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2653)
AUTHORS Kosaki,K., Kosaki,R., Bassi,M.T. and Casey,B.
TITLE Human homologues of murine lefty gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2653)
AUTHORS Kosaki,K., Kosaki,R., Bassi,M.T. and Casey,B.
TITLE Direct Submission
JOURNAL Submitted (03-AUG-1998) Department of Pathology, Baylor College of
Medicine, One Baylor Plaza S230, Houston, TX 77030, USA
COMMENT On or before Jun 10, 2016 this sequence version replaced
AF081504.1, AF081505.1, AF081506.1, AF081507.1, AH006405.1.
FEATURES Location/Qualifiers
source 1..2653
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q42"
regulatory 2..21
/regulatory_class="enhancer"
/note="retinoic acid response element"
regulatory 72..77
/regulatory_class="TATA_box"
mRNA join(111..430,938..1184,1468..1707,1943..>2653)
/product="signaling molecule LEFTY-B"
exon 111..430
/number=1
5'UTR 111..180
CDS join(181..430,938..1184,1468..1707,1943..2306)
/note="TGF-beta type secreted signaling molecule"
/codon_start=1
/product="signaling molecule LEFTY-B"
/protein_id="AAC33967.1"
/translation="MQPLWLCWALWVLPLASPGAALTGEQLLGSLLRQLQLKEVPTLD
RADMEELVIPTHVRAQYVALLQRSHGDRSRGKRFSQSFREVAGRFLALEASTHLLVFG
MEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWLRVRDDGSNRT
SLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKL
VRFASQGAPAGLGEPQLELHTLDLGDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMK
WAENWVLEPPGFLAYECVGTCRQPPEALAFKWPFLGPRQCIASETDSLPMIVSIKEGG
RTRPQVVSLPNMRVQKCSCASDGALVPRRLQP"
gap 771..870
/estimated_length=unknown
exon 938..1184
/number=2
gap 1234..1333
/estimated_length=unknown
exon 1468..1707
/number=3
gap 1769..1868
/estimated_length=unknown
exon 1943..>2653
/number=4
3'UTR 2304..>2653
BASE COUNT 390 a 740 c 757 g 466 t
ORIGIN
1 gaggtctcag gggtgtgacc tccctcccct ccttccctcc ccactcccta cctcctccct
61 ccaccccagg ctataaagct gcccaggctt ggctctcagc acatccagct gcctgagacc
121 ctcctgcagc cttctcaagg gacagcccca ctctgcctct tgctcctcca gggcagcacc
181 atgcagcccc tgtggctctg ctgggcactc tgggtgttgc ccctggccag ccccggggcc
241 gccctgaccg gggagcagct cctgggcagc ctgctgcggc agctgcagct caaagaggtg
301 cccaccctgg acagggccga catggaggag ctggtcatcc ccacccacgt gagggcccag
361 tacgtggccc tgctgcagcg cagccacggg gaccgctccc gcggaaagag gttcagccag
421 agcttccgag gtgaggccct ccctccctgc tgcccctggt cccatggggc aggtcagatg
481 tgcccactcc ggtggtgtca aagggctcct ggccttgcag aagtctgtgg gaggctgagt
541 gagggccacg gtctaagggg cagtgaggtg gggccgggcc tgtgaagatg gcggggcctc
601 agcatgcagc ggtgcatgca gtcaggactc cgggggtctg ttttcgtact gccactctgg
661 tctgagttct acttggagca tattgcttta aaatcatctc acgaccattt gctcacatgg
721 aactggggta taactatgtc ttgccatctt ccagcattgt gaacatcaga nnnnnnnnnn
781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ggccctgcca tcctcagagc tcccctggag
901 tcgggggagg ccctgctgac cctgctcttg tccccagagg tggccggcag gttcctggcg
961 ttggaggcca gcacacacct gctggtgttc ggcatggagc agcggctgcc gcccaacagc
1021 gagctggtgc aggccgtgct gcggctcttc caggagccgg tccccaaggc cgcgctgcac
1081 aggcacgggc ggctgtcccc gcgcagcgcc cgggcccggg tgaccgtcga gtggctgcgc
1141 gtccgcgacg acggctccaa ccgcacctcc ctcatcgact ccaggtgggg gtcgcggggg
1201 cgcgcagggt agggggaggg cgctgctagg cccnnnnnnn nnnnnnnnnn nnnnnnnnnn
1261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1321 nnnnnnnnnn nnngggcgcg cagggtaggg ggagggcgct gctaggcccg gcttgggggc
1381 ggggacgcgg gggggcggtg cggggtcctc ggggcccgtc ccagtccccg ccctcaagcg
1441 gcgctgggtc tctgtgtcat gtctcaggct ggtgtccgtc cacgagagcg gctggaaggc
1501 cttcgacgtg accgaggccg tgaacttctg gcagcagctg agccggcccc ggcagccgct
1561 gctgctacag gtgtcggtgc agagggagca tctgggcccg ctggcgtccg gcgcccacaa
1621 gctggtccgc tttgcctcgc agggggcgcc agccgggctt ggggagcccc agctggagct
1681 gcacaccctg gaccttgggg actatgggta ggtgctgagg gtcaaactgg taagccggaa
1741 taaagagaca ggcaattaca tttattttnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1861 nnnnnnnnaa tctccatccc agacgccctc tgacctcagc cctcccagct gaccgctgac
1921 cctgctctct ttgcccacac agagctcagg gcgactgtga ccctgaagca ccaatgaccg
1981 agggcacccg ctgctgccgc caggagatgt acattgacct gcaggggatg aagtgggccg
2041 agaactgggt gctggagccc ccgggcttcc tggcttatga gtgtgtgggc acctgccggc
2101 agcccccgga ggccctggcc ttcaagtggc cgtttctggg gcctcgacag tgcatcgcct
2161 cggagactga ctcgctgccc atgatcgtca gcatcaagga gggaggcagg accaggcccc
2221 aggtggtcag cctgcccaac atgagggtgc agaagtgcag ctgtgcctcg gatggtgcgc
2281 tcgtgccaag gaggctccag ccataggcgc ctagtgtagc catcgaggga cttgacttgt
2341 gtgtgtttct gaagtgttcg agggtaccag gagagctggc gatgactgaa ctgctgatgg
2401 acaaatgctc tgtgctctct agtgagccct gaatttgctt cctctgacaa gttacctcac
2461 ctaatttttg cttctcagga atgagaatct ttggccactg gagagccctt gctcagtttt
2521 ctctattctt attattcact gcactatatt ctaagcactt acatgtggag atactgtaac
2581 ctgagggcag aaagcccaat gtgtcattgt ttacttgtcc tgtcactgga tctgggctaa
2641 agtcctccac cac
//