LOCUS AF081363 2653 bp mRNA linear HUM 21-NOV-2011
DEFINITION Homo sapiens retina copper-containing monoamine oxidase (AOC2)
mRNA, complete cds.
ACCESSION AF081363
VERSION AF081363.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2653)
AUTHORS Zhang,X. and McIntire,W.S.
TITLE Human Copper-Containing Amine Oxidases
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2653)
AUTHORS Zhang,X. and McIntire,W.S.
TITLE Direct Submission
JOURNAL Submitted (29-JUL-1998) Molecular Biology (151-S), VA Medical
Center, 4150 Clement Street, San Francisco, CA 94121, USA
COMMENT This is the gene for a long form of the human retina amine oxidase
(RAO-n). Cloning and sequencing of a truncated form of this gene
has been published: Imamura et al. Genomics 40:277-283 (1997).
FEATURES Location/Qualifiers
source 1..2653
/db_xref="H-InvDB:HIT000066474"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21"
/tissue_type="retina"
gene 1..2653
/gene="AOC2"
/gene_synonym="rao-n"
CDS 27..2297
/gene="AOC2"
/gene_synonym="rao-n"
/codon_start=1
/product="retina copper-containing monoamine oxidase"
/protein_id="AAD39345.1"
/translation="MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRA
QPWPHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPK
AAALAHLDRGSPPPAREALAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPL
PYHRRPVLRAEFTQMWRHLKEVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRA
TWMALYHNISGVGLFLHPVGLELLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFK
SGRLEVVRVPLPPPNGASSLRSRNSPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFG
HGVFSGLRIFDVRFQGERIAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGL
VRGVDCPYQATMVDIHILVGKGAVQLLPGAVCVFEEAQGLPLRRHHNYLQNHFYGGLA
SSALVVRSVSSVGNYDYIWDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVG
ERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLG
KEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYRIQIHSPLGIHIPLESDMERALSWG
RYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFINNETLLGEDLVAWVTASFLHIP
HAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVYFEKGQDAGLCSINPVACLPD
LAACVPDLPPFSYHGF"
misc_feature 39..101
/gene="AOC2"
/gene_synonym="rao-n"
/note="Integral membrane anchor of mature enzyme; other
site"
misc_feature 1419..1421
/gene="AOC2"
/gene_synonym="rao-n"
/note="Tyrosyl residue that is converted to the topa
quinone (TPQ) cofactor in the mature enzyme; modified
site"
misc_feature 1572..1574
/gene="AOC2"
/gene_synonym="rao-n"
/note="Copper histidyl ligand of mature protein;
metal-binding site"
misc_feature 1578..1580
/gene="AOC2"
/gene_synonym="rao-n"
/note="Copper histidyl ligand of mature protein;
metal-binding site"
misc_feature 2064..2066
/gene="AOC2"
/gene_synonym="rao-n"
/note="Copper histidyl ligand of mature protein;
metal-binding site"
misc_difference 567..569
/gene="AOC2"
/gene_synonym="rao-n"
/note="Codon for amino acyl group that is different in RAO
(GenBank Accession Number D88213)"
misc_difference 669..671
/gene="AOC2"
/gene_synonym="rao-n"
/note="Codon for amino acyl group that is different in RAO
(GenBank Accession Number D88213)"
misc_difference 672..674
/gene="AOC2"
/gene_synonym="rao-n"
/note="Codon for amino acyl group that is different in RAO
(GenBank Accession Number D88213)"
misc_difference 678..680
/gene="AOC2"
/gene_synonym="rao-n"
/note="Codon for amino acyl group that is different in RAO
(GenBank Accession Number D88213)"
misc_difference 687..689
/gene="AOC2"
/gene_synonym="rao-n"
/note="Codon for amino acyl group that is different in RAO
(GenBank Accession Number D88213)"
misc_difference 690..692
/gene="AOC2"
/gene_synonym="rao-n"
/note="Codon for amino acyl group that is different in RAO
(GenBank Accession Number D88213)"
misc_difference 1824..1904
/gene="AOC2"
/gene_synonym="rao-n"
/note="81-bp segment missing from rao (GenBank Accession
Number D88213)"
/replace=""
BASE COUNT 555 a 764 c 695 g 639 t
ORIGIN
1 tctgatttca cctctcagca tccaccatgc atctcaagat agtcctggcg ttcctggcac
61 tgtccctcat taccatcttt gccctggcct atgttttgct gaccagccca ggtggttcca
121 gccagcctcc ccactgcccc tctgtatccc atagggccca gccctggcca caccctggcc
181 agagccagct gtttgcagac ctgagccgag aggagttgac agctgtgatg cgctttctga
241 cccagcggct ggggccaggg ctggtggacg cagcccaggc tcagccctcg gacaactgca
301 tcttctcagt ggagctgcag ctgcccccca aggctgcagc cctggcccac ctggacaggg
361 ggagcccccc acctgcccgg gaggcactgg ccatcgtcct ctttggtgga caaccccaac
421 ccaatgtgag tgagctggtg gtggggccgc tgcctcaccc ctcgtacatg cgggatgtga
481 ctgtggagcg tcacggcggg cccctgccct atcaccgtcg cccggtgctg agagctgagt
541 ttacacagat gtggaggcat ctgaaagagg tggagctacc caaggcaccc atcttcctgt
601 cgtccacctt caactacaat ggctctaccc tggcagctgt gcatgccacc cctcggggct
661 tgcgctcagg ggaccgagct acctggatgg ccctctacca taacatctca ggggttggtc
721 ttttccttca ccccgtgggg ctggagctac tactggacca cagggccctg gaccctgccc
781 actggactgt ccagcaggtc ttctaccttg ggcactacta tgcagacttg ggccagttgg
841 aacgggagtt taagtctggc cggttggaag tggttagagt ccctctacct ccaccaaatg
901 gagcttcatc cctgaggtct cggaactctc caggtcctct tccccctctt cagttctcgc
961 cccagggttc ccagtacagt gtgcaaggaa acctggtggt atcctccctc tggtcattta
1021 cctttggcca tggggtgttc agcggcctga ggatttttga tgttcggttc cagggtgagc
1081 gaatagccta tgaagtcagt gtccaggagt gtgtatctat ctatggtgcc gattcaccca
1141 agacgatgct gactcgctat ttggatagca gctttggact cggccgtaac agccgaggct
1201 tggtgcgggg agtggactgc ccctatcaag ccacgatggt ggacatccat atattagtgg
1261 gcaaaggggc agtccagctg cttccagggg ctgtgtgtgt atttgaggaa gcccagggac
1321 tgccccttcg aaggcaccac aattaccttc aaaatcattt ctatggtggt ttggccagct
1381 cagcccttgt ggtcaggtct gtgtcatctg tgggcaacta tgactacatt tgggactttg
1441 tgttgtaccc aaatggggca cttgaagggc gggtccatgc cacgggttat atcaacacag
1501 ctttcctgaa agggggagag gagggcctcc tctttgggaa ccgtgtgggg gaaagagtgc
1561 tgggaacggt gcacacacat gccttccact tcaagctgga cctggatgtg gcagggctga
1621 aaaactgggt ggtagctgaa gacgtggtgt ttaaacctgt ggctgccccc tggaacccgg
1681 agcactggct acagcgccca cagctgactc ggcaggtcct gggaaaggag gacctgacag
1741 ctttttcctt gggaagcccc ctaccccgct acctctacct ggctagcaac cagactaatg
1801 cgtggggtca ccagcgcggg taccgaatcc agatccacag cccccttggc atacacatac
1861 ccctggagag tgacatggag agggccctca gctgggggag ataccagctt gtggtgaccc
1921 agagaaagga ggaggagtca cagagcagta gcatctatca ccagaatgac atctggacac
1981 ccacagttac ctttgctgac ttcatcaaca atgaaaccct cttaggagag gatctggtgg
2041 cttgggtcac agccagcttc ctgcacattc cccatgccga ggacatccca aacacagtga
2101 ctctggggaa cagagttggc ttcttgctcc gaccctataa cttctttgat gaggacccct
2161 ccatcttctc ccctggcagt gtctactttg agaagggcca ggatgctggg ctctgcagca
2221 tcaatcctgt ggcctgcctc cccgacctgg cagcctgtgt cccggactta ccccctttct
2281 cttaccacgg cttctagtcc tgagggtgtg gcgggcggcg tggttaggca catgtacttt
2341 tccctgtttc tactttctat tctccgtgtt tttatcacac ctgctcccca gattcccacc
2401 ccctcaatgt tcctctcaca cgaaaccccc atcagtccct ttggttaatt cttacttcct
2461 gttcatctct aaagtgttaa attataaaaa tgatttttaa atattcaaag aaaaatatca
2521 caaatcctac tactcagaaa taggtggtca cattacatca gacatctctt tatgcatgtg
2581 cattcaaaag gaagagtaga tagaattttg taaaacagat gttgtatgta atttataata
2641 aaaagtatta aag
//