LOCUS AF081195 5075 bp mRNA linear HUM 28-NOV-1998
DEFINITION Homo sapiens calcium and DAG-regulated guanine nucleotide exchange
factor II mRNA, complete cds.
ACCESSION AF081195
VERSION AF081195.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5075)
AUTHORS Kawasaki,H., Springett,G.M., Toki,S., Canales,J.J., Harlan,P.,
Blumenstiel,J.P., Chen,E.J., Bany,I.A., Mochizuki,N., Ashbacher,A.,
Matsuda,M., Housman,D.E. and Graybiel,A.M.
TITLE A Rap guanine nucleotide exchange factor enriched highly in the
basal ganglia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (22), 13278-13283 (1998)
PUBMED 9789079
REFERENCE 2 (bases 1 to 5075)
AUTHORS Kawasaki,H., Springett,G.M., Chen,E.J., Housman,D.E. and
Graybiel,A.M.
TITLE Direct Submission
JOURNAL Submitted (31-JUL-1998) Center for Cancer Research, Massachusetts
Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA
02139, USA
FEATURES Location/Qualifiers
source 1..5075
/db_xref="H-InvDB:HIT000066462"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 104..2497
/note="CalDAG-GEFII"
/codon_start=1
/product="calcium and DAG-regulated guanine nucleotide
exchange factor II"
/protein_id="AAC79699.1"
/translation="MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHI
TQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAEL
LQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAK
GEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEF
KSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFI
KFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSS
RNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLGDGKVNVHKLLALYNHISE
LVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPV
VVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCV
MDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVI
KQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLH
APEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKISLRLKRAVAHKATQTESQPWIG
SEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVRKRAFVKWENKDSLIKSKEEL
RHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLEKSNHVLAQMEQGDCS"
BASE COUNT 1573 a 1104 c 1020 g 1378 t
ORIGIN
1 cccggggggg agagagccgg caggcggcgg cggtggtggc gggggcgatg cgccgcgccc
61 ggccgcgcta ggtgagccgg caccgggagc gcgggccgcg gccatgggca ccctgggcaa
121 ggcgagagag gctccgcgga aaccttccca tggctgcaga gctgcctcta aagcaagact
181 agaggcaaag ccagccaaca gccccttccc ctcccatccc agcttggccc acatcaccca
241 gttccgaatg atggtgtctc tgggacattt agccaaagga gccagcctgg acgatctcat
301 tgacagctgc attcaatctt ttgatgcaga tggaaacctg tgtcgaagta accaactgtt
361 gcaagtcatg ctgaccatgc accgaattgt catctcctct gcagaactgc tccaaaaagt
421 tatcaccctc tataaggatg ctttggcaaa gaattcacca ggactttgcc tgaagatctg
481 ttattttgta aggtattgga taacagaatt ctgggtcatg tttaaaatgg acgccagctt
541 gacagacact atggaggagt ttcaggaact ggtgaaagct aagggtgagg agttacattg
601 ccgcctgatt gacacaactc aaatcaatgc ccgtgactgg tccaggaaac ttactcaaag
661 gataaaatca aataccagca agaaacggaa agtctccctg ctctttgacc atctggaacc
721 agaagagcta tccgagcacc tcacctacct tgagttcaag tctttccgga ggatatcgtt
781 ctctgattat cagaattacc ttgtaaatag ctgtgtgaag gaaaacccca ccatggagcg
841 atctattgct ctgtgcaacg gcatctccca gtgggtacaa ctgatggttc tcagccgccc
901 cacgccgcag ctccgagcag aagtcttcat caagttcatc caggtggctc agaagctcca
961 ccaactacag aacttcaata cactgatggc tgtgataggt gggctgtgtc acagctcaat
1021 ctcgaggctc aaggagacaa gttcgcatgt cccacatgaa atcaataagg ttctcggtga
1081 gatgactgag ctgctgtcct cctccagaaa ctacgacaat taccggcgag cctatggaga
1141 gtgcaccgac ttcaagatcc ccattctggg tgtgcatctc aaggacctca tctccctgta
1201 tgaagccatg cctgactatc tgggggacgg gaaagtgaac gtccataagc tactggccct
1261 atacaatcat atcagtgaat tggtccagct gcaagaggtg gccccaccct tggaggctaa
1321 caaggacttg gtacacttgc tgacgttatc cctggatctt tactacactg aggatgaaat
1381 ctatgagctt tcctatgccc gggaaccaag gaaccacaga gctccaccac taacaccttc
1441 aaagccacca gtagtagtgg actgggcttc tggagtgtct cccaaacctg atccaaaaac
1501 cattagcaaa cacgtccaga ggatggtgga ttctgtcttc aagaactatg atcacgacca
1561 ggatggatac atttctcagg aagaatttga aaagattgct gcgagttttc cattttcctt
1621 ctgtgtgatg gacaaagaca gggaaggcct catcagcagg gatgagatca cagcctactt
1681 catgagagcc agctcaatct attccaagct gggcctgggc tttcctcaca acttccaaga
1741 gaccacctac ctgaagccca ctttttgtga caactgtgct ggatttctct ggggagtgat
1801 caaacaagga tatcgatgta aagactgcgg gatgaactgt cacaaacaat gcaaagatct
1861 ggttgtgttt gagtgtaaga agcgagccaa gaacccagta gctcccacag agaacaacac
1921 ttctgtgggg ccagtgtcca acctttgctc attgggagcc aaagatctgc tccatgcacc
1981 tgaggaagga ccttttacat tccctaatgg ggaggctgtg gaacatggtg aggagagtaa
2041 ggatcggacc atcatgctga tgggagtgtc ctcacagaag atttctcttc ggctgaagag
2101 ggctgttgcc cacaaggcca cccagactga atcacagcct tggattggca gtgagggccc
2161 ttcaggtccc tttgtgctgt cttccccaag gaagacagcc caggatactc tatatgtgct
2221 tcccagtccc acctctccat gtcctagccc agtcttggtc agaaagcggg cttttgtcaa
2281 gtgggagaat aaagactccc tcataaaatc aaaggaggag ctccgtcacc tcagactgcc
2341 tacctaccaa gaactggaac aggaaataaa tactctgaaa gcagataatg atgccctaaa
2401 gatccaactg aaatatgcac agaagaaaat agaatccctc cagcttgaaa aaagcaatca
2461 tgtcttagct caaatggagc agggtgactg ttcttagccc agaaactaag tagcacaatc
2521 tgtagatgag tatagtgatc tcatttccta aactgtaatg cacagacctg aggaacttta
2581 cactgaccag ctttaaaaca gtactttaaa aggaaaagcc tgttactgtt tatttaccta
2641 aaagattcct aatgtgcagc actgttttct ctttcagtta gttgactcaa agggggaaaa
2701 ctaaagaatg caaaactttt gctattcata ccactgatgt tcatcaaaag tatgcgatct
2761 aaaacatgac tatcatttcc tgacaatggg gcatctcggt ggcctgcctg gctgattctt
2821 ccttaaaact aaaatctctg gaaaatggat ttgcttctta ccctgtgttt tctgcaaact
2881 gacttacttt gttccagcca aagcttgcta ataatagaaa actacccata ttccaaaagt
2941 agatttcctc tgtatcccag catactttgt gaacctggct ccttcttcac tacctcagat
3001 ctaatcaatt agtccatgta ccctccttcc tcactacagt cataacacat gagcatatct
3061 acctagaagc caatttctac tgatgtagcc acaacttttt agaggcctat taaacatgac
3121 gttatccaat tgcaggtcaa cttatagttg tagccttaca acttacaggc atcagaaaat
3181 aagtaatcaa attaggtacc tggaaacata gctattacca tctcatatta ctgtctaatt
3241 aaaataaaca taacgcaaac atgtttgtcc ttatatattc tacagtggat agaattagga
3301 attgatggct taaaaaaaaa agtctatgaa gagtctgttt aactcttcat gttccatctt
3361 tctcttctga agtaaactat tttgaaagtt ctctttttga aatgaatttg tgcttaactg
3421 tcttcactat taatactatt tagaaataag ctaattggat cagtggctta aataatagct
3481 gactgtgtgt acatatgtat ataatatgta tatacaatat caggcatgca tgtggcttgg
3541 aattttgttt cctccataaa atgtggaagt gaattaaaca agttttagtc atttatacaa
3601 agtcacaaat ataaagttca gtttgtcaca agattaaatt gctcacaagg taaaattgta
3661 ttgtttggca aaatcacaag taacaatcct gtgagttttc tattatgaag gttaataata
3721 aatgggctca tttagttgcc tgggcaccta ttcacaaatt catttgtcag cctcttttta
3781 gttctcttaa aaaaaaaaaa atcatatgat cattttcctt tttgggggta cttagcttcc
3841 atgcctataa agtctggtac cagactgact tgaaattcat aaacaagttg tccaattgcc
3901 aagaatatgt taacaattaa aagttccaaa ctaaagccaa tagcaccaag tcttcataag
3961 aatacaaagt atacatacag tattgcttac ctggaggatt cagatcattt aggaattctc
4021 tttgatgaaa gatcagttcc catttgagtt cctccttgca ctgagtttta gtgatataga
4081 actagcttgt agttagtgtt tcattacatt ataaagaata gttttacaca cgtatttacc
4141 gttttccaaa tttaaactca gaaataccca aagcaggcct gcttaagccc actacctggc
4201 atataaactt atagtaacac tttgttactt tctttttaat aggacaagca tgagttagga
4261 caaactctaa aaattcatat tcttcactat tcttgttttc ctttgattga tatagaccaa
4321 agatggtgta ctctaatttt ttaaaacagt aatggaacac aatttttttc attcttcctc
4381 ctctccattc gaagtaaaga tccccagtta gtttttatat aaataatcta tagggattca
4441 aaaggtgtca cagtccactt aattagtcaa attagcaatg gctaaacagt atcaagtact
4501 gcagaattta tcactgaaat ggataagagg aaatagttta gtcacaggtt tttacagtcc
4561 agcaagggcc aaagaggtat agtatacaag ttaatagtat ttgtgttgag caacatgggg
4621 ctagtgggat cacagaaatc tggaaaaaaa aaaaaaaagg ctttggctta tcaagcctag
4681 tgtaaatttc tgcatctcac acgactttag tttggccagg tatttatctg ccaaaacaag
4741 gacaaatctt gttgtattaa cagcagggtc acttctcatt ttctttgctg acttaccttt
4801 ttactgaccg ttgtgaattt ctgtctcaaa atgtataata tagaaatgca agaaaaaaac
4861 aaatgtacag attgtaaagt tttttgatac ctaatgtaag ttttctttgt gtaatattta
4921 tatgataaaa gacattagga tccctacaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
4981 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa agggatcgac aattacgact
5041 ccccgggggg gcccggtcca attcccccaa aaggg
//