LOCUS AF080157 3579 bp mRNA linear HUM 24-JAN-1999
DEFINITION Homo sapiens IkB kinase-a (IKK-alpha) mRNA, complete cds.
ACCESSION AF080157
VERSION AF080157.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3579)
AUTHORS Hu,M.C. and Wang,Y.
TITLE IkappaB kinase-alpha and -beta genes are coexpressed in adult and
embryonic tissues but localized to different human chromosomes
JOURNAL Gene 222 (1), 31-40 (1998)
PUBMED 9813230
REFERENCE 2 (bases 1 to 3579)
AUTHORS Hu,M.C.T. and Wang,Y.-P.
TITLE Direct Submission
JOURNAL Submitted (25-JUL-1998) Cell Biology, Amgen, Inc., 14-1-D, One
Amgen Center Road, Thousand Oaks, CA 91320, USA
FEATURES Location/Qualifiers
source 1..3579
/db_xref="H-InvDB:HIT000066435"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3579
/gene="IKK-alpha"
CDS 96..2333
/gene="IKK-alpha"
/codon_start=1
/product="IkB kinase-a"
/protein_id="AAD08996.1"
/translation="MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIK
SCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGD
LRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKII
HKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGY
RPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENWL
QLMLNWDPQQRGGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESL
HSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKT
VYEGPFASRSLSDCVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRA
AMLSLLRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKML
KAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAID
LYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPK
VEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAW
LPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDW
SWLTE"
BASE COUNT 1106 a 641 c 769 g 1063 t
ORIGIN
1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg
61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc
121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg
181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag
241 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga
301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg
361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca
421 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag
481 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa
541 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg
601 ccaaagatgt tgatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg
661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga
721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta
781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt
841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag
901 tagaacccat ggaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag
961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga
1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac
1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata
1141 ctggttctca agaacttctt tcagagacag gaatttctct ggatcctcgg aaaccagcct
1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta tatggtttat ttgtttgata
1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt
1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg
1381 aagcagtgca ctatgtgtct ggactaaaag aagactatag caggctcttt cagggacaaa
1441 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt
1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc
1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa
1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat
1681 acctggagga tcagattatg tctttgcatg ctgaaatcat ggagctacag aagagcccct
1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata
1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa
1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga
1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc
1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag
2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat
2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag
2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa
2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattcat gaggcaaatg
2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca
2341 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt
2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact
2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca
2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta
2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat
2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg
2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa
2761 gtaaaagtct acctgtgttt ttttctaaaa aggctgctca caagttctat ttcttgaaga
2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt
2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat
2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg
3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt
3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg
3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat
3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa
3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt
3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt
3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa
3421 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag
3481 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt
3541 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa
//