LOCUS       AF079529                3567 bp    mRNA    linear   HUM 06-NOV-2002
DEFINITION  Homo sapiens cAMP-specific phosphodiesterase 8B1 (PDE8B) mRNA,
            complete cds; alternatively spliced.
ACCESSION   AF079529 AY129947
VERSION     AF079529.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3567)
  AUTHORS   Hayashi,M., Matsushima,K., Ohashi,H., Tsunoda,H., Murase,S.,
            Kawarada,Y. and Tanaka,T.
  TITLE     Molecular cloning and characterization of human PDE8B, a novel
            thyroid-specific isozyme of 3',5'-cyclic nucleotide
            phosphodiesterase
  JOURNAL   Biochem. Biophys. Res. Commun. 250 (3), 751-756 (1998)
   PUBMED   9784418
REFERENCE   2  (bases 1 to 3567)
  AUTHORS   Hayashi,M., Shimada,Y., Nishimura,Y., Hama,T. and Tanaka,T.
  TITLE     Genomic organization, chromosomal localization, and alternative
            splicing of the human phosphodiesterase 8B gene
  JOURNAL   Biochem. Biophys. Res. Commun. 297 (5), 1253-1258 (2002)
   PUBMED   12372422
REFERENCE   3  (bases 1 to 3567)
  AUTHORS   Hayashi,M. and Tanaka,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUL-1998) Mie University School of Medicine,
            Molecular and Cellular Pharmacology, 2-174 Edobashi, Tsu, Mie
            514-8507, Japan
REFERENCE   4  (bases 1 to 3567)
  AUTHORS   Hayashi,M. and Tanaka,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2002) Mie University School of Medicine,
            Molecular and Cellular Pharmacology, 2-174 Edobashi, Tsu, Mie
            514-8507, Japan
  REMARK    Sequence update by submitter
COMMENT     On Nov 4, 2002 this sequence version replaced AF079529.1.
FEATURES             Location/Qualifiers
     source          1..3567
                     /db_xref="H-InvDB:HIT000066424"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..3567
                     /gene="PDE8B"
     CDS             46..2703
                     /gene="PDE8B"
                     /note="PDE8B1; 3',5'-cyclic nucleotide phosphodiesterase;
                     thyroid-specific isozyme; alternatively spliced"
                     /codon_start=1
                     /product="cAMP-specific phosphodiesterase 8B1"
                     /protein_id="AAC69564.2"
                     /translation="MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLF
                     VQTDAADAIPPSRASGPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAE
                     AETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCN
                     IARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVS
                     DDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALD
                     HCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTC
                     IKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHK
                     IHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIE
                     APITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGL
                     MTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEA
                     ITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVL
                     HATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA
                     VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFV
                     NSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGR
                     ISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPA
                     LMQHLADNYKHWKTLDDLKCKSLRLPSDS"
BASE COUNT          993 a          893 c          862 g          819 t
ORIGIN      
        1 gcggccgcgg gcgcgggcgg gcgcgcgggg gagcccggcc gagggatggg ctgcgccccc
       61 agcatccatg tctcgcagag cggcgtgatc tactgccggg actcggacga gtccagctcg
      121 ccccgccaga ccaccagcgt gtcgcagggc ccggcggcac ccctgcccgg cctcttcgtc
      181 cagaccgacg ccgccgacgc catccccccg agccgcgcgt cgggaccccc cagcgtagcc
      241 cgcgtccgca gggcccgcac cgagctgggc agcggtagca gcgcgggttc cgcagccccc
      301 gccgcgacca ccagcagggg ccggaggcgc cactgctgca gcagcgccga ggccgagact
      361 cagacctgct acaccagcgt gaagcaggtg tcttctgcgg aggtgcgcat cgggcccatg
      421 agactgacgc aggaccctat tcaggttttg ctgatctttg caaaggaaga tagtcagagc
      481 gatggcttct ggtgggcctg cgacagagct ggttatagat gcaatattgc tcggactcca
      541 gagtcagccc ttgaatgctt tcttgataag catcatgaaa ttattgtaat tgatcataga
      601 caaactcaga acttcgatgc agaagcagtg tgcaggtcga tccgggccac aaatccctcc
      661 gagcacacgg tgatcctcgc agtggtttcg cgagtatcgg atgaccatga agaggcgtca
      721 gtccttcctc ttctccacgc aggcttcaac aggagattta tggagaatag cagcataatt
      781 gcttgctata atgaactgat tcaaatagaa catggggaag ttcgctccca gttcaaatta
      841 cgggcctgta attcagtgtt tacagcatta gatcactgtc atgaagccat agaaataaca
      901 agcgatgacc acgtgattca gtatgtcaac ccagccttcg aaaggatgat gggctaccac
      961 aaaggtgagc tcctgggaaa agaactcgct gatctgccca aaagcgataa gaaccgggca
     1021 gaccttctcg acaccatcaa tacatgcatc aagaagggaa aggagtggca gggggtttac
     1081 tatgccagac ggaaatccgg ggacagcatc caacagcacg tgaagatcac cccagtgatt
     1141 ggccaaggag ggaaaattag gcattttgtc tcgctcaaga aactgtgttg taccactgac
     1201 aataataagc agattcacaa gattcatcgt gattcaggag ataattctca gacagagcct
     1261 cattcattca gatataagaa caggaggaaa gagtccattg acgtgaaatc gatatcatct
     1321 cgaggcagtg atgcaccaag cctgcagaat cgtcgctatc cgtccatggc gaggatccac
     1381 tccatgacca tcgaggctcc catcacaaag gttataaata taatcaatgc agcccaagaa
     1441 aacagcccag tcacagtagc ggaagccttg gacagagttc tagagatttt acggaccaca
     1501 gaactgtact cccctcagct gggtaccaaa gatgaagatc cccacaccag tgatcttgtt
     1561 ggaggcctga tgactgacgg cttgagaaga ctgtcaggaa acgagtatgt gtttactaag
     1621 aatgtgcacc agagtcacag tcaccttgca atgccaataa ccatcaatga tgttccccct
     1681 tgtatctctc aattacttga taatgaggag agttgggact tcaacatctt tgaattggaa
     1741 gccattacgc ataaaaggcc attggtttat ctgggcttaa aggtcttctc tcggtttgga
     1801 gtatgtgagt ttttaaactg ttctgaaacc actcttcggg cctggttcca agtgatcgaa
     1861 gccaactacc actcttccaa tgcctaccac aactccaccc atgctgccga cgtcctgcac
     1921 gccaccgctt tctttcttgg aaaggaaaga gtaaagggaa gcctcgatca gttggatgag
     1981 gtggcagccc tcattgctgc cacagtccat gacgtggatc acccgggaag gaccaactct
     2041 ttcctctgca atgcaggcag tgagcttgct gtgctctaca atgacactgc tgttctggag
     2101 agtcaccaca ccgccctggc cttccagctc acggtcaagg acaccaaatg caacattttc
     2161 aagaatattg acaggaacca ttatcgaacg ctgcgccagg ctattattga catggttttg
     2221 gcaacagaga tgacaaaaca ctttgaacat gtgaataagt ttgtgaacag catcaacaag
     2281 ccaatggcag ctgagattga aggcagcgac tgtgaatgca accctgctgg gaagaacttc
     2341 cctgaaaacc aaatcctgat caaacgcatg atgattaagt gtgctgacgt ggccaaccca
     2401 tgccgcccct tggacctgtg cattgaatgg gctgggagga tctctgagga gtattttgca
     2461 cagactgatg aagagaagag acagggacta cctgtggtga tgccagtgtt tgaccggaat
     2521 acctgtagca tccccaagtc tcagatctct ttcattgact acttcataac agacatgttt
     2581 gatgcttggg atgcctttgc acatctacca gccctgatgc aacatttggc tgacaactac
     2641 aaacactgga agacactaga tgacctaaag tgcaaaagtt tgaggcttcc atctgacagc
     2701 taaagccaag ccacagaggg ggcctcttga ccgacaaagg acactgtgaa tcacagtagc
     2761 gtaaacaaga ggccttcctt tctaatgaca atgacaggta ttggtgaagg agctaatgtt
     2821 taatatttga ccttgaatca ttcaagtccc caaatttcat tcttagaaag ttatgttcca
     2881 tgaagaaaaa tatatgttct tttgaatact taatgacaga acaaatactt ggcaaactcc
     2941 tttgctctgc tgtcatcctg tgtacccttg tcaatccatg gagctggttc actgtaacta
     3001 gcaggccaca ggaagcaaag ccttggtgcc tgtgagctca tctcccagga tggtgactaa
     3061 gtagcttagc tagtgatcag ctcatccttt accataaaag tcatcattgc tgtttagctt
     3121 gactgttttc ctcaagaaca tcgatctgaa ggattcataa ggagcttatc tgaacagatt
     3181 tatctaagaa aaaaaaaaaa gacataaaat aagcgaaaca actaggacca aattacagat
     3241 aaactagtta gcttcacagc ctctatggct acatggttct tctggccgat ggtatgacac
     3301 ctaagttaga acacagcctt ggctggtggg tgccctctct agactggtat cagcagcctg
     3361 tgtaacccct ttcctgtaaa aggggttcat cttaacaaag tcatccatga tgagggaaaa
     3421 agtggcattt catttttggg gaatccatga gcttccttta tttctggctc acagaggcag
     3481 ccacgaggca ctacaccaag tattatataa aagccattaa atttgaatgc ccttggacaa
     3541 gcttttctta aaaaaaaaaa aaaaaaa
//