LOCUS AF078776 6266 bp mRNA linear HUM 01-OCT-1998
DEFINITION Homo sapiens p53 tumor suppressor-binding protein 1 mRNA, complete
cds.
ACCESSION AF078776
VERSION AF078776.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6266)
AUTHORS Iwabuchi,K., Li,B., Massa,H.F., Trask,B.J., Date,T. and Fields,S.
TITLE Stimulation of p53-mediated transcriptional activation by the
p53-binding proteins, 53BP1 and 53BP2
JOURNAL J. Biol. Chem. 273 (40), 26061-26068 (1998)
PUBMED 9748285
REFERENCE 2 (bases 1 to 6266)
AUTHORS Iwabuchi,K., Li,B., Massa,H.F., Trask,B.J., Date,T. and Fields,S.
TITLE Direct Submission
JOURNAL Submitted (16-JUL-1998) Genetics, University of Washington, 1959 NE
Pacific St., Seattle, WA 98195, USA
FEATURES Location/Qualifiers
source 1..6266
/db_xref="H-InvDB:HIT000066277"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q15-q21"
/cell_line="Jurkat"
/cell_type="B"
/tissue_type="skeletal muscle"
CDS 174..6092
/function="stimulates p53-mediated transcriptional
activation"
/note="53BP1; encodes a BRCT domain"
/codon_start=1
/product="p53 tumor suppressor-binding protein 1"
/protein_id="AAC62018.1"
/translation="MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLS
RHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCG
SISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGA
EDTASSQLGFGVLELSQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKH
EEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAK
EQLSAQELMESGLQIQKSPEPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLAST
PATTLHLLQLSGQRSLVQDSLSTNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPM
DTSVLSEEGGEPFQKKLQSGEPVELENPPLLPESTVSPQASTPISQSTPVFPPGSLPI
PSQPQFSHDIFIPSPSLEEQSNDGKKDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSL
TGDSCKLMLSTSEYSQSPKMESLSSHRIDEDGENTQIEDTEPMSPVLNSKFVPAENDS
ILMNPAQDGEVQLSQNDDKTKGDDTDTRDDISILATGCKGREETVAEDVCIDLTCDSG
SQAVPSPATRSEALSSVLDQEEAMEIKEHHPEEGSSGSEVEEIPETPCESQGEELKEE
NMESVPLHLSLTETQSQGLCLQKEMPKKECSEAMEVETSVISIDSPQKLAILDQELEH
KEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPLEGVEKCSDSQSWEDIAPEIEPCA
ENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSLPLVRADDPLRLDQELQQPQTQ
EKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSFCESSSETPFHFTLPKEGDI
IPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDVMSESMVETHDPILGSGK
GDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGERKNGSTAVAESVASPQ
KTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKEKLEGDHTIRQSQQ
PMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTNKENPSKALIER
PSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDATVQTERGSGE
KPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVITDVYYVDG
TEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRTSSGTS
LSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVCEED
GDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKSF
SRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAK
WSSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEY
FSAGVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTP
LTKAADISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKR
KLITSEEERSPAKRGRKSATVKPGAVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNK
TLFLGYAFLLTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGA
GYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQN
YRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASV
KQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIG
FKQHPKYKHDYVSH"
BASE COUNT 1771 a 1404 c 1603 g 1488 t
ORIGIN
1 cgttgtttgg cgtgtttttt tttttgtttt ttgtcactgc ctgcctgggt cctgcccgag
61 gtctccatcc tcggtttccc tgtccttgcc ccgggccctg ggagtgctct ggaaggctgc
121 gcagtattgg aggggacaga atgaccttcc ggccttgagt ccctggggag cagatggacc
181 ctactggaag tcagttggat tcagatttct ctcagcaaga tactccttgc ctgataattg
241 aagattctca gcctgaaagc caggttctag aggatgattc tggttctcac ttcagtatgc
301 tatctcgaca ccttcctaat ctccagacgc acaaagaaaa tcctgtgttg gatgttgtgt
361 ccaatcctga acaaacagct ggagaagaac gaggagacgg taatagtggg ttcaatgaac
421 atttgaaaga aaacaaggtt gcagaccctg tggattcttc taacttggac acatgtggtt
481 ccatcagtca ggtcattgag cagttacctc agccaaacag gacaagcagt gttctgggaa
541 tgtcagtgga atctgctcct gctgtggagg aagagaaggg agaagagttg gaacagaagg
601 agaaagagaa ggaagaagat acttcaggca atactacaca ttcccttggt gctgaagata
661 ctgcctcatc acagttgggt tttggggttc tggaactctc ccagagccag gatgttgagg
721 aaaatactgt gccatatgaa gtggacaaag agcagctaca atcagtaacc accaactctg
781 gttataccag gctgtctgat gtggatgcta atactgcaat taagcatgaa gaacagtcca
841 acgaagatat ccccatagca gaacagtcca gcaaggacat ccctgtgaca gcacagccca
901 gtaaggatgt acatgttgta aaagagcaaa atccaccacc tgcaaggtca gaggacatgc
961 cttttagccc caaagcatct gttgctgcta tggaagcaaa agaacagttg tctgcacaag
1021 aacttatgga aagtggactg cagattcaga agtcaccaga gcctgaggtt ttgtcaactc
1081 aggaagactt gtttgaccag agcaataaaa cagtatcttc tgatggttgc tctactcctt
1141 caagggagga aggtgggtgt tctttggctt ccactcctgc caccactctg catctcctgc
1201 agctctctgg tcagaggtcc cttgttcagg acagtctttc cacgaattct tcagatcttg
1261 ttgctccttc tcctgatgct ttccgatcta ctccttttat cgttcctagc agtcccacag
1321 agcaagaagg gagacaagat aagccaatgg acacgtcagt gttatctgaa gaaggaggag
1381 agccttttca gaagaaactt caaagtggtg aaccagtgga gttagaaaac ccccctctcc
1441 tgcctgagtc cactgtatca ccacaagcct caacaccaat atctcagagc acaccagtct
1501 tccctcctgg gtcacttcct atcccatccc agcctcagtt ttctcatgac atttttattc
1561 cttccccaag tctggaagaa caatcaaatg atgggaagaa agatggagat atgcatagtt
1621 catctttgac agttgagtgt tctaaaactt cagagattga accaaagaat tcccctgagg
1681 atcttgggct atctttgaca ggggattctt gcaagttgat gctttctaca agtgaatata
1741 gtcagtcccc aaagatggag agcttgagtt ctcacagaat tgatgaagat ggagaaaaca
1801 cacagattga ggatacggaa cccatgtctc cagttctcaa ttctaaattt gttcctgctg
1861 aaaatgatag tatcctgatg aatccagcac aggatggtga agtacaactg agtcagaatg
1921 atgacaaaac aaagggagat gatacagaca ccagggatga cattagtatt ttagccactg
1981 gttgcaaggg cagagaagaa acggtagcag aagatgtttg tattgatctc acttgtgatt
2041 cggggagtca ggcagttccg tcaccagcta ctcgatctga ggcactttct agtgtgttag
2101 atcaggagga agctatggaa attaaagaac accatccaga ggaggggtct tcagggtctg
2161 aggtggaaga aatccctgag acaccttgtg aaagtcaagg agaggaactc aaagaagaaa
2221 atatggagag tgttccgttg cacctttctc tgactgaaac tcagtcccaa gggttgtgtc
2281 ttcaaaagga aatgccaaaa aaagaatgct cagaagctat ggaagttgaa accagtgtga
2341 ttagtattga ttcccctcaa aagttggcaa tacttgacca agaattggaa cataaggaac
2401 aggaagcttg ggaagaagct acttcagagg actccagtgt tgtcattgta gatgtgaaag
2461 agccatctcc cagagttgat gtttcttgtg aacctttgga gggagtggag aagtgctcag
2521 attcccagtc atgggaggat attgctccag aaatagaacc atgtgctgag aatagattag
2581 acaccaagga agaaaagagt gtagaatatg aaggagatct gaaatcaggg actgcagaaa
2641 cagaacctgt agagcaagat tcttcacagc cttccttacc tttagtgaga gcagatgatc
2701 ctttaagact tgaccaggag ttgcagcagc cccaaactca ggagaaaaca agtaattcat
2761 taacagaaga ctcaaaaatg gctaatgcaa agcagctaag ctcagatgca gaggcccaga
2821 agctggggaa gccctctgcc catgcctcac aaagcttctg tgaaagttct agtgaaaccc
2881 catttcattt cactttgcct aaagaaggtg atatcatccc accattgact ggtgcaaccc
2941 cacctcttat tgggcaccta aaattggagc ccaagagaca cagtactcct attggtatta
3001 gcaactatcc agaaagcacc atagcaacca gtgatgtcat gtctgaaagc atggtggaga
3061 cccatgatcc catacttggg agtggaaaag gggattctgg ggctgcccca gacgtggatg
3121 ataaattatg tctaagaatg aaactggtta gtcctgagac tgaggcgagt gaagagtctt
3181 tgcagttcaa cctggaaaag cctgcaactg gtgaaagaaa aaatggatct actgctgttg
3241 ctgagtctgt tgccagtccc cagaagacca tgtctgtgtt gagctgtatc tgtgaagcca
3301 ggcaagagaa tgaggctcga agtgaggatc cccccaccac acccatcagg gggaacttgc
3361 tccactttcc aagttctcaa ggagaagagg agaaagaaaa attggagggt gaccatacaa
3421 tcaggcagag tcaacagcct atgaagccca ttagtcctgt caaggaccct gtttctcctg
3481 cttcccagaa gatggtcata caagggccat ccagtcctca aggagaggca atggtgacag
3541 atgtgctaga agaccagaaa gaaggacgga gtactaataa ggaaaatcct agtaaggcct
3601 tgattgaaag gcccagccaa aataacatag gaatccaaac catggagtgt tccttgaggg
3661 tcccagaaac tgtttcagca gcaacccaga ctataaagaa tgtgtgtgag caggggacca
3721 gtacagtgga ccagaacttt ggaaagcaag atgccacagt tcagactgag agggggagtg
3781 gtgagaaacc agtcagtgct cctggggatg atacagagtc gctccatagc cagggagaag
3841 aagagtttga tatgcctcag cctccacatg gccatgtctt acatcgtcac atgagaacaa
3901 tccgggaagt acgcacactt gtcactcgtg tcattacaga tgtgtattat gtggatggaa
3961 cagaagtaga aagaaaagta actgaggaga ctgaagagcc aattgtagag tgtcaggagt
4021 gtgaaactga agtttcccct tcacagactg ggggctcctc aggtgacctg ggggatatca
4081 gctccttctc ctccaaggca tccagcttac accgcacatc aagtgggaca agtctctcag
4141 ctatgcacag cagtggaagc tcagggaaag gagccggacc actcagaggg aaaaccagcg
4201 ggacagaacc cgcagatttt gccttaccca gctcccgagg aggcccagga aaactgagtc
4261 ctagaaaagg ggtcagtcag acagggacgc cagtgtgtga ggaggatggt gatgcaggcc
4321 ttggcatcag acagggaggg aaggctccag tcacgcctcg tgggcgtggg cgaaggggcc
4381 gcccaccttc tcggaccact ggaaccagag aaacagctgt gcctggcccc ttgggcatag
4441 aggacatttc acctaacttg tcaccagatg ataaatcctt cagccgtgtc gtgccccgag
4501 tgccagactc caccagacga acagatgtgg gtgctggtgc tttgcgtcgt agtgactctc
4561 cagaaattcc tttccaggct gctgctggcc cttctgatgg cttagatgcc tcctctccag
4621 gaaatagctt tgtagggctc cgtgttgtag ccaagtggtc atccaatggc tacttttact
4681 ctgggaaaat cacacgagat gtcggagctg ggaagtataa attgctcttt gatgatgggt
4741 acgaatgtga tgtgttgggc aaagacattc tgttatgtga ccccatcccg ctggacactg
4801 aagtgacggc cctctcggag gatgagtatt tcagtgcagg agtggtgaaa ggacatagga
4861 aggagtctgg ggaactgtac tacagcattg aaaaagaagg ccaaagaaag tggtataagc
4921 gaatggctgt catcctgtcc ttggagcaag gaaacagact gagagagcag tatgggcttg
4981 gcccctatga agcagtaaca cctcttacaa aggcagcaga tatcagctta gacaatttgg
5041 tggaagggaa gcggaaacgg cgcagtaacg tcagctcccc agccacccct actgcctcca
5101 gtagcagcag cacaacccct acccgaaaga tcacagaaag tcctcgtgcc tccatgggag
5161 ttctctcagg caaaagaaaa cttatcactt ctgaagagga acggtcccct gccaagcgag
5221 gtcgcaagtc tgccacagta aaacctggtg cagtaggggc aggagagttt gtgagcccct
5281 gtgagagtgg agacaacacc ggtgaaccct ctgccctgga agagcagaga gggcctttgc
5341 ctctcaacaa gaccttgttt ctgggctacg catttctcct taccatggcc acaaccagtg
5401 acaagttggc cagccgctcc aaactgccag atggtcctac aggaagcagt gaagaagagg
5461 aggaattttt ggaaattcct cctttcaaca agcagtatac agaatcccag cttcgagcag
5521 gagctggcta tatccttgaa gatttcaatg aagcccagtg taacacagct taccagtgtc
5581 ttctaattgc ggatcagcat tgtcgaaccc ggaagtactt cctgtgcctt gccagtggga
5641 ttccttgtgt gtctcatgtc tgggtccatg atagttgcca tgccaaccag ctccagaact
5701 accgtaatta tctgttgcca gctgggtaca gccttgagga gcaaagaatt ctggactggc
5761 aaccccgtga aaatcctttc cagaatctga aggtactctt ggtatcagac caacagcaga
5821 acttcctgga gctctggtct gagatcctca tgactggtgg tgcagcctct gtgaagcagc
5881 accattcaag tgcccataac aaagatattg ctttaggggt atttgatgtg gtggtgacgg
5941 acccctcatg cccagcctcg gtgctgaagt gtgctgaagc attgcagctg cctgtggtgt
6001 cacaagagtg ggtgatccag tgcctcattg ttggggagag aattggattc aagcagcatc
6061 caaaatataa acacgattat gtttctcact aaagatactt ggtcttactg gttttattcc
6121 ctgctatcgt ggagattgtg ttttaaccag gttttaaatg tgtcttgtgt gtaactggat
6181 tccttgcatg gatcttgtat atagttttat ttgctgaact tttatgataa aataaatgtt
6241 gaatctcttt ggttgtagta actggg
//