LOCUS AF076929 3432 bp mRNA linear HUM 17-MAY-1999
DEFINITION Homo sapiens synphilin 1 mRNA, complete cds.
ACCESSION AF076929
VERSION AF076929.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3432)
AUTHORS Engelender,S., Kaminsky,Z., Guo,X., Sharp,A.H., Amaravi,R.K.,
Kleiderlein,J.J., Margolis,R.L., Troncoso,J.C., Lanahan,A.A.,
Worley,P.F., Dawson,V.L., Dawson,T.M. and Ross,C.A.
TITLE Synphilin-1 associates with alpha-synuclein and promotes the
formation of cytosolic inclusions
JOURNAL Nat. Genet. 22 (1), 110-114 (1999)
PUBMED 10319874
REFERENCE 2 (bases 1 to 3432)
AUTHORS Engelender,S.
TITLE Direct Submission
JOURNAL Submitted (06-JUL-1998) Dept. of Psychiatry, Johns Hopkins
University, 720 Rutland Avenue, Ross 615, Baltimore, MD 21205, USA
FEATURES Location/Qualifiers
source 1..3432
/db_xref="H-InvDB:HIT000066198"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q22"
/tissue_type="brain"
CDS 94..2853
/note="ankyrin-like repeats; coiled coil domain; ATP/GTP
binding domain"
/codon_start=1
/product="synphilin 1"
/protein_id="AAD30362.1"
/translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSA
SSSSWNCGISTLITNTQKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKV
VEYQKGGESDLGPQPQELGPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIK
SSQQLASFTKVTSEKRILGLCTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHL
RKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTP
DCQLRAFHLQSSAAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLL
PHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLA
IKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISL
DEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRY
LVVVETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSS
PASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKILRQLL
GKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDS
NNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSIKAS
KSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDSTAAQKVATSPKSA
LKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGDQ
LKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRKTDAKGNPASSASKG
KNKAA"
BASE COUNT 1055 a 832 c 786 g 759 t
ORIGIN
1 gtcagtccct tcgcgctcct gagccgccgg cgcgccgggc gccccgggaa tttataagta
61 tttgaccgta ctcaaaatgt gcaaggaaga ataatggaag cccctgaata ccttgatttg
121 gatgaaattg actttagtga tgacatatct tattcagtca catcactcaa gacgatccca
181 gaactgtgcc gaagatgtga tacgcaaaac gaagacagat cagcttctag ctctagctgg
241 aattgtggca tctcaactct tattacaaac acgcaaaagc ccacaggaat cgctgatgtg
301 tacagtaagt tccgcccagt gaagcgggtt tcgccactga aacatcagcc agagactctg
361 gagaacaatg aaagtgatga ccaaaagaac cagaaagtgg ttgagtacca gaaagggggt
421 gagtctgacc tgggccccca gcctcaggag cttggccctg gagatggagt gggcggccca
481 ccaggtaaga gctctgagcc cagcacatcg ctgggtgaac tggagcacta cgacctcgac
541 atggatgaga ttctggatgt gccttatatt aaatccagtc agcagcttgc ctcttttacc
601 aaggtgactt cagaaaaaag aattttgggc ttatgcacaa ccatcaatgg cctttctggc
661 aaagcctgct ctacaggaag ttctgagagc tcatcatcca acatggcacc attttgtgtt
721 ctttctcccg tgaaaagccc tcacttgaga aaagcatcag ctgtcatcca cgaccagcac
781 aagctgtcca ctgaagaaac cgagatctca cctcctctgg ttaaatgtgg ctctgcatat
841 gagcctgaaa accagagtaa agacttccta aacaagacat ttagtgatcc tcatggtcga
901 aaagttgaga agacaacacc agactgccag ctcagggcct tccacctaca atcctcagca
961 gcagaatcca aaccagaaga gcaggtcagt ggcctaaacc ggaccagctc ccaaggccca
1021 gaagaaagga gtgagtatct gaaaaaagtg aaaagcatct tgaacattgt taaagaagga
1081 cagatctctc tcctgccaca cctagctgca gacaatctag acaaaattca cgacgaaaat
1141 ggaaacaatc tattacatat tgcggcgtca cagggacacg cagagtgtct acagcacctc
1201 acttctttga tgggagaaga ctgcctcaat gagcgcaaca ctgagaagtt gactccagca
1261 ggcctggcca ttaagaatgg tcagttggag tgcgtacgct ggatggtgag cgaaacagaa
1321 gccattgcag aactgagttg ttctaaggat tttccaagcc ttattcatta cgcaggttgc
1381 tatggccagg aaaagattct tctgtggctt cttcagttta tgcaagaaca gggcatctcg
1441 ttggatgaag tagaccagga tggcaacagt gccgttcacg tagcctcaca gcatggctac
1501 cttggatgca tacagacctt ggttgaatat ggagcaaatg tcaccatgca gaaccacgct
1561 ggggaaaagc cctcccagag cgccgagcgg caggggcaca ccctgtgctc caggtacctg
1621 gtggtggtgg agacctgcat gtcgctggcc tctcaagtgg tgaagttaac caagcagcta
1681 aaggaacaaa cagtagaacg tgtcacgctg cagaaccaac tccaacaatt tctagaagcc
1741 cagaaatcag agggcaagtc actcccttct tcacccagtt caccatcctc acctgcctcc
1801 agaaagtccc agtggaaatc tccagatgca gatgatgatt ctgtagccaa aagcaagcca
1861 ggagtccaag aggggattca ggttcttgga agcctgtcag cctccagccg ggctagaccc
1921 aaagcaaaag atgaagattc tgataaaatc ttacgccagt tattgggaaa ggaaatctca
1981 gaaaatgtct gcacccagga aaaactgtcc ttggaattcc aggatgctca ggcttcctct
2041 agaaattcta aaaagatccc actggagaag agggaactga agttagccag gctgagacag
2101 ctgatgcaga ggtcactgag tgagtctgac acagactcca acaactctga ggaccccaag
2161 actaccccag tgaggaaggc tgaccgacca aggccgcagc ccattgtaga aagcgtagag
2221 agtatggaca gcgcagaaag cctgcacctg atgattaaga aacacacctt ggcatcaggg
2281 ggacgcaggt ttcctttcag catcaaggcc tccaaatccc tggatggcca cagcccatct
2341 cccacctcag agagcagcga accagactta gaatcccagt atccaggctc agggagtatt
2401 cctccaaacc agccctctgg tgaccctcag cagcccagcc ctgacagtac tgctgcccag
2461 aaagttgcca caagtcccaa gagtgccctc aagtctccat cttccaagcg taggacatct
2521 cagaacttaa aactgagagt tacctttgag gagcctgtgg tgcagatgga gcagcctagc
2581 cttgaactga atggagaaaa agacaaagat aagggcagga ctctccagcg gacctccaca
2641 agtaacgaat cgggggatca actgaaaagg ccttttggag cctttcgatc tatcatggag
2701 acactaagtg gcaaccaaaa caataataat aactaccagg cagccaacca gctgaaaacc
2761 tctacattgc ccttgacctc acttgggagg aagacagatg ccaagggaaa ccctgccagc
2821 tccgctagca aaggaaagaa taaggcagca taatgacatc aatagaaaaa tgaagaaatc
2881 ctacagcata aagcacattg ctgagccaga gtcaaaagaa ctcttcttgt aaatcacttt
2941 ttaaattttc tctcactgat gccctttgga aattattgga aatttctgga ctatcctctt
3001 tggaaagaga accatgaaaa caatgcctca ccagcagaag aacagaatat caggatgcct
3061 taaatttata gtagtagact gtaaaagatt cattttgggg tgatatctgt atatataact
3121 tgttttttta aaagatgccg tttaaaagca tgattgggaa aatgtacgtt ttttaagagt
3181 agattgattc accctaccca caggacattc accaagccac tgataccatt ttatatttca
3241 tcaattgcat gagtatttgc taatgttgat tgaacctccc tttccccata atgtgggcag
3301 atttggctca gctccttcat gagatcaggt cagtggtatt gtttctgtca agagtgtttt
3361 ttctgtcatt tctacttttt gtataaagga aataaaacaa tgttaacagc caaaaaaaaa
3421 aaaaaaaaaa aa
//