LOCUS AF076622 4535 bp mRNA linear HUM 27-DEC-1999
DEFINITION Homo sapiens MRP6 (MRP6) mRNA, complete cds.
ACCESSION AF076622
VERSION AF076622.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4535)
AUTHORS Kool,M., van der Linden,M., de Haas,M., Baas,F. and Borst,P.
TITLE Expression of human MRP6, a homologue of the multidrug resistance
protein gene MRP1, in tissues and cancer cells
JOURNAL Cancer Res. 59 (1), 175-182 (1999)
PUBMED 9892204
REFERENCE 2 (bases 1 to 4535)
AUTHORS Kool,M.
TITLE Direct Submission
JOURNAL Submitted (05-JUL-1998) Molecular Biology, The Netherlands Cancer
Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
FEATURES Location/Qualifiers
source 1..4535
/db_xref="H-InvDB:HIT000066192"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13"
gene 1..4535
/gene="MRP6"
CDS 24..4535
/gene="MRP6"
/note="similar to multidrug resistance protein MRP1"
/codon_start=1
/product="MRP6"
/protein_id="AAC79696.1"
/translation="MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYL
WVLGPIYLLFIHHHGRGYLWMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAP
EFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGF
QSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWW
VSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKG
GSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSL
FLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRK
VLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGP
SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEG
AFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEK
AFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAA
GKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSK
VEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPE
GIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGP
GGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQ
PGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPD
RAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWA
DDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVR
SPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLAT
VAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPF
VAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGF
SVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQG
GQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE
GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETV
QLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGT
ELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY
RLAQESGLV"
BASE COUNT 842 a 1389 c 1361 g 943 t
ORIGIN
1 acccacgacg acagaaggcg ccgatggccg cgcctgctga gccctgcgcg gggcaggggg
61 tctggaacca gacagagcct gaacctgccg ccaccagcct gctgagcctg tgcttcctga
121 gaacagcagg ggtctgggta ccccccatgt acctctgggt ccttggtccc atctacctcc
181 tcttcatcca ccaccatggc cggggctacc tgtggatgtc cccactcttc aaagccaaga
241 tggtgcttgg attcgccctc atagtcctgt gtacctccag cgtggctgtc gctctttgga
301 aaatccaaca gggaacgcct gaggccccag aattcctcat tcatcctact gtgtggctca
361 ccacgatgag cttcgcagtg ttcctgattc acaccgagag gaaaaaggga gtccagtcat
421 ctggagtgct gtttggttac tggcttctct gctttgtctt gccagctacc aacgctgccc
481 agcaggcctc cggagcgggc ttccagagcg accctgtccg ccacctgtcc acctacctat
541 gcctgtctct ggtggtggca cagtttgtgc tgtcctgcct ggcggatcaa ccccccttct
601 tccctgaaga cccccagcag tctaacccct gtccagagac tggggcagcc ttcccctcca
661 aagccacgtt ctggtgggtt tctggcctgg tctggagggg atacaggagg ccactgagac
721 caaaagacct ctggtcgctt gggagagaaa actcctcaga agaacttgtt tcccggcttg
781 aaaaggagtg gatgaggaac cgcagtgcag cccggaggca caacaaggca atagcattta
841 aaaggaaagg cggcagtggc atgaaggctc cagagaccga gcccttccta cggcaagaag
901 ggagccagtg gcgcccactg ctgaaggcca tctggcaggt gttccattct accttcctcc
961 tggggaccct cagcctcatc atcagtgatg tcttcaggtt cactgtcccc aagctgctca
1021 gccttttcct ggagtttatt ggtgatccca agcctccagc ctggaagggc tacctcctcg
1081 ccgtgctgat gttcctctca gcctgcctgc aaacgctgtt tgagcagcag aacatgtaca
1141 ggctcaaggt gctgcagatg aggttgcggt cggccatcac tggcctggtg tacagaaagg
1201 tcctggctct gtccagcggc tccagaaagg ccagtgcggt gggtgatgtg gtcaatctgg
1261 tgtccgtgga cgtgcagcgg ctgaccgaga gcgtcctcta cctcaacggg ctgtggctgc
1321 ctctcgtctg gatcgtggtc tgcttcgtct atctctggca gctcctgggg ccctccgccc
1381 tcactgccat cgctgtcttc ctgagcctcc tccctctgaa tttcttcatc tccaagaaaa
1441 ggaaccacca tcaggaggag caaatgaggc agaaggactc acgggcacgg ctcaccagct
1501 ctatcctcag gaactcgaag accatcaagt tccatggctg ggagggagcc tttctggaca
1561 gagtcctggg catccgaggc caggagctgg gcgccttgcg gacctccggc ctcctcttct
1621 ctgtgtcgct ggtgtccttc caagtgtcta catttctggt cgcactggtg gtgtttgctg
1681 tccacactct ggtggccgag aatgctatga atgcagagaa agcctttgtg actctcacag
1741 ttctcaacat cctcaacaag gcccaggctt tcctgccctt ctccatccac tccctcgtcc
1801 aggcccgggt gtcctttgac cgtctggtca ccttcctctg cctggaagaa gttgaccctg
1861 gtgtcgtaga ctcaagttcc tctggaagcg ctgccgggaa ggattgcatc accatacaca
1921 gtgccacctt cgcctggtcc caggaaagcc ctccctgcct ccacagaata aacctcacgg
1981 tgccccaggg ctgtctgctg gctgttgtcg gtccagtggg ggcagggaag tcctccctgc
2041 tgtccgccct ccttggggag ctgtcaaagg tggaggggtt cgtgagcatc gagggtgctg
2101 tggcctacgt gccccaggag gcctgggtgc agaacacctc tgtggtagag aatgtgtgct
2161 tcgggcagga gctggaccca ccctggctgg agagagtact agaagcctgt gccctgcagc
2221 cagatgtgga cagcttccct gagggaatcc acacttcaat tggggagcag ggcatgaatc
2281 tctccggagg ccagaagcag cggctgagcc tggcccgggc tgtatacaga aaggcagctg
2341 tgtacctgct ggatgacccc ctggcggccc tggatgccca cgttggccag catgtcttca
2401 accaggtcat tgggcctggt gggctactcc agggaacaac acggattctc gtgacgcacg
2461 cactccacat cctgccccag gctgattgga tcatagtgct ggcaaatggg gccatcgcag
2521 agatgggttc ctaccaggag cttctgcaga ggaagggggc cctcgtgtgt cttctggatc
2581 aagccagaca gccaggagat agaggagaag gagaaacaga acctgggacc agcaccaagg
2641 accccagagg cacctctgca ggcaggaggc ccgagcttag acgcgagagg tccatcaagt
2701 cagtccctga gaaggaccgt accacttcag aagcccagac agaggttcct ctggatgacc
2761 ctgacagggc aggatggcca gcaggaaagg acagcatcca atacggcagg gtgaaggcca
2821 cagtgcacct ggcctacctg cgtgccgtgg gcacccccct ctgcctctac gcactcttcc
2881 tcttcctctg ccagcaagtg gcctccttct gccggggcta ctggctgagc ctgtgggcgg
2941 acgaccctgc agtaggtggg cagcagacgc aggcagccct gcgtggcggg atcttcgggc
3001 tcctcggctg tctccaagcc attgggctgt ttgcctccat ggctgcggtg ctcctaggtg
3061 gggcccgggc atccaggttg ctcttccaga ggctcctgtg ggatgtggtg cgatctccca
3121 tcagcttctt tgagcggaca cccattggtc acctgctaaa ccgcttctcc aaggagacag
3181 acacggttga cgtggacatt ccagacaaac tccggtccct gctgatgtac gcctttggac
3241 tcctggaggt cagcctggtg gtggcagtgg ctaccccact ggccactgtg gccatcctgc
3301 cactgtttct cctctacgct gggtttcaga gcctgtatgt ggttagctca tgccagctga
3361 gacgcttgga gtcagccagc tactcgtctg tctgctccca catggctgag acgttccagg
3421 gcagcacagt ggtccgggca ttccgaaccc aggccccctt tgtggctcag aacaatgctc
3481 gcgtagatga aagccagagg atcagtttcc cgcgactggt ggctgacagg tggcttgcgg
3541 ccaatgtgga gctcctgggg aatggcctgg tgtttgcagc tgccacgtgt gctgtgctga
3601 gcaaagccca cctcagtgct ggcctcgtgg gcttctctgt ctctgctgcc ctccaggtga
3661 cccagacact gcagtgggtt gttcgcaact ggacagacct agagaacagc atcgtgtcag
3721 tggagcggat gcaggactat gcctggacgc ccaaggaggc tccctggagg ctgcccacat
3781 gtgcagctca gcccccctgg cctcagggcg ggcagatcga gttccgggac tttgggctaa
3841 gataccgacc tgagctcccg ctggctgtgc agggcgtgtc cttcaagatc cacgcaggag
3901 agaaggtggg catcgttggc aggaccgggg cagggaagtc ctccctggcc agtgggctgc
3961 tgcggctcca ggaggcagct gagggtggga tctggatcga cggggtcccc attgcccacg
4021 tggggctgca cacactgcgc tccaggatca gcatcatccc ccaggacccc atcctgttcc
4081 ctggctctct gcggatgaac ctcgacctgc tgcaggagca ctcggacgag gctatctggg
4141 cagccctgga gacggtgcag ctcaaagcct tggtggccag cctgcccggc cagctgcagt
4201 acaagtgtgc tgaccgaggc gaggacctga gcgtgggcca gaaacagctc ctgtgtctgg
4261 cacgtgccct tctccggaag acccagatcc tcatcctgga cgaggctact gctgccgtgg
4321 accctggcac ggagctgcag atgcaggcca tgctcgggag ctggtttgca cagtgcactg
4381 tgctgctcat tgcccaccgc ctgcgctccg tgatggactg tgcccgggtt ctggtcatgg
4441 acaaggggca ggtggcagag agcggcagcc cggcccagct gctggcccag aagggcctgt
4501 tttacagact ggcccaggag tcaggcctgg tctga
//