LOCUS AF075240 2553 bp mRNA linear HUM 09-MAR-1999
DEFINITION Homo sapiens SLIT1 protein (SLIL2) mRNA, partial cds.
ACCESSION AF075240
VERSION AF075240.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2553)
AUTHORS Holmes,G.P., Negus,K., Burridge,L., Raman,S., Algar,E., Yamada,T.
and Little,M.H.
TITLE Distinct but overlapping expression patterns of two vertebrate slit
homologs implies functional roles in CNS development and
organogenesis
JOURNAL Mech. Dev. 79 (1-2), 57-72 (1998)
PUBMED 10349621
REFERENCE 2 (bases 1 to 2553)
AUTHORS Holmes,G.P., Negus,K., Raman,S. and Little,M.
TITLE Direct Submission
JOURNAL Submitted (29-JUN-1998) Centre for Molecular and Cellular Biology,
University of Queensland, St. Lucia, Brisbane, Queensland 4072,
Australia
FEATURES Location/Qualifiers
source 1..2553
/db_xref="H-InvDB:HIT000066143"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q35"
/clone="IMAGE Consortium ID 21651"
gene <1..2553
/gene="SLIL2"
/note="SLIT1"
CDS <1..2553
/gene="SLIL2"
/note="extracelluar leucine-rich protein; contains
leucine-rich and EGF-like repeats; similar to Drosophila
neurogenic extracellular slit protein"
/codon_start=1
/product="SLIT1 protein"
/protein_id="AAD19336.1"
/translation="EGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLI
GCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLG
KWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCME
TVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLT
NYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSL
SHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKG
PVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQ
HGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICP
PNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAH
KCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVYDSLSSPPTTVYSVETVNDGQFH
SVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDR
PLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCEC
RPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACS
AFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATAS
KVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS"
misc_feature 10..69
/gene="SLIL2"
/note="Region: LRR3-2"
misc_feature 82..141
/gene="SLIL2"
/note="Region: LRR3-3"
misc_feature 154..213
/gene="SLIL2"
/note="Region: LRR3-4"
misc_feature 226..261
/gene="SLIL2"
/note="Region: LRR3-5"
misc_feature 247..264
/gene="SLIL2"
/note="Region: LRR4-4"
misc_feature 268..453
/gene="SLIL2"
/note="Region: LRR carboxy-flanking region"
misc_feature 454..549
/gene="SLIL2"
/note="Region: LRR amino-flanking region"
misc_feature 550..582
/gene="SLIL2"
/note="Region: LRR4-1"
misc_feature 592..651
/gene="SLIL2"
/note="Region: LRR4-2"
misc_feature 664..723
/gene="SLIL2"
/note="Region: LRR4-3"
misc_feature 808..843
/gene="SLIL2"
/note="Region: LRR4-5"
misc_feature 850..1023
/gene="SLIL2"
/note="Region: LRR carboxy-flanking region"
misc_feature 1033..1140
/gene="SLIL2"
/note="Region: EGF1"
misc_feature 1144..1263
/gene="SLIL2"
/note="Region: EGF2"
misc_feature 1267..1377
/gene="SLIL2"
/note="Region: EGF3"
misc_feature 1381..1497
/gene="SLIL2"
/note="Region: EGF4"
misc_feature 1501..1611
/gene="SLIL2"
/note="Region: EGF5"
misc_feature 1966..2076
/gene="SLIL2"
/note="Region: EGF6A"
misc_feature 2083..2190
/gene="SLIL2"
/note="Region: EGF7"
misc_feature 2203..2313
/gene="SLIL2"
/note="Region: EGF8"
misc_feature 2413..2550
/gene="SLIL2"
/note="Region: CTC Knot"
BASE COUNT 561 a 798 c 719 g 475 t
ORIGIN
1 gagggagctt tcgatggagc agccagcgtg caggagctga tgctgacagg gaaccagctg
61 gagaccgtgc acgggcgcgt gttccgtggc ctcagtggcc tcaaaacctt gatgctgagg
121 agtaacttga tcggctgtgt gagtaatgac acctttgccg gcctgagttc ggtgagactg
181 ctgtccctct atgacaatcg gatcaccacc atcacccctg gggccttcac cacgcttgtc
241 tccctgtcca ccataaacct cctgtccaac cccttcaact gcaactgcca cctggcctgg
301 ctcggcaagt ggttgaggaa gaggcggatc gtcagtggga accctaggtg ccagaagcca
361 tttttcctca aggagattcc catccaggat gtggccatcc aggacttcac ctgtgatggc
421 aacgaggaga gtagctgcca gctgagcccg cgctgcccgg agcagtgcac ctgtatggag
481 acagtggtgc gatgcagcaa caaggggctc cgcgccctcc ccagaggcat gcccaaggat
541 gtgaccgagc tgtacctgga aggaaaccac ctaacagccg tgcccagaga gctgtccgcc
601 ctccgacacc tgacgcttat tgacctgagc aacaacagca tcagcatgct gaccaattac
661 accttcagta acatgtctca cctctccact ctgatcctga gctacaaccg gctgaggtgc
721 atccccgtcc acgccttcaa cgggctgcgg tccctgcgag tgctaaccct ccatggcaat
781 gacatttcca gcgttcctga aggctccttc aacgacctca catctctttc ccatctggcg
841 ctgggaacca acccactcca ctgtgactgc agtcttcggt ggctgtcgga gtgggtgaag
901 gcggggtaca aggagcctgg catcgcccgc tgcagtagcc ctgagcccat ggctgacagg
961 ctcctgctca ccaccccaac ccaccgcttc cagtgcaaag ggccagtgga catcaacatt
1021 gtggccaaat gcaatgcctg cctctccagc ccgtgcaaga ataacgggac atgcacccag
1081 gaccctgtgg agctgtaccg ctgtgcctgc ccctacagct acaagggcaa ggactgcact
1141 gtgcccatca acacctgcat ccagaacccc tgtcagcatg gaggcacctg ccacctgagt
1201 gacagccaca aggatgggtt cagctgctcc tgccctctgg gctttgaggg gcagcggtgt
1261 gagatcaacc cagatgactg tgaggacaac gactgcgaaa acaatgccac ctgcgtggac
1321 gggatcaaca actacgtgtg tatctgtccg cctaactaca caggtgagct atgcgacgag
1381 gtgattgacc actgtgtgcc tgagctgaac ctctgtcagc atgaggccaa gtgcatcccc
1441 ctggacaaag gattcagctg cgagtgtgtc cctggctaca gcgggaagct ctgtgagaca
1501 gacaatgatg actgtgtggc ccacaagtgc cgccacgggg cccagtgcgt ggacacaatc
1561 aatggctaca catgcacctg cccccagggc ttcagtggac ccttctgtga acacccccca
1621 cccatggtct atgacagcct gagttcccct ccaaccacag tgtacagtgt ggagacagtg
1681 aatgatgggc agtttcacag tgtggagctg gtgacgctaa accagaccct gaacctagta
1741 gtggacaaag gaactccaaa gagcctgggg aagctccaga agcagccagc agtgggcatc
1801 aacagccccc tctaccttgg aggcatcccc acctccaccg gcctctccgc cttgcgccag
1861 ggcacggacc ggcctctagg cggcttccac ggatgcatcc atgaggtgcg catcaacaac
1921 gagctgcagg acttcaaggc cctcccacca cagtccctgg gggtgtcacc aggctgcaag
1981 tcctgcaccg tgtgcaagca cggcctgtgc cgctccgtgg agaaggacag cgtggtgtgc
2041 gagtgccgcc caggctggac cggcccactc tgcgatcagg aggcccggga cccctgcctc
2101 ggccacagat gccaccatgg aaaatgtgtg gcaactggga cctcatacat gtgcaagtgt
2161 gccgagggct atggagggga cttgtgtgac aacaagaatg actctgccaa tgcctgctca
2221 gccttcaagt gtcaccatgg gcagtgccac atctcagacc aaggggagcc ctactgcctg
2281 tgccagcccg gctttagcgg cgagcactgc caacaagaga atccgtgcct gggacaagta
2341 gtccgagagg tgatccgccg ccagaaaggt tatgcatcat gtgccacagc ctccaaggtg
2401 cccatcatgg aatgtcgtgg gggctgtggg ccccagtgct gccagcccac ccgcagcaag
2461 cggcggaaat acgtcttcca gtgcacggat ggctcctcgt ttgtagaaga ggtggagaga
2521 cacttagagt gcggctgcct cgcgtgttcc taa
//