LOCUS AF074393 3131 bp mRNA linear HUM 28-MAY-1999
DEFINITION Homo sapiens nuclear mitogen- and stress-activated protein kinase-1
(MSK1) mRNA, complete cds.
ACCESSION AF074393
VERSION AF074393.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3131)
AUTHORS Deak,M., Clifton,A.D., Lucocq,L.M. and Alessi,D.R.
TITLE Mitogen- and stress-activated protein kinase-1 (MSK1) is directly
activated by MAPK and SAPK2/p38, and may mediate activation of CREB
JOURNAL EMBO J. 17 (15), 4426-4441 (1998)
PUBMED 9687510
REFERENCE 2 (bases 1 to 3131)
AUTHORS Deak,M., Clifton,A.D., Lucocq,J.M. and Alessi,D.R.
TITLE Direct Submission
JOURNAL Submitted (25-JUN-1998) Department of Biochemistry, University of
Dundee, Dow Street, Dundee DD1 5EH, UK
FEATURES Location/Qualifiers
source 1..3131
/db_xref="H-InvDB:HIT000065988"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3131
/gene="MSK1"
CDS 166..2574
/gene="MSK1"
/function="may mediate phosphorylation of CREB at S133"
/note="contains two catalytic domains; phosphorylated and
activated in vitro by both MAPK/ERK and SAPK2/p38 kinases;
in vivo activation induced by growth factors, cellular
stresses and cytokines"
/codon_start=1
/product="nuclear mitogen- and stress-activated protein
kinase-1"
/protein_id="AAC31171.1"
/translation="MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKV
GIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER
QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE
IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIE
YMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEP
PYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAP
FKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVID
PLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQ
AFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFE
RIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDF
GFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQS
HDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLR
YNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPL
AKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFS
DSVA"
BASE COUNT 914 a 637 c 740 g 840 t
ORIGIN
1 cgagccgtgc ggccagagcg ggaaagagac tcgtctttgc gtccgagttc tggagccgcc
61 gcaccccgac tcctggggcc gcggcagcgg ctgcgagggg acgggcgtcc gctgtctcct
121 gggttcccct cgtagcgacc cgcgggatcg gaaaaaaagg agaagatgga ggaggagggt
181 ggcagcagcg gcggcgccgc ggggaccagc gcggacggcg gcgacggagg agagcagctc
241 ctcactgtca agcacgagct gcggactgct aatttgacag gacatgctga gaaggtggga
301 atagaaaatt ttgagctcct gaaggtccta ggaactggag cttatggaaa agtatttcta
361 gttcgtaaaa taagtggcca tgatactgga aagctgtatg ccatgaaagt tttgaaaaag
421 gcaacaatcg ttcaaaaggc caaaaccaca gagcatacaa ggacagaacg acaagtcctg
481 gaacacatta ggcagtcgcc atttttggta acattacatt atgctttcca gacagaaacc
541 aaacttcatc tcattttaga ttatataaat ggtggtgaac tttttactca tctttctcaa
601 agagagcgtt tcacagagca tgaggtgcag atttatgttg gagagattgt gcttgccctc
661 gaacatctcc acaagttggg gattatatat cgtgatatta agcttgagaa tattctactt
721 gattctaatg gccatgtggt gctgacagat tttggtctga gtaaggagtt tgtggctgat
781 gaaactgaaa gagcatattc cttttgtgga actattgaat acatggcacc agatattgtc
841 agagggggag attcaggaca tgacaaggca gttgactggt ggagtttggg tgttctaatg
901 tatgaattac taactggagc atctcctttc actgttgatg gagaaaaaaa ttcccaagct
961 gagatatcta ggagaatatt aaaaagtgag cctccatatc cccaagaaat gagtgcttta
1021 gcgaaagacc taattcagcg tcttttgatg aaagatccca agaagagatt gggatgtggt
1081 ccacgtgatg cagatgaaat caaagaacat ctcttctttc agaaaataaa ttgggatgat
1141 ttagccgcca aaaaagtgcc tgcaccattt aagccagtca ttcgagatga attagatgtg
1201 agtaactttg cagaagagtt cacagaaatg gatcccactt attctcccgc agccctgccc
1261 cagagttctg agaagctgtt tcagggctat tcctttgttg ctccttccat cctattcaag
1321 cgtaatgcag ctgtcataga ccctcttcag tttcacatgg gagttgaacg tcctggagtg
1381 acaaatgttg ccaggagtgc aatgatgaag gactctccat tctatcaaca ctatgaccta
1441 gatttgaagg acaaacccct gggagaaggt agtttttcaa tttgtcgaaa gtgtgtgcat
1501 aaaaaaagta accaagcttt tgcagtcaaa ataatcagca aaaggatgga agccaatact
1561 caaaaggaaa taacagctct gaaactctgt gaaggacacc ccaatattgt gaagttgcat
1621 gaagtttttc atgatcagct tcacacgttt ctagtgatgg aacttctgaa tggaggagaa
1681 ctgtttgagc gcattaagaa aaagaagcac ttcagtgaga cggaagccag ctacatcatg
1741 aggaagcttg tttcagctgt aagccacatg catgatgttg gagtggtgca cagggatctg
1801 aaacctgaga atttattgtt caccgatgaa aatgacaatt tggaaattaa aataattgat
1861 tttggatttg cacggctaaa gccaccggat aatcagcccc tgaagactcc atgcttcacc
1921 cttcattatg ccgccccaga gctcttgaat cagaacggct acgatgagtc ctgtgacctg
1981 tggagcttgg gcgtcatttt gtacacaatg ttgtcaggac aggttccctt ccaatctcat
2041 gaccgaagtt tgacgtgtac cagcgcggtg gaaatcatga agaaaattaa aaagggagat
2101 ttctcctttg aaggagaagc ctggaagaat gtatcccaag aggctaaaga tttgatccaa
2161 ggacttctca cagtagatcc aaacaaaagg cttaaaatgt ctggcttgag gtacaatgaa
2221 tggctacaag atggaagtca gctgtcctcc aatcctctga tgactccgga tattctagga
2281 tcttccggag ctgccgtgca tacctgtgtg aaagcaacct tccacgcctt taacaaatac
2341 aagagagagg ggttttgcct tcagaatgtt gataaggccc ctttggctaa gagaagaaaa
2401 atgaaaaaga ctagcaccag taccgagacg cgcagcagtt ccagtgagag ttcccattct
2461 tcttcctctc attctcacgg taaaactaca cccaccaaga cactgcagcc cagcaatcct
2521 gccgacagca ataacccgga gaccctcttc cagttctcgg actcagtagc ttaggcatgg
2581 taggagtgta tcagtgatcc attgcacctt tattccctca gcatatgcct gaggcgatct
2641 tttatgcttt taaaaatgtt tcccgttggt ctcattggaa tctgcctcct aatgattttt
2701 tttcaggaaa acctgtttgg ttatcctcat tcaaaagcac tggacagaga atgttactgt
2761 gaatagagca catattactc tttttagcaa cctagcatga tgccaacaag actatttttg
2821 aaagagcaaa ggttcctgta aatttaatta gggctagatt tgagctgctt gtaagtcaca
2881 ggttttccag atgtctgcca acaagaaatg actcatactg tgatgatacc ttttgctttg
2941 ccttgtggac aatgtgggtt tttgaaattt gcacccttca aacaatgatt tatcagagaa
3001 aggggtctgt tttcaaaaaa gattctgtaa tgaattttat gtgtggcata tacttatttc
3061 ttgagagaag attttaactt attgttttta ttttatggtt acatatgatg ataacctgct
3121 attattaaac t
//