LOCUS AF074264 5301 bp mRNA linear HUM 27-AUG-1998
DEFINITION Homo sapiens LDL receptor-related protein 6 (LRP6) mRNA, complete
cds.
ACCESSION AF074264
VERSION AF074264.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5301)
AUTHORS Brown,S.D., Twells,R.C., Hey,P.J., Cox,R.D., Levy,E.R.,
Soderman,A.R., Metzker,M.L., Caskey,C.T., Todd,J.A. and Hess,J.F.
TITLE Isolation and characterization of LRP6, a novel member of the low
density lipoprotein receptor gene family
JOURNAL Biochem. Biophys. Res. Commun. 248 (3), 879-888 (1998)
PUBMED 9704021
REFERENCE 2 (bases 1 to 5301)
AUTHORS Brown,S.D.
TITLE Direct Submission
JOURNAL Submitted (24-JUN-1998) Human Genetics, Merck Research
Laboratories, P.O. Box 4, West Point, PA 19486, USA
FEATURES Location/Qualifiers
source 1..5301
/db_xref="H-InvDB:HIT000065984"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p11.2-p13.3, between D12S358 and D12S364"
/tissue_type="kidney"
gene 1..5301
/gene="LRP6"
CDS 78..4919
/gene="LRP6"
/note="transmembrane protein"
/codon_start=1
/product="LDL receptor-related protein 6"
/protein_id="AAC33006.1"
/translation="MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENAT
IVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLAC
DWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEV
PKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQA
VVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQ
QRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLA
RRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS
GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGD
AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAERE
VIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDM
KTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDIS
LKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQ
VLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTI
DYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIE
RANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVC
GCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDY
DPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYW
TCEATNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAAL
DGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQ
PVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQ
HPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEID
CIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVI
GVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSL
PGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATE
RSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVAT
AKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCT
DSS"
BASE COUNT 1467 a 1135 c 1307 g 1392 t
ORIGIN
1 gcggccgccc cggctcctcg cctcccccac ttctggccac ccctcgccgg tgagagaaga
61 gaacgcgaga agggaagatg ggggccgtcc tgaggagcct cctggcctgc agcttctgtg
121 tgctcctgag agcggcccct ttgttgcttt atgcaaacag acgggacttg cgattggttg
181 atgctacaaa tggcaaagag aatgctacga ttgtagttgg aggcttggag gatgcagctg
241 cggtggactt tgtgtttagt catggcttga tatactggag tgatgtcagc gaagaagcca
301 ttaaacgaac agaatttaac aaaactgaga gtgtgcagaa tgttgttgtt tctggattat
361 tgtcccccga tgggctggca tgtgattggc ttggagaaaa attgtactgg acagattctg
421 aaactaatcg gattgaagtt tctaatttag atggatcttt acgaaaagtt ttattttggc
481 aagagttgga tcaacccaga gctattgcct tagatccttc aagtgggttc atgtactgga
541 cagactgggg agaagtgcca aagatagaac gtgctggaat ggatggttca agtcgcttca
601 ttataataaa cagtgaaatt tactggccaa atggactgac tttggattat gaagaacaaa
661 agctttattg ggcagatgca aaacttaatt tcatccacaa atcaaatctg gatggaacaa
721 atcggcaggc agtggttaaa ggttcccttc cacatccttt tgccttgacg ttatttgagg
781 acatattgta ctggactgac tggagcacac actccatttt ggcttgcaac aagtatactg
841 gtgagggtct gcgtgaaatc cattctgaca tcttctctcc catggatata catgccttca
901 gccaacagag gcagccaaat gccacaaatc catgtggaat tgacaatggg ggttgttccc
961 atttgtgttt gatgtctcca gtcaagcctt tttatcagtg tgcttgcccc actggggtca
1021 aactcctgga gaatggaaaa acctgcaaag atggtgccac agaattattg cttttagctc
1081 gaaggacaga cttgagacgc atttctttgg atacaccaga ttttacagac attgttctgc
1141 agttagaaga catccgtcat gccattgcca tagattacga tcctgtggaa ggctacatct
1201 actggactga tgatgaagtg agggccatac gccgttcatt tatagatgga tctggcagtc
1261 agtttgtggt cactgctcaa attgcccatc ctgatggtat tgctgtggac tgggttgcac
1321 gaaatcttta ttggacagac actggcactg atcgaataga agtgacaagg ctcaatggga
1381 ccatgaggaa gatcttgatt tcagaggact tagaggaacc ccgggctatt gtgttagatc
1441 ccatggttgg gtacatgtat tggactgact ggggagaaat tccgaaaatt gagcgagcag
1501 ctctggatgg ttctgaccgt gtagtattgg ttaacacttc tcttggttgg ccaaatggtt
1561 tagccttgga ttatgatgaa ggcaaaatat actggggaga tgccaaaaca gacaagattg
1621 aggttatgaa tactgatggc actgggagac gagtactagt ggaagacaaa attcctcaca
1681 tatttggatt tactttgttg ggtgactatg tttactggac tgactggcag aggcgtagca
1741 ttgaaagagt tcataaacga agtgcagaga gggaagtgat catagatcag ctgcctgacc
1801 tcatgggcct aaaggctaca aatgttcatc gagtgattgg ttccaacccc tgtgctgagg
1861 aaaacggggg atgtagccat ctctgcctct atagacctca gggccttcgc tgtgcttgcc
1921 ctattggctt tgaactcatc agtgacatga agacctgcat tgtcccagag gctttccttt
1981 tgttttcacg gagagcagat atcagacgaa tttctctgga aacaaacaat aataatgtgg
2041 ctattccact cactggtgtc aaagaagctt ctgctttgga ttttgatgtg acagacaacc
2101 gaatttattg gactgatata tcactcaaga ccatcagcag agcctttatg aatggcagtg
2161 cactggaaca tgtggtagaa ttcggcttag attatccaga aggcatggca gtagactggc
2221 ttgggaagaa cttgtactgg gcagacacag gaacgaatcg aattgaggtg tcaaagttgg
2281 atgggcagca ccgacaagtt ttggtgtgga aagacctaga tagtcccaga gctctcgcgt
2341 tggaccctgc cgaaggattt atgtattgga ctgaatgggg tggaaaacct aagatagaca
2401 gagctgcaat ggatggaagt gaacgtacta ccttagttcc aaatgtgggg cgggcaaacg
2461 gcctaactat tgattatgct aaaaggaggc tttattggac agacctggac accaacttaa
2521 tagaatcttc aaatatgctt gggctcaacc gtgaagttat agcagatgac ttgcctcatc
2581 cttttggctt aactcagtac caagattata tctactggac ggactggagc cgacgcagca
2641 ttgagcgtgc caacaaaacc agtggccaaa accgcaccat cattcagggc catttggatt
2701 atgtgatgga catcctcgtc tttcactcat ctcgacagtc agggtggaat gaatgtgctt
2761 ccagcaatgg gcactgctcc cacctctgct tggctgtgcc agttgggggt tttgtttgtg
2821 gatgccctgc ccactactct cttaatgctg acaacaggac ttgtagtgct cctacgactt
2881 tcctgctctt cagtcaaaag agtgccatca accgcatggt gattgatgaa caacagagcc
2941 ccgacatcat ccttcccatc cacagccttc ggaatgtccg ggccattgac tatgacccac
3001 tggacaagca actctattgg attgactcac gacaaaacat gatccgaaag gcacaagaag
3061 atggcagcca gggctttact gtggttgtga gctcagttcc gagtcagaac ctggaaatac
3121 aaccctatga cctcagcatt gatatttaca gccgctacat ctactggact tgtgaggcta
3181 ccaatgtcat taatgtgaca agattagatg ggagatcagt tggagtggtg ctgaaaggcg
3241 agcaggacag acctcgagcc attgtggtaa acccagagaa agggtatatg tattttacca
3301 atcttcagga aaggtctcct aaaattgaac gggctgcttt ggatgggaca gaacgggagg
3361 tcctcttttt cagtggctta agtaaaccaa ttgctttagc ccttgatagc aggctgggca
3421 agctcttttg ggctgattca gatctccggc gaattgaaag cagtgatctc tcaggtgcta
3481 accggatagt attagaagac tccaatatct tgcagcctgt gggacttact gtgtttgaaa
3541 actggctcta ttggattgat aaacagcagc aaatgattga aaaaattgac atgacaggtc
3601 gagagggtag aaccaaagtc caagctcgaa ttgcccagct tagtgacatt catgcagtaa
3661 aggagctgaa ccttcaagaa tacagacagc acccttgtgc tcaggataat ggtggctgtt
3721 cacatatttg tcttgtaaag ggggatggta ctacaaggtg ttcttgcccc atgcacctgg
3781 ttctacttca agatgagcta tcatgtggag aacctccaac atgttctcct cagcagttta
3841 cttgtttcac gggggaaatt gactgtatcc ctgtggcttg gcggtgcgat gggtttactg
3901 aatgtgaaga ccacagtgat gaactcaatt gtcctgtatg ctcagagtcc cagttccagt
3961 gtgccagtgg gcagtgtatt gatggtgccc tccgatgcaa tggagatgca aactgccagg
4021 acaaatcaga tgagaagaac tgtgaagtgc tttgtttaat tgatcagttc cgctgtgcca
4081 atggtcagtg cattggaaag cacaagaagt gtgatcataa tgtggattgc agtgacaagt
4141 cagatgaact ggattgttat ccgactgaag aaccagcacc acaggccacc aatacagttg
4201 gttctgttat tggcgtaatt gtcaccattt ttgtgtctgg aactgtatac tttatctgcc
4261 agaggatgtt gtgtccacgt atgaagggag atggggaaac tatgactaat gactatgtag
4321 ttcatggacc agcttctgtg cctcttggtt atgtgccaca cccaagttct ttgtcaggat
4381 ctcttccagg aatgtctcga ggtaaatcaa tgatcagctc cctcagtatc atggggggaa
4441 gcagtggacc cccctatgac cgagcccatg ttacaggagc atcatcaagt agttcttcaa
4501 gcaccaaagg cacttacttc cctgcaattt tgaaccctcc accatcccca gccacagagc
4561 gatcacatta cactatggaa tttggatatt cttcaaacag tccttccact cataggtcat
4621 acagctacag gccatatagc taccggcact ttgcaccccc caccacaccc tgcagcacag
4681 atgtttgtga cagtgactat gctcctagtc ggagaatgac ctcagtggca acagccaagg
4741 gctataccag tgacttgaac tatgattcag aacctgtgcc cccacctccc acaccccgaa
4801 gccaatactt gtcagcagag gagaactatg aaagctgccc accttctcca tacacagaga
4861 ggagctattc tcatcacctc tacccaccgc caccctctcc ctgtacagac tcctcctgag
4921 gaggggccct cctcctctga ctgcctccaa cgtaaaaatg taaatataaa tttggttgag
4981 atctggaggg ggggagggag ctattagaga aggatgaggc agaccatgta cagttaaaat
5041 tataaaatgg ggtagggaat actggagata tttgtacaga agaaaaggat atttatatat
5101 tttcttaaaa cagcagattt gctgcttgtg ccataaaagt ttgtataaaa aaaatttgta
5161 ctaaaagttt tatttttgca aactaaatac acaaagcatg ccttaaaccc agtgaagcaa
5221 ctgagtacaa aggaaacagg aataataaag gcatcactga ccaggaatat ctgggcttta
5281 ttgataccaa aaaaaaaaaa a
//