LOCUS AF074247 3195 bp mRNA linear HUM 16-FEB-2001
DEFINITION Homo sapiens neuronal delayed-rectifier voltage-gated potassium
channel splice variant (KCNQ2) mRNA, complete cds.
ACCESSION AF074247
VERSION AF074247.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3195)
AUTHORS Iannotti,C.A., Dargis,P.G., Christian,E.P. and Aiyar,J.
TITLE The expression pattern of KCNQ2 splice variants in neuronal
proliferation and differentiation
JOURNAL Abstr. - Soc. Neurosci. (1998) In press
REFERENCE 2 (bases 1 to 3195)
AUTHORS Smith,J.S., Iannotti,C.A., Dargis,P., Christian,E.P. and Aiyar,J.
TITLE Differential expression of kcnq2 splice variants: implications to m
current function during neuronal development
JOURNAL J. Neurosci. 21 (4), 1096-1103 (2001)
PUBMED 11160379
REMARK Erratum:[J Neurosci 2001 Mar 15;21(6):1b]
REFERENCE 3 (bases 1 to 3195)
AUTHORS Iannotti,C.A. and Aiyar,J.
TITLE Direct Submission
JOURNAL Submitted (24-JUN-1998) Target Discovery Department, Zeneca
Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850-5437, USA
FEATURES Location/Qualifiers
source 1..3195
/db_xref="H-InvDB:HIT000065983"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
gene 1..3195
/gene="KCNQ2"
CDS 176..2740
/gene="KCNQ2"
/codon_start=1
/product="neuronal delayed-rectifier voltage-gated
potassium channel splice variant"
/protein_id="AAC25921.1"
/translation="MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAG
SEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLL
VFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGR
LKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTW
KLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLT
TIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRN
PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLE
LLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPS
ADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCE
FVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKS
LQSRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVN
IYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKN
FSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGG
NRASMEFLRQEDTPGCRPPEGTLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDA
LNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK"
BASE COUNT 559 a 1048 c 1068 g 520 t
ORIGIN
1 cggagcgagg tggccgcagc gtctccgcgc gcggcccaag cccggcagga gtgcggaacc
61 gccgcctcgg ccatgcggct cccggccggg gggcctgggc tggggcccgc gccgcccccc
121 gcgctccgcc cccgctgagc ctgagcccga cccggggcgc ctcccgccag gcaccatggt
181 gcagaagtcg cgcaacggcg gcgtataccc cggcccgagc ggggagaaga agctgaaggt
241 gggcttcgtg gggctggacc ccggcgcgcc cgactccacc cgggacgggg cgctgctgat
301 cgccggctcc gaggccccca agcgcggcag catcctcagc aaacctcgcg cgggcggcgc
361 gggcgccggg aagcccccca agcgcaacgc cttctaccgc aagctgcaga atttcctcta
421 caacgtgctg gagcggccgc gcggctgggc gttcatctac cacgcctacg tgttcctcct
481 ggttttctcc tgcctcgtgc tgtctgtgtt ttccaccatc aaggagtatg agaagagctc
541 ggagggggcc ctctacatcc tggaaatcgt gactatcgtg gtgtttggcg tggagtactt
601 cgtgcggatc tgggccgcag gctgctgctg ccggtaccgt ggctggaggg ggcggctcaa
661 gtttgcccgg aaaccgttct gtgtgattga catcatggtg ctcatcgcct ccattgcggt
721 gctggccgcc ggctcccagg gcaacgtctt tgccacatct gcgctccgga gcctgcgctt
781 cctgcagatt ctgcggatga tccgcatgga ccggcgggga ggcacctgga agctgctggg
841 ctctgtggtc tatgcccaca gcaaggagct ggtcactgcc tggtacatcg gcttcctttg
901 tctcatcctg gcctcgttcc tggtgtactt ggcagagaag ggggagaacg accactttga
961 cacctacgcg gatgcactct ggtggggcct gatcacgctg accaccattg gctacgggga
1021 caagtacccc cagacctgga acggcaggct ccttgcggca accttcaccc tcatcggtgt
1081 ctccttcttc gcgctgcctg caggcatctt ggggtctggg tttgccctga aggttcagga
1141 gcagcacagg cagaagcact ttgagaagag gcggaacccg gcagcaggcc tgatccagtc
1201 ggcctggaga ttctacgcca ccaacctctc gcgcacagac ctgcactcca cgtggcagta
1261 ctacgagcga acggtcaccg tgcccatgta cagttcgcaa actcaaacct acggggcctc
1321 cagacttatc cccccgctga accagctgga gctgctgagg aacctcaaga gtaaatctgg
1381 actcgctttc aggaaggacc ccccgccgga gccgtctcca agccagaagg tcagtttgaa
1441 agatcgtgtc ttctccagcc cccgaggcgt ggctgccaag gggaaggggt ccccgcaggc
1501 ccagactgtg aggcggtcac ccagcgccga ccagagcctc gaggacagcc ccagcaaggt
1561 gcccaagagc tggagcttcg gggaccgcag ccgggcacgc caggctttcc gcatcaaggg
1621 tgccgcgtca cggcagaact cagaagaagc aagcctcccc ggagaggaca ttgtggatga
1681 caagagctgc ccctgcgagt ttgtgaccga ggacctgacc ccgggcctca aagtcagcat
1741 cagagccgtg tgtgtcatgc ggttcctggt gtccaagcgg aagttcaagg agagcctgcg
1801 gccctacgac gtgatggacg tcatcgagca gtactcagcc ggccacctgg acatgctgtc
1861 ccgaattaag agcctgcagt ccagagtgga ccagatcgtg gggcggggcc cagcgatcac
1921 ggacaaggac cgcaccaagg gcccggccga ggcggagctg cccgaggacc ccagcatgat
1981 gggacggctc gggaaggtgg agaagcaggt cttgtccatg gagaagaagc tggacttcct
2041 ggtgaatatc tacatgcagc ggatgggcat ccccccgaca gagaccgagg cctactttgg
2101 ggccaaagag ccggagccgg cgccgccgta ccacagcccg gaagacagcc gggagcatgt
2161 cgacaggcac ggctgcattg tcaagatcgt gcgctccagc agctccacgg gccagaagaa
2221 cttctcggcg cccccggccg cgccccctgt ccagtgtccg ccctccacct cctggcagcc
2281 acagagccac ccgcgccagg gccacggcac ctcccccgtg ggggaccacg gctccctggt
2341 gcgcatcccg ccgccgcctg cccacgagcg gtcgctgtcc gcctacggcg ggggcaaccg
2401 cgccagcatg gagttcctgc ggcaggagga caccccgggc tgcaggcccc ccgaggggac
2461 cctgcgggac agcgacacgt ccatctccat cccgtccgtg gaccacgagg agctggagcg
2521 ttccttcagc ggcttcagca tctcccagtc caaggagaac ctggatgctc tcaacagctg
2581 ctacgcggcc gtggcgcctt gtgccaaagt caggccctac attgcggagg gagagtcaga
2641 caccgactcc gacctctgta ccccgtgcgg gcccccgcca cgctcggcca ccggcgaggg
2701 tccctttggt gacgtgggct gggccgggcc caggaagtga ggcggcgctg ggccagtgga
2761 cccgcccgcg gccctcctca gcacggtgcc tccgaggttt tgaggcggga accctctggg
2821 gcccttttct tacagtaact gagtgtggcg ggaagggtgg gccctggagg ggcccatgtg
2881 ggctgaagga tgggggctcc tggcagtgac cttttacaaa agttattttc caacaggggc
2941 tggagggctg ggcagggccc tgtggctcca ggagcagcgt gcaggagcaa ggctgccctg
3001 tccactctgc tcagggccgc ggccgacatc agcccggtgt gaggaggggc gggagtgatg
3061 acggggtgtt gccagcgtgg caacaggcgg ggggttgtct cagccgagcc caggggaggc
3121 acaaagggca ggcctgttcc ctgaggacct gcgcaaaggg cgggcctgtt tggtgaggac
3181 ctgcggcctt gggtc
//