LOCUS AF073745 2478 bp mRNA linear HUM 14-DEC-2001
DEFINITION Homo sapiens cyclic AMP-specific phosphodiesterase HSPDE4A10
(PDE4A) mRNA, complete cds.
ACCESSION AF073745
VERSION AF073745.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2478)
AUTHORS Rena,G., Begg,F., Ross,A., MacKenzie,C., McPhee,I., Campbell,L.,
Huston,E., Sullivan,M. and Houslay,M.D.
TITLE Molecular cloning, genomic positioning, promoter identification,
and characterization of the novel cyclic amp-specific
phosphodiesterase PDE4A10
JOURNAL Mol. Pharmacol. 59 (5), 996-1011 (2001)
PUBMED 11306681
REFERENCE 2 (bases 1 to 2478)
AUTHORS Rena,G. and Houslay,M.D.
TITLE Direct Submission
JOURNAL Submitted (22-JUN-1998) Biochemistry & Molecular Biology,
University of Glasgow, University Avenue, Glasgow, Scotland G12
8QQ, UK
REFERENCE 3 (bases 1 to 2478)
AUTHORS Rena,G. and Houslay,M.D.
TITLE Direct Submission
JOURNAL Submitted (09-JAN-2001) Biochemistry & Molecular Biology,
University of Glasgow, University Avenue, Glasgow, Scotland G12
8QQ, UK
REMARK Sequence update by submitter
COMMENT On Jan 9, 2001 this sequence version replaced AF073745.1.
FEATURES Location/Qualifiers
source 1..2478
/db_xref="H-InvDB:HIT000065959"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.2"
/tissue_type="brain"
gene 1..2478
/gene="PDE4A"
CDS 1..2478
/gene="PDE4A"
/codon_start=1
/product="cyclic AMP-specific phosphodiesterase HSPDE4A10"
/protein_id="AAD34217.2"
/translation="MRSGAAPRARPRPPALALPPTGPESLTHFPFSDEDTRRHPPGRS
VSFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSR
NSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKAT
LSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRS
GNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITG
LKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIM
YMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPA
LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGF
KLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSG
VLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQ
SPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVE
EALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREE
FVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRAC
SACAGTFGEDTSALPAPGGGGSGGDPT"
BASE COUNT 554 a 796 c 700 g 428 t
ORIGIN
1 atgcgctccg gtgcagcgcc ccgggcccgg ccccggcccc ctgccctggc actgcccccc
61 acgggccccg agtccctgac ccacttcccc ttcagcgatg aggacacccg tcggcaccct
121 ccgggcagat ctgtcagctt cgaggcagag aatgggccga caccatctcc tggccgcagc
181 cccctggact cgcaggcgag cccaggactc gtgctgcacg ccggggcggc caccagccag
241 cgccgggagt ccttcctgta ccgctcagac agcgactatg acatgtcacc caagaccatg
301 tcccggaact catcggtcac cagcgaggcg cacgctgaag acctcatcgt aacaccattt
361 gctcaggtgc tggccagcct ccggagcgtc cgtagcaact tctcactcct gaccaatgtg
421 cccgttccca gtaacaagcg gtccccgctg ggcggcccca cccctgtctg caaggccacg
481 ctgtcagaag aaacgtgtca gcagttggcc cgggagactc tggaggagct ggactggtgt
541 ctggagcagc tggagaccat gcagacctat cgctctgtca gcgagatggc ctcgcacaag
601 ttcaaaagga tgttgaaccg tgagctcaca cacctgtcag aaatgagcag gtccggaaac
661 caggtctcag agtacatttc cacaacattc ctggacaaac agaatgaagt ggagatccca
721 tcacccacga tgaaggaacg agaaaaacag caagcgccgc gaccaagacc ctcccagccg
781 cccccgcccc ctgtaccaca cttacagccc atgtcccaaa tcacagggtt gaaaaagttg
841 atgcatagta acagcctgaa caactctaac attccccgat ttggggtgaa gaccgatcaa
901 gaagagctcc tggcccaaga actggagaac ctgaacaagt ggggcctgaa catcttttgc
961 gtgtcggatt acgctggagg ccgctcactc acctgcatca tgtacatgat attccaggag
1021 cgggacctgc tgaagaaatt ccgcatcccg gtggacacga tggtgacata catgctgacg
1081 ctggaggatc actaccacgc tgacgtggcc taccataaca gcctgcacgc agctgacgtg
1141 ctgcagtcca cccacgtact gctggccacg cctgcactag atgcagtgtt cacggacctg
1201 gagattctcg ccgccctctt cgcggctgcc atccacgatg tggatcaccc tggggtctcc
1261 aaccagttcc tcatcaacac caattcggag ctggcgctca tgtacaacga tgagtcggtg
1321 ctcgagaatc accacctggc cgtgggcttc aagctgctgc aggaggacaa ctgcgacatc
1381 ttccagaacc tcagcaagcg ccagcggcag agcctacgca agatggtcat cgacatggtg
1441 ctggccacgg acatgtccaa gcacatgacc ctcctggctg acctgaagac catggtggag
1501 accaagaaag tgaccagctc aggggtcctc ctgctagata actactccga ccgcatccag
1561 gtcctccgga acatggtgca ctgtgccgac ctcagcaacc ccaccaagcc gctggagctg
1621 taccgccagt ggacagaccg catcatggcc gagttcttcc agcagggtga ccgagagcgc
1681 gagcgtggca tggaaatcag ccccatgtgt gacaagcaca ctgcctccgt ggagaagtct
1741 caggtgggtt ttattgacta cattgtgcac ccattgtggg agacctgggc ggaccttgtc
1801 cacccagatg cccaggagat cttggacact ttggaggaca accgggactg gtactacagc
1861 gccatccggc agagcccatc tccgccaccc gaggaggagt caagggggcc aggccaccca
1921 cccctgcctg acaagttcca gtttgagctg acgctggagg aggaagagga ggaagaaata
1981 tcaatggccc agataccgtg cacagcccaa gaggcattga ctgcgcaggg attgtcagga
2041 gtcgaggaag ctctggatgc aaccatagcc tgggaggcat ccccggccca ggagtcgttg
2101 gaagttatgg cacaggaagc atccctggag gccgagctgg aggcagtgta tttgacacag
2161 caggcacagt ccacaggcag tgcacctgtg gctccggatg agttctcgtc ccgggaggaa
2221 ttcgtggttg ctgtaagcca cagcagcccc tctgccctgg ctcttcaaag cccccttctc
2281 cctgcttgga ggaccctgtc tgtttcagag catgccccgg gcctcccggg cctcccctcc
2341 acggcggccg aggtggaggc ccaacgagag caccaggctg ccaagagggc ttgcagtgcc
2401 tgcgcaggga catttgggga ggacacatcc gcactcccag ctcctggtgg cggggggtca
2461 ggtggagacc ctacctga
//