LOCUS       AF073528                1010 bp    mRNA    linear   HUM 24-MAR-2003
DEFINITION  Homo sapiens ovarian cancer gene-2 protein (OVCA2) mRNA, complete
            cds.
ACCESSION   AF073528
VERSION     AF073528.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1010)
  AUTHORS   Schultz,D.C., Vanderveer,L., Berman,D.B., Hamilton,T.C., Wong,A.J.
            and Godwin,A.K.
  TITLE     Identification of two candidate tumor suppressor genes on
            chromosome 17p13.3
  JOURNAL   Cancer Res. 56 (9), 1997-2002 (1996)
   PUBMED   8616839
REFERENCE   2  (bases 1 to 1010)
  AUTHORS   White,T.E.K., Prowse,A.H., Bruening,W., Sauter,E., Klein-Szanto,A.
            and Godwin,A.K.
  TITLE     Characterization of OVCA2: A new human secreted protein whose gene
            maps to a region of frequent LOH in ovarian cancer
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 1010)
  AUTHORS   Godwin,A.K., Vanderveer,L. and White,T.E.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-1998) Medical Oncology, Fox Chase Cancer Center,
            Rm. W304, 7701 Burholme Ave., Philadelphia, PA 19111, USA
FEATURES             Location/Qualifiers
     source          1..1010
                     /db_xref="H-InvDB:HIT000065945"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="between D17S5 and D17S28"
                     /cell_line="ovarian cancer line C200"
                     /tissue_type="ovary; brain"
                     /dev_stage="fetal brain"
     gene            1..1010
                     /gene="OVCA2"
                     /note="candidate tumor suppressor gene"
     CDS             1..684
                     /gene="OVCA2"
                     /function="secretory protein"
                     /note="produced by secretory tissues such as breast,
                     ovary, placenta, testis, and stomach; 25 kDa; putatively
                     processed posttranslation to 21 kDa"
                     /codon_start=1
                     /product="ovarian cancer gene-2 protein"
                     /protein_id="AAC62628.1"
                     /translation="MAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSG
                     PHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMV
                     AQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSSFCPRGIGFKE
                     SILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAY
                     LKFLDQFAE"
BASE COUNT          197 a          302 c          300 g          211 t
ORIGIN      
        1 atggccgcgc agcgacccct gcgggtcctg tgcctggcgg gcttccggca gagcgagcgg
       61 ggcttccgtg agaagaccgg ggcgctgagg aaggcgctgc ggggtcgcgc cgagctcgtg
      121 tgcctcagcg gcccgcaccc ggtccccgac cccccgggcc ccgagggcgc cagatcagac
      181 ttcgggtcct gccctccgga ggagcagcct cgaggctggt ggttttcaga gcaggaggcc
      241 gacgttttct ccgcattgga agagcccgcc gtctgcaggg gcctggagga atcactgggg
      301 atggtggcac aggcactgaa caggctgggg ccttttgacg gccttcttgg tttcagccaa
      361 ggggctgcgc tagcagccct tgtgtgtgcc ctgggccagg caggcgatcc ccgcttcccc
      421 ttgccacggt ttatcctctt ggtgtctagt ttctgtcccc ggggcattgg gttcaaggaa
      481 tccatcctcc aaaggccctt gtcattgcct tcgctccatg tttttgggga cactgacaaa
      541 gtcatcccct ctcaggagag tgtgcaactg gccagccaat ttcccggagc catcaccctc
      601 acccactctg gtggccactt cattccagca gctgcacccc agcgtcaggc ctacctcaag
      661 ttcttggacc agtttgcaga gtgaaagatc aagaaatgtc tctgctccta catccagctc
      721 ctctaggggc agcctccgtc atccatgccc tcccaggacc ctccactcac tgctgtgagt
      781 gcgcctcacc agaaccagtt aagagacaac tatcaattct tgagacccaa attataaggg
      841 ccctgccctg tactgaagaa aaggggagca caaggcctta atggacattg acttgtgaaa
      901 acgcaaacat gaatatggtt ggagagccct ggattaggag ggtgacatgg ggaaggcaga
      961 ggctggcacg atggtgactg ccacataata aagtggtgat ttggattttg
//