LOCUS AF073528 1010 bp mRNA linear HUM 24-MAR-2003 DEFINITION Homo sapiens ovarian cancer gene-2 protein (OVCA2) mRNA, complete cds. ACCESSION AF073528 VERSION AF073528.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1010) AUTHORS Schultz,D.C., Vanderveer,L., Berman,D.B., Hamilton,T.C., Wong,A.J. and Godwin,A.K. TITLE Identification of two candidate tumor suppressor genes on chromosome 17p13.3 JOURNAL Cancer Res. 56 (9), 1997-2002 (1996) PUBMED 8616839 REFERENCE 2 (bases 1 to 1010) AUTHORS White,T.E.K., Prowse,A.H., Bruening,W., Sauter,E., Klein-Szanto,A. and Godwin,A.K. TITLE Characterization of OVCA2: A new human secreted protein whose gene maps to a region of frequent LOH in ovarian cancer JOURNAL Unpublished REFERENCE 3 (bases 1 to 1010) AUTHORS Godwin,A.K., Vanderveer,L. and White,T.E.K. TITLE Direct Submission JOURNAL Submitted (11-JUN-1998) Medical Oncology, Fox Chase Cancer Center, Rm. W304, 7701 Burholme Ave., Philadelphia, PA 19111, USA FEATURES Location/Qualifiers source 1..1010 /db_xref="H-InvDB:HIT000065945" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="between D17S5 and D17S28" /cell_line="ovarian cancer line C200" /tissue_type="ovary; brain" /dev_stage="fetal brain" gene 1..1010 /gene="OVCA2" /note="candidate tumor suppressor gene" CDS 1..684 /gene="OVCA2" /function="secretory protein" /note="produced by secretory tissues such as breast, ovary, placenta, testis, and stomach; 25 kDa; putatively processed posttranslation to 21 kDa" /codon_start=1 /product="ovarian cancer gene-2 protein" /protein_id="AAC62628.1" /translation="MAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSG PHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMV AQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSSFCPRGIGFKE SILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAY LKFLDQFAE" BASE COUNT 197 a 302 c 300 g 211 t ORIGIN 1 atggccgcgc agcgacccct gcgggtcctg tgcctggcgg gcttccggca gagcgagcgg 61 ggcttccgtg agaagaccgg ggcgctgagg aaggcgctgc ggggtcgcgc cgagctcgtg 121 tgcctcagcg gcccgcaccc ggtccccgac cccccgggcc ccgagggcgc cagatcagac 181 ttcgggtcct gccctccgga ggagcagcct cgaggctggt ggttttcaga gcaggaggcc 241 gacgttttct ccgcattgga agagcccgcc gtctgcaggg gcctggagga atcactgggg 301 atggtggcac aggcactgaa caggctgggg ccttttgacg gccttcttgg tttcagccaa 361 ggggctgcgc tagcagccct tgtgtgtgcc ctgggccagg caggcgatcc ccgcttcccc 421 ttgccacggt ttatcctctt ggtgtctagt ttctgtcccc ggggcattgg gttcaaggaa 481 tccatcctcc aaaggccctt gtcattgcct tcgctccatg tttttgggga cactgacaaa 541 gtcatcccct ctcaggagag tgtgcaactg gccagccaat ttcccggagc catcaccctc 601 acccactctg gtggccactt cattccagca gctgcacccc agcgtcaggc ctacctcaag 661 ttcttggacc agtttgcaga gtgaaagatc aagaaatgtc tctgctccta catccagctc 721 ctctaggggc agcctccgtc atccatgccc tcccaggacc ctccactcac tgctgtgagt 781 gcgcctcacc agaaccagtt aagagacaac tatcaattct tgagacccaa attataaggg 841 ccctgccctg tactgaagaa aaggggagca caaggcctta atggacattg acttgtgaaa 901 acgcaaacat gaatatggtt ggagagccct ggattaggag ggtgacatgg ggaaggcaga 961 ggctggcacg atggtgactg ccacataata aagtggtgat ttggattttg //