LOCUS AF073481 3044 bp mRNA linear HUM 01-JUL-1999
DEFINITION Homo sapiens polycystin-L (PKDL) mRNA, complete cds.
ACCESSION AF073481
VERSION AF073481.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3044)
AUTHORS Nomura,H., Turco,A.E., Pei,Y., Kalaydjieva,L., Weremowicz,S.,
Ji,W., Morton,C.C., Meisler,M., Reeders,S.T. and Zhou,J.
TITLE Identification of a novel polycystic kidney disease 2 like gene on
human chromosome 10q24 whose murine homolog is deleted in mice with
kidney and retinal defects
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3044)
AUTHORS Nomura,H., Reeders,S.T. and Zhou,J.
TITLE Direct Submission
JOURNAL Submitted (19-JUN-1998) Renal Division, Brigham and Women's
Hospital and Harvard Medical School, 77 Ave. Louis Pasteur #520,
Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..3044
/db_xref="H-InvDB:HIT000065936"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24; D10S603"
gene 1..3044
/gene="PKDL"
CDS 384..2801
/gene="PKDL"
/note="polycystin-2 homolog"
/codon_start=1
/product="polycystin-L"
/protein_id="AAD41638.1"
/translation="MNAVGSPEGQELHKLGSGAWDNPAYSGPPSPHGTLRVCTISSTG
PLQPQPKKPEDEPQETAYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLR
ELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDF
AQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFRE
DILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPG
SRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSW
QIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLV
IILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAW
IKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFST
FIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSE
VKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNT
LRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEKLGRS
IVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETVLEGVVSQIDAVGSKLKMLER
KGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEVPYKREEEALEERRLSRGE
IPTLQRS"
BASE COUNT 708 a 846 c 794 g 696 t
ORIGIN
1 cagcatcgcc ttttcctccc gtttctcctt ccactcccag ctccacatcc tcctcctatt
61 ctcccctctc ccctcttcaa acccccacct tccagttccc tcacctcccc tttcggctgg
121 tcccctgggg cttgcagcaa gagggagaga gagctcctga caggattgat ggtccttccc
181 caccctgtcc tctcatccgc tccctcccca gcaggcacag acatccccct acaaaaggca
241 ggagcccagg ctgtgtggaa acagctgctc tcagacgcct ttccatttgc tctctgctgg
301 ctaggctggg ctgtgcctct gctccctctt cctctagctg agagtgggca cctggggtac
361 cgggcccccc cacctcattc cccatgaatg ctgtgggaag tcctgagggg caggagctgc
421 acaagctggg gagtggagcc tgggacaacc ccgcctacag tggtccccct tccccacacg
481 ggacgctgag agtctgcacc atctccagca cggggcctct ccagccccaa cccaagaagc
541 ctgaagatga accccaggag acggcataca ggacccaggt gtccagctgc tgcctccata
601 tctgtcaagg catcagagga ctttggggaa caaccctgac tgagaacaca gctgagaacc
661 gggaacttta tatcaagacc accctgaggg agctgttggt atatattgtg ttcctggtgg
721 acatctgtct actgacctat ggaatgacaa gctccagtgc ttattactac accaaagtga
781 tgtctgagct cttcttacat actccatcag acactggagt ctcctttcag gccatcagca
841 gcatggcgga cttctgggat tttgcccagg gcccactact ggacagtttg tattggacca
901 aatggtacaa caaccagagc ctgggccatg gctcccactc cttcatctac tatgagaaca
961 tgctgctggg ggttccgagg ctgcggcagc taaaggtccg caatgactcc tgtgtggtgc
1021 atgaagactt ccgggaggac attctgagct gctatgatgt ctactctcca gacaaagaag
1081 aacaactccc ctttgggccc ttcaatggca cagcgtggac ataccactcg caggatgagt
1141 tggggggctt ctcccactgg ggcaggctca caagctacag cggaggtggc tactacctgg
1201 accttccagg atcccgacag ggtagtgcag aggctctccg ggcccttcag gaggggctgt
1261 ggctggacag gggcactcga gtggtgttca tcgacttctc agtctacaat gccaatatca
1321 atcttttctg tgtcctgagg ctggtggtgg agtttccagc tacaggaggt gccatcccat
1381 cctggcaaat ccgcacagtc aagctgatcc gctatgtcag caactgggac ttctttatcg
1441 ttggctgtga ggtcatcttc tgcgtcttca tcttctacta tgtggtggaa gagatcctgg
1501 agctccacat tcaccggctt cgctacctca gcagcatctg gaacatactg gacctggtga
1561 tcatcttgct ctccattgtg gctgtgggct tccacatatt ccgaaccctc gaggtgaatc
1621 ggctcatggg gaagctcctg cagcagccaa acacgtatgc agactttgag ttcctcgcct
1681 tctggcagac acagtacaac aacatgaatg ctgtcaacct cttcttcgcc tggatcaaga
1741 tattcaagta catcagcttc aacaaaacca tgacccagct ctcctccacg ctggcccgct
1801 gtgccaagga catcctgggc ttcgccgtca tgttcttcat tgttttcttc gcctatgccc
1861 aactcggcta cctgcttttc gggacccaag tggaaaactt tagcactttc atcaagtgca
1921 ttttcactca gttccggata atcctcgggg actttgacta caatgctatc gacaatgcca
1981 accgcatcct gggccctgcc tactttgtca cctatgtctt cttcgtcttc ttcgtgctcc
2041 tgaacatgtt cctggccatc atcaatgaca catattcaga ggtcaaggag gagctggctg
2101 gacagaagga tgagctgcaa ctttctgacc tcctgaaaca gggctacaac aagaccctac
2161 taagactgcg tctgaggaag gagagggttt cggatgtgca gaaggtcctg cagggtgggg
2221 agcaggagat ccagtttgag gatttcacca acaccttaag ggaactggga cacgcagagc
2281 atgaaatcac tgagctcacg gccaccttca ccaagtttga cagagatggg aatcgtattc
2341 tggatgagaa ggaacaggaa aaaatgcgac aggacctgga ggaagagagg gtggccctca
2401 acactgagat tgagaaacta ggccgatcta ttgtgagcag cccacaaggc aaatcgggtc
2461 cagaggctgc cagagcagga ggctgggttt caggagaaga attctacatg ctcacaagga
2521 gagttctgca gctggagact gtcctggaag gagtagtgtc ccagattgat gctgtaggct
2581 caaagctgaa aatgctggag aggaaggggt ggctggctcc ctccccaggc gtgaaggaac
2641 aagctatttg gaagcacccg cagccagccc cagctgtgac cccagacccc tggggagtcc
2701 agggtgggca ggagagtgag gttccctata aaagagaaga ggaagcctta gaggagagga
2761 gactctcccg tggtgagatt ccaacgttgc agaggagtta agtgtgaggc actcccggag
2821 caaagtctat gaaggatctt ctgcaagagg ctgcctcctg gtccactgaa cctggaaact
2881 gagtgggctt taaccaggag ataaaaatgg agcctgaagg gaatcaggca aggaaatgaa
2941 ctcaggattc agagatcttt gaattaatat gtggtgggtt ctgacattat tcttccataa
3001 gaccatgtgg gtttccatgg tggctatcaa taaaactcct tagt
//