LOCUS AF073310 6996 bp mRNA linear HUM 25-MAR-1999
DEFINITION Homo sapiens insulin receptor substrate-2 (IRS2) mRNA, complete
cds.
ACCESSION AF073310
VERSION AF073310.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6996)
AUTHORS Vassen,L., Wegrzyn,W. and Klein-Hitpass,L.
TITLE Human insulin receptor substrate-2 (IRS-2) is a primary
progesterone response gene
JOURNAL Mol. Endocrinol. 13 (3), 485-494 (1999)
PUBMED 10077005
REFERENCE 2 (bases 1 to 6996)
AUTHORS Vassen,L., Wegrzyn,W. and Klein-Hitpass,L.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-1998) Institut fuer Zellbiologie,
Universitaetsklinikum, Virchowstr. 173, Essen D-45122, Germany
FEATURES Location/Qualifiers
source 1..6996
/db_xref="H-InvDB:HIT000065930"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..6996
/gene="IRS2"
5'UTR 1..516
/gene="IRS2"
CDS 517..4533
/gene="IRS2"
/codon_start=1
/product="insulin receptor substrate-2"
/protein_id="AAD21531.1"
/translation="MASPPRHGPPGPASGDGPNLNNNNNNNNNHSVRKCGYLRNEEHG
HKRFFVLRGPGAGGDEATAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNI
NKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAP
AASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVY
RLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQAD
DSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPP
SQTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGRAAGAAAAAQRLVSVAGSPLS
PGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLS
SSSGHGSGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSP
GDLRAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQ
DLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSAGRLCPSCPASSPKV
AYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAAFAGSGSGSCRSDDYMPMSPA
SVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTFPASGGGYKASSPAESSPED
SGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTPPDFFSAALHPGGEPLRG
VPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLEPQATPGPSQAASAFG
AGPTQPPHPVVPSPVRRSGRRSGFLGQRGRAVRPTRLSLEGLPSLPSMHEYPLPPEPK
SPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQR
SPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQ
PPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIA
APPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRR
HSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSP
RQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEP
GLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTY
ASIDFLSHHLKEATIVKE"
3'UTR 4534..6996
/gene="IRS2"
BASE COUNT 1374 a 2250 c 2030 g 1342 t
ORIGIN
1 gcggggaccg cgacgagccc gggtcgccgt tggcagcagc agcagcaaca ccagcagcag
61 cagcagcccc ggcggcggcg cggaaccccg agcgcccggg cgcaccccgg cttcccggag
121 cgcgacgcgg cggcagcagc cccggtgcgg ccgcgcgcgc cttaggctcg gccccgcggc
181 tcggggaccc cgactcccgg cccagcgagc gcgtcccccg gcgccgcccg agagcccgag
241 gaggcagcgg ccgcagagcc cgggggaggg gggcggccac cgcccgcgcc gggcatcctc
301 aggagcccca gagcgcggag ggcgcggcgc cgccgagcgg tgctggcccc cgcgggctcc
361 ccggaccttc cccaccgcct gggcccgagg gacgcgtgat cgggcgggcg gccgggcgca
421 agggtgggag ggagccgccc ccgcccgcgc cccctccgcc cctcgcccca aacccctggg
481 cgccgggccc gggccgcgcg gcctgaagcg cccgcgatgg cgagcccgcc gcggcacggg
541 ccgcccgggc cggcgagcgg agacggcccc aacctcaaca acaacaacaa caacaacaac
601 aaccacagcg tgcgcaagtg cggctacctg cgcaacgaag agcatggcca caagcgcttc
661 ttcgtgctgc gcggacccgg cgcgggcggc gacgaggcga cggcgggcgg ggggtcggcg
721 ccgcaaccgc cgcggctcga gtactacgag agcgagaaaa agtggcggag caaggcaggc
781 gcgccgaaac gggtgatcgc tctcgactgc tgcctgaaca tcaacaagcg cgccgacgcc
841 aagcacaagt acctgatcgc cctctacacc aaggacgagt acttcgccgt ggccgccgag
901 aacgagcagg agcaggaggg ctggtaccgc gcgctcaccg acctggtcag cgagggccgc
961 gcggccgccg gagacgcgcc ccccgccgcc gcgcccgccg cgtcctgcag cgcctccctg
1021 cccggcgccc tgggcggctc tgccggcgcc gccggggccg aggacagcta cgggctggtg
1081 gctcccgcca cggccgccta ccgtgaggtg tggcaggtga acctgaagcc caagggtctg
1141 ggccagagca agaacctgac gggggtgtac cgtctgtgcc tgtctgcgcg caccatcggc
1201 ttcgtgaagc tcaactgcga gcagccgtcg gtgacgctgc agctcatgaa catccgccgc
1261 tgcggccact cggacagctt cttcttcatc gaggtgggcc gctcggccgt cacaggcccc
1321 ggcgagctgt ggatgcaggc ggacgactcg gtggtggcgc agaacatcca cgagaccatc
1381 ctggaggcca tgaaggcgct caaggagctc ttcgagttcc ggccgcgcag taagagccaa
1441 tcgtcggggt cgtcggccac gcaccccatc agcgtccccg gcgcgcgccg ccaccaccac
1501 ctggtcaacc tgccccccag ccagacgggc ctggtgcgcc gctcgcgcac cgacagcctg
1561 gccgccaccc cgccggcggc caagtgcagc tcgtgccggg tgcgcaccgc cagcgagggc
1621 gacggcggcc gggctgcggg agcggcggcc gcggcgcaga ggctggtgtc ggtggctggg
1681 agccccctga gccccgggcc ggtgcgcgcg cccctgagcc gctcgcacac cctgagcggc
1741 ggctgcggcg gccgcgggag caaggtggcg ctgctgccgg cagggggcgc gctgcaacac
1801 agccgctcca tgtccatgcc cgtggcgcac tcgccgcccg ccgccaccag ccccggctcc
1861 ctgtcgtcca gcagcggcca cggctcgggc tcctacccgc cgccgcccgg cccgcacccg
1921 cctctgccgc atccgctgca ccacggcccc ggccagcggc cctccagcgg cagcgcctcc
1981 gcctcgggct cccccagcga ccccggcttc atgtccctgg acgagtacgg ctccagccca
2041 ggcgacctgc gcgccttctg cagccaccga agcaacacgc ccgagtccat cgcggagacg
2101 cccccggccc gagacggcgg cggcggcggt gagttctacg ggtacatgac catggacagg
2161 cccctgagcc actgtggccg ctcctaccgc cgggtctcgg gggacgcggc ccaggacctg
2221 gaccgagggc tgcgcaagag gacctactcc ctgaccacgc cagcccggca gcggccggtg
2281 ccccagccct cctctgcctc gctggatgaa tacaccctga tgcgggccac cttctcgggc
2341 agcgcgggcc gcctctgccc gtcctgcccc gcgtcctctc ccaaggtggc ctaccacccc
2401 tacccagagg actacggaga catcgagatc ggctcccaca ggagctccag cagcaacctg
2461 ggggcagacg acggctacat gcccatgacg cccggcgcgg ccttcgcggg cagtgggagc
2521 ggcagctgca ggagcgacga ctacatgccc atgagccccg ccagcgtgtc cgcccccaag
2581 cagatcttgc agcccagggc cgccgccgcc gccgccgccg ccgtgccttc tgcggggcct
2641 gcggggccag cacccacctc tgcggcgggc aggacattcc cggcgagcgg gggcggctac
2701 aaggccagct cgcccgccga gagctccccc gaggacagtg ggtacatgcg catgtggtgc
2761 ggttccaagc tgtccatgga gcatgcagat ggcaagctgc tgcccaacgg ggactacctc
2821 aacgtgtccc ccagcgacgc ggtcaccacg ggcaccccgc ccgacttctt ctccgcagcc
2881 ctgcaccccg gcggggagcc gctcaggggc gttcccggct gctgctacag ctccttgccc
2941 cgctcctaca aggcccccta cacctgtggc ggggacagcg accagtacgt gctcatgagc
3001 tcccccgtgg ggcgcatcct ggaggaggag cgtctggagc ctcaggccac gccagggccc
3061 agccaggcgg ccagcgcctt cggggccggc cccacgcagc cccctcaccc tgtagtgcct
3121 tcgcccgtgc ggcgtagcgg ccgccggtca ggtttcttgg gccagcgcgg ccgggcggtg
3181 aggcccacgc gcctgtccct ggaggggctg cccagcctgc ccagcatgca cgagtaccca
3241 ctgccaccgg agcccaagag ccccggcgag tacatcaaca tcgactttgg cgagcccggg
3301 gcccgcctgt cgccgcccgc gcctcccctg ctggcgtcgg cggcctcgtc ctcctcgctc
3361 ttgtccgcca gcagcccggc ctcgtcgctg ggctcaggca ccccgggcac cagcagcgac
3421 agccggcagc ggtctccgct ctccgactac atgaacctcg acttcagctc ccccaagtct
3481 cctaagccgg gcgccccgag cggccacccc gtgggctcct tggacggcct cctgtccccc
3541 gaggcctcct ccccgtatcc gccgttgccc ccgcgtccgt ccgcgtcccc gtcgtcgtct
3601 ctgcagccgc cgccaccgcc gccggccccg ggggagctgt accgcctgcc ccccgcctcg
3661 gccgttgcca ccgcccaggg cccgggcgcc gcctcatcgt tgtcctcgga caccggggac
3721 aatggtgact acaccgagat ggcttttggt gtggccgcca ccccgccgca acctatcgcg
3781 gcccccccga agccagaagc tgcccgcgtg gccagcccga cgtcgggcgt gaagaggctg
3841 agcctcatgg agcaggtgtc gggagtcgag gccttcctgc aggccagcca gcccccggac
3901 ccccaccgcg gcgccaaggt catccgcgca gacccgcagg ggggccgccg ccgccacagt
3961 tccgagacct tctcctccac cacgacggtc acccccgtgt ccccgtcctt cgcccacaac
4021 cccaagcgcc acaactcggc ctccgtggaa aatgtctctc tcaggaaaag cagcgagggc
4081 ggcgtgggtg tcggccctgg agggggcgac gagccgccca cctccccacg acagttgcag
4141 ccggcgcccc ctttggcacc gcagggccgg ccgtggaccc cgggtcagcc cgggggcttg
4201 gtcggttgtc ctgggagcgg tggatcgccc atgcgcagag agacctctgc cggcttccag
4261 aatggtctca actacatcgc catcgacgtg agggaggagc ccgggctgcc accccagccg
4321 cagccgccgc cgccgccgct tcctcagccg ggagacaaga gctcctgggg ccggacccga
4381 agcctcgggg gtctcatcag cgctgtgggc gtcggcagca ccggcggcgg gtgcgggggg
4441 ccgggtcccg gtgccctgcc ccctgccaac acctacgcca gcattgactt cttgtcccac
4501 cacttgaagg aggccaccat cgtgaaagag tgaagatctg tctggcttta tcaccaggat
4561 gtcacatgtc agagaatatc attaaaagaa gacgctcagc gctgtttcag cccgaagctg
4621 cttgcagttt tcttttggat ctgagcaatg actgtgtttg gaaacatctg tggactctga
4681 tagatggggc acaacaaggc aaggtcacct gcctctttcc cttgttcccg gatgggcatt
4741 catcattgtg ctgtttgcgt tttgttttgt tttgttttaa caaaattagc tgaagaagtt
4801 attctcaaga aaattggatg ttttcattgg ccttcttaaa ttgtggccag tgtcttttaa
4861 tttcttcttc ttttcctttt ggcaaagcag atataaccct cagcatgcta ggagagtgca
4921 cccgtaccta tggaagtggt aaaatctggt atttactggc ttacactcaa aacgaccaca
4981 gtcctacctc agttcaaggt aaagccggat ttccgtggcg ggggtccaca ggacctcctg
5041 tagtagcccc tgcgctgtgt gtctggagcg cgtcctcgcc ttatttaaat ggtccagtag
5101 acagctgctt gttggattcc agtgcaggta cctgcgatgt ttacgtccac accgagccca
5161 gtgtgggact gacatttctc aatggaagtg aaatttggga ttggactttg aagacgatta
5221 ctaaataata attattatat gtaactgaag caacctactt ttgaaaatca actgtattgg
5281 gtagtgggag gtgggaggga agggctttgg gaaggggatg aatatctctt tttaccttta
5341 acagacttgt ttaatcttct cgatgtagat gtttatgtag gtacttcaca ttgcaaacgc
5401 cttttattct atttacaagc tcagatgtct ctgctctcct gaatcttggg catgcctttc
5461 tgtaaccaaa aatccctgta ggcgtgctag caattccagg gtggtccggg tttggcagat
5521 ttgattttta aaaaatgtat tatctttaat aaaaatgtta ttatgtcaac cagtgaggct
5581 gccctgaaca aaaaaaaaca aaaagaaaaa aaaaaaaagg aaagaaagaa actgataaaa
5641 agaggcatcc agcccctatg ttattgatgg aaaaagaaaa agaagaaaag caatctcgca
5701 gtacatgtta cttgtcgaaa aaattccgga caagactacc cttgttttat gttttcagta
5761 ttctgaaaat accagtgtgt ggcagttctc gcagatgtta cctaaaactg ctgaacttga
5821 ccggcagaat gttctgccgt tttctgctcc ctcgacactt gattggaggg ctgtcgacct
5881 ctcctcccgt gggggcttcc ccagtgccta tcttctctga tagtcatgga gaggttacac
5941 taattcattg gagatgtaag ttgttggttt tgttttgttt tgtttttaga aaaatatata
6001 taaatatata atagatatct atcgctatag aataatgcat taataaaatg aggctttttt
6061 agaggaagac caaaaaattc aatgtcttaa aaatatattt aatggcaatg caaaagtctt
6121 cctgcttccg tgctgaactt tagaacagag gattgtattg caagacaaag ttgaatgtaa
6181 agtgatctcc ctgaacattt ttaaggtttt acttttctga aattatacat cacagcagtg
6241 cataggccat ataatgttag ctggaaggtc aatttcagtg tatgatatac tttattaaga
6301 tgtataaaac atcctgaagt ttttatttag ttttgggaat aggcatcagt gggtggtatt
6361 tgctttgtaa ctccccccag gtacgatagg gactgaatat ggaccctgct gaaagcagtg
6421 tattgacgca tatttaactc gccctctatc cgtagagtag tcatgacact atacagatgg
6481 ttcgtgttca tactgcagct taaaacaagc aaaatacaca gatgataata tgctaaattt
6541 tcctctatcc tgtacatttc acaaaaaggc atatgcaata tttacatttt taatttagtt
6601 tacagaatgg aaccaaaatg tataaatgtt atgtttgcta aaacttcaca atgtatattg
6661 ggtctttgta cattttgcct gacttacctt aaatttaaaa tattttttgc tatataaact
6721 ttaacagtta ttaaacagtg ttttcctttt gggtacgtat tgtttctgga tatcaagatg
6781 ttaaatatat ttcttgctat tgtgatatga caagagactt aacttatctt gctctgtctt
6841 ccactgtaca cgctgtatat aggggtcaat gtgatgctgc tggagacgag aataaactgg
6901 actagaatag tgcattgtat ttagtctgta ttgatcatgg atgccctcct taatagccat
6961 atgcaataaa ataaagtaca ttatttatga aatgaa
//