LOCUS AF073299 2711 bp mRNA linear HUM 26-JUL-1999
DEFINITION Homo sapiens Na+/H+ exchanger isoform 2 (NHE2) mRNA, complete cds.
ACCESSION AF073299
VERSION AF073299.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2711)
AUTHORS Malakooti,J., Dahdal,R.Y., Schmidt,L., Layden,T.J., Dudeja,P.K. and
Ramaswamy,K.
TITLE Molecular Cloning, Tissue Distribution and Expression of the Human
Na+/H+ exchanger NHE-2
JOURNAL Am. J. Physiol. 40 (2), 383-390 (1999)
REFERENCE 2 (bases 1 to 2711)
AUTHORS Malakooti,J. and Ramaswamy,K.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-1998) Medicine, University of Illinois at
Chicago, 840 S. Wood, Chicago, IL 60612, USA
FEATURES Location/Qualifiers
source 1..2711
/db_xref="H-InvDB:HIT000065928"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q11.2"
/tissue_type="colon"
gene 1..2711
/gene="NHE2"
CDS 91..2529
/gene="NHE2"
/function="ion exchanger"
/function="antiporter"
/function="mediates the electroneutral exchange of
extracellular Na+ for intracellular H+ across the plasma
membrane"
/note="Na+/H+ exchanger family member"
/codon_start=1
/product="Na+/H+ exchanger isoform 2"
/protein_id="AAD41635.1"
/translation="MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMG
TSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYH
KLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTR
PFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVD
PVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIA
NFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIM
AITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWA
FVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLP
AAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFD
HVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIE
MAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSL
TADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQK
RRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSG
RDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRAS
EPGSRKARFGSEKP"
BASE COUNT 682 a 661 c 675 g 693 t
ORIGIN
1 taggcggagc gggctgagca gcccgggcgc gatgcgttga gcgctcggag ggccaaccgc
61 cggtcccctt ggcggcaacc ggcggcaccc atggaaccac tgggcaactg gaggagcctg
121 cgggcgccac tgcctccgat gctgttgctg ctgctcctgc aggtggcggg gcccgtgggc
181 gccctggcgg agaccttgct gaacgcgccg agggccatgg gcaccagttc cagcccgcct
241 agccctgcga gcgtggtggc tcccggaacg acgctgttcg aggagagccg gctgcctgtg
301 tttacgctgg attaccccca cgtgcagatc cccttcgaga tcaccctttg gatcctgctg
361 gcctccctgg ccaagattgg cttccatctg tatcacaagt tgcccacaat agtgcctgag
421 agctgccttc ttataatggt tggacttcta ctaggtggga ttatttttgg tgttgatgag
481 aagtctcccc ctgcaatgaa gactgatgta tttttcttgt acctcctccc acccatcgtg
541 ctggatgccg gctatttcat gcccactcgc ccattctttg agaacattgg cacgattttc
601 tggtatgctg tggtagggac actttggaat tccattggca ttggggtgtc tttgtttggt
661 atctgccaga tcgaagcatt cggcctcagc gacatcactt tgctccagaa cctgctcttt
721 ggcagcttaa tctcagctgt cgatcctgtg gctgtgcttg ctgtctttga gaacattcac
781 gtcaatgagc agctctacat cctggtcttt ggagagtccc tgctgaatga tgcagtaaca
841 gtggtcctgt acaacttgtt caagtcgttt tgccagatga aaaccattga gaccattgat
901 gtgtttgcag gaatcgccaa cttctttgtt gtgggaatcg gtggggtgct gattggcatc
961 ttcttgggct ttatagcggc atttactact cgattcaccc ataatatccg agtgatcgag
1021 ccactgtttg ttttcctgta cagttatttg tcctacatca cagctgaaat gtttcacctc
1081 tcaggcatca tggcaatcac tgcttgtgca atgactatga ataagtacgt agaagaaaat
1141 gtatctcaga aatcctacac gaccatcaag tacttcatga agatgctgag cagtgtcagc
1201 gaaaccttga tcttcatctt catgggtgtg tctaccgtgg gcaagaacca cgagtggaac
1261 tgggccttcg tctgcttcac cctggccttc tgcctcatgt ggcgagccct gggtgttttt
1321 gtcctgactc aggtcattaa taggttccgg accattcccc tgacctttaa ggaccagttc
1381 atcattgcct atggaggact tcgaggtgcc atctgttttg cgttagtgtt tctccttcct
1441 gctgctgtgt ttcctcggaa aaaattgttt attacggctg ccattgttgt catattcttt
1501 actgtcttca ttctgggaat aactattcga ccactggtgg agtttcttga tgtcaagagg
1561 tccaataaga aacaacaagc tgtcagtgaa gaaatctatt gtcggttgtt tgatcatgtg
1621 aagactggaa ttgaagatgt ttgtggacat tggggtcaca acttttggag agacaagttt
1681 aagaagtttg atgataaata tctgcggaag cttttgattc gggaaaacca accaaagtca
1741 agtattgtat ctttatataa aaagcttgaa ataaaacatg ccattgagat ggcagagact
1801 gggatgataa gtactgtccc tacatttgca tctctaaatg attgtcgtga agaaaaaata
1861 aggaaggtca cgtccagtga aactgatgaa attcgagaac tcttatcaag aaatctctat
1921 caaatccgtc agcgaacttt atcctacaac agacacagtc tgacagccga cacaagtgag
1981 agacaagcca aggagattct gattcgccgg cgacacagtt tgcgagaaag cattaggaag
2041 gacagcagct tgaatcgaga acacagggct tccacttcaa cctcccgata tttatcctta
2101 cctaaaaata cgaagcttcc agaaaagcta caaaagagga ggactatttc tattgcagat
2161 ggcaatagca gcgactcaga cgcagatgcc gggaccaccg tgctcaattt gcagcccaga
2221 gccaggcgct tcttgccaga acagttctcc aagaaatccc cccagtccta taaaatggaa
2281 tggaagaatg aggtagatgt tgattctggc cgagatatgc ccagcacccc cccaacaccc
2341 cacagcagag aaaagggcac ccagacgtca ggcttactac agcagcccct tctctctaaa
2401 gaccagtctg gctcagagag ggaagacagt ttgactgaag gcatcccgcc caagccgcca
2461 ccacggctgg tctggagggc atcggaacct ggaagccgga aagcccgatt tgggagtgag
2521 aagccttaag agaagcagcg aaagcagatc tgagtgtctg acccaggaca gctgtggttt
2581 gtcactctga aacctgatgc aacagtggaa tccatgtaaa actctctgtg catctaaata
2641 cttctggagg gcgacagatt catgccacgg ataaatgagg caaatccgaa gaaaaaaaaa
2701 aaaaaaaaaa a
//