LOCUS AF071787 5433 bp mRNA linear HUM 26-NOV-1998
DEFINITION Homo sapiens melastatin 1 (MLSN1) mRNA, complete cds.
ACCESSION AF071787
VERSION AF071787.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5433)
AUTHORS Hunter,J.J., Shao,J., Smutko,J.S., Dussault,B.J., Nagle,D.L.,
Woolf,E.A., Holmgren,L.M., Moore,K.J. and Shyjan,A.W.
TITLE Chromosomal localization and genomic characterization of the mouse
melastatin gene (Mlsn1)
JOURNAL Genomics 54 (1), 116-123 (1998)
PUBMED 9806836
REFERENCE 2 (bases 1 to 5433)
AUTHORS Shao,J., Woolf,E.A., Holmgren,L.M., Hunter,J.J. and Shyjan,A.W.
TITLE Direct Submission
JOURNAL Submitted (11-JUN-1998) Oncology, Millennium Pharmaceuticals, Inc.,
640 Memorial Drive, Cambridge, MA 02139, USA
FEATURES Location/Qualifiers
source 1..5433
/db_xref="H-InvDB:HIT000065871"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q13-q14"
/tissue_type="retina"
gene 1..5433
/gene="MLSN1"
CDS 321..4922
/gene="MLSN1"
/function="putative melanoma metastasis suppressor"
/note="similar to TRP calcium channel"
/codon_start=1
/product="melastatin 1"
/protein_id="AAC80000.1"
/translation="MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQP
KLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWG
IVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLL
EKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDI
LSFAHKYCEEGGIINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFR
MGSEGQQDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWTPLGSL
APPTDSKATEKEKKPPMATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALE
QAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKS
NLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDD
EPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGE
ESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQI
AMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVI
MGILLPPTILFLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKK
QRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYI
VSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGY
GRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVAR
QAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRL
PPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT
FHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEF
EEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLR
LAQLEELSNRMVNALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADGYSLYR
YHFNGEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPECQNSLHLSLGTST
SATPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQ
DKSDVQNTQLTVETTNIEGTISYPLEETKITRYFPDETINACKTMKSRSFVYSRGRKL
VGGVNQDVEYSSITDQQLTTEWQCQVQKITRSHSTDIPYIVSEAAVQAEQKEQFADMQ
DEHHVAEAIPRIPRLSLTITDRNGMENLLSVKPDQTLGFPSLRSKSLHGHPRNVKSIQ
GKLDRSGHASSVSSLVIVSGMTAEEKKVKKEKASTETEC"
BASE COUNT 1604 a 1246 c 1345 g 1236 t
ORIGIN
1 ggctgaaaga gcctgagctg tgcctctcca ttccactgct gtggcagggt cagaaatctt
61 ggatagagaa aaccttttgc aaacgggaat gtatctttgt aattcctagc acgaaagact
121 ctaacaggtg ttgctgtggc cagttcacca accagcatat cccccctctg ccaagtgcaa
181 cacccagcaa aaatgaagag gaaagcaaac aggtggagac tcagcctgag aaatggtctg
241 ttgccaagca cacccagagc tacccaacag attcctatgg agttcttgaa ttccagggtg
301 gcggatattc caataaagcc atgtatatcc gtgtatccta tgacaccaag ccagactcac
361 tgctccatct catggtgaaa gattggcagc tggaactccc caagctctta atatctgtgc
421 atggaggcct ccagaacttt gagatgcagc ccaagctgaa acaagtcttt gggaaaggcc
481 tgatcaaggc tgctatgacc accggggcct ggatcttcac cgggggtgtc agcacaggtg
541 ttatcagcca cgtaggggat gccttgaaag accactcctc caagtccaga ggccgggttt
601 gtgctatagg aattgctcca tggggcatcg tggagaataa ggaagacctg gttggaaagg
661 atgtaacaag agtgtaccag accatgtcca accctctaag taagctctct gtgctcaaca
721 actcccacac ccacttcatc ctggctgaca atggcaccct gggcaagtat ggcgccgagg
781 tgaagctgcg aaggctgctg gaaaagcaca tctccctcca gaagatcaac acaagactgg
841 ggcagggcgt gcccctcgtg ggtctcgtgg tggagggggg ccctaacgtg gtgtccatcg
901 tcttggaata cctgcaagaa gagcctccca tccctgtggt gatttgtgat ggcagcggac
961 gtgcctcgga catcctgtcc tttgcgcaca agtactgtga agaaggcgga ataataaatg
1021 agtccctcag ggagcagctt ctagttacca ttcagaaaac atttaattat aataaggcac
1081 aatcacatca gctgtttgca attataatgg agtgcatgaa gaagaaagaa ctcgtcactg
1141 tgttcagaat gggttctgag ggccagcagg acatcgagat ggcaatttta actgccctgc
1201 tgaaaggaac aaacgtatct gctccagatc agctgagctt ggcactggct tggaaccgcg
1261 tggacatagc acgaagccag atctttgtct ttgggcccca ctggacgccc ctgggaagcc
1321 tggcaccccc gacggacagc aaagccacgg agaaggagaa gaagccaccc atggccacca
1381 ccaagggagg aagaggaaaa gggaaaggca agaagaaagg gaaagtgaaa gaggaagtgg
1441 aggaagaaac tgacccccgg aagatagagc tgctgaactg ggtgaatgct ttggagcaag
1501 cgatgctaga tgctttagtc ttagatcgtg tcgactttgt gaagctcctg attgaaaacg
1561 gagtgaacat gcaacacttt ctgaccattc cgaggctgga ggagctctat aacacaagac
1621 tgggtccacc aaacacactt catctgctgg tgagggatgt gaaaaagagc aaccttccgc
1681 ctgattacca catcagcctc atagacatcg ggctcgtgct ggagtacctc atgggaggag
1741 cctaccgctg caactacact cggaaaaact ttcggaccct ttacaacaac ttgtttggac
1801 caaagaggcc taaagctctt aaacttctgg gaatggaaga tgatgagcct ccagctaaag
1861 ggaagaaaaa aaaaaaaaag aaaaaggagg aagagatcga cattgatgtg gacgaccctg
1921 ccgtgagtcg gttccagtat cccttccacg agctgatggt gtgggcagtg ctgatgaaac
1981 gccagaaaat ggcagtgttc ctctggcagc gaggggaaga gagcatggcc aaggccctgg
2041 tggcctgcaa gctctacaag gccatggccc acgagtcctc cgagagtgat ctggtggatg
2101 acatctccca ggacttggat aacaattcca aagacttcgg ccagcttgct ttggagttat
2161 tagaccagtc ctataagcat gacgagcaga tcgctatgaa actcctgacc tacgagctga
2221 aaaactggag caactcgacc tgcctcaaac tggccgtggc agccaaacac cgggacttca
2281 ttgctcacac ctgcagccag atgctgctga ccgatatgtg gatgggaaga ctgcggatgc
2341 ggaagaaccc cggcctgaag gttatcatgg ggattcttct accccccacc atcttgtttt
2401 tggaatttcg cacatatgat gatttctcgt atcaaacatc caaggaaaac gaggatggca
2461 aagaaaaaga agaggaaaat acggatgcaa atgcagatgc tggctcaaga aagggggatg
2521 aggagaacga gcataaaaaa cagagaagta ttcccatcgg aacaaagatc tgtgaattct
2581 ataacgcgcc cattgtcaag ttctggtttt acacaatatc atacttgggc tacctgctgc
2641 tgtttaacta cgtcatcctg gtgcggatgg atggctggcc gtccctccag gagtggatcg
2701 tcatctccta catcgtgagc ctggcgttag agaagatacg agagatcctc atgtcagaac
2761 caggcaaact cagccagaaa atcaaagttt ggcttcagga gtactggaac atcacagatc
2821 tcgtggccat ttccacattc atgattggag caattcttcg cctacagaac cagccctaca
2881 tgggctatgg ccgggtgatc tactgtgtgg atatcatctt ctggtacatc cgtgtcctgg
2941 acatctttgg tgtcaacaag tatctggggc catacgtgat gatgattgga aagatgatga
3001 tcgacatgct gtactttgtg gtcatcatgc tggtcgtgct catgagtttc ggagtagccc
3061 gtcaagccat tctgcatcca gaggagaagc cctcttggaa actggcccga aacatcttct
3121 acatgcccta ctggatgatc tatggagagg tgtttgcaga ccagatagac ctctacgcca
3181 tggaaattaa tcctccttgt ggtgagaacc tatatgatga ggagggcaag cggcttcctc
3241 cctgtatccc cggcgcctgg ctcactccag cactcatggc gtgctatcta ctggtcgcca
3301 acatcctgct ggtgaacctg ctgattgctg tgttcaacaa tactttcttt gaagtaaaat
3361 caatatccaa ccaggtgtgg aagttccagc gatatcagct gattatgaca tttcatgaca
3421 ggccagtcct gcccccaccg atgatcattt taagccacat ctacatcatc attatgcgtc
3481 tcagcggccg ctgcaggaaa aagagagaag gggaccaaga ggaacgggat cgtggattga
3541 agctcttcct tagcgacgag gagctaaaga ggctgcatga gttcgaggag cagtgcgtgc
3601 aggagcactt ccgggagaag gaggatgagc agcagtcgtc cagcgacgag cgcatccggg
3661 tcacttctga aagagttgaa aatatgtcaa tgaggttgga agaaatcaat gaaagagaaa
3721 cttttatgaa aacttccctg cagactgttg accttcgact tgctcagcta gaagaattat
3781 ctaacagaat ggtgaatgct cttgaaaatc ttgcgggaat cgacaggtct gacctgatcc
3841 aggcacggtc ccgggcttct tctgaatgtg aggcaacgta tcttctccgg caaagcagca
3901 tcaatagcgc tgatggctac agcttgtatc gatatcattt taacggagaa gagttattat
3961 ttgaggatac atctctctcc acgtcaccag ggacaggagt caggaaaaaa acctgttcct
4021 tccgtataaa ggaagagaag gacgtgaaaa cgcacctagt cccagaatgt cagaacagtc
4081 ttcacctttc actgggcaca agcacatcag caaccccaga tggcagtcac cttgcagtag
4141 atgacttaaa gaacgctgaa gagtcaaaat taggtccaga tattgggatt tcaaaggaag
4201 atgatgaaag acagacagac tctaaaaaag aagaaactat ttccccaagt ttaaataaaa
4261 cagatgtgat acatggacag gacaaatcag atgttcaaaa cactcagcta acagtggaaa
4321 cgacaaatat agaaggcact atttcctatc ccctggaaga aaccaaaatt acacgctatt
4381 tccccgatga aacgatcaat gcttgtaaaa caatgaagtc cagaagcttc gtctattccc
4441 ggggaagaaa gctggtcggt ggggttaacc aggatgtaga gtacagttca atcacggacc
4501 agcaattgac gacggaatgg caatgccaag ttcaaaagat cacgcgctct catagcacag
4561 atattcctta cattgtgtcg gaagctgcag tgcaagctga gcaaaaagag cagtttgcag
4621 atatgcaaga tgaacaccat gtcgctgaag caattcctcg aatccctcgc ttgtccctaa
4681 ccattactga cagaaatggg atggaaaact tactgtctgt gaagccagat caaactttgg
4741 gattcccatc tctcaggtca aaaagtttac atggacatcc taggaatgtg aaatccattc
4801 agggaaagtt agacagatct ggacatgcca gtagtgtaag cagcttagta attgtgtctg
4861 gaatgacagc agaagaaaaa aaggttaaga aagagaaagc ttccacagaa actgaatgct
4921 agtctgtttt gtttctttaa tttttttttt taacagtcag aaacccacta atgggtgtca
4981 tcttggccca tcctaaacac atmtccaatt tcctaaaaac attttccctt aaaaaatttt
5041 ggaaattcag acttgattta caatttaatg cactaaaagt agtattttgt tagnatatgt
5101 tagtaggctt agttttttca gttgcagtag tatcaaatga aagtgatgat actgtaacga
5161 agataaattg gctaatcagt atacaagatt atacaatctc tttattactg agggccacca
5221 aatagcctag gaagtgccct cgagcactga agtcaccatt aggtcactca agaagtaagc
5281 aactagctgg gcacagtggc tcatgcctgt aatcctagca ctttgggagg ccaaggcaga
5341 aagatagctt gagtccagga gtttgagacc agcctgggca acatagtgat accccatctc
5401 ttaaaaaaaa aaaaaaaaaa ctgccctcgt gcc
//