LOCUS AF071077 5646 bp mRNA linear HUM 31-MAR-1999
DEFINITION Homo sapiens cell-line HeLa Nup98-Nup96 precursor splice variant 1
mRNA, complete cds.
ACCESSION AF071077
VERSION AF071077.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5646)
AUTHORS Fontoura,B.M., Blobel,G. and Matunis,M.J.
TITLE A conserved biogenesis pathway for nucleoporins: proteolytic
processing of a 186-kilodalton precursor generates Nup98 and the
novel nucleoporin, Nup96
JOURNAL J. Cell Biol. 144 (6), 1097-1112 (1999)
PUBMED 10087256
REFERENCE 2 (bases 1 to 5646)
AUTHORS Fontoura,B.M.A., Blobel,G. and Matunis,M.J.
TITLE Direct Submission
JOURNAL Submitted (08-JUN-1998) Cell Biology, The Rockefeller University,
1230 York Avenue, New York, NY 10021, USA
FEATURES Location/Qualifiers
source 1..5646
/db_xref="H-InvDB:HIT000065836"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HeLa"
CDS 125..5041
/note="alternatively spliced"
/codon_start=1
/product="Nup98-Nup96 precursor splice variant 1"
/protein_id="AAD22396.1"
/translation="MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGS
SNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLF
SSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGT
TIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQ
VGAGTTTGLFGSSPATSSATGLFSSSTTNSGFAYGQNKTAFGTSTTGFGTNPGGLFGQ
QNQQTTSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTNTMGLFGVTQASQPGGLFGTA
TNTSTGTAFGTGTGLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAPSFGTTSGGLFG
FGTNTSGNSIFGSKPAPGTLGTGLGAGFGTALGAGQASLFGNNQPKIGGPLGTGAFGA
PGFNTTTATLGFGAPQAPVALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDE
PSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPV
DENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRN
GLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNVF
GECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGL
NRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSW
VFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ
SQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPH
VLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGG
LLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVP
LKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGS
HELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLEL
KLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEAL
WAHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSY
LTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDER
LRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAF
QNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVREL
LTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHW
NRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIE
MLRHIQQVEHFNDSNIVQVMTWSSYTSK"
BASE COUNT 1556 a 1396 c 1282 g 1412 t
ORIGIN
1 gcggcggcga cggtttcgtg ggggccgcgc gctgctctgt gagcggcggg tggcagcagg
61 ggactcctga cacttcccct tccccaccga accgcgcttt ctgaaacaaa gactcatttt
121 gaagatgttt aacaaatcat ttggaacacc ctttgggggt ggcacaggtg gctttggcac
181 aacttcaaca tttggacaga atactggctt tggcactact agtggagggg catttggaac
241 atctgcattt ggttctagca acaatactgg aggcctcttt ggaaattcac agactaaacc
301 aggaggattg tttggaacca gttcatttag ccagccagct acctccacaa gcactggctt
361 tgggtttggt acgtcaacag gaacagcaaa taccttgttt ggaactgcaa gcacagggac
421 cagtctcttc tcatcccaaa acaatgcctt tgcacaaaat aaaccaactg gctttggcaa
481 ttttggaacc agtactagca gtggaggact ctttggaacc acaaatacca cctctaatcc
541 ttttggcagc acatctggct ccctctttgg gccaagtagt tttacagctg ctcctactgg
601 gactactatt aaatttaacc ctccaactgg tacagatact atggtcaaag ctggagttag
661 cactaacata agtaccaagc accagtgtat tactgctatg aaagaatatg aaagcaagtc
721 actagaggaa cttcgtttag aggattatca ggctaacagg aagggcccac agaaccaggt
781 gggagcaggt accacaactg gcttgtttgg gtcttctcca gccacttcca gcgcaacagg
841 actcttcagc tcctccacca ctaattcagg ctttgcatat ggtcagaaca aaactgcctt
901 tggaactagt acaactggat ttggaacaaa tccaggtggt ctctttggcc aacagaatca
961 gcagactacc agcctcttca gcaaaccatt tggccaggct acaaccaccc agaacactgg
1021 cttttccttt ggtaatacca gcaccatagg acagccaagc accaacacca tgggattatt
1081 tggagtaacc caagcctcac agcctggagg tctttttggg acagctacaa acaccagcac
1141 tgggacagca tttggaacag gaacaggtct ctttgggcag accaatactg gatttggtgc
1201 tgttggttcg accctgtttg gcaataacaa gcttactaca tttggaagca gcacaaccag
1261 tgcaccttca tttggtacaa ccagtggcgg gctctttggt tttggcacaa ataccagtgg
1321 gaatagtatt tttggaagta aaccagcacc tgggactctt ggaactgggc ttggtgcagg
1381 atttggaaca gctcttggtg ctggacaggc atctttgttt gggaacaacc aacctaagat
1441 tggagggcct cttggtacag gagcctttgg ggcccctgga tttaatacta cgacagccac
1501 tttgggcttt ggagcccccc aggccccagt agctttgaca gatccaaatg cttctgctgc
1561 ccagcaggct gttctccagc agcacatcaa tagtctaaca tactcacctt ttggagactc
1621 tcctctcttc cggaatccga tgtcagaccc taagaagaag gaagagagat tgaaaccaac
1681 aaatccagca gcccagaagg ctcttactac acctactcat tataaactga caccccgccc
1741 tgccactaga gtccggccaa aggctttaca aacaacaggc acagccaagt cacatctctt
1801 tgatgggctg gatgacgatg aaccatccct agccaatgga gcattcatgc ccaagaagag
1861 cattaagaag ttggttttga agaaccttaa taatagcaat ctcttttctc ctgttaatcg
1921 tgattcagaa aatctagctt caccatctga atatccagaa aatggagaga gatttagttt
1981 cctaagcaaa cctgttgatg agaatcacca gcaggatgga gatgaagatt cccttgtttc
2041 acatttttat actaacccta ttgccaaacc tattcctcaa accccagaaa gtgctggaaa
2101 taaacacagc aacagcaaca gtgtggatga taccattgtt gcattaaaca tgcgtgctgc
2161 tttgcgaaat gggctggaag gaagcagtga agaaacgtct tttcatgatg agtcacttca
2221 ggatgaccga gaagaaatag aaaataattc ttaccatatg cacccagcag gtattattct
2281 cactaaggtt ggttactata ctattccatc tatggatgac cttgctaaaa ttaccaatgt
2341 ttttggagag tgcattgtct ctgatttcac tattggtcgg aaaggttatg gttcaatcta
2401 ttttgaagga gatgtgaatt tgacaaatct aaatttggat gatattgtgc atatccggag
2461 gaaagaagta gttgtctact tagatgataa ccaaaaacca cctgtgggtg aagggctaaa
2521 taggaaggct gaagttacat tggatggagt ttggccaaca gataaaacat ctcgttgttt
2581 aataaagagc ccagatcgcc ttgctgatat caactatgaa ggaagattgg aagcagtttc
2641 aaggaaacag ggagctcaat tcaaagaata ccggcctgaa actggttctt gggtgtttaa
2701 ggtctcccat ttttctaagt atggccttca ggattctgat gaagaggagg aggagcatcc
2761 gtctaaaact agtacaaaga agttgaagac tgctcctttg cctcctgcaa gccagactac
2821 gcccttgcag atggctctta atggcaaacc tgcacctcca cctcagagcc agagcccaga
2881 ggtggagcag ttagggaggg ttgtggaact ggacagtgac atggtagata tcacccagga
2941 gccagttttg gataccatgt tagaagagag catgcctgag gatcaggaac ctgtgtctgc
3001 ctcaacacat attgcatctt cactgggaat taatccacat gtcttacaga tcatgaaagc
3061 atcattgctt actgatgaag aagatgtaga tatggcactg gatcaacgct tcagtcgcct
3121 gccttccaaa gcagatactt ctcaagaaat ctgttctccc agactcccca tttcagcatc
3181 ccactcgtcg aaaactcgtt cactagttgg tgggttacta caatcaaaat ttacaagtgg
3241 agcttttctt tcaccaagtg tctctgtgca agaatgtcgt actcccagag cagcatcttt
3301 aatgaatatc ccatccacat cctcttggtc tgtccctcca cccctgactt ctgtgttcac
3361 aatgcccagc ccagcccctg aggttccgtt gaaaacagtg ggtacacgta ggcaactagg
3421 cctagtccct cgtgaaaagt ctgtcaccta tggcaaggga aaactcttga tggacatggc
3481 cctattcatg ggacgctcat ttcgtgttgg ttggggcccc aactggactc ttgctaatag
3541 tggagaacag ctgaatggct ctcatgaact agaaaatcat cagattgccg attccatgga
3601 gtttggattc ctgcccaatc cagtagctgt taaaccccta actgagtccc cattcaaagt
3661 tcacttagaa aaactcagtt tgagacaaag aaagccagat gaagacatga aattatatca
3721 gacacctctg gagctcaaat taaaacacag cactgtccat gtggatgaac tgtgtcctct
3781 cattgtcccc aatctgggag ttgctgtcat tcatgactat gcagattggg ttaaagaagc
3841 atcaggagac ttaccagaag cacaaattgt gaagcactgg agcctgacat ggacactatg
3901 tgaagcccta tgggcccacc tgaaggagct tgacagccag ctaaatgaac cccgtgaata
3961 cattcaaatt ctggagcgaa gaagagcttt ctcccgctgg ctatcctgta ctgccacacc
4021 tcagattgaa gaggaagtct ccttaaccca aaaaaacagc cctgtggagg ctgtattcag
4081 ctacctcaca ggcaaaagga tcagtgaggc ctgctctctg gcccagcagt caggggatca
4141 tcgtcttgct cttcttttat ctcagtttgt gggtagccag tcagtccggg agctgctcac
4201 catgcagttg gtggactggc atcagctcca agcagactcc ttcatccagg atgagagact
4261 gcgcatcttt gctctgttgg ctggaaaacc ggtgtggcag ctctcagaaa agaagcaaat
4321 aaacgtgtgc tcccagttgg attggaaacg ctccctggct atccatcttt ggtatttgct
4381 tccaccaaca gcctccattt ctagggcgct cagcatgtat gaagaagcat ttcagaatac
4441 ctctgacagt gacagatatg cctgctcccc acttccttcg tatctggagg gttctggctg
4501 tgtgatagcg gaggagcaaa actcacagac accacttcga gatgtctgct ttcaccttct
4561 aaaactctac agtgacagca tacgtgagaa ggctgttcga gagctgctta cccggcactg
4621 ccagctgttg gagacccctg aatcttgggc taaagagact ttccttaccc agaagctccg
4681 tgtacctgcc aaatggatcc acgaggccaa agctgtgcga gcacacatgg aatctgacaa
4741 gcacttagag gccctttgct tatttaaggc tgagcactgg aaccgctgcc acaagctcat
4801 catccgacac ttagcttctg atgccatcat taatgagaac tatgactacc tgaaggggtt
4861 cttggaagac ctggcacctc cagagcgcag cagcctaatt caggattggg aaacatctgg
4921 gcttgtttac ctggactata ttagagtcat tgaaatgctc cgccatatac agcaggtgga
4981 gcatttcaat gactctaata tagtccaggt aatgacctgg agcagttaca catcaaagtg
5041 acttcactgt gcagtcggat agagcagatt cagtgttaca gtgctaaaga tcgcctggct
5101 cagtcagaca tggccaaacg tgtagccaac ctgctgcgcg tggtgctgag tctgcatcat
5161 cctcctgata gaacctccga ctcaacacca gaccctcagc gagtcccttt gcgcctcttg
5221 gctccccaca ttggccggct tcccatgcct gaggactatg ccatggacga actgcgcagc
5281 cttacccagt cctatctgcg agaactggct gttgggagcc tgtgagcccc aggcactttg
5341 catcacagtc acatgcccat tcacaccaca cagaggttcc ctgccttgtt tggattggca
5401 ctgtttgcca ttctctgggt tggctgtggc atctaccctc ccgtcccctg ctgccagaag
5461 cagcatcctc cacttgttca gggcttttct taatactgaa cgtagcataa gggcttctgg
5521 aacccagaag aggagacagt ttaccatcct caagatcatt cagtgttttt cctttaaaaa
5581 aatggtcaat aaagctcctt tggcagaatc ccccaaaaaa aaaaaaaaaa aaaaaaaaaa
5641 aaaaaa
//