LOCUS AF069984 4079 bp DNA linear HUM 23-JUL-1998
DEFINITION Homo sapiens nitrilase homolog 1 (NIT1) gene, alternatively spliced
product, complete cds.
ACCESSION AF069984
VERSION AF069984.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4079)
AUTHORS Pekarsky,Y., Campiglio,M., Siprashvili,Z., Druck,T., Sedkov,Y.,
Tillib,S., Draganescu,A., Wermuth,P., Rothman,J.H., Huebner,K.,
Buchberg,A.M., Mazo,A., Brenner,C. and Croce,C.M.
TITLE Nitrilase and Fhit homologs are encoded as fusion proteins in
Drosophila melanogaster and Caenorhabditis elegans
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (15), 8744-8749 (1998)
PUBMED 9671749
REFERENCE 2 (bases 1 to 4079)
AUTHORS Pekarsky,Y., Campiglio,M., Siprashvili,Z., Druck,T., Sedkov,Y.,
Tillib,S., Draganescu,A., Wermuth,P., Rothman,J., Huebner,K.,
Buchberg,A.M., Mazo,A., Brenner,C. and Croce,C.M.
TITLE Direct Submission
JOURNAL Submitted (03-JUN-1998) Kimmel Cancer Inst., Thomas Jefferson
Univ., 233 S. Tenth St., Philadelphia, PA 19107, USA
FEATURES Location/Qualifiers
source 1..4079
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21-q22"
gene 635..3569
/gene="NIT1"
mRNA join(635..680,1288..1383,1636..1890,2011..2114,2321..2454,
2609..2734,3001..3569)
/gene="NIT1"
/product="nitrilase homolog 1"
/note="alternatively spliced"
exon 635..680
/gene="NIT1"
/note="alternatively spliced"
/number=1
CDS join(679..680,1288..1383,1636..1890,2011..2114,2321..2454,
2609..2734,3001..3267)
/gene="NIT1"
/note="Nit1; alternatively spliced"
/codon_start=1
/product="nitrilase homolog 1"
/protein_id="AAC39901.1"
/translation="MLGFITRPPHRFLSLLCPGLRIPQLSVLCAQPRPRAMAISSSSC
ELPLVAVCQVTSTPDKQQNFKTCAELVREAARLGACLAFLPEAFDFIARDPAETLHLS
EPLGGKLLEEYTQLARECGLWLSLGGFHERGQDWEQTQKIYNCHVLLNSKGAVVATYR
KTHLCDVEIPGQGPMCESNSTMPGPSLESPVSTPAGKIGLAVCYDMRFPELSLALAQA
GAEILTYPSAFGSITGPAHWEVLLRARAIETQCYVVAAAQCGRHHEKRASYGHSMVVD
PWGTVVARCSEGPGLCLARIDLNYLRQLRRHLPVFQHRRPDLYGNLGHPLS"
exon 681..711
/gene="NIT1"
/note="1A; alternatively spliced"
exon 712..741
/gene="NIT1"
/note="1B; alternatively spliced"
exon 940..1053
/gene="NIT1"
/note="1C; alternatively spliced"
exon 1288..1383
/gene="NIT1"
/number=2
exon 1636..1890
/gene="NIT1"
/number=3
exon 2011..2114
/gene="NIT1"
/number=4
exon 2321..2454
/gene="NIT1"
/number=5
exon 2609..2734
/gene="NIT1"
/number=6
exon 3001..3569
/gene="NIT1"
/number=7
BASE COUNT 940 a 1082 c 1043 g 1012 t
ORIGIN
1 gagtatgaga gtcacgtggc tctgcagcgt gacggcgatt gtcaacgtgg gttcaggatc
61 acgtaacaga ctacacagcc agcccgttaa ctaattctct agggttagtt tcgagctgtc
121 ttgcccagcc ataacctgtt tggagaggct gaggagagat agagaaagca gcaaaccatc
181 tcccctcaga cctgtgcatc ttcccagacc ctacatgtca gggctttccc cttgctcagg
241 ctcacccacc acctcacgga ggcgtggctc tcacctaccc acccgtctac ctctccgaag
301 gggttcggct agcttttccg gggacccttc cctctctagg tgccacgcac atgtggtgct
361 ggagtaaagg cctgcacaag ccacaggctc ccccttctcg ctagtattcc agacccaggt
421 gggtaccctg cttcgcgtta gccactcctc acctgctctg cggacaccgc ccccttcccc
481 gcgccgctcc cgctgctctt gccggcgcga ccgctgttct ccgccatctt cgccgcctgc
541 tgggtttccg gccggcgcag ctcagccccc gccttgcgtc acgtccggcc tgcgagttac
601 cgcccactcg ctgcggcgct tctggctcca gaccgccctc cggatcggac cctgcgaaat
661 ggttttggct atatcttcat gtaggaccta ctccctatcc cgtcggccgc ggtgaatccc
721 acctgcggtg ctttaacttg tgtaacagag atgctgcctc tgggagaggc ggggagggac
781 gggccaactg gagcgggcgg cgggagggtg gagggcgggg cgcggcttgg ggcctgggtt
841 cctttgcccc ttgcccacca gggaggggtg ggagacgaga gagggtgaac tttcccctgc
901 gagattctgg tgaaagggga aatatgcttc gagtcagtaa agctgcgcaa gtgcacagtc
961 aaggagagag tcttgggaaa accaaggata gttcccggag atgacttttg gactgcggaa
1021 acgtttgtca gaggaaagag gcttcagttt aatgtgagat cattggaagt tgaactattc
1081 aggcggcgag cagagcccct ttctccatct tcccactgta tggtcttgtc ccttagccta
1141 taatttctta taaagagcgt tttgaagact aggtttttac tggcagggcc ctgattcagg
1201 ctcacagtat aaagagagaa gtcagagaat cctagaaatt tattgcttga agaaggggtt
1261 ggtgtcctca tatctcacct tcctcaggct gggcttcatc accaggcctc ctcacagatt
1321 cctgtccctt ctgtgtcctg gactccggat acctcaactc tcagtacttt gtgctcagcc
1381 caggtaacac gttttgttgt gtcctcagtg cctggcactt agatgctcag tttgttaaat
1441 ggatagtggg agacacagga gtgtcaacta tccacacatt tgattggtga gccctactag
1501 ccctgggtca acgtgccctg taagagcatg atcaaaagga agtccagctt tcctgcctct
1561 ccacttgcac cccttagcat taaatttgct tccctgtgct atgaaatctg agaatcctgc
1621 ctatgctgtt cacaggccca gagccatggc tatctcctct tcctcctgcg aactgcccct
1681 ggtggctgtg tgccaggtaa catcgacgcc agacaagcaa cagaacttta aaacatgtgc
1741 tgagctggtt cgagaggctg ccagactggg tgcctgcctg gctttcctgc ctgaggcatt
1801 tgacttcatt gcacgggacc ctgcagagac gctacacctg tctgaaccac tgggtgggaa
1861 acttttggaa gaatacaccc agcttgccag gtatcaggga aatagcgagg gagaggtaga
1921 atctttgttg gacagtgtcc ctgggttgcc agatatgagg gtagagcctt gagaagtcag
1981 tgaagagttg tcagtgtccc ttccccccag ggaatgtgga ctctggctgt ccttgggtgg
2041 tttccatgag cgtggccaag actgggagca gactcagaaa atctacaatt gtcacgtgct
2101 gctgaacagc aaaggtgaga ctttataacc ctttagcctg cctcttccca tgctcttcta
2161 cctagattct ccagaattgt ttctcaactc ttatttcctt gacccaagga tttaggggtg
2221 gtcctacttc agttcctagc ctataaacta tctcctcctt gggaggagta agcaaggctt
2281 ctagaacacc agcactgata ttccttcttt cttactgtag gggcagtagt ggccacttac
2341 aggaagacac atctgtgtga cgtagagatt ccagggcagg ggcctatgtg tgaaagcaac
2401 tctaccatgc ctgggcccag tcttgagtca cctgtcagca caccagcagg caaggtagga
2461 gttgtgaaag gatgagggag gggaacagga atactttgaa ctggcagtag aggatagaaa
2521 gccctaagag agggggtaat ggaaatatga ctagatgctg tgacaaacag agcaggaaga
2581 ctactaagta ggctgttttt cattccagat tggtctagct gtctgctatg acatgcggtt
2641 ccctgaactc tctctggcat tggctcaagc tggagcagag atacttacct atccttcagc
2701 ttttggatcc attacaggcc cagcccactg ggaggtaaga tgatgccttt ttaaaacata
2761 agggcctttt cttaacctca tcttcccccc ttggccctac cagttaaatt ccttcccctt
2821 tccacctaat gggaaaactc attccccaga tatttctctc atgaatagtt aaaatagtaa
2881 atcattccta ggcaattacc aaaatagtca caatgggtag attggtctgt aatgtccctc
2941 acctgtcact tccccactat ttgctacatg tacttaagtg aacacacatc tcatgcccag
3001 gtgttgctgc gggcccgtgc tatcgaaacc cagtgctatg tagtggcagc agcacagtgt
3061 ggacgccacc atgagaagag agcaagttat ggccacagca tggtggtaga cccctgggga
3121 acagtggtgg cccgctgctc tgaggggcca ggcctctgcc ttgcccgaat agacctcaac
3181 tatctgcgac agttgcgccg acacctgcct gtgttccagc accgcaggcc tgacctctat
3241 ggcaatctgg gtcacccact gtcttaagac ttgacttctg tgagtttaga cctgcccctc
3301 ccacccccac cctgccacta tgagctagtg ctcatgtgac ttggaggcag gatccaggca
3361 cagctcccct cacttggaga accttgactc tcttgatgga acacagatgg gctgcttggg
3421 aaagaaactt tcacctgagc ttcacctgag gtcagactgc agtttcagaa aggtggaatt
3481 ttatatagtc attgtttatt tcatggaaac tgaagttctg ctgagggctg agcagcactg
3541 gcattgaaaa atataataat cataaagtct gtgtctggac atcgcctttg ggaactagaa
3601 ggggagttgg tattgtacca gctggactaa gctccagttc tagacctcct ggctcattca
3661 acatgcctcc ctacctaaat aaaagtgcaa cactcagtgc atgtcccagc cccattctcc
3721 caagcatggg agtgggcgta ggagtggagg agggggaagg aaaaaggaat tacttcactt
3781 acacctatga tgccctttgc ccaagccaga agaaagcaaa ggggaaaagg gctgcagggt
3841 acattattta ttttcacttg aacatggaaa gaaagtgtca cactccccct tcccctttat
3901 agggggagtg tattttaatc agcaacctct tctccatcca ccctgtgtat gtgtgtacac
3961 atataccacc acagttggga ggcatgacta ggctgaccca gtcttatctg ktcctycttt
4021 gaagagggtt tgacaaatgg gaaaaaggaa ggagccacat caggcagagg tttcaagcc
//