LOCUS AF069510 4220 bp mRNA linear HUM 31-JAN-2000
DEFINITION Homo sapiens sodium bicarbonate cotransporter (NBC) mRNA, complete
cds.
ACCESSION AF069510
VERSION AF069510.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4220)
AUTHORS Choi,I., Romero,M.F., Khandoudi,N., Bril,A. and Boron,W.F.
TITLE Cloning and characterization of a human electrogenic Na+-HCO-3
cotransporter isoform (hhNBC)
JOURNAL Am. J. Physiol. 276 (3 Pt 1), C576-C584 (1999)
PUBMED 10069984
REFERENCE 2 (bases 1 to 4220)
AUTHORS Choi,I. and Boron,W.F.
TITLE Direct Submission
JOURNAL Submitted (01-JUN-1998) Cellular and Molecular Physiology, Yale
University, 333 Cedar Street, New Haven, CT 06510, USA
FEATURES Location/Qualifiers
source 1..4220
/db_xref="H-InvDB:HIT000065656_03"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="heart"
gene 1..4220
/gene="NBC"
CDS 45..3284
/gene="NBC"
/note="NBC isoform; electrogenic"
/codon_start=1
/product="sodium bicarbonate cotransporter"
/protein_id="AAD42020.1"
/translation="MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRR
HKRKTGHKEKKEKERISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEEDDS
PAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFE
LRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK
SNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSFSLNDISDKPEKDQLKNKFMK
KLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKA
KSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIE
PPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDI
KRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGT
AVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCL
ILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTL
FSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLV
GNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC
VIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMD
QQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLK
METETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGV
ASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVA
AIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSD
NDDSDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERSPTFLERHTSC"
BASE COUNT 1145 a 921 c 920 g 1234 t
ORIGIN
1 aggagaagtc tgagcattct ttttttcttt tttattacta taggatggag gatgaagctg
61 tcctggacag aggggcttcc ttcctcaagc atgtgtgtga tgaagaagaa gtagaaggcc
121 accataccat ttacatcgga gtccatgtgc cgaagagtta caggagaagg agacgtcaca
181 agagaaagac agggcacaaa gaaaagaagg aaaaggagag aatctctgag aactactctg
241 acaaatcaga tattgaaaat gctgatgaat ccagcagcag catcctaaaa cctctcatct
301 ctcctgctgc agaacgcatc cgattcatct tgggagagga ggatgacagc ccagctcccc
361 ctcagctctt cacggaactg gatgagctgc tggccgtgga tgggcaggag atggagtgga
421 aggaaacagc caggtggatc aagtttgaag aaaaagtgga acagggtggg gaaagatgga
481 gcaagcccca tgtggccaca ttgtcccttc atagtttatt tgagctgagg acatgtatgg
541 agaaaggatc catcatgctt gatcgggagg cttcttctct cccacagttg gtggagatga
601 ttgttgacca tcagattgag acaggcctat tgaaacctga acttaaggat aaggtgacct
661 atactttgct ccggaagcac cggcatcaaa ccaagaaatc caaccttcgg tccctggctg
721 acattgggaa gacagtctcc agtgcaagta ggatgtttac caaccctgat aatggtagcc
781 cagccatgac ccataggaat ctgacttcct tcagtctgaa tgacatttct gataaaccgg
841 agaaggacca gctgaagaat aagttcatga aaaaattgcc acgtgatgca gaagcttcca
901 acgtgcttgt tggggaggtt gactttttgg atactccttt cattgccttt gttaggctac
961 agcaggctgt catgctgggt gccctgactg aagttcctgt gcccacaagg ttcttgttca
1021 ttctcttagg tcctaagggg aaagccaagt cctaccacga gattggcaga gccattgcca
1081 ccctgatgtc tgatgaggtg ttccatgaca ttgcttataa agcaaaagac aggcacgacc
1141 tgattgctgg tattgatgag ttcctagatg aagtcatcgt ccttccacct ggggaatggg
1201 atccagcaat taggatagag cctcctaaga gtcttccatc ctctgacaaa agaaagaata
1261 tgtactcagg tggagagaat gttcagatga atggggatac gccccatgat ggaggtcacg
1321 gaggaggagg acatggggat tgtgaagaat tgcagcgaac tggacggttc tgtggtggac
1381 taattaaaga cataaagagg aaagcgccat tttttgccag tgatttttat gatgctttaa
1441 atattcaagc tctttcggca attctcttca tttatctggc aactgtaact aatgctatca
1501 cttttggagg actgcttggg gatgccactg acaacatgca gggcgtgttg gagagtttcc
1561 tgggcactgc tgtctctgga gccatctttt gcctttttgc tggtcaacca ctcactattc
1621 tgagcagcac cggacctgtc ctagtttttg agaggcttct atttaatttc agcaaggaca
1681 ataattttga ctatttggaa tttcgccttt ggattggcct gtggtccgcc ttcctatgtc
1741 tcattttggt agccactgat gccagcttct tggttcaata cttcacacgt ttcacggagg
1801 agggcttttc ctctctgatt agcttcatct ttatctatga tgctttcaag aagatgatca
1861 agcttgcaga ttactacccc atcaactcca acttcaaagt gggctacaac actctctttt
1921 cctgtacctg tgtgccacct gacccagcta atatctcaat atctaatgac accacactgg
1981 ccccagagta tttgccaact atgtcttcta ctgacatgta ccataatact acctttgact
2041 gggcattttt gtcgaagaag gagtgttcaa aatacggagg aaacctcgtc gggaacaact
2101 gtaattttgt tcctgatatc acactcatgt cttttatcct cttcttggga acctacacct
2161 cttccatggc tctgaaaaaa ttcaaaacta gtccttattt tccaaccaca gcaagaaaac
2221 tgatcagtga ttttgccatt atcttgtcca ttctcatctt ttgtgtaata gatgccctag
2281 taggcgtgga caccccaaaa ctaattgtgc caagtgagtt caagccaaca agtccaaacc
2341 gaggttggtt cgttccaccg tttggagaaa acccctggtg ggtgtgcctt gctgctgcta
2401 tcccggcttt gttggtcact atactgattt tcatggacca acaaattaca gctgtgattg
2461 taaacaggaa agaacataaa ctcaagaaag gagcagggta tcacttggat ctcttttggg
2521 tggccatcct catggttata tgctccctca tggctcttcc gtggtatgta gctgctacgg
2581 tcatctccat tgctcacatc gacagtttga agatggagac agagacttct gcacctggag
2641 aacaaccaaa gtttctagga gtgagggaac aaagagtcac tggaaccctt gtgtttattc
2701 tgactggtct gtcagtcttt atggctccca tcttgaagtt tatacccatg cctgtactct
2761 atggtgtgtt cctgtatatg ggagtagcat cccttaatgg tgtgcagttc atggatcgtc
2821 tgaagctgct tctgatgcct ctgaagcatc agcctgactt catctacctg cgtcatgttc
2881 ctctgcgcag agtccacctg ttcactttcc tgcaggtgtt gtgtctggcc ctgctttgga
2941 tcctcaagtc aacggtggct gctatcattt ttccagtaat gatcttggca cttgtagctg
3001 tcagaaaagg catggactac ctcttctccc agcatgacct cagcttcctg gatgatgtca
3061 ttccagaaaa ggacaagaaa aagaaggagg atgagaagaa aaagaaaaag aagaagggaa
3121 gtctggacag tgacaatgat gattctgact gcccatactc agaaaaagtt ccaagtatta
3181 aaattccaat ggacatcatg gaacagcaac ctttcctaag cgatagcaaa ccttctgaca
3241 gagaaagatc accaacattc cttgaacgcc acacatcatg ctgaaattcc tttccttcag
3301 tcactcggta tgccaagtcc tcctagaact ccagtaaaag ttgtgcctca aattagaata
3361 gaacttgaac ctgaagacaa tgattatttc tggaggagca agggaacaga aactacattg
3421 taacctgttt gtctttctta aaactgacat ttgttgttaa tgtcatttgt ttttgtttgg
3481 ctgtttgttt attttttaac ttttatttcg tctcagtttt tggtcacagg ccaaataata
3541 cagcgctctc tctgcttctc tcttgcatag atacaatcaa gacaatagtg caccgttcct
3601 taaaaacagc atctgaggaa tccccctttt gttcttaaac tttcagatgt gtcctttgat
3661 aaccaaattc tgtcactcaa gacacagaca cccacagacc ctgtcctttg cctctattaa
3721 gcagaggatg gaagtattaa ggattttgta acacctttta tgaaaatgtt gaaggaactt
3781 aaaactttag ctttggagct gtgcttactg gcttgtcttt gtctggtaga acaaaccttg
3841 acctccagac agagtccctt ctcacttata gagctctcca ggactggaaa aagtgctgct
3901 attttaactt gctcttgctt gtaaatccta atcttagagt tatcaaaaga agaaaaaact
3961 gaaggtactt tactccctat agagaaacca ttgccatcat tgtagcaagt gctggaatgt
4021 cccttttttc ctatgcaact ttttttaacc ctttaatgaa cttatctgtt gagtacattg
4081 aagaatattt ttcttcctag attttgttgt ttaaattatg gggcctaacc tgccacttat
4141 tttttgtcaa tttttaaaac ttttttttaa ttactgtaaa gaaaatgaat tttttcctgc
4201 agcaggaaac ataattttga
//