LOCUS AF068892 1569 bp mRNA linear HUM 07-JUL-1998
DEFINITION Homo sapiens Duke's type B colon adenocarcinoma truncated
suppressin mRNA, complete cds.
ACCESSION AF068892
VERSION AF068892.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1569)
AUTHORS Manne,U., Grizzle,W.E., Oelschlager,D.K., Gary,B.D., Frost,A.R.,
Weiss,H.L. and LeBoeuf,R.D.
TITLE Altered subcellular localization of suppressin, a novel inhibitor
of cell-cycle entry, is an independent prognostic factor in
colorectal adenocarcinoma
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1569)
AUTHORS LeBoeuf,R.D. and Gary,B.D.
TITLE Direct Submission
JOURNAL Submitted (29-MAY-1998) Physiology, University of Alabama at
Birmingham, 1918 University Blvd, MCLM 850, Birmingham, AL 35209,
USA
FEATURES Location/Qualifiers
source 1..1569
/db_xref="H-InvDB:HIT000065628"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="female"
/cell_line="LS180"
/tissue_type="Duke's type B colon adenocarcinoma"
/dev_stage="58 year old adult"
CDS 25..909
/function="cell cycle inhibitor"
/note="includes premature stop codon that results in a
truncated protein"
/codon_start=1
/product="truncated suppressin"
/protein_id="AAC25714.1"
/translation="MAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGAAADN
VFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPL
TPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSDLPVRCRNISGTLYKNRLGSGGRGRCI
KQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCD
DMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTS
GALTFDRASTVEATAVIS"
BASE COUNT 354 a 507 c 457 g 251 t
ORIGIN
1 ccgcgggtca cggcagtggc ggtgatggcg gcggagcccg ggcacatgga catgggcgcc
61 gaggccctgc ccggccccga cgaggccgcc gctgccgcag ccttcgcaga ggtgaccaca
121 gtgacagtgg ccaacgtggg ggctgctgca gacaatgtct tcaccacgtc tgtggcgaac
181 gcggcatcca tctcaggaca tgttctgtct ggtaggacgg cccttcagat cggggacagc
241 ctgaacaccg aaaaagcgac actgattgtc gtccacacag atgggagcat cgtggagacc
301 accgggctga aaggcccggc agctcccctc accccaggtc ctcagtctcc tccaacccct
361 ctggctcccg gccaagaaaa aggtggaact aaatacaact gggacccttc tgtgtacgac
421 agtgacctgc ccgtacggtg ccggaacatc agcggcactc tgtacaagaa caggctcggc
481 tcaggcggcc ggggacggtg catcaagcag ggggagaact ggtacagtcc caccgagttt
541 gaggccatgg caggaagagc cagcagtaag gactggaaaa gaagcattcg ctacgcgggc
601 cgacccttgc agtgcctcat ccaggatggg atcttaaacc ctcacgctgc ctcttgcacc
661 tgtgctgcct gctgcgacga catgacctta agtggcccag tcaggctttt tgtgccttac
721 aaaaggcgca agaaggagaa tgaactgccc acaactcccg tgaagaagga ctcccccaag
781 aacatcacat tgcttccagc caccgcggct accaccttca ccgtgacccc ctcgggacag
841 atcacgacct cgggggcact gacctttgac cgagcgtcca cggtagaggc cactgctgtc
901 atatcataga atccggccca gggcgacgtc ttcgcagggg ccacagtcca agaggccagc
961 gtgcagcccc catgcagggc cagccaccct gagcctcact accccggcta tcaggacagc
1021 tgccagatcg caccgtttcc agaagctgcg ttgccaacgt cacatcccaa aatagtgttg
1081 acatccctgc ctgcgctggc ggtcccaccc ccgactccca ccaaagcggc acctcccgcg
1141 taggtcaatg ggctggagct gtcagagccg cggagctggc tgtacctaga agagatggtc
1201 aactccttgc tcaacacagc gcagcagctg aagacgctgt ttgagcaagc caagcatgcc
1261 agcacctacc gagaagctgc cacaaaccag gccaagatcc acgctgacgc agagcggaag
1321 gagcagtcct gcgttaactg cggccgggag gctatgagcg agtgcaccgg ttgccacaag
1381 gtcaactact gctccaactt ctgccaacgc aaggactgga aggatcacca gcacatatgc
1441 ggccagtcag cagctgtcac cgtccaggca gacgaagtcc acgtggctga aagcgtgatg
1501 gagaaggtga ccgtgtgagg ctccatcggc cgccctggga gcttggggcc cctcgcactc
1561 ctgtgaggc
//