LOCUS AF068846 3500 bp mRNA linear HUM 17-FEB-2000
DEFINITION Homo sapiens scaffold attachment factor A (SAF-A) mRNA, complete
cds.
ACCESSION AF068846
VERSION AF068846.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3500)
AUTHORS Kipp,M., Schwab,B.L., Przybylski,M., Nicotera,P. and
Fackelmayer,F.O.
TITLE Apoptotic cleavage of scaffold attachment factor A (SAF-A) by
caspase-3 occurs at a noncanonical cleavage site
JOURNAL J. Biol. Chem. 275 (7), 5031-5036 (2000)
PUBMED 10671544
REFERENCE 2 (bases 1 to 3500)
AUTHORS Fackelmayer,F.O.
TITLE A variant of human Scaffold Attachment Factor A (SAF-A), also known
as Heterogeneous Nuclear Ribonucleoprotein U (hnRNP-U)
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 3500)
AUTHORS Fackelmayer,F.O.
TITLE Direct Submission
JOURNAL Submitted (29-MAY-1998) Department of Biology, University of
Konstanz, Universitaetsstrasse 10, Konstanz D-78434, Germany
FEATURES Location/Qualifiers
source 1..3500
/db_xref="H-InvDB:HIT000065624"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HeLa S3"
gene 1..3500
/gene="SAF-A"
CDS 218..2692
/gene="SAF-A"
/note="SAR-DNA binding protein of the nuclear scaffold;
similar to hnRNP-U encoded by the sequence presented in
GenBank Accession Number X65488"
/codon_start=1
/product="scaffold attachment factor A"
/protein_id="AAC19382.1"
/translation="MSSSPVNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALDD
EEAGGRPAMEPGNGSLDLGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGD
QMELGEENGAAGAADSGPMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGE
QQPQPPATQQQQPQQQRGAAKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEG
GGGGGRPGAPAGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVE
EEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVC
FEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCET
EDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCH
NCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAG
KTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFI
EIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEG
KDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQ
NTGSKKSNKNKSGKNQFNRGGGHRGRGGLNMRGGNFRGGAPGNRGGYNRRGNMPQRGG
GGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQS
QGYNQWQQGQFWGQKPWSQHYHQGYY"
misc_difference 853..906
/gene="SAF-A"
/note="compared to GenBank Accession Number X65488"
/replace=""
misc_feature 854..907
/gene="SAF-A"
/note="encodes glycine-rich region"
regulatory 2700..2705
/regulatory_class="polyA_signal_sequence"
/gene="SAF-A"
regulatory 3463..3468
/regulatory_class="polyA_signal_sequence"
/gene="SAF-A"
BASE COUNT 1050 a 693 c 975 g 782 t
ORIGIN
1 ctcgcgccag gcgagtctcc gcgtctccct cgcgaactcg gtgaaaggaa ttggcgccgt
61 tcgacaccag gcggatccgc tctgcagcac gaacccatct ccagccgcag ccgcagccgc
121 cgcccgggcc gaggagcagc cgcagcagcc gccaccagtg gccgagtgag cggagccgag
181 tttgaggcag cgctagcggt gaatcggggc cctcaccatg agttcctcgc ctgttaatgt
241 aaaaaagctg aaggtgtcgg agctgaaaga ggagctcaag aagcgacgcc tttctgacaa
301 gggtctcaag gccgagctca tggagcgact ccaggctgcg ctggacgacg aggaggccgg
361 gggccgcccc gccatggagc ccgggaacgg cagcctagac ctgggcgggg attccgctgg
421 gcgctcggga gcaggcctcg agcaggaggc cgcggccggc ggcgatgaag aggaggaaga
481 agaggaagag gaggaggaag gaatctccgc tctggacggc gaccagatgg agctaggaga
541 ggagaacggg gccgcggggg cggccgactc gggcccgatg gaggaggagg aggccgcctc
601 ggaagacgag aacggcgacg atcagggttt ccaggaaggg gaagatgagc tcggggacga
661 agaggaaggc gcgggcgacg agaacgggca cggggagcag cagcctcaac cgccggcgac
721 gcagcagcaa cagccccaac agcagcgcgg ggccgccaag gaggccgcgg ggaagagcag
781 cggccccacc tcgctgttcg cggtgacggt ggcgccgccc ggggcgaggc agggccagca
841 gcaggcggga ggtaagaaga aggcggaagg cggcggaggc ggcggtcgcc ccggggctcc
901 ggcgggggac ggcaaaacag aacagaaagg cggagataaa aagaggggtg ttaaaagacc
961 acgagaagat catggccgtg gatattttga gtacattgaa gagaacaagt atagcagagc
1021 caaatctcct cagccacctg ttgaagaaga agatgaacac ttcgatgaca cagtggtttg
1081 tcttgatact tataattgtg atctacattt taaaatatca agagatcgtc tcagtgcttc
1141 ttcccttaca atggagagtt ttgcttttct ttgggctgga ggaagagcat cctatggtgt
1201 gtcaaaaggc aaagtgtgtt ttgagatgaa ggttacagag aagatcccag taaggcattt
1261 atatacaaaa gatattgaca tacatgaagt tcgtattggc tggtcactaa ctacaagtgg
1321 aatgttactt ggtgaagaag aattttctta tgggtattct ctaaaaggaa taaaaacatg
1381 caactgtgag actgaagatt atggagaaaa gtttgatgaa aatgatgtga ttacatgttt
1441 tgctaacttt gaaagtgatg aagtagaact ctcgtatgct aagaatggac aagatcttgg
1501 cgttgccttc aaaatcagta aggaagttct tgctggacgg ccactgttcc cgcatgttct
1561 ctgccacaac tgtgcagttg aatttaattt tggtcagaag gaaaagccat attttccaat
1621 acctgaagag tatactttca tccagaacgt ccccttagag gatcgagtta gaggaccaaa
1681 ggggcctgaa gagaagaaag attgtgaagt tgtgatgatg attggcttgc caggagctgg
1741 aaaaactacc tgggttacta aacatgcagc agaaaatcca gggaaatata acattcttgg
1801 cacaaatact attatggata agatgatggt ggcaggtttt aagaagcaaa tggcagatac
1861 tggaaaactg aacacactgt tgcagagagc cccccagtgt cttgggaaat ttattgagat
1921 tgctgcccga aagaagcgaa attttattct ggatcagaca aatgtgtctg ctgctgccca
1981 gaggagaaaa atgtgcctgt ttgcaggctt ccagcgaaaa gctgttgtag tttgcccaaa
2041 agatgaagac tataagcaaa gaacacagaa gaaagcagaa gtagagggga aagacctacc
2101 agaacatgcg gtcctcaaaa tgaaaggaaa ctttaccctc ccagaggtag ctgagtgctt
2161 tgatgaaata acctatgttg aacttcagaa ggaagaagcc caaaaactct tggagcaata
2221 taaggaagaa agcaaaaagg ctcttccacc agaaaagaaa cagaacactg gctcaaagaa
2281 aagcaataaa aataagagtg gcaagaacca gtttaacaga ggtggtggcc atagaggacg
2341 tggaggactc aatatgcgtg gtggaaattt cagaggagga gcccctggga atcgtggcgg
2401 atataatagg aggggcaaca tgccacagag aggtggtggc ggtggaggaa gtggtggaat
2461 cggctatcca taccctcgtg cccctgtttt tcctggccgt ggtagttact caaacagagg
2521 gaactacaac agaggtggaa tgcccaacag agggaactac aaccagaact tcagaggacg
2581 aggaaacaat cgtggctaca aaaatcaatc tcagggctac aaccagtggc agcagggtca
2641 attctggggt cagaagccat ggagtcagca ttatcaccaa ggatattatt gaatacccaa
2701 ataaaacgaa ctgatacata tttctccaaa accttcacaa gaagtcgact gttttcttta
2761 gtaggctaac tttttaaaca ttccacaaga ggaagtgcct gcgggttcct tttttagaag
2821 ctttgtgggt tgattttttt tcttttcttt tttgtacatt tttaattgca gtttaaaagt
2881 gaatcgtaag agaacctcag cattgtgcac gataagagaa tgtgtcagta tttcagggtt
2941 ctacatttat ctgtaaaatg tgactttttt ttttttttat cacaacagaa gtaaaatgtt
3001 gctttgtacc tggtgtcttt tattaagaat ttactccccc catttctcac agagaataac
3061 agtcgggagt cattgtcaca atataataga aatgttagca accagattca tgtaaggact
3121 aagtggtcct catgaattgc attaagactc tgtactgctc atattacact ccatcctctc
3181 tgtagtttgc tgggtagtgg agggggtaag ctaaatcata gtttctgaca ataactggga
3241 aggttttttc ttaaaataac aatggaattg gtataattgg gattgaaaac taaaacttgg
3301 aactaagata gagaagatgg agtgtatgta gaagggctgt taaaaatgta aaacttggtt
3361 gcattatttg tggaggctca aacttgtgaa ggttaatacc ataatttttc catttgttct
3421 gcattttgat tctgaaaaga aagctggctt tgcccatttc ttattaaaaa aacttgttgt
3481 aaaaaaaaaa aaaaaaaaaa
//