LOCUS AF068180 1806 bp mRNA linear HUM 09-AUG-1998
DEFINITION Homo sapiens B cell linker protein BLNK mRNA, alternatively
spliced, complete cds.
ACCESSION AF068180
VERSION AF068180.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1806)
AUTHORS Fu,C. and Chan,A.C.
TITLE Identification of two tyrosine phosphoproteins, pp70 and pp68,
which interact with phospholipase Cgamma, Grb2, and Vav after B
cell antigen receptor activation
JOURNAL J. Biol. Chem. 272 (43), 27362-27368 (1997)
PUBMED 9341187
REFERENCE 2 (bases 1 to 1806)
AUTHORS Fu,C., Turck,C.W., Kurosaki,T. and Chan,A.C.
TITLE BLNK: a central linker protein in B cell activation
JOURNAL Immunity 9 (1), 93-103 (1998)
PUBMED 9697839
REFERENCE 3 (bases 1 to 1806)
AUTHORS Fu,C., Turck,C.W., Kurosaki,T. and Chan,A.C.
TITLE Direct Submission
JOURNAL Submitted (27-MAY-1998) Internal Medicine, Washington University
School of Medicine, Box 8022, 660 South Euclid Ave., St. Louis, MO
63110, USA
FEATURES Location/Qualifiers
source 1..1806
/db_xref="H-InvDB:HIT000065590"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q23.33"
CDS 154..1524
/function="interacts with PLC, Vav, Grb2, and nck
following B cell receptor activation"
/note="alternatively spliced"
/codon_start=1
/product="B cell linker protein BLNK"
/protein_id="AAC39936.1"
/translation="MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAP
PSVPRRDYASESPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEENADDSYEPPPVE
QETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQ
KPQVPPKPKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKAPMVNRSTKPNSSTPA
SPPGTASGRNSGAWETKSPPPAAPSPLPRAGKKPTTPLKTTPVASQQNASSVCEEKPI
PAERHRGSSHRQEAVQSPVFPPAQKQIHQKPIPLPRFTEGGNPTVDGPLPSFSSNSTI
SEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVVFFNKR
VYNIPVRFIEATKQYALGRKKNGEEYFGSVAEIIRNHQHSPLVLIDSQNNTKDSTRLK
YAVKVS"
BASE COUNT 571 a 448 c 379 g 408 t
ORIGIN
1 ccttcgtggc cgcagcctgc actctcagaa atcagacttg agtggccgga acccttgaga
61 ccagaggctt accatgctgc tccctaggag ggccaggaac tgctgacgtg accactggac
121 agttattcgt gtctcttaca attaccaaac agaatggaca agcttaataa aataaccgtc
181 cccgccagtc agaagttgag gcagcttcaa aagatggtcc atgatattaa aaacaatgaa
241 ggtggaataa tgaataaaat caaaaagcta aaagtcaaag cacctccaag tgttcctcga
301 agggactacg cttcagagag ccccgctgac gaagaggagc agtggtccga tgactttgac
361 agcgactatg aaaatccaga tgagcactcg gactcagaga tgtacgtgat gcccgccgag
421 gagaacgctg atgacagcta cgagccgcct ccagtagagc aggaaaccag gccggttcac
481 ccagccctgc ccttcgccag aggcgagtat atagacaatc gatcaagcca gaggcattcc
541 ccacccttca gcaagacact tcccagtaag cccagctggc cttcagagaa agcaaggctc
601 acctccaccc tgccggccct gactgctttg cagaaacctc aagtcccacc caaacccaaa
661 ggcctccttg aggatgaggc tgattatgtg gtccccgtgg aagataatga tgaaaactat
721 attcatccca cagaaagcag ttcacctcca cctgaaaaag ctcccatggt gaatagatca
781 accaagccaa attcctcaac gcccgcctct cctccaggaa cagcttcagg tcgaaacagt
841 ggggcctggg aaaccaagtc acctccacca gctgcaccat ccccgttgcc acgggccggg
901 aaaaaaccaa cgacaccact gaagacaact ccagttgcct ctcaacagaa tgcttcaagt
961 gtttgtgaag aaaaacctat acctgctgaa cgccaccgag ggtcaagtca cagacaagaa
1021 gctgtgcagt caccagtgtt tcctcctgcc cagaaacaaa tccaccaaaa acccatacct
1081 ctgccaagat ttacagaagg gggaaaccca actgtggatg ggcccctacc cagcttttca
1141 tctaattcca ctatttcaga acaggaagct ggcgttctct gcaagccatg gtatgctgga
1201 gcctgtgatc gaaagtctgc tgaagaggca ttgcacagat caaacaagga tggatcattt
1261 cttattcgga aaagctctgg ccatgattcc aaacaaccat atacactagt tgtattcttt
1321 aataagcgag tatataatat tcctgtgcga tttattgaag caacaaaaca atatgccttg
1381 ggcagaaaga aaaatggtga agagtacttt ggaagtgttg ctgaaatcat caggaatcat
1441 caacatagtc ctttggttct tattgacagt cagaataaca caaaagattc caccagactg
1501 aagtatgcag ttaaagtttc ataaaggggg aaaaaaaaga tcaataccat tgcttcagac
1561 actttcccaa agtttctcct tttgagaaaa agtcccaaaa cttcatattt tggattatga
1621 atcatccagt aataaaatgg aagatggagt cagctattga agtggtcatc catttctttt
1681 taagaagctc atgtggactt gttctattgc ctgacctgat gaactgttaa tatctggtga
1741 ggttgagtta tcatgctact aatattttcc aaataaatat ttttattttt aaaaaaaaaa
1801 aaaaaa
//