LOCUS AF064589 6471 bp DNA linear HUM 03-JUN-1998
DEFINITION Homo sapiens melanoma-associated antigen (MAGE-C1) gene, complete
cds.
ACCESSION AF064589
VERSION AF064589.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6471)
AUTHORS Lucas,S., De Smet,C., Arden,K.C., Viars,C.S., Lethe,B., Lurquin,C.
and Boon,T.
TITLE Identification of a new MAGE gene with tumor-specific expression by
representational difference analysis
JOURNAL Cancer Res. 58 (4), 743-752 (1998)
PUBMED 9485030
REFERENCE 2 (bases 1 to 6471)
AUTHORS Lucas,S., De Smet,C., Arden,K.C., Lethe,B., Lurquin,C. and Boon,T.
TITLE Direct Submission
JOURNAL Submitted (11-MAY-1998) Ludwig Institute for Cancer Research, av
Hippocrate, 74, UCL 7459, Brussels 1200, Belgium
FEATURES Location/Qualifiers
source 1..6471
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq26-q27; between DXS1227 and WI-3482"
/cell_line="LB33-MEL.A-1"
/tissue_type="melanoma"
gene 972..6422
/gene="MAGE-C1"
/allele="A"
mRNA join(972..1025,1764..1861,2019..2125,2458..6422)
/gene="MAGE-C1"
/allele="A"
/product="melanoma-associated antigen"
exon 972..1025
/gene="MAGE-C1"
/allele="A"
/number=1
intron 1026..1763
/gene="MAGE-C1"
/allele="A"
/number=1
exon 1764..1861
/gene="MAGE-C1"
/allele="A"
/number=2
intron 1862..2018
/gene="MAGE-C1"
/allele="A"
/number=2
exon 2019..2125
/gene="MAGE-C1"
/allele="A"
/number=3
CDS join(2122..2125,2458..5882)
/gene="MAGE-C1"
/allele="A"
/note="MAGE melanoma-associated antigens family member"
/codon_start=1
/product="melanoma-associated antigen"
/protein_id="AAC18837.1"
/translation="MGDKDMPTAGMPSLLQSSSESPQSYPEGEDSQSPLQIPQSSPES
DDTLYPLQSPQSRSEGEDSSDPLQRPPEGKDSQSPLQIPQSSPEGDDTQSPLQNSQSS
PEGKDSLSPLEISQSPPEGEDVQSPLQNPASSFFSSALLSIFQSSPESIQSPFEGFPQ
SVLQIPVSAASSSTLVSIFQSSPESTQSPFEGFPQSPLQIPVSRSFSSTLLSIFQSSP
ERSQRTSEGFAQSPLQIPVSSSSSSTLLSLFQSSPERTQSTFEGFPQSPLQIPVSRSF
SSTLLSIFQSSPERTQSTFEGFAQSPLQIPVSSSSSSTLLSLFQSSPERTQSTFEGFP
QSLLQIPMTSSFSSTLLSIFQSSPESAQSTFEGFPQSPLQIPGSPSFSSTLLSLFQSS
PERTHSTFEGFPQSPLQIPMTSSFSSTLLSILQSSPESAQSAFEGFPQSPLQIPVSSS
FSYTLLSLFQSSPERTQSTFEGFPQSPLQIPVSSSSSSSTLLSLFQSSPECTQSTFEG
FPQSPLQIPQSPPEGENTHSPLQIVPSLPEWEDSLSPHYFPQSPPQGEDSLSPHYFPQ
SPPQGEDSLSPHYFPQSPQGEDSLSPHYFPQSPPQGEDSMSPLYFPQSPLQGEEFQSS
LQSPVSICSSSTPSSLPQSFPESSQSPPEGPVQSPLHSPQSPPEGMHSQSPLQSPESA
PEGEDSLSPLQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSL
QSPVSICSSSTSLSLPQSFPESPQSPPEGPAQSPLQRPVSSFFSYTLASLLQSSHESP
QSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQSPVI
SFSSSTSLSPFSEESSSPVDEYTSSSDTLLESDSLTDSESLIESEPLFTYTLDEKVDE
LARFLLLKYQVKQPITKAEMLTNVISRYTGYFPVIFRKAREFIEILFGISLREVDPDD
SYVFVNTLDLTSEGCLSDEQGMSQNRLLILILSIIFIKGTYASEEVIWDVLSGIGVRA
GREHFAFGEPRELLTKVWVQEHYLEYREVPNSSPPRYEFLWGPRAHSEVIKRKVVEFL
AMLKNTVPITFPSSYKDALKDVEERAQAIIDTTDDSTATESASSSVMSPSFSSE"
intron 2126..2457
/gene="MAGE-C1"
/allele="A"
/number=3
exon 2458..6422
/gene="MAGE-C1"
/allele="A"
/number=4
repeat_region 2526..5053
/gene="MAGE-C1"
/allele="A"
/note="imperfect"
/rpt_type=tandem
BASE COUNT 1346 a 1790 c 1619 g 1716 t
ORIGIN
1 ccaaaaacct gcccgttttc actgctagga ggccttggga gggcattagg gagagacgct
61 agcgtgctcc agtcctcttg ggggttcatg gaatgggaac ttgatctgaa aaacagtcct
121 ggagagaaga gggagggagt ggaggccgta tcaggaataa taggttgagg aagactgagg
181 gtcctccatg ccatttcaga cggagggcag tggagcccta cctggagtct gggaggccat
241 accccactgt ggatggatgt gattctacct ctcttgcacc ttgcaggtct caaggatggg
301 aggggcttat tcggaggtga aagactcaga tgcatagagg cagggagcca gacaatgtca
361 ggagtccagg aacagcctct caggaaggca ggaagggaac accatgactg gtagtgctgc
421 ctgtcctgtc cctgtgcctg ctgccagcca tggaggagcc catcaggtcc ccagatttac
481 aaatttctga cttccatttt gggagtcagc cagagggaga tttctctgag gagggcagct
541 tcagttaaac agagggagta gcccagggct gggcactcaa caagaagaga actctgtcga
601 aggacagtga cctccgaaca cggggggagg gcacaggctg caccctgcca ctccctgctg
661 tcagccctgg aaaaggtggg tgtgagtgtc aagactgggg aggtgggagg gaagaggtca
721 gcagggctta gggagtgagc agaaaggttt ggagcacatc ctggaggtgg gaaggaaggg
781 atggaaagga ggctgacaag cgggcggcgg gcggggggcc gccttcctcc tctgagagga
841 ggccccgccc cacgctatcc gggctgtcag ccctgatcaa ccctgacaga gttcccggat
901 gtgctttgcc ggatgtgctt tcccggcggc catcttggga gtctgaagga cctgaggcat
961 tttgtgacga ggatcgtctc aggtcagcgg agggaggaga cttatagacc tatccagtct
1021 tcaaggtgag ggccccgagg gagaagttga gggacaaccc caccacagag agaagcagcc
1081 ctggcctgcc ctatccctgc ggtggcactt gtaggtggcg gaaacgaaga tggtagccga
1141 gggctgaggg acgtgtcctc acggcagaag aagggaggaa atgccggccc tctagagaat
1201 aaataggaag gcattgagga ggaccggggg aacccccacc tcagaggaca gattcccaga
1261 gattcccacc tgctcctcaa atcagccccc atagagctct ccaggtggct gaggctgagc
1321 ggccaccctc tcactgctgg gtgagggggt gtgggggagg gggaggagga ggccttgttc
1381 tgggggtccc atggcaagtc agcatgggga gctgcctcca gttggcagag ggaagattcc
1441 caggccctgc tgggaacaag agtgaggact gaggggtcac atgtgcgtca gaacagacgt
1501 gaggccacag ggaccgcgtc ccgtggtaga gtgctgggag gtgctgccac ctcactacct
1561 cccactgctc tcagtgatgt ggagttttcc tgaggttttt cctcaggcca gcagagtggt
1621 ggggcctggc cctgtctgag aaaatgtgac aatgctaatt gaattctgag ggggtcacga
1681 acctcagaat tgtgggactc tgggagtctg gccagcccca gctgccgtct tagctggagg
1741 ggctccctcc cttcctcttg caggtgctcc agaaagcagg agttgaagac ctgggtgtga
1801 gggacacata catcctaaaa gcaccacagc agaggaggcc caggcagtgc caggagtcaa
1861 ggtgagtgca cgacctgact gtgtaccaag ggccgtaccc ccagaaacag tgtcagacct
1921 ggcagcaccg gccctgtagc cacccactgt cattcctggt gcctcatggc tctgcctgcc
1981 agctgtgccc cgaggtgctt tctcgcgtcc ttctacaggt tcccagaaga caaaccccct
2041 aggaagacag gcgacctgtg aggccctaga gcaccacctt aagagaagaa gagctgtaag
2101 ccggcctttg tcagagccat catgggtgag tttctcagct gaggccactg gcactgtccc
2161 tctctccctc agtcctgtgg gatcccatca tacctattcg tgttcacacg tttacctgct
2221 gctcctgaac aatattcatc atgcctctct ttctaaacct tccacgcccc agctttgagc
2281 aaggcttcca gaaggcaatt ttcatactgg agttggtaga tgcagaggat cccccagatg
2341 aggaagagga ggaagcttcc tccattttct cttcctcttt ccacttttta ttcccctcgt
2401 cctcctcctg tttttctttc tcatcctcat cctcctctct gcttctgcgt tctccagggg
2461 acaaggatat gcctactgct gggatgccga gtcttctcca gagttcctct gagagtcctc
2521 agagttatcc tgagggggag gactcccagt ctcctctcca gattccccag agttctcctg
2581 agagcgacga caccctgtat cctctccaga gtcctcagag tcgttctgag ggggaggact
2641 cctcggatcc tctccagaga cctcctgagg ggaaggactc ccagtctcct ctccagattc
2701 cccagagttc tcctgagggc gacgacaccc agtctcctct ccagaattct cagagttctc
2761 ctgaggggaa ggactccctg tctcctctag agatttctca gagccctcct gagggtgagg
2821 atgtccagtc tcctctgcag aatcctgcga gttccttctt ctcctctgct ttattgagta
2881 ttttccagag ttcccctgag agtattcaaa gtccttttga gggttttccc cagtctgttc
2941 tccagattcc tgtgagcgcc gcctcctcct ccactttagt gagtattttc cagagttccc
3001 ctgagagtac tcaaagtcct tttgagggtt ttccccagtc tccactccag attcctgtga
3061 gccgctcctt ctcctccact ttattgagta ttttccagag ttcccctgag agaagtcaga
3121 gaacttctga gggttttgca cagtctcctc tccagattcc tgtgagctcc tcctcgtcct
3181 ccactttact gagtcttttc cagagttccc ctgagagaac tcagagtact tttgagggtt
3241 ttccccagtc tccactccag attcctgtga gccgctcctt ctcctccact ttattgagta
3301 ttttccagag ttcccctgag agaactcaga gtacttttga gggttttgcc cagtctcctc
3361 tccagattcc tgtgagctcc tcctcctcct ccactttatt gagtcttttc cagagttccc
3421 ctgagagaac tcagagtact tttgagggtt ttccccagtc tcttctccag attcctatga
3481 cctcctcctt ctcctctact ttattgagta ttttccagag ttctcctgag agtgctcaaa
3541 gtacttttga gggttttccc cagtctcctc tccagattcc tgggagcccc tccttctcct
3601 ccactttact gagtcttttc cagagttccc ctgagagaac tcacagtact tttgagggtt
3661 ttccccagtc tcctctccag attcctatga cctcctcctt ctcctctact ttattgagta
3721 ttttacagag ttctcctgag agtgctcaaa gtgcttttga gggttttccc cagtctcctc
3781 tccagattcc tgtgagctcc tctttctcct acactttatt gagtcttttc cagagttccc
3841 ctgagagaac tcagagtact tttgagggtt ttccccagtc tcctctccag attcctgtga
3901 gctcctcctc ctcctcctcc actttattga gtcttttcca gagttcccct gagtgtactc
3961 aaagtacttt tgagggtttt ccccagtctc ctctccagat tcctcagagt cctcctgaag
4021 gggagaatac ccattctcct ctccagattg ttccaagtct tcctgagtgg gaggactccc
4081 tgtctcctca ctactttcct cagagccctc ctcaggggga ggactcccta tctcctcact
4141 actttcctca gagccctcct cagggggagg actccctgtc tcctcactac tttcctcaga
4201 gccctcaggg ggaggactcc ctgtctcctc actactttcc tcagagccct cctcaggggg
4261 aggactccat gtctcctctc tactttcctc agagtcctct tcagggggag gaattccagt
4321 cttctctcca gagccctgtg agcatctgct cctcctccac tccatccagt cttccccaga
4381 gtttccctga gagttctcag agtcctcctg aggggcctgt ccagtctcct ctccatagtc
4441 ctcagagccc tcctgagggg atgcactccc aatctcctct ccagagtcct gagagtgctc
4501 ctgaggggga ggattccctg tctcctctcc aaattcctca gagtcctctt gagggagagg
4561 actccctgtc ttctctccat tttcctcaga gtcctcctga gtgggaggac tccctctctc
4621 ctctccactt tcctcagttt cctcctcagg gggaggactt ccagtcttct ctccagagtc
4681 ctgtgagtat ctgctcctcc tccacttctt tgagtcttcc ccagagtttc cctgagagtc
4741 ctcagagtcc tcctgagggg cctgctcagt ctcctctcca gagacctgtc agctccttct
4801 tctcctacac tttagcgagt cttctccaaa gttcccatga gagtcctcag agtcctcctg
4861 aggggcctgc ccagtctcct ctccagagtc ctgtgagctc cttcccctcc tccacttcat
4921 cgagtctttc ccagagttct cctgtgagct ccttcccctc ctccacttca tcgagtcttt
4981 ccaagagttc ccctgagagt cctctccaga gtcctgtgat ctccttctcc tcctccactt
5041 cattgagccc attcagtgaa gagtccagca gcccagtaga tgaatataca agttcctcag
5101 acaccttgct agagagtgat tccttgacag acagcgagtc cttgatagag agcgagccct
5161 tgttcactta tacactggat gaaaaggtgg acgagttggc gcggtttctt ctcctcaaat
5221 atcaagtgaa gcagcctatc acaaaggcag agatgctgac gaatgtcatc agcaggtaca
5281 cgggctactt tcctgtgatc ttcaggaaag cccgtgagtt catagagata ctttttggca
5341 tttccctgag agaagtggac cctgatgact cctatgtctt tgtaaacaca ttagacctca
5401 cctctgaggg gtgtctgagt gatgagcagg gcatgtccca gaaccgcctc ctgattctta
5461 ttctgagtat catcttcata aagggcacct atgcctctga ggaggtcatc tgggatgtgc
5521 tgagtggaat aggggtgcgt gctgggaggg agcactttgc ctttggggag cccagggagc
5581 tcctcactaa agtttgggtg caggaacatt acctagagta ccgggaggtg cccaactctt
5641 ctcctcctcg ttacgaattc ctgtggggtc caagagctca ttcagaagtc attaagagga
5701 aagtagtaga gtttttggcc atgctaaaga ataccgtccc tattaccttt ccatcctctt
5761 acaaggatgc tttgaaagat gtggaagaga gagcccaggc cataattgac accacagatg
5821 attcgactgc cacagaaagt gcaagctcca gtgtcatgtc ccccagcttc tcttctgagt
5881 gaagtctagg gcagattctt ccctctgagt ttgaaggggg cagtcgagtt tctacgtggt
5941 ggagggcctg gttgaggctg gagagaacac agtgctattt gcatttctgt tccatatggg
6001 tagttatggg gtttacctgt tttacttttg ggtatttttc aaatgctttt cctattaata
6061 acaggtttaa atagcttcag aatcctagtt tatgcacatg agtcgcacat gtattgctgt
6121 ttttctggtt taagagtaac agtttgatat tttgtaaaaa caaaaacaca cccaaacaca
6181 ccacattggg aaaaccttct gcctcatttt gtgatgtgtc acaggttaat gtggtgttac
6241 tgtaggaatt ttcttgaaac tgtgaaggaa ctctgcagtt aaatagtgga ataaagtaaa
6301 ggattgttaa tgtttgcatt tcctcaggtc ctttagtctg ttgttcttga aaactaaaga
6361 tacatacctg gtttgcttgg cttacgtaag aaagtagaag aaagtaaact gtaataaata
6421 aagtgtcagt gactcattat ttgatgacat tgtatcagca tttgcccata g
//