LOCUS AF064548 5100 bp mRNA linear HUM 22-SEP-1998
DEFINITION Homo sapiens low-density lipoprotein receptor-related protein 5
(LRP5) mRNA, complete cds.
ACCESSION AF064548
VERSION AF064548.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5100)
AUTHORS Hey,P.J., Twells,R.C., Phillips,M.S., Yusuke,Nakagawa., Brown,S.D.,
Kawaguchi,Y., Cox,R., Guochun,Xie., Dugan,V., Hammond,H.,
Metzker,M.L., Todd,J.A. and Hess,J.F.
TITLE Cloning of a novel member of the low-density lipoprotein receptor
family
JOURNAL Gene 216 (1), 103-111 (1998)
PUBMED 9714764
REFERENCE 2 (bases 1 to 5100)
AUTHORS Hey,P.J., Twells,R.C.J., Phillips,M.S., Nakagawa,Y., Brown,S.D.,
Kawaguchi,Y., Cox,R., Xie,G., Dugan,V., Hammond,H., Metzker,M.L.,
Todd,J.A. and Hess,J.F.
TITLE Direct Submission
JOURNAL Submitted (11-MAY-1998) Human Genetics, Merck Research Lab,
Sumneytown Pike, West Point, PA 19486, USA
FEATURES Location/Qualifiers
source 1..5100
/db_xref="H-InvDB:HIT000065428"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13"
gene 1..5100
/gene="LRP5"
CDS 49..4896
/gene="LRP5"
/codon_start=1
/product="low-density lipoprotein receptor-related protein
5"
/protein_id="AAC36467.1"
/translation="MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVR
LVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNV
VISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDP
AHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSF
IHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILS
ALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGR
TCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDD
EVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGL
ALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRR
SIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATR
CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDF
DVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTN
RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMT
LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD
YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCG
QLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILP
LHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS
IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQD
RAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR
LTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAV
EEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPD
QFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGE
ADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSD
DSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLN
FIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLY
PPILNPPPSPATDPSLYNMDMFYSSNIPATVRPYRPYIIRGMAPPTTPCSTDVCDSDY
SASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSP
CTDSS"
BASE COUNT 1035 a 1646 c 1542 g 877 t
ORIGIN
1 atggagcccg agtgagcgcg gcgcgggccc gtccggccgc cggacaacat ggaggcagcg
61 ccgcccgggc cgccgtggcc gctgctgctg ctgctgctgc tgctgctggc gctgtgcggc
121 tgcccggccc ccgccgcggc ctcgccgctc ctgctatttg ccaaccgccg ggacgtacgg
181 ctggtggacg ccggcggagt caagctggag tccaccatcg tggtcagcgg cctggaggat
241 gcggccgcag tggacttcca gttttccaag ggagccgtgt actggacaga cgtgagcgag
301 gaggccatca agcagaccta cctgaaccag acgggggccg ccgtgcagaa cgtggtcatc
361 tccggcctgg tctctcccga cggcctcgcc tgcgactggg tgggcaagaa gctgtactgg
421 acggactcag agaccaaccg catcgaggtg gccaacctca atggcacatc ccggaaggtg
481 ctcttctggc aggaccttga ccagccgagg gccatcgcct tggaccccgc tcacgggtac
541 atgtactgga cagactgggg tgagacgccc cggattgagc gggcagggat ggatggcagc
601 acccggaaga tcattgtgga ctcggacatt tactggccca atggactgac catcgacctg
661 gaggagcaga agctctactg ggctgacgcc aagctcagct tcatccaccg tgccaacctg
721 gacggctcgt tccggcagaa ggtggtggag ggcagcctga cgcacccctt cgccctgacg
781 ctctccgggg acactctgta ctggacagac tggcagaccc gctccatcca tgcctgcaac
841 aagcgcactg gggggaagag gaaggagatc ctgagtgccc tctactcacc catggacatc
901 caggtgctga gccaggagcg gcagcctttc ttccacactc gctgtgagga ggacaatggc
961 ggctgctccc acctgtgcct gctgtcccca agcgagcctt tctacacatg cgcctgcccc
1021 acgggtgtgc agctgcagga caacggcagg acgtgtaagg caggagccga ggaggtgctg
1081 ctgctggccc ggcggacgga cctacggagg atctcgctgg acacgccgga ctttaccgac
1141 atcgtgctgc aggtggacga catccggcac gccattgcca tcgactacga cccgctagag
1201 ggctatgtct actggacaga tgacgaggtg cgggccatcc gcagggcgta cctggacggg
1261 tctggggcgc agacgctggt caacaccgag atcaacgacc ccgatggcat cgcggtcgac
1321 tgggtggccc gaaacctcta ctggaccgac acgggcacgg accgcatcga ggtgacgcgc
1381 ctcaacggca cctcccgcaa gatcctggtg tcggaggacc tggacgagcc ccgagccatc
1441 gcactgcacc ccgtgatggg cctcatgtac tggacagact ggggagagaa ccctaaaatc
1501 gagtgtgcca acttggatgg gcaggagcgg cgtgtgctgg tcaatgcctc cctcgggtgg
1561 cccaacggcc tggccctgga cctgcaggag gggaagctct actggggaga cgccaagaca
1621 gacaagatcg aggtgatcaa tgttgatggg acgaagaggc ggaccctcct ggaggacaag
1681 ctcccgcaca ttttcgggtt cacgctgctg ggggacttca tctactggac tgactggcag
1741 cgccgcagca tcgagcgggt gcacaaggtc aaggccagcc gggacgtcat cattgaccag
1801 ctgcccgacc tgatggggct caaagctgtg aatgtggcca aggtcgtcgg aaccaacccg
1861 tgtgcggaca ggaacggggg gtgcagccac ctgtgcttct tcacacccca cgcaacccgg
1921 tgtggctgcc ccatcggcct ggagctgctg agtgacatga agacctgcat cgtgcctgag
1981 gccttcttgg tcttcaccag cagagccgcc atccacagga tctccctcga gaccaataac
2041 aacgacgtgg ccatcccgct cacgggcgtc aaggaggcct cagccctgga ctttgatgtg
2101 tccaacaacc acatctactg gacagacgtc agcctgaaga ccatcagccg cgccttcatg
2161 aacgggagct cggtggagca cgtggtggag tttggccttg actaccccga gggcatggcc
2221 gttgactgga tgggcaagaa cctctactgg gccgacactg ggaccaacag aatcgaagtg
2281 gcgcggctgg acgggcagtt ccggcaagtc ctcgtgtgga gggacttgga caacccgagg
2341 tcgctggccc tggatcccac caagggctac atctactgga ccgagtgggg cggcaagccg
2401 aggatcgtgc gggccttcat ggacgggacc aactgcatga cgctggtgga caaggtgggc
2461 cgggccaacg acctcaccat tgactacgct gaccagcgcc tctactggac cgacctggac
2521 accaacatga tcgagtcgtc caacatgctg ggtcaggagc gggtcgtgat tgccgacgat
2581 ctcccgcacc cgttcggtct gacgcagtac agcgattata tctactggac agactggaat
2641 ctgcacagca ttgagcgggc cgacaagact agcggccgga accgcaccct catccagggc
2701 cacctggact tcgtgatgga catcctggtg ttccactcct cccgccagga tggcctcaat
2761 gactgtatgc acaacaacgg gcagtgtggg cagctgtgcc ttgccatccc cggcggccac
2821 cgctgcggct gcgcctcaca ctacaccctg gaccccagca gccgcaactg cagcccgccc
2881 accaccttct tgctgttcag ccagaaatct gccatcagtc ggatgatccc ggacgaccag
2941 cacagcccgg atctcatcct gcccctgcat ggactgagga acgtcaaagc catcgactat
3001 gacccactgg acaagttcat ctactgggtg gatgggcgcc agaacatcaa gcgagccaag
3061 gacgacggga cccagccctt tgttttgacc tctctgagcc aaggccaaaa cccagacagg
3121 cagccccacg acctcagcat cgacatctac agccggacac tgttctggac gtgcgaggcc
3181 accaatacca tcaacgtcca caggctgagc ggggaagcca tgggggtggt gctgcgtggg
3241 gaccgcgaca agcccagggc catcgtcgtc aacgcggagc gagggtacct gtacttcacc
3301 aacatgcagg accgggcagc caagatcgaa cgcgcagccc tggacggcac cgagcgcgag
3361 gtcctcttca ccaccggcct catccgccct gtggccctgg tggtagacaa cacactgggc
3421 aagctgttct gggtggacgc ggacctgaag cgcattgaga gctgtgacct gtcaggggcc
3481 aaccgcctga ccctggagga cgccaacatc gtgcagcctc tgggcctgac catccttggc
3541 aagcatctct actggatcga ccgccagcag cagatgatcg agcgtgtgga gaagaccacc
3601 ggggacaagc ggactcgcat ccagggccgt gtcgcccacc tcactggcat ccatgcagtg
3661 gaggaagtca gcctggagga gttctcagcc cacccatgtg cccgtgacaa tggtggctgc
3721 tcccacatct gtattgccaa gggtgatggg acaccacggt gctcatgccc agtccacctc
3781 gtgctcctgc agaacctgct gacctgtgga gagccgccca cctgctcccc ggaccagttt
3841 gcatgtgcca caggggagat cgactgtatc cccggggcct ggcgctgtga cggctttccc
3901 gagtgcgatg accagagcga cgaggagggc tgccccgtgt gctccgccgc ccagttcccc
3961 tgcgcgcggg gtcagtgtgt ggacctgcgc ctgcgctgcg acggcgaggc agactgtcag
4021 gaccgctcag acgaggcgga ctgtgacgcc atctgcctgc ccaaccagtt ccggtgtgcg
4081 agcggccagt gtgtcctcat caaacagcag tgcgactcct tccccgactg tatcgacggc
4141 tccgacgagc tcatgtgtga aatcaccaag ccgccctcag acgacagccc ggcccacagc
4201 agtgccatcg ggcccgtcat tggcatcatc ctctctctct tcgtcatggg tggtgtctat
4261 tttgtgtgcc agcgcgtggt gtgccagcgc tatgcggggg ccaacgggcc cttcccgcac
4321 gagtatgtca gcgggacccc gcacgtgccc ctcaatttca tagccccggg cggttcccag
4381 catggcccct tcacaggcat cgcatgcgga aagtccatga tgagctccgt gagcctgatg
4441 gggggccggg gcggggtgcc cctctacgac cggaaccacg tcacaggggc ctcgtccagc
4501 agctcgtcca gcacgaaggc cacgctgtac ccgccgatcc tgaacccgcc gccctccccg
4561 gccacggacc cctccctgta caacatggac atgttctact cttcaaacat tccggccact
4621 gtgagaccgt acaggcccta catcattcga ggaatggcgc ccccgacgac gccctgcagc
4681 accgacgtgt gtgacagcga ctacagcgcc agccgctgga aggccagcaa gtactacctg
4741 gatttgaact cggactcaga cccctatcca cccccaccca cgccccacag ccagtacctg
4801 tcggcggagg acagctgccc gccctcgccc gccaccgaga ggagctactt ccatctcttc
4861 ccgccccctc cgtccccctg cacggactca tcctgacctc ggccgggcca ctctggcttc
4921 tctgtgcccc tgtaaatagt tttaaatatg aacaaagaaa aaaatatatt ttatgattta
4981 aaaaataaat ataattggga ttttaaaaac atgagaaatg tgaactgtga tggggtgggc
5041 agggctggga gaactttgta cagtggaaca aatatttata aacttaattt tgtaaaacag
//