LOCUS AF063657 4017 bp mRNA linear HUM 06-DEC-2004
DEFINITION Homo sapiens vascular endothelial growth factor receptor (FLT1)
mRNA, complete cds.
ACCESSION AF063657
VERSION AF063657.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4017)
AUTHORS Herley,M.T., Yu,Y., Whitney,R.G. and Sato,J.D.
TITLE Characterization of the VEGF binding site on the Flt-1 receptor
JOURNAL Biochem. Biophys. Res. Commun. 262 (3), 731-738 (1999)
PUBMED 10471394
REFERENCE 2 (bases 1 to 4017)
AUTHORS Yu,Y., Whitney,R.G. and Sato,J.D.
TITLE Direct Submission
JOURNAL Submitted (06-MAY-1998) Adirondack Biomedical Research Institute,
10 Old Barn Rd., Lake Placid, NY 12946, USA
REFERENCE 3 (bases 1 to 4017)
AUTHORS Yu,Y., Whitney,R.G. and Sato,J.D.
TITLE Direct Submission
JOURNAL Submitted (06-DEC-2004) Adirondack Biomedical Research Institute,
10 Old Barn Rd., Lake Placid, NY 12946, USA
REMARK Sequence update by submitter
COMMENT On Dec 6, 2004 this sequence version replaced AF063657.1.
FEATURES Location/Qualifiers
source 1..4017
/db_xref="H-InvDB:HIT000065289"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="endothelium"
/tissue_type="umbilical vein"
gene 1..4017
/gene="FLT1"
CDS 1..4017
/gene="FLT1"
/note="VEGFR; tyrosine kinase"
/codon_start=1
/product="vascular endothelial growth factor receptor"
/protein_id="AAC16449.2"
/translation="MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQ
AGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHT
GFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV
TSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT
NYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRA
SVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFI
TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLII
KDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQ
ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESSILDADSNMGNRIESITQR
MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM
PTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIM
NVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDC
HANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSV
ESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSII
MDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR
TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY
GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQ
EDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL
SENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVL
LWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPR
FAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFN
SGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTWTD
SKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIAC
CSPPPDYNSVVLYSTPPI"
BASE COUNT 1236 a 916 c 903 g 962 t
ORIGIN
1 atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc
61 acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag
121 cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa
181 tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc
241 tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac
301 cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca
361 gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt
421 gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt
481 acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat
541 ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa
601 gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat
661 ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc
721 aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg
781 agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga
841 cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa
901 atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa
961 tctgttaaca cctcagtgca tatatatgat aaagcattca tcactgtgaa acatcgaaaa
1021 cagcaggtgc ttgaaaccgt agctggcaag cggtcttacc ggctctctat gaaagtgaag
1081 gcatttccct cgccggaagt tgtatggtta aaagatgggt tacctgcgac tgagaaatct
1141 gctcgctatt tgactcgtgg ctactcgtta attatcaagg acgtaactga agaggatgca
1201 gggaattata caatcttgct gagcataaaa cagtcaaatg tgtttaaaaa cctcactgcc
1261 actctaattg tcaatgtgaa accccagatt tacgaaaagg ccgtgtcatc gtttccagac
1321 ccggctctct acccactggg cagcagacaa atcctgactt gtaccgcata tggtatccct
1381 caacctacaa tcaagtggtt ctggcacccc tgtaaccata atcattccga agcaaggtgt
1441 gacttttgtt ccaataatga agagtcctct atcctggatg ctgacagcaa catgggaaac
1501 agaattgaga gcatcactca gcgcatggca ataatagaag gaaagaataa gatggctagc
1561 accttggttg tggctgactc tagaatttct ggaatctaca tttgcatagc ttccaataaa
1621 gttgggactg tgggaagaaa cataagcttt tatatcacag atgtgccaaa tgggtttcat
1681 gttaacttgg aaaaaatgcc gacggaagga gaggacctga aactgtcttg cacagttaac
1741 aagttcttat acagagacgt tacttggatt ttactgcgga cagttaataa cagaacaatg
1801 cactacagta ttagcaagca aaaaatggcc atcactaagg agcactccat cactcttaat
1861 cttaccatca tgaatgtttc cctgcaagat tcaggcacct atgcctgcag agccaggaat
1921 gtatacacag gggaagaaat cctccagaag aaagaaatta caatcagaga tcaggaagca
1981 ccatacctcc tgcgaaacct cagtgatcac acagtggcca tcagcagttc caccacttta
2041 gactgtcatg ctaatggtgt ccccgagcct cagatcactt ggtttaaaaa caaccacaaa
2101 atacaacaag agcctggaat tattttagga ccaggaagca gcacgctgtt tattgaaaga
2161 gtcacagaag aggatgaagg tgtctatcac tgcaaagcca ccaaccagaa gggctctgtg
2221 gaaagttcag catacctcac tgttcaagga acctcggaca agtctaatct ggagctgatc
2281 actctaacat gcacctgtgt ggctgcgact ctcttctggc tcctattaac cctctttatc
2341 cgaaaaatga aaaggtcttc ttctgaaata aagactgact acctatcaat tataatggac
2401 ccagatgaag ttcctttgga tgagcagtgt gagcggctcc cttatgatgc cagcaagtgg
2461 gagtttgccc gggagagact taaactgggc aaatcacttg gaagaggggc ttttggaaaa
2521 gtggttcaag catcagcatt tggcattaag aaatcaccta cgtgccggac tgtggctgtg
2581 aaaatgctga aagagggggc cacggccagc gagtacaaag ctctgatgac tgagctaaaa
2641 atcttgaccc acattggcca ccatctgaac gtggttaacc tgctgggagc ctgcaccaag
2701 caaggagggc ctctgatggt gattgttgaa tactgcaaat atggaaatct ctccaactac
2761 ctcaagagca aacgtgactt attttttctc aacaaggatg cagcactaca catggagcct
2821 aagaaagaaa aaatggagcc aggcctggaa caaggcaaga aaccaagact agatagcgtc
2881 accagcagcg aaagctttgc gagctccggc tttcaggaag ataaaagtct gagtgatgtt
2941 gaggaagagg aggattctga cggtttctac aaggagccca tcactatgga agatctgatt
3001 tcttacagtt ttcaagtggc cagaggcatg gagttcctgt cttccagaaa gtgcattcat
3061 cgggacctgg cagcgagaaa cattctttta tctgagaaca acgtggtgaa gatttgtgat
3121 tttggccttg cccgggatat ttataagaac cccgattatg tgagaaaagg agatactcga
3181 cttcctctga aatggatggc tcctgaatct atctttgaca aaatctacag caccaagagc
3241 gacgtgtggt cttacggagt attgctgtgg gaaatcttct ccttaggtgg gtctccatac
3301 ccaggagtac aaatggatga ggacttttgc agtcgcctga gggaaggcat gaggatgaga
3361 gctcctgagt actctactcc tgaaatctat cagatcatgc tggactgctg gcacagagac
3421 ccaaaagaaa ggccaagatt tgcagaactt gtggaaaaac taggtgattt gcttcaagca
3481 aatgtacaac aggatggtaa agactacatc ccaatcaatg ccatactgac aggaaatagt
3541 gggtttacat actcaactcc tgccttctct gaggacttct tcaaggaaag tatttcagct
3601 ccgaagttta attcaggaag ctctgatgat gtcagatatg taaatgcttt caagttcatg
3661 agcctggaaa gaatcaaaac ctttgaagaa cttttaccga atgccacctc catgtttgat
3721 gactaccagg gcgacagcag cactctgttg gcctctccca tgctgaagcg cttcacctgg
3781 actgacagca aacccaaggc ctcgctcaag attgacttga gagtaaccag taaaagtaag
3841 gagtcggggc tgtctgatgt cagcaggccc agtttctgcc attccagctg tgggcacgtc
3901 agcgaaggca agcgcaggtt cacctacgac cacgctgagc tggaaaggaa aatcgcgtgc
3961 tgctccccgc ccccagacta caactcggtg gtcctgtact ccaccccacc catctag
//