LOCUS AF061056 2146 bp mRNA linear HUM 20-JAN-1999
DEFINITION Homo sapiens orphan nuclear receptor PXR mRNA, complete cds.
ACCESSION AF061056
VERSION AF061056.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2146)
AUTHORS Lehmann,J.M., McKee,D.D., Watson,M.A., Willson,T.M., Moore,J.T. and
Kliewer,S.A.
TITLE The human orphan nuclear receptor PXR is activated by compounds
that regulate CYP3A4 gene expression and cause drug interactions
JOURNAL J. Clin. Invest. 102 (5), 1016-1023 (1998)
PUBMED 9727070
REFERENCE 2 (bases 1 to 2146)
AUTHORS Lehmann,J.M., McKee,D.D., Watson,M.A., Willson,T.M., Moore,J.T. and
Kliewer,S.A.
TITLE Direct Submission
JOURNAL Submitted (21-APR-1998) Molecular Endocrinology, Glaxo Wellcome, 5
Moore Drive, RTP, NC 27709, USA
FEATURES Location/Qualifiers
source 1..2146
/db_xref="H-InvDB:HIT000064948"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
CDS 304..1608
/codon_start=1
/product="orphan nuclear receptor PXR"
/protein_id="AAD05436.1"
/translation="MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVC
GDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKC
LESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK
TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGE
DGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLL
KGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQ
LHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLK
IMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS"
BASE COUNT 509 a 593 c 605 g 439 t
ORIGIN
1 tgaaatatag gtgagagaca agattgtctc atatccgggg aaatcataac ctatgactag
61 gacgggaaga ggaagcactg cctttacttc agtgggaatc tcggcctcag cctgcaagcc
121 aagtgttcac agtgagaaaa gcaagagaat aagctaatac tcctgtcctg aacaaggcag
181 cggctccttg gtaaagctac tccttgatcg atcctttgca ccggattgtt caaagtggac
241 cccaggggag aagtcggagc aaagaactta ccaccaagca gtccaagagg cccagaagca
301 aacctggagg tgagacccaa agaaagctgg aaccatgctg actttgtaca ctgtgaggac
361 acagagtctg ttcctggaaa gcccagtgtc aacgcagatg aggaagtcgg aggtccccaa
421 atctgccgtg tatgtgggga caaggccact ggctatcact tcaatgtcat gacatgtgaa
481 ggatgcaagg gctttttcag gagggccatg aaacgcaacg cccggctgag gtgccccttc
541 cggaagggcg cctgcgagat cacccggaag acccggcgac agtgccaggc ctgccgcctg
601 cgcaagtgcc tggagagcgg catgaagaag gagatgatca tgtccgacga ggccgtggag
661 gagaggcggg ccttgatcaa gcggaagaaa agtgaacgga cagggactca gccactggga
721 gtgcaggggc tgacagagga gcagcggatg atgatcaggg agctgatgga cgctcagatg
781 aaaacctttg acactacctt ctcccatttc aagaatttcc ggctgccagg ggtgcttagc
841 agtggctgcg agttgccaga gtctctgcag gccccatcga gggaagaagc tgccaagtgg
901 agccaggtcc ggaaagatct gtgctctttg aaggtctctc tgcagctgcg gggggaggat
961 ggcagtgtct ggaactacaa acccccagcc gacagtggcg ggaaagagat cttctccctg
1021 ctgccccaca tggctgacat gtcaacctac atgttcaaag gcatcatcag ctttgccaaa
1081 gtcatctcct acttcaggga cttgcccatc gaggaccaga tctccctgct gaagggggcc
1141 gctttcgagc tgtgtcaact gagattcaac acagtgttca acgcggagac tggaacctgg
1201 gagtgtggcc ggctgtccta ctgcttggaa gacactgcag gtggcttcca gcaacttcta
1261 ctggagccca tgctgaaatt ccactacatg ctgaagaagc tgcagctgca tgaggaggag
1321 tatgtgctga tgcaggccat ctccctcttc tccccagacc gcccaggtgt gctgcagcac
1381 cgcgtggtgg accagctgca ggagcaattc gccattactc tgaagtccta cattgaatgc
1441 aatcggcccc agcctgctca taggttcttg ttcctgaaga tcatggctat gctcaccgag
1501 ctccgcagca tcaatgctca gcacacccag cggctgctgc gcatccagga catacacccc
1561 tttgctacgc ccctcatgca ggagttgttc ggcatcacag gtagctgagc ggctgccctt
1621 gggtgacacc tccgagaggc agccagaccc agagccctct gagccgccac tcccgggcca
1681 agacagatgg acactgccaa gagccgacaa tgccctgctg gcctgtctcc ctagggaatt
1741 cctgctatga cagctggcta gcattcctca ggaaggacat gggtgccccc cacccccagt
1801 tcagtctgta gggagtgaag ccacagactc ttacgtggag agtgcactga cctgtaggtc
1861 aggaccatca gagaggcaag gttgcccttt ccttttaaaa ggccctgtgg tctggggaga
1921 aatccctcag atcccactaa agtgtcaagg tgtggaaggg accaagcgac caaggatagg
1981 ccatctgggg tctatgccca catacccacg tttgttcgct tcctgagtct tttcattgct
2041 acctctaata gtcctgtctc ccacttccca ctcgttcccc tcctcttccg agctgctttg
2101 tgggctccag gcctgtactc atcggcaggt gcatgagtat ctgtgg
//