LOCUS AF060153 3711 bp mRNA linear HUM 11-AUG-1999
DEFINITION Homo sapiens METH2 protein (METH2) mRNA, complete cds.
ACCESSION AF060153
VERSION AF060153.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3711)
AUTHORS Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S.,
Lombardo,M. and Iruela-Arispe,M.L.
TITLE METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a
new family of proteins with angio-inhibitory activity
JOURNAL J. Biol. Chem. 274 (33), 23349-23357 (1999)
PUBMED 10438512
REFERENCE 2 (bases 1 to 3711)
AUTHORS Vazquez,F., Hastings,G., Ortega,M.-A., Lane,T.F., Lombardo,M.,
Oikemus,S. and Iruela-Arispe,M.L.
TITLE Direct Submission
JOURNAL Submitted (16-APR-1998) Pathology, Beth Israel Deaconess Medical
Center, 99, Brookline Avenue, Boston, MA 02214, USA
FEATURES Location/Qualifiers
source 1..3711
/db_xref="H-InvDB:HIT000064884"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3711
/gene="METH2"
CDS 706..3378
/gene="METH2"
/note="extracellular protein with metalloprotease and TSP
domains"
/codon_start=1
/product="METH2 protein"
/protein_id="AAD48081.1"
/translation="MFPAPAAPRWLPFLLLLLLLLLPLARGAPARPAAGGQASELVVP
TRLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCF
FSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGAR
PLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSE
ARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVED
EKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLG
VADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHV
MAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPGAALPLPTGLPGRMALYQLD
QQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLC
SEGSCLPEEEVERPKPVVDGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYC
LGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRC
KLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGV
CGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTAD
GQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEV
FPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRR
TVECRDPSGQASATCNKALKPEDAKPCESQLCPL"
BASE COUNT 733 a 1126 c 1201 g 646 t
ORIGIN
1 acagggtcgc tgagaccagt gcacgagcct cttcggaaga tgcatcctgg actcttggcc
61 gcagaagaga aagcggttgg ggtctcccag ggactctttc taaagggtca gtccaccatg
121 gtaggggtta acgtgggtcc acccgtatag ggaaaggaaa gaaattgtat ttgacacttc
181 aggggggcgg gtggcggacg ggtctcgctg cctgattggt tttgcatttc atcccaattt
241 ttttttctcc actctctctc cctcttttca gtttctctct ctgatcccag gggaggggaa
301 acgggaatag tgagagatca aaaataaacc tcttatgtca agccgggaag gaagtataaa
361 taagaagggc tcggcagccc actcggtgct tcccggggtg gggaggaggc aggaggcggc
421 tgcgcggggc tggcgcgggc aggggcggag gacgggcgca cgcgggccgg ggccagctgc
481 tcgcgctcgg ctcgggggcg gcggcgcggg aggagcgggc tgcgccagcc agaggggccg
541 ccgggggagc gctcccgccg ccgggccccg cgggcggagt cggccttgca cccgattgat
601 tccgttttcc tggagagagc ggccgggccg cgctcgggcc gccagcacct gcccgcgcct
661 ggcgggtttt tccttttcct gcgcgcagcc accgccgcag cccccatgtt ccccgccccc
721 gccgcccccc ggtggcttcc gttcctgctg ctgctgctgc tgctgctgct gccgctggcc
781 cgcggcgccc cggcccggcc cgcagccggg gggcaggcct cggagctggt ggtgcccacg
841 cggttgcccg gcagcgcggg cgagctcgcg ctccacctgt ccgccttcgg caagggcttc
901 gtgttgcgcc tggcgcccga cgacagcttc ctggcgcccg agttcaagat cgagcgcctc
961 gggggctccg gccgggcgac cgggggcgag cgggggctgc gcggctgttt tttttccggc
1021 accgtgaatg gggagcccga gtcgctggcg gcggtcagcc tgtgccgcgg gctgagcggc
1081 tccttcctgc tggacggcga ggagttcacc atccagccgc agggcgcggg gggctccctg
1141 gctcagccgc accgcctgca gcgctggggt cccgccggag cccgccccct cccgcgagga
1201 cccgagtggg aggtggagac gggagagggt cagaggcagg agagaggaga ccaccaggag
1261 gacagcgagg aggagagcca agaagaggag gcagaaggcg ctagcgagcc gccaccgccc
1321 ctgggggcca cgagtaggac caagcggttt gtgtctgagg cgcgcttcgt ggagacgctg
1381 ctggtggccg atgcgtccat ggctgccttc tacggggccg acctgcagaa ccacatcctg
1441 acgttaatgt ctgtggcagc ccgaatctac aagcacccca gcatcaagaa ttccatcaac
1501 ctgatggtgg taaaagtgct gatcgtagaa gatgaaaaat ggggcccaga ggtgtccgac
1561 aatggggggc ttacactgcg taacttctgc aactggcagc ggcgtttcaa ccagcccagc
1621 gaccgccacc cagagcacta cgacacggcc atcctgctca ccagacagaa cttctgtggg
1681 caggaggggc tgtgtgacac cctgggtgtg gcagacatcg ggaccatttg tgaccccaac
1741 aaaagctgct ccgtgatcga ggatgagggg ctccaggcgg cccacaccct ggcccatgaa
1801 ctagggcacg tcctcagcat gccccacgac gactccaagc cctgcacacg gctcttcggg
1861 cccatgggca agcaccacgt gatggcaccg ctgttcgtcc acctgaacca gacgctgccc
1921 tggtccccct gcagcgccat gtatctcaca gagcttctgg acggcgggca cggagactgt
1981 ctcctggatg cccctggtgc ggccctgccc ctccccacag gcctcccggg ccgcatggcc
2041 ctgtaccagc tggaccagca gtgcaggcag atctttgggc cggatttccg ccactgcccc
2101 aacacctctg ctcaggacgt ctgcgcccag ctttggtgcc acactgatgg ggctgagccc
2161 ctgtgccaca cgaagaatgg cagcctgccc tgggctgacg gcacgccgtg cgggcctggg
2221 cacctctgct cagaaggcag ctgtctacct gaggaggaag tggagaggcc caagcccgtg
2281 gtagatggag gctgggcacc gtggggaccc tggggagaat gttctcggac ctgtggagga
2341 ggagtacagt tttcacaccg tgagtgcaag gaccccgagc ctcagaatgg aggaagatac
2401 tgcctgggtc ggagagccaa gtaccagtca tgccacacgg aggaatgccc ccctgacggg
2461 aaaagcttca gggagcagca gtgtgagaag tataatgcct acaattacac tgacatggac
2521 gggaatctcc tgcagtgggt ccccaagtat gctggggtgt ccccccggga ccgctgcaag
2581 ttgttctgcc gagcccgggg gaggagcgag ttcaaagtgt tcgaggccaa ggtgattgat
2641 ggcaccctgt gtgggccaga aacactggcc atctgtgtcc gtggccagtg tgtcaaggcc
2701 ggctgtgacc atgtggtgga ctcgcctcgg aagctggaca aatgcggggt gtgtgggggc
2761 aaaggcaact cctgcaggaa ggtctccggg tccctcaccc ccaccaatta tggctacaat
2821 gacattgtca ccatcccagc tggtgccact aatattgacg tgaagcagcg gagccacccg
2881 ggtgtgcaga acgatgggaa ctacctggcg ctgaagacgg ctgatgggca gtacctgctc
2941 aacggcaacc tggccatctc tgccatagag caggacatct tggtgaaggg gaccatcctg
3001 aagtacagcg gctccatcgc caccctggag cgcctgcaga gcttccggcc cttgccagag
3061 cctctgacag tgcagctcct gacagtccct ggcgaggtct tccccccaaa agtcaaatac
3121 accttctttg ttcctaatga cgtggacttt agcatgcaga gcagcaaaga gagagcaacc
3181 accaacatca tccagccgct gctccacgca cagtgggtgc tgggggactg gtctgagtgc
3241 tctagcacct gcggggccgg ctggcagagg cgaactgtag agtgcaggga cccctccggc
3301 caggcctctg ccacctgcaa caaggctctg aaacccgagg atgccaagcc ctgcgaaagc
3361 cagctgtgcc ccctgtgatt caggggggca ggggccagtc ttgtgctcct ggacatgcgg
3421 tactgaggtg cagacaaggt ctccactgtg gtgactgggt cccttggcca tatcaaggca
3481 gcacggccca cccaggcctc ccattgccgc aacccctcca gtactgcaca aattcctaag
3541 ggggaagaga aaaggtatgg ggcggcaaaa cctatcatca actgtccawt gnaatggaac
3601 ttgctcgggt tcaattaaag gcataagtta aagtaaattc attatgatca acagacctca
3661 cntcatctgt tgcangatac aactantaaa aaaaaaaaaa aaaaaaaaaa a
//