LOCUS AF060152 3430 bp mRNA linear HUM 17-OCT-2005
DEFINITION Homo sapiens METH1 protein (METH1) mRNA, complete cds.
ACCESSION AF060152
VERSION AF060152.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3430)
AUTHORS Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S.,
Lombardo,M. and Iruela-Arispe,M.L.
TITLE METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a
new family of proteins with angio-inhibitory activity
JOURNAL J. Biol. Chem. 274 (33), 23349-23357 (1999)
PUBMED 10438512
REFERENCE 2 (bases 1 to 3430)
AUTHORS Lee,N.V., Rodriguez-Manzaneque,J.C., Thai,S.N., Twal,W.O.,
Luque,A., Lyons,K.M., Argraves,W.S. and Iruela-Arispe,M.L.
TITLE Fibulin-1 acts as a cofactor for the matrix metalloprotease
ADAMTS-1
JOURNAL J. Biol. Chem. 280 (41), 34796-34804 (2005)
PUBMED 16061471
REFERENCE 3 (bases 1 to 3430)
AUTHORS Vazquez,F., Hastings,G., Ortega,M.-A., Lane,T.F., Lombardo,M.,
Oikemus,S. and Iruela-Arispe,M.L.
TITLE Direct Submission
JOURNAL Submitted (16-APR-1998) Pathology, Beth Israel Deaconess Medical
Center, 99, Brookline Avenue, Boston, MA 02214, USA
FEATURES Location/Qualifiers
source 1..3430
/db_xref="H-InvDB:HIT000064883"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3430
/gene="METH1"
CDS 238..3090
/gene="METH1"
/note="extracellular protein with metalloprotease and TSP
domains"
/codon_start=1
/product="METH1 protein"
/protein_id="AAD48080.1"
/translation="MGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELV
VPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETD
LAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKP
PAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGPQWSPQDPA
LQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLY
KHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYD
TAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNM
PHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP
QNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKH
FPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTM
RECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGP
AVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKA
GCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRN
QRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFS
PLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELG
WQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKR
SLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS"
BASE COUNT 877 a 845 c 971 g 736 t
ORIGIN
1 tgcagcgcct cctcttagtg actccgggag cttcggctgt agccggctct gcgcgccctt
61 ccaacgaata atagaaattg ttaattttaa caatccagag caggccaacg aggctttgct
121 ctcccgaccc gaactaaagc tccctcgctc cgtgcgctgc tacgagcggt gtctcctggg
181 gctccaatgc agcgagctgt gcccgagggg ttcggaaggc gcaagctggg cagcgacatg
241 gggaacgcgg agcgggctcc ggggtctcgg agctttgggc ccgtacccac gctgctgctg
301 ctcgccgcgg cgctactggc cgtgtcggac gcactcgggc gcccctccga ggaggacgag
361 gagctagtgg tgccggagct ggagcgcgcc ccgggacacg ggaccacgcg cctccgcctg
421 cacgcctttg accagcagct ggatctggag ctgcggcccg acagcagctt tttggcgccc
481 ggcttcacgc tccagaacgt ggggcgcaaa tccgggtccg agacgccgct tccggaaacc
541 gacctggcgc actgcttcta ctccggcacc gtgaatggcg atcccagctc ggctgccgcc
601 ctcagcctct gcgagggcgt gcgcggcgcc ttctacctgc tgggggaggc gtatttcatc
661 cagccgctgc ccgccgccag cgagcgcctc gccaccgccg ccccagggga gaagccgccg
721 gcaccactac agttccacct cctgcggcgg aatcggcagg gcgacgtagg cggcacgtgc
781 ggggtcgtgg acgacgagcc ccggccgact gggaaagcgg agaccgaaga cgaggacgaa
841 gggactgagg gcgaggacga agggcctcag tggtcgccgc aggacccggc actgcaaggc
901 gtaggacagc ccacaggaac tggaagcata agaaagaagc gatttgtgtc cagtcaccgc
961 tatgtggaaa ccatgcttgt ggcagaccag tcgatggcag aattccacgg cagtggtcta
1021 aagcattacc ttctcacgtt gttttcggtg gcagccagat tgtacaaaca ccccagcatt
1081 cgtaattcag ttagcctggt ggtggtgaag atcttggtca tccacgatga acagaagggg
1141 ccggaagtga cctccaatgc tgccctcact ctgcggaact tttgcaactg gcagaagcag
1201 cacaacccac ccagtgaccg ggatgcagag cactatgaca cagcaattct tttcaccaga
1261 caggacttgt gtgggtccca gacatgtgat actcttggga tggctgatgt tggaactgtg
1321 tgtgatccga gcagaagctg ctccgtcata gaagatgatg gtttacaagc tgccttcacc
1381 acagcccatg aattaggcca cgtgtttaac atgccacatg atgatgcaaa gcagtgtgcc
1441 agccttaatg gtgtgaacca ggattcccac atgatggcgt caatgctttc caacctggac
1501 cacagccagc cttggtctcc ttgcagtgcc tacatgatta catcatttct ggataatggt
1561 catggggaat gtttgatgga caagcctcag aatcccatac agctcccagg cgatctccct
1621 ggcacctcgt acgatgccaa ccggcagtgc cagtttacat ttggggagga ctccaaacac
1681 tgccctgatg cagccagcac atgtagcacc ttgtggtgta ccggcacctc tggtggggtg
1741 ctggtgtgtc aaaccaaaca cttcccgtgg gcggatggca ccagctgtgg agaagggaaa
1801 tggtgtatca acggcaagtg tgtgaacaaa accgacagaa agcattttga tacgcctttt
1861 catggaagct ggggaatgtg ggggccttgg ggagactgtt cgagaacgtg cggtggagga
1921 gtccagtaca cgatgaggga atgtgacaac ccagtcccaa agaatggagg gaagtactgt
1981 gaaggcaaac gagtgcgcta cagatcctgt aaccttgagg actgtccaga caataatgga
2041 aaaaccttta gagaggaaca atgtgaagca cacaacgagt tttcaaaagc ttcctttggg
2101 agtgggcctg cggtggaatg gattcccaag tacgctggcg tctcaccaaa ggacaggtgc
2161 aagctcatct gccaagccaa aggcattggc tacttcttcg ttttgcagcc caaggttgta
2221 gatggtactc catgtagccc agattccacc tctgtctgtg tgcaaggaca gtgtgtaaaa
2281 gctggttgtg atcgcatcat agactccaaa aagaagtttg ataaatgtgg tgtttgcggg
2341 ggaaatggat ctacttgtaa aaaaatatca ggatcagtta ctagtgcaaa acctggatat
2401 catgatatca tcacaattcc aactggagcc accaacatcg aagtgaaaca gcggaaccag
2461 aggggatcca ggaacaatgg cagctttctt gccatcaaag ctgctgatgg cacatatatt
2521 cttaatggtg actacacttt gtccacctta gagcaagaca ttatgtacaa aggtgttgtc
2581 ttgaggtaca gcggctcctc tgcggcattg gaaagaattc gcagctttag ccctctcaaa
2641 gagcccttga ccatccaggt tcttactgtg ggcaatgccc ttcgacctaa aattaaatac
2701 acctacttcg taaagaagaa gaaggaatct ttcaatgcta tccccacttt ttcagcatgg
2761 gtcattgaag agtggggcga atgttctaag tcatgtgaat tgggttggca gagaagactg
2821 gtagaatgcc gagacattaa tggacagcct gcttccgagt gtgcaaagga agtgaagcca
2881 gccagcacca gaccttgtgc agaccatccc tgcccccagt ggcagctggg ggagtggtca
2941 tcatgttcta agacctgtgg gaagggttac aaaaaaagaa gcttgaagtg tctgtcccat
3001 gatggagggg tgttatctca tgagagctgt gatcctttaa agaaacctaa acatttcata
3061 gacttttgca caatggcaga atgcagttaa gtggtttaag tggtgttagc tttgaggcaa
3121 ggcaaagtga ggaagggctg gtgcagggaa agcaagaagg ctggagggat ccagcgtatc
3181 ttgccagtaa ccagtgaggt gtatcagtaa ggtgggatta tgggggtaga tagaaaagga
3241 gttgaatcat cagagtaaac tgccagttgc aaatttgata ggatagttag tgaggattat
3301 taacctctga gcagtgatat agcataataa anccccgggc attattatta ttatttcttt
3361 tgttacatct attacaagtt tagaaaaaac aaagcaattg tcaaaaaaaa aaaaaaaaaa
3421 aaaaaaaaaa
//