LOCUS AF059734 2401 bp DNA linear HUM 26-JUN-1998
DEFINITION Homo sapiens homeodomain transcription factor (HESX1) gene,
complete cds.
ACCESSION AF059734
VERSION AF059734.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2401)
AUTHORS Thomas,P.Q., Johnson,B.V., Rathjen,J. and Rathjen,P.D.
TITLE Sequence, genomic organization, and expression of the novel
homeobox gene Hesx1
JOURNAL J. Biol. Chem. 270 (8), 3869-3875 (1995)
PUBMED 7876132
REFERENCE 2 (bases 1 to 2401)
AUTHORS Dattani,M.T., Martinez-Barbera,J.P., Thomas,P.Q., Brickman,J.M.,
Gupta,R., Martensson,I.L., Toresson,H., Fox,M., Wales,J.,
Hindmarsh,P.C., Krauss,S., Beddington,R.S.P. and Robinson,I.C.A.F.
TITLE Mutations in the homeobox gene HESX1/Hesx1 associated with
septo-optic dysplasia in human and mouse
JOURNAL Nat. Genet. 19 (2), 125-133 (1998)
PUBMED 9620767
REFERENCE 3 (bases 1 to 2401)
AUTHORS Dattani,M.T., Martinez-Barbera,J.P., Thomas,P.Q., Brickman,J.M.,
Gupta,R., Martensson,I.L., Toresson,H., Fox,M., Wales,J.,
Hindmarsh,P.C., Krauss,S., Beddington,R.S.P. and Robinson,I.C.A.F.
TITLE Direct Submission
JOURNAL Submitted (16-APR-1998) Mammalian Development, National Institute
for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
FEATURES Location/Qualifiers
source 1..2401
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.1-p21.2"
/cell_line="HT-1080"
/cell_type="fibrosarcoma; ES"
gene 1..>2051
/gene="HESX1"
mRNA join(1..491,1296..1495,1756..1857,1953..>2051)
/gene="HESX1"
/product="homeodomain transcription factor"
5'UTR 1..334
/gene="HESX1"
CDS join(335..491,1296..1495,1756..1857,1953..2051)
/gene="HESX1"
/note="paired-like homeobox"
/codon_start=1
/product="homeodomain transcription factor"
/protein_id="AAC24523.1"
/translation="MSPSLQEGAQLGENKPSTCSFSIERILGLDQKKDCVPLMKPHRP
WADTCSSSGKDGNLCLHVPNPPSGISFPSVVDHPMPEERASKYENYFSASERLSLKRE
LSWYRGRRPRTAFTQNQIEVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRR
AKLKRSHRESQFLMAKKNFNTNLLE"
misc_feature join(1460..1495,1756..1857,1953..1994)
/gene="HESX1"
/note="homeobox"
BASE COUNT 744 a 450 c 452 g 755 t
ORIGIN
1 ccacatttgt gcatcacttc tttagagaaa gttaagtctg tgttctgctt aggagagata
61 acactttttg tccctgtagg tggcccccct ggtgtagcca ttagttgcta attacttgca
121 aacaaataaa caattaactc cttaagctgc tggctgggca agtgttcatt gacatgctaa
181 aactttctaa gacaggattt taattagtga cgttctaaat ccagccccct tgtcagcgga
241 gctataaggt gaactgcagg aagatcccag ccctatacac gtggggcaga gccagcagag
301 gccagagctg ttgctctgtg cagaccacga gaggatgtct cccagccttc aggaaggcgc
361 tcagctcggg gaaaacaaac cctcaacttg ctccttttca attgagagaa tcttaggact
421 ggaccagaag aaagactgtg ttccattaat gaaaccccac aggccctggg cagacacctg
481 cagctcatca ggtatgccac agcttaattg tttcaattct ttgttatttc atttacagtg
541 tttaatttgc cctttatttc atactacata gagctagagt ttaggacttt aatttattat
601 tattatttat tattattttt ttttttctga gacagagtgt tggtcttgtt gccaagactg
661 gagtgcaatg gcataatctt ggctcactgc agcctccgcc tcctgggttc aaacgattct
721 cctgcctcag cctgccaagt agctgggatt acaggcatgc accaccatgg cctgctaatt
781 tttgtatttt ttagtagagg ggggtttcac cctgttggtc aggctagtct cgaactcctg
841 acctcaggtg atccgcctgc ctcagcctcc caaagtgtta ggattacagg catgacccac
901 cacgcccagc cagagtctag gacttttaat gcctccaact gagtcctatg ggaaattaaa
961 agaatatcag ctttggattg agcaaagtgg ataaattcac tcacaggaaa tcccaagaac
1021 ctgcatttac ttcagaagat ctctccctgt ttgacacatc agatatttga aatctctttt
1081 cactgaaaaa taaacgacat tcagagacca aagaggcagg attaccaaga caggatcttc
1141 attttttatt ggtttttggt taacggggtg caattctctt gtgaacccca gaattccact
1201 aggaaatgaa agatgagttc ctgaaactac ctctatagaa ctttgtggaa cataagattg
1261 accatctaag acagggctta tttttttgtt tttagggaaa gatggtaact tatgtctaca
1321 tgtcccaaat cctcccagtg ggatttcatt ccctagcgtg gtggatcacc caatgccaga
1381 agaaagagct tcgaaatatg aaaattactt ttcagcctca gaaagactgt ctttgaaaag
1441 agagttgagt tggtatagag gccgaagacc aagaactgct tttactcaaa accaggtggg
1501 aagttttttc acccaataat gataatataa aggctttaat tgacaccaag ttgagcaaaa
1561 gcccactcac tttggtatct cagtttagaa gccttattaa tgaaacagta gactaccata
1621 ttttaacaat ttccaggtaa tcatttttaa aaaggcatcc agattaattg ccaagattta
1681 aatgtagtca ttttactcta gaaattaaag ctcatttttg gagacatact gaatatcaac
1741 attttttttt cttagattga agtgttagaa aatgtcttta gagtaaactg ctatcctggt
1801 atcgatatta gagaagactt agctcaaaaa ttgaatctag aggaagacag aatccaggta
1861 attttcaaat ttagttgtta ttcatgatgt tgaaatgtta agaataataa aataatgttt
1921 ctgagaccta ttttattttt ccttaacttt agatttggtt tcaaaatcgg cgtgcaaaac
1981 tgaaaaggtc ccatagagaa tcacagtttc taatggcgaa aaaaaatttc aacacaaatc
2041 tgctggaata gatagaaaac taaacaagtg aaattatctt ctaattgcag agcatgaaga
2101 atcagtggaa atattaagtg ttaaaatgtg atgttttctt tcctgcattt aatctgaata
2161 ttgtcatttt ttctgaaaat atattgtaaa tactattata gcatggtaca tatttgggca
2221 cttttagtta tagtaaagac cttttatata tattttaata aacattttca gaaaagattg
2281 ctatttttta agtaagccaa attaatctaa taaattagtt tgttaaaatc aatagactca
2341 tgactaagtg attccacaag ctggattcta attataaagt atttcaagtt aaaataatct
2401 g
//