LOCUS AF059198 3629 bp mRNA linear HUM 11-JUL-1998
DEFINITION Homo sapiens protein kinase/endoribonulcease (IRE1) mRNA, complete
cds.
ACCESSION AF059198
VERSION AF059198.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3629)
AUTHORS Tirasophon,W., Welihinda,A.A. and Kaufman,R.J.
TITLE A stress response pathway from the endoplasmic reticulum to the
nucleus requires a novel bifunctional protein
kinase/endoribonuclease (Ire1p) in mammalian cells
JOURNAL Genes Dev. 12 (12), 1812-1824 (1998)
PUBMED 9637683
REFERENCE 2 (bases 1 to 3629)
AUTHORS Tirasophon,W. and Kaufman,R.J.
TITLE Direct Submission
JOURNAL Submitted (13-APR-1998) Biological Chemistry, University of
Michigan, 1301 Catherine Rd., Ann Arbor, MI 48109-0606, USA
FEATURES Location/Qualifiers
source 1..3629
/db_xref="H-InvDB:HIT000064820"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
/dev_stage="fetal"
gene 1..3629
/gene="IRE1"
CDS 97..3030
/gene="IRE1"
/note="Ire1p"
/codon_start=1
/product="protein kinase/endoribonulcease"
/protein_id="AAC25991.1"
/translation="MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHA
VSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPE
LVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTE
YTITMYDTKTRELRWNATYFDYAASLPEDEGDYKMSHFVSNGDGLVVTVDSESGDVLW
IQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEA
KSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVI
TPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIP
ADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILS
TFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDG
ELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIV
GKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPN
VIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL
NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAP
EMLSEDCKENPTYTVDIFSAGCVFYYVVSEGSHPFGKSLQRQANILLGACSLDCLHPE
KHEDVIARELIEKMIAMDPQKRPSANDVLKHPFFWSLEKQLQFFQDVSDRIEKESLDG
PIVKQLERGGRAVVKMDWRENITDPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYREL
PAEVRETLGTLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPV
TPDAL"
BASE COUNT 837 a 1062 c 1003 g 727 t
ORIGIN
1 ccggctcgac ggctcggtca ccgcctcgct gtcgtcgcgg cgcccccggc cgtcctctgt
61 ccgtaccgcc cccggagcca gggccgagtc ctcgccatgc cggcccggcg gctgctgctg
121 ctgctgacgc tgctgctgcc cggcctcggg atttttggaa gtaccagcac agtgacgctt
181 cctgaaacct tgttgtttgt gtcaacgctg gatggaagtt tgcatgctgt cagcaagagg
241 acaggctcaa tcaaatggac tttaaaagaa gatccagtcc tgcaggtccc aacacatgtg
301 gaagagcctg cctttctccc agatcctaat gatggcagcc tgtatacgct tggaagcaag
361 aataatgaag gcctgacgaa acttcctttt accatcccag aattggtgca ggcatcccca
421 tgccgaagtt cagatggaat cctctacatg ggtaaaaagc aggacatctg gtatgttatt
481 gacctcctga ccggagagaa gcagcagact ttgtcatcgg cctttgcaga tagtctctgc
541 ccatcaacct ctcttctgta tcttgggcga acagaataca ccatcaccat gtacgacacc
601 aaaacccgag agctccggtg gaatgccacc tactttgact atgcggcctc actgcctgag
661 gacgaagggg actacaagat gtcccacttt gtgtccaatg gtgatgggct ggtggtgact
721 gtggacagtg aatctgggga cgtcctgtgg atccaaaact acgcctcccc tgtggtggcc
781 ttttatgtct ggcagcggga gggtctgagg aaggtgatgc acatcaatgt cgctgtggag
841 accctgcgct atctgacctt catgtctggg gaggtggggc gcatcacaaa gtggaagtac
901 ccgttcccca aggagacaga ggccaagagc aagctgacgc ccactctgta tgttgggaaa
961 tactctacca gcctctatgc ctctccctca atggtacacg agggggttgc tgtcgtgccc
1021 cgcggcagca cacttccttt gctggaaggg ccccagactg atggcgtcac catcggggac
1081 aagggggagt gtgtgatcac gcccagcacg gacgtcaagt ttgatcccgg actcaaaagc
1141 aagaacaagc tcaactactt gaggaattac tggcttctga taggacacca tgaaacccca
1201 ctgtctgcgt ctaccaagat gctggagaga tttcccaaca atctacccaa acatcgggaa
1261 aatgtgattc ctgctgattc agagaaaaag agctttgagg aagttatcaa cctggttgac
1321 cagacttcag aaaacgcacc taccaccgtg tctcgggatg tggaggagaa gcccgcccat
1381 gcccctgccc ggcccgaggc ccccgtggac tccatgctta aggacatggc taccatcatc
1441 ctgagcacct tcctgctgat tggctgggtg gccttcatca tcacctatcc cctgagcatg
1501 catcagcagc agcagctcca gcaccagcag ttccagaagg aactggagaa gatccagctc
1561 ctgcagcagc agcagcagca gctgcccttc cacccacctg gagacacggc tcaggacggc
1621 gagctcctgg acacgtctgg cccgtactca gagagctcgg gcaccagcag ccccagcacg
1681 tcccccaggg cctccaacca ctcgctctgc tccggcagct ctgcctccaa ggctggcagc
1741 agcccctccc tggaacaaga cgatggagat gaggaaacca gcgtggtgat agttgggaaa
1801 atttccttct gtcccaagga tgtcctgggc catggagctg agggcacaat tgtgtaccgg
1861 ggcatgtttg acaaccgcga cgtggccgtg aagaggatcc tccccgagtg ttttagcttc
1921 gcagaccgtg aggtccagct gttgcgagaa tcggatgagc acccgaacgt gatccgctac
1981 ttctgcacgg agaaggaccg gcaattccag tacattgcca tcgagctgtg tgcagccacc
2041 ctgcaagagt atgtggagca gaaggacttt gcgcatctcg gcctggagcc catcaccttg
2101 ctgcagcaga ccacctcggg cctggcccac ctccactccc tcaacatcgt tcacagagac
2161 ctaaagccac acaacatcct catatccatg cccaatgcac acggcaagat caaggccatg
2221 atctccgact ttggcctctg caagaagctg gcagtgggca gacacagttt cagccgccga
2281 tctggggtgc ctggcacaga aggctggatc gctccagaga tgctgagcga agactgtaag
2341 gagaacccta cctacacggt ggacatcttt tctgcaggct gcgtctttta ctacgtggtc
2401 tctgagggca gccacccttt tggcaagtcc ctgcagcggc aggccaacat cctcctgggt
2461 gcctgcagcc ttgactgctt gcacccagag aagcacgaag acgtcattgc acgagaattg
2521 atagagaaga tgattgcgat ggatcctcag aaacgcccct cagcgaacga cgtgctcaaa
2581 cacccgttct tctggagcct agagaagcag ctccagttct tccaggacgt gagcgacaga
2641 atagaaaagg aatccctgga tggcccgatc gtgaagcagt tagagagagg cgggagagcc
2701 gtggtgaaga tggactggcg ggagaacatc actgaccccc tccagacaga cctgcgtaaa
2761 ttcaggacct ataaaggtgg ttctgtcaga gatctcctcc gagccatgag aaataagaag
2821 caccactacc gggagctgcc tgcagaggtg cgggagacgc tggggaccct ccccgacgac
2881 ttcgtgtgct acttcacgtc tcgcttcccc cacctcctcg cacacaccta ccgggccatg
2941 gagctgtgca gccacgagag actcttccag ccctactact tccacgagcc cccagagccc
3001 cagcccccag tgactccaga cgccctctga gcgagggcgg cccctctgtt ctggtggccc
3061 cagctgtgac tgagggcctg gtcaccacaa ttagagcttg atgcctcccg gctttgcagg
3121 gagaccaggc ttcccaaacc aagtgccttg agctgcctgc tctgcagccc acagaggaca
3181 gtgctgaccc caggaagtgg gagaagtggc ccctcgtgac ctacagggaa ctgggaagat
3241 gctggcccca aaagccttac ggtcatgatg tctgcaaagg agggcctcag agacagcgcg
3301 agtagcaccc ccagccatct actggataaa cttgcttcag actttttaaa ttcctgctta
3361 atgtcagtct acaggccttt caggaaggga gaggagggaa tcgtacattt tgcttgcgtg
3421 ctgggacagc taggctgaga tgcaccaagt acagccttca ctggagaccg gaattgagag
3481 gtgggggatg ctgaggaggg ggaggacgga gttcagaggg tgtcgtcctg cagtatgaga
3541 tttctcattg atcacagatg tgcccagagt agcccaggtc actgttaact agtgtttctg
3601 cagaggcagc aggagccagc ccggaattc
//