LOCUS       AF055636                2254 bp    mRNA    linear   HUM 01-JAN-1999
DEFINITION  Homo sapiens leucine-rich glioma-inactivated protein precursor
            (LGI1) mRNA, complete cds.
ACCESSION   AF055636
VERSION     AF055636.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Chernova,O.B., Somerville,R.P. and Cowell,J.K.
  TITLE     A novel gene, LGI1, from 10q24 is rearranged and downregulated in
            malignant brain tumors
  JOURNAL   Oncogene 17 (22), 2873-2881 (1998)
   PUBMED   9879993
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Chernova,O.B. and Cowell,J.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAR-1998) Neurosciences, Cleveland Clinic Foundation,
            9500 Euclid Ave, Cleveland, OH 44195, USA
FEATURES             Location/Qualifiers
     source          1..2254
                     /db_xref="H-InvDB:HIT000064667"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24"
                     /tissue_type="brain"
                     /dev_stage="fetus"
     gene            1..2254
                     /gene="LGI1"
     CDS             225..1898
                     /gene="LGI1"
                     /codon_start=1
                     /product="leucine-rich glioma-inactivated protein
                     precursor"
                     /protein_id="AAC99316.1"
                     /translation="MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPA
                     VCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNS
                     FDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK
                     GLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKD
                     FDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD
                     NITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPND
                     IETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQ
                     TLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTR
                     FIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEK
                     AKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA"
     sig_peptide     225..326
                     /gene="LGI1"
     mat_peptide     327..1895
                     /gene="LGI1"
                     /product="leucine-rich glioma-inactivated protein"
     misc_feature    498..569
                     /gene="LGI1"
                     /note="predicted to encode Leucine-rich repeat 1; LPR1"
     misc_feature    570..641
                     /gene="LGI1"
                     /note="predicted to encode Leucine-rich repeat 2; LPR2"
     misc_feature    642..713
                     /gene="LGI1"
                     /note="predicted to encode Leucine-rich repeat 3; LPR3"
     misc_feature    714..749
                     /gene="LGI1"
                     /note="predicted to encode half of Leucine-rich repeat 4;
                     LPR4"
     misc_feature    846..1151
                     /gene="LGI1"
                     /note="predicted to encode putative transmembrane region"
BASE COUNT          689 a          476 c          431 g          658 t
ORIGIN      
        1 gatccctccc atctcacagt acctcacagg tctcttcccc cgagcagtgc attgctggag
       61 cgaggagaag ctcacgaatc agctgcaggt ctctgttttg aaaaagcaga gatacagagg
      121 cagaggaaag gggtggactc ctatgtgacc tgttcttaga gcaagacaat caccatctga
      181 attccagaag ccctgttcat ggttggggat attttctcga ctgcatggaa tcagaaagaa
      241 gcaaaaggat gggaaatgcc tgcattcccc tgaaaagaat tgcttatttc ctatgtctct
      301 tatctgcgct tttgctgact gaggggaaga aaccagcgaa gccaaaatgc cctgccgtgt
      361 gtacttgtac caaagataat gctttatgtg agaatgccag atccattcca cgcaccgttc
      421 ctcctgatgt tatctcatta tcctttgtga gatctggttt tactgaaatc tcagaaggga
      481 gttttttatt cacgccatcg ctgcagctct tgttattcac atcgaactcc tttgatgtga
      541 tcagtgatga tgcttttatt ggtcttccac atctagagta tttattcata gaaaacaaca
      601 acatcaagtc aatttcaaga catactttcc ggggactaaa gtcattaatt cacttgagcc
      661 ttgcaaacaa caatctccag acactcccaa aagatatttt caaaggcctg gattctttaa
      721 caaatgtgga cctgaggggt aattcattta attgtgactg taaactgaaa tggctagtgg
      781 aatggcttgg ccacaccaat gcaactgttg aagacatcta ctgcgaaggc cccccagaat
      841 acaagaagcg caaaatcaat agtctctcct cgaaggattt cgattgcatc attacagaat
      901 ttgcaaagtc tcaagacctg ccttatcaat cattgtccat agacactttt tcttatttga
      961 atgatgagta tgtagtcatc gctcagcctt ttactggaaa atgcattttc cttgaatggg
     1021 accatgtgga aaagaccttc cggaattatg acaacattac aggcacatcc actgtagtat
     1081 gcaagcctat agtcattgaa actcagctct atgttattgt ggcccagctg tttggtggct
     1141 ctcacatcta taagcgagac agttttgcaa ataaattcat aaaaatccag gatattgaaa
     1201 ttctcaaaat ccgaaaaccc aatgacattg aaacattcaa gattgaaaac aactggtact
     1261 ttgttgttgc tgacagttca aaagctggtt ttactaccat ttacaaatgg aacggaaacg
     1321 gattctactc ccatcaatcc ttacacgcgt ggtacaggga cactgatgtg gaatatctag
     1381 aaatagtcag aacacctcag acactcagaa cgcctcattt aattctgtct agtagttccc
     1441 agcgtcctgt aatttatcag tggaacaaag caacacaatt attcactaac caaactgaca
     1501 ttcctaacat ggaggatgtg tacgcagtga agcacttctc agtgaaaggg gacgtgtaca
     1561 tttgcttgac aagattcatt ggtgattcca aagtcatgaa atggggaggc tcctcgttcc
     1621 aggatattca gaggatgcca tcgcgaggat ccatggtgtt ccagcctctt caaataaata
     1681 attaccaata tgcaattctt ggaagtgatt actcctttac tcaagtgtat aactgggatg
     1741 cagagaaagc caaatttgtg aaatttcagg aattaaatgt tcaggcacca agatcattca
     1801 cacatgtgtc cattaataag cgtaattttc tttttgcttc cagttttaag ggaaatacac
     1861 agatttacaa acatgtcata gttgacttaa gcgcatgaga caccaaattc tgtggctgcc
     1921 atcagaaatt ttctacagta catgacccgg atgaactcaa tgcatgatga ctcttcttat
     1981 cacacttgca aatgaatgcc tttcaaacat tgagactgct agaaccaagc actaccagta
     2041 tctccatcct taactgtcca gtccagtgat gtgggaagtt accttttata agacaaaatt
     2101 taattgtgta actgttcttt gcagtgaaga tgtgtaaata agcgtttaat ggtatctgtt
     2161 actccaaaaa gaaatattaa tatgtacttt tccatttatt tattcatgtg tacagaaaca
     2221 actgccaaat aaaatgttta cattttcttt cata
//