LOCUS AF055585 5233 bp mRNA linear HUM 04-MAR-1999
DEFINITION Homo sapiens neurogenic extracellular slit protein Slit2 mRNA,
complete cds.
ACCESSION AF055585
VERSION AF055585.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5233)
AUTHORS Holmes,G.P., Negus,K., Burridge,L., Raman,S., Algar,E., Yamada,T.
and Little,M.H.
TITLE Distinct but overlapping expression patterns of two vertebrate slit
homologs implies functional roles in CNS development and
organogenesis
JOURNAL Mech. Dev. 79 (1-2), 57-72 (1998)
PUBMED 10349621
REFERENCE 2 (bases 1 to 5233)
AUTHORS Holmes,G.P., Burridge,L., Negus,K., Raman,S. and Little,M.
TITLE Direct Submission
JOURNAL Submitted (25-MAR-1998) Center for Molecular and Cellular Biology,
University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia
FEATURES Location/Qualifiers
source 1..5233
/db_xref="H-InvDB:HIT000064665"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p16.3"
/tissue_type="kidney; brain"
/dev_stage="fetal"
CDS 557..5122
/note="leucine-rich repeat EGF-like repeat secreted
protein; similar to Drosophila neurogenic extracellular
slit protein; expressed in developing CNS, limbs and
metanephros"
/codon_start=1
/product="neurogenic extracellular slit protein Slit2"
/protein_id="AAD04309.1"
/translation="MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGL
ALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDL
KELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDY
NQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLA
WLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAA
CTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNN
QISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF
QDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPI
ETSGARCTSPRRLANKRIGQIKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTT
VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIE
EGAFEGASGVNEILLTSNRLENVQHKMFKGLEKPQNLMLRSNRITCVGNDSFIGLSSV
RMLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPR
CQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVL
PKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTL
ILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCD
CNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPC
LSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEED
GFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLD
FCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN
GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGE
KCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYR
GRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQ
STLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTG
ILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL
PINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTG
DSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKY
SFECTDGSSFVDEVEKVVKCGCTRCVS"
misc_feature 638..730
/note="Region: amino-flanking"
misc_feature 734..766
/note="Region: leucine-rich region 1-1"
misc_feature 779..838
/note="Region: leucine-rich region 1-2"
misc_feature 851..907
/note="Region: leucine-rich region 1-3"
misc_feature 923..982
/note="Region: leucine-rich region 1-4"
misc_feature 995..1054
/note="Region: leucine-rich region 1-5"
misc_feature 1067..1126
/note="Region: leucine-rich region 1-6"
misc_feature 1139..1174
/note="Region: leucine-rich region 1-7"
misc_feature 1181..1372
/note="Region: carboxy-flanking"
misc_feature 1373..1465
/note="Region: amino-flanking"
misc_feature 1469..1501
/note="Region: leucine-rich region 2-1"
misc_feature 1514..1573
/note="Region: leucine-rich region 2-2"
misc_feature 1586..1645
/note="Region: leucine-rich region 2-3"
misc_feature 1658..1717
/note="Region: leucine-rich region 2-4"
misc_feature 1730..1789
/note="Region: leucine-rich region 2-5"
misc_feature 1802..1837
/note="Region: leucine-rich region 2-6"
misc_feature 1844..2047
/note="Region: carboxy-flanking"
misc_feature 2048..2140
/note="Region: amino-flanking"
misc_feature 2144..2176
/note="Region: leucine-rich region 3-1"
misc_feature 2192..2251
/note="Region: leucine-rich region 3-1A"
misc_feature 2264..2323
/note="Region: leucine-rich region 3-2"
misc_feature 2336..2395
/note="Region: leucine-rich region 3-3"
misc_feature 2408..2467
/note="Region: leucine-rich region 3-4"
misc_feature 2480..2515
/note="Region: leucine-rich region 3-5"
misc_feature 2522..2710
/note="Region: carboxy-flanking"
misc_feature 2711..2803
/note="Region: amino-flanking"
misc_feature 2807..2839
/note="Region: leucine-rich region 4-1"
misc_feature 2849..2908
/note="Region: leucine-rich region 4-2"
misc_feature 2921..2980
/note="Region: leucine-rich region 4-3"
misc_feature 2993..3052
/note="Region: leucine-rich region 4-4"
misc_feature 3065..3100
/note="Region: leucine-rich region 4-5"
misc_feature 3107..3280
/note="Region: carboxy-flanking"
misc_feature 3284..3397
/note="Region: EGF-like repeat 1"
misc_feature 3401..3520
/note="Region: EGF-like repeat 2"
misc_feature 3524..3634
/note="Region: EGF-like repeat 3"
misc_feature 3638..3754
/note="Region: EGF-like repeat 4"
misc_feature 3758..3868
/note="Region: EGF-like repeat 5"
misc_feature 3893..4003
/note="Region: EGF-like repeat 6"
misc_feature 4520..4636
/note="Region: EGF-like repeat 6A"
misc_feature 4643..4753
/note="Region: EGF-like repeat 7"
misc_feature 4766..4876
/note="Region: EGF-like repeat 8"
misc_feature 4976..5119
/note="Region: CTC knot"
BASE COUNT 1393 a 1253 c 1264 g 1322 t
ORIGIN
1 tgccccgcgc gctctgctac gggcccgctg ggcctccgcg ccttctagct tccggagccc
61 actttgatcg gggccataat acctattgag atcccctctt ctgtcttgta ccttcgccac
121 tggcatcgga tttgcagaag cctgcgtggg atcagaggac cgccctcccc acaacaaccg
181 gcccctgcat cttagcagcc gttggaagcc ccagctcttt taccgccaag ttcatccttg
241 ggagacagaa gacgcgtgat ctcctctccg ctgctcttgg ggtctccttg cagccctggc
301 caggcggatt catcctcagg acctaaagtt gcccaaggag ctcctgctct gccanaggag
361 ggtggaaagg gcggtgggag gcgtgtgcct gagtgggctc tactgccttg ttccatatta
421 ttttgtgcac attttccctg gcactctggg ttgctagccc cgccgggcac tgggcctcag
481 acactgcgcg gttccctcgg agcagcaagc taaagaaagc ccccagtgcc ggcgaggaag
541 gaggcggcgg ggaaagatgc gcggcgttgg ctggcagatg ctgtccctgt cgctggggtt
601 agtgctggcg atcctgaaca aggtggcacc gcaggcgtgc ccggcgcagt gctcttgctc
661 gggcagcaca gtggactgtc acgggctggc gctgcgcagc gtgcccagga atatcccccg
721 caacaccgag agactggatt taaatggaaa taacatcaca agaattacga agacagattt
781 tgctggtctt agacatctaa gagttcttca gcttatggag aataagatta gcaccattga
841 aagaggagca ttccaggatc ttaaagaact agagagactg cgtttaaaca gaaatcacct
901 tcagctgttt cctgagttgc tgtttcttgg gactgcgaag ctatacaggc ttgatctcag
961 tgaaaaccaa attcaggcaa tcccaaggaa agctttccgt ggggcagttg acataaaaaa
1021 tttgcaactg gattacaacc agatcagctg tattgaagat ggggcattca gggctctccg
1081 ggacctggaa gtgctcactc tcaacaataa caacattact agactttctg tggcaagttt
1141 caaccatatg cctaaactta ggacttttcg actgcattca aacaacctgt attgtgactg
1201 ccacctggcc tggctctccg actggcttcg ccaaaggcct cgggttggtc tgtacactca
1261 gtgtatgggc ccctcccacc tgagaggcca taatgtagcc gaggttcaaa aacgagaatt
1321 tgtctgcagt ggtcaccagt catttatggc tccttcttgt agtgttttgc actgccctgc
1381 cgcctgtacc tgtagcaaca atatcgtaga ctgtcgtggg aaaggtctca ctgagatccc
1441 cacaaatctt ccagagacca tcacagaaat acgtttggaa cagaacacaa tcaaagtcat
1501 ccctcctgga gctttctcac catataaaaa gcttagacga attgacctga gcaataatca
1561 gatctctgaa cttgcaccag atgctttcca aggactacgc tctctgaatt cacttgtcct
1621 ctatggaaat aaaatcacag aactccccaa aagtttattt gaaggactgt tttccttaca
1681 gctcctatta ttgaatgcca acaagataaa ctgccttcgg gtagatgctt ttcaggatct
1741 ccacaacttg aaccttctct ccctatatga caacaagctt cagaccatcg ccaaggggac
1801 cttttcacct cttcgggcca ttcaaactat gcatttggcc cagaacccct ttatttgtga
1861 ctgccatctc aagtggctag cggattatct ccataccaac ccgattgaga ccagtggtgc
1921 ccgttgcacc agcccccgcc gcctggcaaa caaaagaatt ggacagatca aaagcaagaa
1981 attccgttgt tcaggtacag aagattatcg atcaaaatta agtggagact gctttgcgga
2041 tctggcttgc cctgaaaagt gtcgctgtga aggaaccaca gtagattgct ctaatcaaaa
2101 gctcaacaaa atcccggagc acattcccca gtacactgca gagttgcgtc tcaataataa
2161 tgaatttacc gtgttggaag ccacaggaat ctttaagaaa cttcctcaat tacgtaaaat
2221 aaactttagc aacaataaga tcacagatat tgaggaggga gcatttgaag gagcatctgg
2281 tgtaaatgaa atacttctta cgagtaatcg tttggaaaat gtgcagcata agatgttcaa
2341 gggattggaa aagcctcaaa acttgatgtt gagaagcaat cgaataacct gtgtggggaa
2401 tgacagtttc ataggactca gttctgtgcg tatgctttct ttgtatgata atcaaattac
2461 tacagttgca ccaggggcat ttgatactct ccattcttta tctactctaa acctcttggc
2521 caatcctttt aactgtaact gctacctggc ttggttggga gagtggctga gaaagaagag
2581 aattgtcacg ggaaatccta gatgtcaaaa accatacttc ctgaaagaaa tacccatcca
2641 ggatgtggcc attcaggact tcacttgtga tgacggaaat gatgacaata gttgctcccc
2701 actttctcgc tgtcctactg aatgtacttg cttggataca gtcgtccgat gtagcaacaa
2761 gggtttgaag gtcttgccga aaggtattcc aagagatgtc acagagttgt atctggatgg
2821 aaaccaattt acactggttc ccaaggaact ctccaactac aaacatttaa cacttataga
2881 cttaagtaac aacagaataa gcacgctttc taatcagagc ttcagcaaca tgacccagct
2941 cctcacctta attcttagtt acaaccgtct gagatgtatt cctcctcgca cctttgatgg
3001 attaaagtct cttcgattac tttctctaca tggaaatgac atttctgttg tgcctgaagg
3061 tgctttcaat gatctttctg cattatcaca tctagcaatt ggagccaacc ctctttactg
3121 tgattgtaac atgcagtggt tatccgactg ggtgaagtcg gaatataagg agcctggaat
3181 tgctcgttgt gctggtcctg gagaaatggc agataaactt ttactcacaa ctccctccaa
3241 aaaatttacc tgtcaaggtc ctgtggatgt caatattcta gctaagtgta acccctgcct
3301 atcaaatccg tgtaaaaatg atggcacatg taatagtgat ccagttgact tttaccgatg
3361 cacctgtcca tatggtttca aggggcagga ctgtgatgtc ccaattcatg cctgcatcag
3421 taacccatgt aaacatggag gaacttgcca cttaaaggaa ggagaagaag atggattctg
3481 gtgtatttgt gctgatggat ttgaaggaga aaattgtgaa gtcaacgttg atgattgtga
3541 agataatgac tgtgaaaata attctacatg tgtcgatggc attaataact acacatgcct
3601 ttgcccacct gagtatacag gtgagttgtg tgaggagaag ctggacttct gtgcccagga
3661 cctgaacccc tgccagcacg attcaaagtg catcctaact ccaaagggat tcaaatgtga
3721 ctgcacacca gggtacgtag gtgaacactg cgacatcgat tttgacgact gccaagacaa
3781 caagtgtaaa aacggagccc actgcacaga tgcagtgaac ggctatacgt gcatatgccc
3841 cgaaggttac agtggcttgt tctgtgagtt ttctccaccc atggtcctcc ctcgtaccag
3901 cccctgtgat aattttgatt gtcagaatgg agctcagtgt atcgtcagaa taaatgagcc
3961 aatatgtcag tgtttgcctg gctatcaggg agaaaagtgt gaaaaattgg ttagtgtgaa
4021 ttttataaac aaagagtctt atcttcagat tccttcagcc aaggttcggc ctcagacgaa
4081 cataacactt cagattgcca cagatgaaga cagcggaatc ctcctgtata agggtgacaa
4141 agaccatatc gcggtagaac tctatcgggg gcgtgttcgt gccagctatg acaccggctc
4201 tcatccagct tctgccattt acagtgtgga gacaatcaat gatggaaact tccacattgt
4261 ggaactactt gccttggatc agagtctctc tttgtccgtg gatggtggga accccaaaat
4321 catcactaac ttgtcaaagc agtccactct gaattttgac tctccactct atgtaggagg
4381 catgccaggg aagagtaacg tggcatctct gcgccaggcc cctgggcaga acggaaccag
4441 cttccacggc tgcatccgga acctttacat caacagtgag ctgcaggact tccagaaggt
4501 gccgatgcaa acaggcattt tgcctggctg tgagccatgc cacaagaagg tgtgtgccca
4561 tggcacatgc cagcccagca gccaggcagg cttcacctgc gagtgccagg aaggatggat
4621 ggggcccctc tgtgaccaac ggaccaatga cccttgcctt ggaaataaat gcgtacatgg
4681 cacctgcttg cccatcaatg cgttctccta cagctgtaag tgcttggagg gccatggagg
4741 tgtcctctgt gatgaagagg aggatctgtt taacccatgc caggcgatca agtgcaagca
4801 tgggaagtgc aggctttcag gtctggggca gccctactgt gaatgcagca gtggatacac
4861 gggggacagc tgtgatcgag aaatctcttg tcgaggggaa aggataagag attattacca
4921 aaagcagcag ggctatgctg cttgccaaac aaccaagaag gtgtcccgat tagagtgcag
4981 aggtgggtgt gcaggagggc agtgctgtgg accgctgagg agcaagcggc ggaaatactc
5041 tttcgaatgc actgacggct cctcctttgt ggacgaggtt gagaaagtgg tgaagtgcgg
5101 ctgtacgagg tgtgtgtcct aaacacactc ccggcagctc tgtctttgga aaaggttgta
5161 tacttcttga ccatgtggga ctaatgaatg cttcatagtg gaaatatttg aaatatattg
5221 taaaatacag aac
//