LOCUS AF054589 4152 bp mRNA linear HUM 01-MAR-2000
DEFINITION Homo sapiens HIC protein isoform p40 and HIC protein isoform p32
mRNAs, complete cds.
ACCESSION AF054589
VERSION AF054589.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4152)
AUTHORS Thebault,S., Gachon,F., Lemasson,I., Devaux,C. and Mesnard,J.M.
TITLE Molecular cloning of a novel human I-mfa domain-containing protein
that differently regulates human T-cell leukemia virus type I and
HIV-1 expression
JOURNAL J. Biol. Chem. 275 (7), 4848-4857 (2000)
PUBMED 10671520
REFERENCE 2 (bases 1 to 4152)
AUTHORS Thebault,S., Lemasson,I., Devaux,C. and Mesnard,J.M.
TITLE Direct Submission
JOURNAL Submitted (18-MAR-1998) Laboratoire Infections Retrovirales et
Signalisation Cellulaire, Institut de Biologie, 4 boulevard Henri
IV, Montpellier 34060, France
REFERENCE 3 (bases 1 to 4152)
AUTHORS Thebault,S., Lemasson,I., Devaux,C. and Mesnard,J.M.
TITLE Direct Submission
JOURNAL Submitted (18-AUG-1998) Laboratoire Infections Retrovirales et
Signalisation Cellulaire, Institut de Biologie, 4 boulevard Henri
IV, Montpellier 34060, France
REMARK Sequence update by submitter
COMMENT On Aug 19, 1998 this sequence version replaced gi:3135480.
FEATURES Location/Qualifiers
source 1..4152
/db_xref="H-InvDB:HIT000064552"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="MT2"
/cell_type="T-cell"
/note="transformed by human T-cell leukemia virus type I"
CDS 264..1331
/note="regulated at the translational level; contains
I-mfa domain; untilizes unique GTG start codon"
/codon_start=1
/transl_except=(pos:264..266,aa:Met)
/product="HIC protein isoform p40"
/protein_id="AAF36999.1"
/translation="MRGVRAATAAAVAATAASGLSRREAGGRAGAAAAVVRPPGRKCG
RCRRLANFPGRKRRRRRRKGLGATTGGCGEAVSSLHPAPHSPSSVRPAGRRARRQRRG
AGSAERPMSGAGEALAPGPVGPQRVAEAGGGQLGSTAQGKCDKDNTEKDITQATNSHF
THGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIGKIKNGHTGLSNGNGI
HHGAKHGSADNRKLSAPVSQKMHRKIQSSLSVNSDISKKSKVNAVFSQKTGSSPEDCC
VHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCNCPCDMDCGIMDA
CCESSDCLEICMECCGICFPS"
CDS 591..1331
/note="regulated at the translational level; contains
I-mfa domain"
/codon_start=1
/product="HIC protein isoform p32"
/protein_id="AAF36998.1"
/translation="MSGAGEALAPGPVGPQRVAEAGGGQLGSTAQGKCDKDNTEKDIT
QATNSHFTHGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIGKIKNGHTG
LSNGNGIHHGAKHGSADNRKLSAPVSQKMHRKIQSSLSVNSDISKKSKVNAVFSQKTG
SSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCNCPCDM
DCGIMDACCESSDCLEICMECCGICFPS"
BASE COUNT 1240 a 789 c 922 g 1201 t
ORIGIN
1 cccaggccgg ctctggcctc ctgacccaga cagcgcaggg cgcgagggat cgcgcggccg
61 agcccgggtc gcgccgctcc cagcatcggg gccgctagcc aagagttcga ggccttcccg
121 atccggatgt gatgaaaaag agcaacagag ggagaagtgt ttcaggattg taggagtgga
181 agaggggaaa gagaggcaga gagggggaag gccccctcgc aggggagccg gctggagtga
241 gctggctgga aagagggggc ggagtgcgcg gagtcagagc cgccaccgct gccgcagttg
301 ccgccactgc ggcgtctggg ctgagccgga gggaggcggg aggacgcgca ggggcggccg
361 ccgccgtcgt caggccaccg gggcgaaaat gcggccgctg ccggaggctc gctaactttc
421 cggggcggaa gaggaggagg aggaggagga aggggcttgg agcgactacg gggggatgcg
481 gagaagcagt cagttccctg cacccagcac ctcacagccc ttcctccgtg cgccctgccg
541 ggcggcgagc taggcggcag cggcgcggcg cgggctcggc ggagcggccc atgtccggcg
601 cgggcgaagc cctcgctccc gggcccgtgg ggccgcagcg cgtggccgag gcgggcggcg
661 gccagctggg ctccacagcc cagggaaaat gtgataaaga caatactgag aaagatataa
721 ctcaagctac caatagccac ttcacacatg gagagatgca agaccagtcc atttggggaa
781 atccttcgga tggtgaactc attagaaccc aacctcagcg cttgcctcag cttcagactt
841 cagcacaggt gccaagtggt gaggaaatag gcaagataaa gaacggccac acaggtctga
901 gcaatggaaa tggaattcac cacggggcca aacacggatc cgcagataat cgcaaacttt
961 cagcacctgt ttctcaaaaa atgcatagaa aaattcagtc cagcttgtct gtaaacagcg
1021 atatcagtaa gaagagcaaa gtaaatgctg tcttttccca aaagacaggc tcttcacctg
1081 aagattgttg tgtccactgt atcctggctt gcttgttctg cgaattcctg accctttgca
1141 acattgtcct gggacaagcg tcatgtggca tctgcacctc agaagcctgc tgctgttgct
1201 gtggtgacga gatgggggat gattgtaact gcccttgtga tatggactgt ggcatcatgg
1261 atgcctgttg tgaatcatca gactgcttgg aaatctgtat ggaatgctgt ggaatttgtt
1321 ttccttcata aatatttatc ttttgtttgt gttaaaactg gagagtgttt aaaaatttcc
1381 ttttgggggg aagaaaagca cattgtaaga ttctcatgaa acaacatgga atttgcactg
1441 ttaactcatt attgtaagta atctctgaaa gcctttttac tttaaccaaa tctacatggt
1501 ttaatatgtg aaattttaac tactttaact agttttataa atttcttaat atgttacaat
1561 aacttaggga cattttgaca ccccccttcc caaatgttaa atgccttctc ctttttaccg
1621 atatttctgt ttcttttaac cgttctcagg agcactttgc tccaaatata ttatttttca
1681 gtgtgtattt aaacgaggca gtttattttg atatgtatct attcatgatt gaaaggaagc
1741 agtcttggcc aggcacggtg gcttacacct gtaaccctgg cattttggga ggccaaggtg
1801 ggcagattgc ctgagctcag gagttcgaga ccagccaggg caacatggtg aaaccccatc
1861 tctactaaaa tacaaaaagt tagctgggct tggcggtgtg cgcctgtagt cccagctact
1921 caggaggctg aggcaggaga attgcttgaa cccgagaggc ggaagttgca gtgagccgag
1981 attgtgccac tgaactccaa cctgcactcc agcctgggca acagagcgag actccatctc
2041 taaataaata aataaataaa taaataaata aataaataaa taaataaaca aaccagtctt
2101 tattttaaaa gaaactttag gaaacaaacc cacataatag ttgggaacca gtgttgatct
2161 ctctccctta ccttctccac ttgttcaaca gactctgaat gccgactgtg tggactctct
2221 tcctcagact gtggggacag atacaattcc actcctgtcc acaggaacat gagatttagc
2281 agactaagga gatctgtaaa gaatgaacca taccacaagg catactgaag tgaggattat
2341 aagagaaata aactcaaaat gctgttggaa tatgcagaga attgctacca gaatattcag
2401 taaggtttca gggagaatgt ggcatttgag gactctctta gaatgagtga ttcacctgct
2461 atttaaatga attatttaga tttttgacaa agatttaggt ggacacccta aactgtgtgt
2521 gcctttaacc agttaaaaga acagtgcctt cagcatactt ttttattagt tgtaggaata
2581 cagctttttg aaaaagctat aaagtttaaa ttaactaaaa atatgcattt tcttacacat
2641 aatttaaatg ttatcatact tttttgatga aaacataatg ccttagtaaa atagctctat
2701 ttaataaaga agattgagta ctctgacaca tttcatttaa attaggaaat ttttaatatt
2761 aaaatcccag tgttctgagt tattgaaagg ctttctttta ttttgagagc tttaggtctt
2821 tttgggatga gaacatttta gttgtttagt ttgtttctta agcagtgcta ttttttgtaa
2881 acacagataa atggaaacca ttcttttcaa tgcagaagaa atctagatat cccctactgt
2941 gaccaaattt ctgtattacg attttatgtt aaattaaact aatatggcag gttataatga
3001 tccttaagtg taaagaaatc agtcaattac aagagtaatt gtatagttat tgagacctat
3061 agtgtgtggc ttagatgaaa gggagagtaa attttcatac catgctctct cctactcagt
3121 ttgatctctc taaaattgta gtttggtttg atttaatata attcttagta gaaattttga
3181 aagtatgctt tgggattaat aattattttt aatttttctg gctgaatatc aaattgatag
3241 taacaacaga agcataattt taggaaggct ttcgcaaacc tagcctttta agagaggttt
3301 ttaacctgaa gcatgagaat atatcacctg tggtttttcc tttgagatga aacgtagttt
3361 ctagttatat cattacttaa agggcttaaa aagaaaaaac ttagcaaact tttgaatctt
3421 tcttttattg ctatttacac atacatacac acatacaaaa cctttaaatt ttgggatctg
3481 aatataattc tggtaaacag ctgtcttcat ttttctcctc taaagaactt aattcatttg
3541 ttacataaaa tataaggaaa tctttatact attttacagt aaccacaatc taaatattta
3601 catataccca aaattaactt atgctcatat attaggatgt gagaatatca tctgtttatg
3661 gacacatgaa acctcctaat gacctggaat tgttagaata tttgactttt tatatgcaaa
3721 gtttttcaac caagtggttt gtctaatatt taaacatgta ctggcacaat ttgtgatgaa
3781 aatattagca catttgcaat aatgtttctc cataacagag aatgttaatg gataccagaa
3841 ttttattttt gtatttatgt tcatagtact tttcctcttg tctactccag acagttattc
3901 cataaagcat ttgtataatt aaaaggaaaa cagaaaaagg aaaagtaggc aaatgtgaaa
3961 atagtttcaa tatatcttat gatttcttaa tgtaaaatgt tttgttgaag tatatggcta
4021 tcatgactaa gtgctagaat ttatagttac aggcggtgtc cttttaaatg tggaaaggct
4081 tttaaaatat tttaaaactg gacctgtatt atcctgaata cactattttg aaaattttta
4141 agaaaaaaaa aa
//